Aklief

Acne Vulgaris
Treatment
19 Active Studies for Aklief

What is Aklief

TrifaroteneThe Generic name of this drug
Treatment SummaryTrifarotene is a cream used to treat acne. It was approved for use in the United States in 2019 and is part of a class of medications related to vitamin A. It is known as a fourth-generation retinoid due to its selectivity, which provides better results and fewer side effects than other older retinoids.
Akliefis the brand name
image of different drug pills on a surface
Aklief Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Aklief
Trifarotene
2019
1

Effectiveness

How Aklief Affects PatientsTrifarotene works by activating certain receptors that help change how certain genes are read, which can reduce acne. It may cause skin irritation and should not be used on cuts or damaged skin. It can also make skin more sensitive to sunlight, so people taking it should be careful to wear sunscreen and protective clothing when out in the sun.
How Aklief works in the bodyTrifarotene is a special type of medicine that works by activating a receptor in the skin cells called the retinoic acid receptor-gamma (RAR-γ). This activation helps the skin to heal and reduce inflammation. It also helps to control how skin cells grow and how they respond to stress. Trifarotene appears to have effects on other pathways in the skin, such as hydration and cell adhesion, that are not observed with other retinoid medicines.

When to interrupt dosage

The encouraged dosage of Aklief is contingent upon the specified situation. The amount of dosage likewise fluctuates as per the technique of delivery (e.g. Cream or Cream - Topical) featured in the table beneath.
Condition
Dosage
Administration
Acne Vulgaris
, 0.00005 mg/mg
Topical, Cream, Cream - Topical,

Warnings

Common Aklief Drug Interactions
Drug Name
Risk Level
Description
Aklief Toxicity & Overdose RiskTrifarotene is safe to use at normal doses and does not appear to increase the risk of cancer. Even when given to mice at extremely high doses, it did not cause any carcinogenic effects. There is no available information on what would happen if someone were to overdose on trifarotene.
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Aklief Novel Uses: Which Conditions Have a Clinical Trial Featuring Aklief?

18 active clinical trials are examining the potential of Aklief to alleviate Acne symptoms.
Condition
Clinical Trials
Trial Phases
Acne Vulgaris
19 Actively Recruiting
Phase 4, Not Applicable, Phase 1, Phase 2, Early Phase 1, Phase 3

Aklief Reviews: What are patients saying about Aklief?

5Patient Review
4/29/2020
Aklief for Acne
I had cystic acne for years and tried many treatments with little success. Spironolactone 50 mg twice a day, Oxexton, RetinA Micro - you name it. But my dermatologist suggested I try Aklief 3 weeks ago, and today is the first day I can ever remember where I have zero zits. My face isn't as red, and there's no peeling like there was with RetinA Micro. So far, very happy with results!
4.7Patient Review
12/16/2021
Aklief for Acne
This cream has been amazing! I've been using it for about 5 weeks now, and my breakouts have completely stopped. It's great for mild acne too - just takes a bit longer to see results. The only downside is that it stings a bit when you first apply it, but that goes away within minutes.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about aklief

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What does Aklief do for the skin?

"Aklief Cream is an innovative retinoid topical cream that is proven safe and effective for acne on your face, shoulders, chest, and back. Aklief Cream works by removing dead skin cells from the surface to help unclog pores and prevents new acne from forming. Aklief Cream may also reduce inflammatory acne often experienced with pimples."

Answered by AI

Is there retinol in Aklief?

"The Aklief cream contains a molecule called trifarotene, which is the first new retinoid to hit the market in two decades. A retinoid is a type of compound that contains retinol, and is used in various skincare products."

Answered by AI

Does Aklief make acne worse?

"It is important to avoid using skin products with high alcohol content during your Aklief treatment, as this can irritate or dry your skin and make your acne worse."

Answered by AI

Is Aklief the same as tretinoin?

"Aklief is a retinoid acne treatment that is the first to be approved by the FDA in over 20 years."

Answered by AI

Clinical Trials for Aklief

Have you considered Aklief clinical trials? We made a collection of clinical trials featuring Aklief, we think they might fit your search criteria.
Have you considered Aklief clinical trials? We made a collection of clinical trials featuring Aklief, we think they might fit your search criteria.
Have you considered Aklief clinical trials? We made a collection of clinical trials featuring Aklief, we think they might fit your search criteria.