Adrenalin

Shock, Cardiogenic, Ventricular Fibrillation, Anaphylaxis + 39 more

Treatment

23 FDA approvals

20 Active Studies for Adrenalin

Treatment for

Shock, Cardiogenic

What is Adrenalin

Epinephrine

The Generic name of this drug

Treatment Summary

Epinephrine, also known as adrenaline, is a hormone and neurotransmitter produced by the adrenal glands. It is used as a drug to treat hypersensitivity reactions, respiratory distress, cardiac arrest, and croup. It is available in auto-injector form (EpiPen) and generic versions. It can be given intravenously, inhaled, nebulized, intramuscularly, or subcutaneously.

Medihaler-Epi

is the brand name

image of different drug pills on a surface

Adrenalin Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Medihaler-Epi

Epinephrine

1956

296

Approved as Treatment by the FDA

Epinephrine, also known as Medihaler-Epi, is approved by the FDA for 23 uses including Anesthesia procedures and Bleeding .

Anesthesia procedures

Bleeding

Angioedema

Dyspnea

Urticaria

anaphylaxis

Wheezing

chest tightness

Asthma

Angioneurotic Edema

Hemostasis

severe hypersensitivity

Idiopathic Anaphylaxis

Hemostatic function

Hemorrhage

Shortness of Breath

Respiratory Sounds

Hives

Shock, Cardiogenic

Syncope

Uterine Contractions

Helps manage Uterine Contractions

Delayed Hypersensitivity

Complete Heart Block

Effectiveness

How Adrenalin Affects Patients

Epinephrine is a drug that mimics the effects of the sympathetic nervous system. It increases heart rate, makes the heart muscle contract more forcefully, and triggers the release of a hormone called renin. It also opens up airways in the lungs, relaxes blood vessels, helps stop labor contractions, and increases the production of fluid in the eyes. In people with croup, nebulized epinephrine has been shown to reduce symptoms. Epinephrine can also help with itching, hives, swelling, and other symptoms of anaphylaxis. It can also relax the muscles of the stomach, intestine, uterus,

How Adrenalin works in the body

Epinephrine works on two types of receptors to help treat allergic reactions and other conditions. It tightens the blood vessels, which can help stop fluid loss, and it also relaxes the muscles in the airways, which can help make it easier to breathe. It also helps raise blood sugar levels and stimulates the liver to release stored sugar. In this way, epinephrine can reduce the symptoms of anaphylaxis and help bring relief.

When to interrupt dosage

The measure of Adrenalin is contingent upon the diagnosed condition, including Asthma, Angioneurotic Edema and Idiopathic Anaphylaxis. The amount also alters as per the method of administration featured in the table below.

Condition

Dosage

Administration

Ventricular Fibrillation

0.02 mg/mL, , 0.0091 mg/mL, 0.005 mg/mL, 0.01 mg/mL, 0.1 mg/mL, 1.0 mg/mL, 0.22 mg, 0.3 mg, 0.018 mg/mL, 3.0 mg/mL, 1.5 mg/mL, 0.005 mg, 0.01 mg, 0.02 mg, 0.0091 mg, 0.15 mg, 0.5 %, 1.0 mg, 3.5 %, 0.0001 mg/mg, 0.001 mg/mL, 0.009 mg/mL, 10.0 mg/mL, 0.182 mg, 0.00016 mg, 1.91 mg, 0.1 %, 1.0 mL, 120.0 mg/mL, 0.125 mg, 0.7 mg, 0.0125 mg/mL, 0.001 mg/mg, 0.036 mg/mL, 0.0204 mg/mL, 0.0407 mg/mL, 1.0 mL/mL, 5.0 mg/mL, 0.0182 mg/mL

Subcutaneous, , Injection, solution - Subcutaneous, Injection, solution, Dental; Infiltration, Injection, solution - Dental; Infiltration, Endotracheal; Intracardiac; Intravenous, Injection, solution - Endotracheal; Intracardiac; Intravenous, Intramuscular; Intravenous; Subcutaneous, Injection, solution - Intramuscular; Intravenous; Subcutaneous, Injection, solution - Intracardiac; Intramuscular; Intravenous; Subcutaneous, Injection, Parenteral, Injection - Parenteral, Respiratory (inhalation), Kit, Capsule, Injection - Subcutaneous, Injection, solution - Intravenous, Injection, solution - Infiltration; Perineural, Infiltration; Perineural, Epidural; Infiltration; Intracaudal; Perineural, Injection, solution - Epidural; Infiltration; Intracaudal; Perineural, Infiltration, Injection, solution - Infiltration, Intramuscular, Injection - Intramuscular, Intracardiac; Intravenous, Injection, solution - Intracardiac; Intravenous, Injection, solution - Epidural; Retrobulbar, Epidural; Retrobulbar, Injection, solution - Epidural; Intracaudal; Perineural, Epidural; Intracaudal; Perineural, Perineural, Injection, solution - Perineural, Dental, Injection, solution - Dental, Solution - Epidural; Infiltration, Solution - Infiltration, Solution, Epidural; Infiltration, Liquid - Infiltration, Liquid, Liquid - Epidural, Epidural, Intracardiac; Intramuscular; Intravenous; Subcutaneous, Capsule - Respiratory (inhalation), Intravenous, Solution - Nasal, Nasal, Dental; Subcutaneous, Aerosol, metered - Respiratory (inhalation), Liquid - Epidural; Infiltration, Solution / drops, Oral; Parenteral, Liquid; Tablet, Liquid; Tablet - Oral; Parenteral, Ophthalmic, Intramuscular; Oral; Subcutaneous, Liquid; Tablet - Intramuscular; Oral; Subcutaneous, Gel, Topical, Gel - Topical, Solution - Topical, Spray - Respiratory (inhalation), Packing, Packing - Dental, Intramuscular; Subcutaneous, Injection, solution - Intramuscular; Subcutaneous, Injection - Intramuscular; Subcutaneous, Injection - Submucosal, Submucosal, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Intramuscular; Intraocular; Subcutaneous, Injection - Intramuscular; Intraocular; Subcutaneous, Spray, Spray - Topical, Kit - Intramuscular; Intraocular; Subcutaneous, Injection, solution - Epidural, Injection - Intracardiac; Intravenous, Injection, solution - Epidural; Infiltration; Intracaudal, Epidural; Infiltration; Intracaudal, Endotracheal; Intracardiac; Intramuscular; Intravenous; Subcutaneous, Injection, solution - Submucosal, Solution - Intramuscular, Injection, solution - Intramuscular, Solution - Ophthalmic, Solution - Epidural, Injection, solution - Parenteral, Liquid - Subcutaneous, Solution - Intracardiac; Intravenous, Solution - Intramuscular; Intravenous; Subcutaneous, Liquid - Dental; Subcutaneous, Aerosol, metered, Solution / drops - Ophthalmic, Liquid - Intramuscular, Liquid - Intracardiac; Intravenous, Solution - Intramuscular; Subcutaneous, Intramuscular; Subcutaneous; Topical, Kit - Intramuscular; Subcutaneous; Topical, Injection, solution - Endotracheal; Intracardiac; Intramuscular; Intravenous; Subcutaneous, Solution - Endotracheal; Intracardiac; Intramuscular; Intravenous; Subcutaneous, Injection - Infiltration, Epidural; Parenteral; Retrobulbar, Injection - Epidural; Parenteral; Retrobulbar, Epidural; Parenteral, Injection - Epidural; Parenteral, Injection - Dental, Aerosol, Aerosol - Respiratory (inhalation), Injection - Intracardiac; Intramuscular; Intraspinal; Intravenous; Subcutaneous, Intracardiac; Intramuscular; Intraspinal; Intravenous; Subcutaneous, Patch - Iontophoresis, Iontophoresis, Inhalant, Inhalant - Oral, Oral, Infiltration; Intramuscular; Intravenous, Kit - Infiltration; Intramuscular; Intravenous, Infiltration; Topical, Parenteral; Topical, Kit - Infiltration; Topical, Liquid - Parenteral; Topical, Dental; Oral; Periodontal, Solution - Dental; Oral; Periodontal, Patch, Kit - Intramuscular; Subcutaneous, Injection - Intramuscular; Intravenous; Subcutaneous, Injection, solution - Epidural; Infiltration, Endotracheal; Intramuscular; Intravenous; Subcutaneous, Solution - Endotracheal; Intramuscular; Intravenous; Subcutaneous, Infiltration; Submucosal, Injection, solution - Infiltration; Submucosal, Injection - Infiltration; Submucosal, Injection - Epidural; Infiltration; Intracaudal; Perineural, Solution - Intravenous, Injection; Kit; Swab, Injection; Kit; Swab - Intramuscular; Subcutaneous; Topical

Respiratory Distress

Shock, Cardiogenic

Bronchial Spasm

Asthma

Respiratory Sounds

Shortness of Breath

Bradycardia

Low Blood Pressure

Hemorrhage

Hemostasis

Asthma

Anesthesia, Conduction

Angioedema

Complete Heart Block

Nasal Congestion

Anesthesia procedures

Asthma

Hypersensitivity

Uterine Contractions

Warnings

Adrenalin Contraindications

Condition

Risk Level

Notes

conditions contraindicating pressor use

Do Not Combine

Coronary Artery Disease

Do Not Combine

Shock

Do Not Combine

Pulse Frequency

Do Not Combine

Glaucoma, Angle-Closure

Do Not Combine

Disease

Do Not Combine

Anaesthesia

Do Not Combine

Neurocognitive Disorders

Do Not Combine

There are 20 known major drug interactions with Adrenalin.

Common Adrenalin Drug Interactions

Drug Name

Risk Level

Description

2,5-Dimethoxy-4-ethylamphetamine

Major

The therapeutic efficacy of 2,5-Dimethoxy-4-ethylamphetamine can be increased when used in combination with Epinephrine.

2,5-Dimethoxy-4-ethylthioamphetamine

Major

The therapeutic efficacy of 2,5-Dimethoxy-4-ethylthioamphetamine can be increased when used in combination with Epinephrine.

4-Bromo-2,5-dimethoxyamphetamine

Major

The therapeutic efficacy of 4-Bromo-2,5-dimethoxyamphetamine can be increased when used in combination with Epinephrine.

Abemaciclib

Major

The metabolism of Abemaciclib can be decreased when combined with Epinephrine.

Acalabrutinib

Major

The metabolism of Acalabrutinib can be decreased when combined with Epinephrine.

Adrenalin Toxicity & Overdose Risk

Epinephrine can cause birth defects in rats when taken at doses much higher than what would be given to humans. It is unknown if epinephrine can cause harm to a fetus in pregnant women, however it should only be administered if absolutely necessary. During labor and delivery, using epinephrine to maintain blood pressure can speed up the baby's heart rate and should not be used if the mother's blood pressure is higher than 130/80. Common side effects of epinephrine include anxiety, headache, fear, palpitations, necrosis at the injection site, cerebral hemorrhage, anginal pain, weakness, dizziness, nausea

image of a doctor in a lab doing drug, clinical research

Adrenalin Novel Uses: Which Conditions Have a Clinical Trial Featuring Adrenalin?

282 active studies are currently examining the potential of Adrenalin in alleviating Asthma, Allergy and Laryngotracheobronchitis.

Condition

Clinical Trials

Trial Phases

Asthma

92 Actively Recruiting

Phase 1, Phase 4, Early Phase 1, Phase 2, Not Applicable, Phase 3

Anaphylaxis

3 Actively Recruiting

Phase 1, Phase 2

Low Blood Pressure

5 Actively Recruiting

Not Applicable, Phase 4, Phase 2

Hypersensitivity

1 Actively Recruiting

Phase 4

Hemostasis

1 Actively Recruiting

Not Applicable

Hemorrhage

0 Actively Recruiting

Hives

0 Actively Recruiting

Idiopathic Anaphylaxis

0 Actively Recruiting

Shortness of Breath

10 Actively Recruiting

Phase 2, Not Applicable

Hemostatic function

0 Actively Recruiting

Local Anaesthesia therapy

0 Actively Recruiting

Anesthesia, Conduction

0 Actively Recruiting

Syncope

6 Actively Recruiting

Not Applicable, Phase 2

Septic Shock

0 Actively Recruiting

Respiratory Distress

0 Actively Recruiting

Asthma

0 Actively Recruiting

Uterine Contractions

1 Actively Recruiting

Not Applicable

Open Angle Glaucoma

10 Actively Recruiting

Phase 3, Not Applicable, Phase 4

induction of Local Anaesthesia

0 Actively Recruiting

Pupil

0 Actively Recruiting

Adrenalin Reviews: What are patients saying about Adrenalin?

Patient Review

4/6/2011

Adrenalin for Life Threatening Allergic Reaction

Patient Review

9/24/2008

Adrenalin for Adams-Stokes Syndrome

image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about adrenalin

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the action of adrenaline?

"The adrenal gland produces adrenaline as a response to stress. This hormone increases heart rate, strengthens heart contractions, and raises blood pressure. It also opens up the bronchioles in the lungs, and raises the blood levels of glucose and lipids among other effects."

Answered by AI

What type of drug is adrenaline?

"Adrenaline (epinephrine) is a drug that belongs to a class of drugs called sympathomimetic agents. It can be used for the emergency treatment of severe allergic reactions."

Answered by AI

Is epinephrine a adrenalin?

"Epinephrine, also known as adrenaline, is a neurotransmitter and hormone that plays an important role in the "fight-or-flight" response. Epinephrine is also used as a medication to treat many life-threatening conditions."

Answered by AI

What is adrenalin used for?

"An adrenaline injection is a quick way to reduce swelling in the throat and open up airways during a severe allergic reaction. It also prevents blood pressure from falling too low."

Answered by AI