Adalat Cc

Anal sphincter hypertonia, Proctalgia, Altitude Sickness + 12 more

Treatment

3 FDA approvals

20 Active Studies for Adalat Cc

What is Adalat Cc

Nifedipine

The Generic name of this drug

Treatment Summary

Nifedipine, also known as BAY a 1040, is a type of calcium channel blocker used to treat high blood pressure. This drug was developed by Bayer in 1972 and approved by the FDA in 1981. It is a first generation dihydropyridine drug and since its development, newer versions have been created that have slower onset and longer lasting effects. The most popular version of this drug is called amlodipine.

Procardia

is the brand name

image of different drug pills on a surface

Adalat Cc Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Procardia

Nifedipine

1981

355

Approved as Treatment by the FDA

Nifedipine, otherwise called Procardia, is approved by the FDA for 3 uses like Angina, Stable and Failed conventional therapy .

Angina, Stable

Helps manage Chronic Stable Angina Pectoris

Failed conventional therapy

Helps manage Failed conventional therapy

Vasospastic Angina

Helps manage Vasospastic Angina

Effectiveness

How Adalat Cc Affects Patients

Nifedipine helps to lower blood pressure and increases the amount of oxygen that the heart receives. To keep these effects going, it should be taken three times per day, typically 10-120mg. Some side effects to be aware of include excessive low blood pressure, chest pain, and heart attack.

How Adalat Cc works in the body

Nifedipine works by blocking calcium from entering cells in your arteries and heart. This reduces the pressure in your vessels and increases the oxygen supply to your heart, helping to relieve angina.

When to interrupt dosage

The recommended dosage of Adalat Cc is based on the diagnosed affliction, such as Achalasia, Ureteral Calculus and Hypertensive disease. The amount deviates according to the delivery approach (e.g. Tablet, film coated, extended release or Capsule) delineated in the table below.

Condition

Dosage

Administration

Ureteral Calculi

30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL

Tablet, film coated, extended release, Oral, , Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release - Oral, Tablet, extended release, Capsule - Oral, Capsule, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, delayed release; Tablet, extended release - Oral, Kit; Tablet, delayed release; Tablet, extended release

Angina, Stable

30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL

Tablet, film coated, extended release, Oral, , Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release - Oral, Tablet, extended release, Capsule - Oral, Capsule, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, delayed release; Tablet, extended release - Oral, Kit; Tablet, delayed release; Tablet, extended release

Fissure in Ano

30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL

Tablet, film coated, extended release, Oral, , Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release - Oral, Tablet, extended release, Capsule - Oral, Capsule, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, delayed release; Tablet, extended release - Oral, Kit; Tablet, delayed release; Tablet, extended release

Vasospastic Angina

30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL

Tablet, film coated, extended release, Oral, , Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release - Oral, Tablet, extended release, Capsule - Oral, Capsule, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, delayed release; Tablet, extended release - Oral, Kit; Tablet, delayed release; Tablet, extended release

Failed conventional therapy

30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL

Tablet, film coated, extended release, Oral, , Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release - Oral, Tablet, extended release, Capsule - Oral, Capsule, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, delayed release; Tablet, extended release - Oral, Kit; Tablet, delayed release; Tablet, extended release

Proctalgia

30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL

Tablet, film coated, extended release, Oral, , Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release - Oral, Tablet, extended release, Capsule - Oral, Capsule, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, delayed release; Tablet, extended release - Oral, Kit; Tablet, delayed release; Tablet, extended release

Pulmonary Edema

30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL

Tablet, film coated, extended release, Oral, , Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release - Oral, Tablet, extended release, Capsule - Oral, Capsule, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, delayed release; Tablet, extended release - Oral, Kit; Tablet, delayed release; Tablet, extended release

Altitude Sickness

30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL

Tablet, film coated, extended release, Oral, , Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release - Oral, Tablet, extended release, Capsule - Oral, Capsule, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, delayed release; Tablet, extended release - Oral, Kit; Tablet, delayed release; Tablet, extended release

Raynaud Disease

30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL

Tablet, film coated, extended release, Oral, , Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release - Oral, Tablet, extended release, Capsule - Oral, Capsule, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, delayed release; Tablet, extended release - Oral, Kit; Tablet, delayed release; Tablet, extended release

Hypertensive disease

30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL

Tablet, film coated, extended release, Oral, , Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release - Oral, Tablet, extended release, Capsule - Oral, Capsule, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, delayed release; Tablet, extended release - Oral, Kit; Tablet, delayed release; Tablet, extended release

Hypertensive Emergency

30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL

Tablet, film coated, extended release, Oral, , Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release - Oral, Tablet, extended release, Capsule - Oral, Capsule, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, delayed release; Tablet, extended release - Oral, Kit; Tablet, delayed release; Tablet, extended release

Anal sphincter hypertonia

30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL

Tablet, film coated, extended release, Oral, , Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release - Oral, Tablet, extended release, Capsule - Oral, Capsule, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, delayed release; Tablet, extended release - Oral, Kit; Tablet, delayed release; Tablet, extended release

Obstetric Labor, Premature

30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL

Tablet, film coated, extended release, Oral, , Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release - Oral, Tablet, extended release, Capsule - Oral, Capsule, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, delayed release; Tablet, extended release - Oral, Kit; Tablet, delayed release; Tablet, extended release

Esophageal Achalasia

30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL

Tablet, film coated, extended release, Oral, , Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release - Oral, Tablet, extended release, Capsule - Oral, Capsule, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, delayed release; Tablet, extended release - Oral, Kit; Tablet, delayed release; Tablet, extended release

Pulmonary Hypertension

30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL

Tablet, film coated, extended release, Oral, , Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release - Oral, Tablet, extended release, Capsule - Oral, Capsule, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, delayed release; Tablet, extended release - Oral, Kit; Tablet, delayed release; Tablet, extended release

Warnings

Adalat Cc has one contraindication, which should be kept in mind when managing any of the conditions mentioned in the table below.

Adalat Cc Contraindications

Condition

Risk Level

Notes

Severe Hypersensitivity Reactions

Do Not Combine

Nifedipine may interact with Pulse Frequency

There are 20 known major drug interactions with Adalat Cc.

Common Adalat Cc Drug Interactions

Drug Name

Risk Level

Description

Amitriptyline

Major

The metabolism of Amitriptyline can be decreased when combined with Nifedipine.

Amoxapine

Major

The metabolism of Amoxapine can be decreased when combined with Nifedipine.

Anagrelide

Major

The risk or severity of QTc prolongation can be increased when Nifedipine is combined with Anagrelide.

Arsenic trioxide

Major

The risk or severity of QTc prolongation can be increased when Nifedipine is combined with Arsenic trioxide.

Artemether

Major

The risk or severity of QTc prolongation can be increased when Nifedipine is combined with Artemether.

Adalat Cc Toxicity & Overdose Risk

The lowest toxic dose of the drug in rats is 1022mg/kg and in mice is 202mg/kg. Those who overdose may experience low blood pressure, abnormal heart rhythm, and a rapid heartbeat. Treatments for overdose include monitoring vital signs, raising the patient's arms and legs, and administering fluids, vasopressors, and calcium.

image of a doctor in a lab doing drug, clinical research

Adalat Cc Novel Uses: Which Conditions Have a Clinical Trial Featuring Adalat Cc?

101 active clinical trials are currently underway to discern if Adalat Cc can be used to alleviate Achalasia, Hypertensive Emergency and Anal Fissure.

Condition

Clinical Trials

Trial Phases

Obstetric Labor, Premature

2 Actively Recruiting

Not Applicable

Pulmonary Edema

0 Actively Recruiting

Hypertensive disease

27 Actively Recruiting

Not Applicable, Phase 1, Phase 2, Phase 3

Angina, Stable

0 Actively Recruiting

Esophageal Achalasia

0 Actively Recruiting

Altitude Sickness

0 Actively Recruiting

Raynaud Disease

1 Actively Recruiting

Phase 4

Pulmonary Hypertension

33 Actively Recruiting

Phase 2, Phase 3, Not Applicable, Phase 1, Early Phase 1

Proctalgia

0 Actively Recruiting

Hypertensive Emergency

1 Actively Recruiting

Phase 4

Fissure in Ano

0 Actively Recruiting

Vasospastic Angina

1 Actively Recruiting

Phase 2, Phase 3

Anal sphincter hypertonia

0 Actively Recruiting

Ureteral Calculi

0 Actively Recruiting

Failed conventional therapy

0 Actively Recruiting

Adalat Cc Reviews: What are patients saying about Adalat Cc?

5

Patient Review

5/26/2008

Adalat Cc for High Blood Pressure

This medication has been incredibly helpful for me.

4.7

Patient Review

9/17/2009

Adalat Cc for Type of Angina Where Chest Pain Occurs at Rest

This lowered my blood pressure for about five hours after taking it, which is good. However, I would prefer if it were more consistent throughout the day and night.

4.7

Patient Review

10/6/2016

Adalat Cc for High Blood Pressure

This drug works well for me in conjunction with Altace. I get the occasional cramping in my lower legs but no other negative side effects that I've noticed.

4.3

Patient Review

9/21/2009

Adalat Cc for High Blood Pressure

I've been on this medication for over six years now. I had originally started because of severe chest pains that were frequent and hospitalizing. After some testing, it was determined that I didn't have any blockages, but rather spasms in my arteries. This medication has helped to almost entirely remove the pain and severity when they do occur.

4.3

Patient Review

12/4/2007

Adalat Cc for High Blood Pressure

I unfortunately had an allergic reaction to the medication. My baby has also been experiencing diarrhea since I started taking it.

4

Patient Review

6/15/2011

Adalat Cc for High Blood Pressure

AdalatXL - 30 mg. was very effective for lowering my blood pressure, to the point where my doctor no longer prescribed it because my readings were too low. However, I began experiencing protein in my urine and chest congestion.

4

Patient Review

7/1/2012

Adalat Cc for Type of Angina Where Chest Pain Occurs at Rest

I was on this medication for a little over two years when my angina first developed. At that time, it was classified as "stable." Unfortunately, this past March it progressed to "unstable" angina. I had an angiogram and there's no blockage. The doctors think the spasms are in the muscles around my heart. Once my angina turned unstable, I had to switch to a different medication because this one didn't work anymore.

4

Patient Review

10/20/2007

Adalat Cc for High Blood Pressure

3.7

Patient Review

10/13/2009

Adalat Cc for High Blood Pressure

I constantly experience muscle cramps and can only sleep for two hours at a time. I also have to use the restroom frequently.

3.7

Patient Review

7/11/2009

Adalat Cc for High Blood Pressure

This treatment helped me with my insomnia, but I found that I had to wake up more often to urinate at night.

3.3

Patient Review

7/26/2012

Adalat Cc for High Blood Pressure

I've been on this medication for years and have only recently started experiencing negative side effects. These include an itchy rash, hot flashes, swollen legs and ankles. I am seeing my doctor tomorrow to get this sorted out and will be finding a new one afterwards.

3

Patient Review

9/28/2010

Adalat Cc for High Blood Pressure

While this medication does effectively control blood pressure, it unfortunately comes with a host of other irritating side effects, such as swelling, flushing, heartburn, and tingling in hands and feet. Additionally, I experienced hair loss while taking this medication. It's frustrating that all hypertension medications seem to come with such a long list of negative side effects.

2.3

Patient Review

12/2/2007

Adalat Cc for High Blood Pressure

I'm concerned about the warnings for use of this medication. May cause kidney damage, reduce white cells, destroy cell to cell communication and increase risk to cancer. I just completed treatments for prostrate cancer. Only med that seems to control high blood press.

1.3

Patient Review

3/2/2008

Adalat Cc for Occasional Numbness, Prickling, or Tingling of Fingers and Toes

My blood pressure has gone down to 125/85.

1

Patient Review

7/7/2008

Adalat Cc for High Blood Pressure

I've been using Adalat CC for eight years now and I'm really happy with it. No negative side effects that I know of, and my blood pressure is great.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about adalat cc

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What does CC stand for in Adalat CC?

"Calcium channel blocking agents are a type of drug that block calcium from entering cells. This can help to reduce blood pressure and treat heart conditions."

Answered by AI

What is the difference between Procardia XL and Adalat CC?

"The main difference between the two drugs is how they release nifedipine. Procardia XL releases nifedipine through an osmotic pump delivery system, while Adalat CC releases it by successively dissolving layers."

Answered by AI

Who makes Adalat CC?

"Aurobindo Pharma's nifedipine extended-release tablets have been approved by the Food and Drug Administration in three dosage strengths. The product, a generic of Alvogen's Adalat CC, is indicated as a treatment for hypertension. Aurobindo's generic will be available in dosage strengths of 30-, 60- and 90mg."

Answered by AI

What are the side effects of Adalat CC?

"anxiety

Perhaps you've been experiencing some side effects from the medication you've been taking. These may include headache, dizziness, fatigue, tiredness, drowsiness, flushing, sleep problems, vivid or abnormal dreams, or anxiety."

Answered by AI

Clinical Trials for Adalat Cc

Image of Miles Square Health Center Chicago in Chicago, United States.

Food is Medicine for High Blood Pressure and Obesity

Any Age
All Sexes
Chicago, IL

The goal of this clinical trial is to treat both hypertension and obesity in adults using a food is medicine framework. Participants will be randomized 1:1 to FIM+DASH or usual-care control. The 24-week trial includes a 12-week FIM+DASH intervention followed by a 12-week maintenance period and leverages existing partnerships with community-based organizations for home food delivery and culinary skill-skill building. The main questions it aims to answer are: (1) What is the effect of FIM+DASH vs. usual care control on blood pressure? (2) What is the effect of FIM+DASH vs. usual care control on DASH diet adherence (diet quality), body weight, and waist circumference? (3) How to identify factors associated with the sustainability and scalability of FIM+DASH in real-world settings?

Phase 2
Waitlist Available

Miles Square Health Center Chicago (+3 Sites)

Image of U Health in Miami, United States.

Cuffless PPG Monitor for High Blood Pressure

18+
All Sexes
Miami, FL

This study aims to validate the accuracy and reliability of blood pressure (BP) estimates obtained over 24 hours using a PPG-based chest-patch device compared to the gold standard ambulatory blood pressure monitoring (ABPM) method using an upper arm cuff-based oscillometric BP device, in both hypertensive and normotensive individuals referred by their provider to undergo a 24-hours ABPM for clinical indication. The Awake/Asleep test, which is the primary test recommended for automated wearable cuffless BP devices that are cuff-calibrated (based on the 2023 European Society of Hypertension (ESH) recommendations for the validation of cuffless blood pressure measuring devices), will be conducted in this study. The secondary aim of the study is to assess the feasibility and convenience of the PPG-based device.

Waitlist Available
Has No Placebo

U Health (+1 Sites)

Ziad Zoghby, M.D., M.B.A.

Biobeat Technologies Ltd.

Image of UPMC Presybeterian in Pittsburgh, United States.

Telaglenastat for Pulmonary Hypertension

18 - 75
All Sexes
Pittsburgh, PA

The research study is being conducted to evaluate the effectiveness of a drug called Telaglenastat in adults diagnosed with Pulmonary Hypertension (PH). PH is a progressive condition that affects the arteries in the lungs, specifically the pulmonary arteries, which carry blood from the right side of the heart to the lungs. Telaglenastat is not currently approved by the Food and Drug Administration for the treatment of PH. However, the study investigators believe that Telaglenastat may help lower blood pressure in the lungs and improve both heart and lung function. It is important to note that the drug will not be available to participants once the study concludes.

Phase 1 & 2
Waitlist Available

UPMC Presybeterian

Michael Risbano, MD

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Image of University of Alabama at Birmingham in Birmingham, United States.

Dietary Interventions for Hypertension

18+
All Sexes
Birmingham, AL

Natriuretic peptides (NPs) are hormones produced by the heart and play an important role in maintaining cardiovascular health and have favorable metabolic benefits. Low NP levels are associated with an increased likelihood of the development of cardiometabolic diseases like diabetes and hypertension. NP levels are known to be highly heritable, with up to half of the differences in NP levels being explained by genetics. The investigators aim to describe the genetic architecture of NPs by examining the genetic variants associated with NPs, and generate and validate a polygenic score (PGS) for NPs. The investigators will use this NP PGS to examine the association of genetically determined NP levels with cardiometabolic and cardiovascular outcomes. The investigators will conduct a genotype-guided physiological clinical trial that aims to assess the genetic factors affecting NP levels and their impact on blood pressure and NP response to saline infusion, high-salt diet, and low-salt diet. These findings will help support personal medicine approaches to lower the increasing burden of hypertension in the United States.

Waitlist Available
Has No Placebo

University of Alabama at Birmingham

Pankaj Arora, MD, FAHA

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We made a collection of clinical trials featuring Adalat Cc, we think they might fit your search criteria.
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PF-07868489 for Pulmonary Hypertension

18+
All Sexes
San Francisco, CA

The purpose of this study is to learn about the long-term safety, tolerability and effects of the study medicine (PF-07868489) for the possible treatment of PAH. PAH is a condition in which there is high blood pressure in the arteries that carry blood from the heart to the lungs. This high pressure makes it harder for the heart to pump blood through those lungs, potentially damaging the right side of the heart. This is an open-label study. Which means that both the healthcare providers and the study participants are aware of the medicine being given. This study is also an extension study with study medicine (PF-07868489). An extension study allows patients from an earlier clinical study (also called as qualifying study) to continue participating to assess long-term benefits and safety of the medicine.

Phase 2
Recruiting

UCSF Health St. Mary's Hospital (+6 Sites)

Pfizer CT.gov Call Center

Pfizer

Have you considered Adalat Cc clinical trials?

We made a collection of clinical trials featuring Adalat Cc, we think they might fit your search criteria.
Go to Trials