Aciphex

Q: What are side effects of Aciphex?

<p>You may experience a <a href="https://www.withpower.com/clinical-trials/ra">ra</a>sh or itching, an upset stomach, diarrhea, gas, a sore throat, a headache, <a href="https://www.withpower.com/clinical-trials/insomnia">insomnia</a>, or nervousness.</p>

Helicobacter Pylori Infection, NSAID Associated Gastric Ulcers, Gastric Ulcer + 8 more

Treatment

7 FDA approvals

20 Active Studies for Aciphex

Treatment for

Helicobacter Pylori Infection

What is Aciphex

RabeprazoleThe Generic name of this drug

Treatment SummaryRabeprazole is a medication used to reduce the production of stomach acid in patients with gastrointestinal disorders. It works by inhibiting the proton pump, the enzyme responsible for making stomach acid. Rabeprazole is in the class of proton pump inhibitors and becomes active when it reacts with the acid in the gastric cells. The drug works to decrease both baseline and stimulated stomach acid production in a dose-dependent manner.

AcipHexis the brand name

image of different drug pills on a surface

Aciphex Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

AcipHex

Rabeprazole

1999

Approved as Treatment by the FDA

Rabeprazole, otherwise called AcipHex, is approved by the FDA for 7 uses such as Esophagitis and Heartburn .

Esophagitis

Heartburn

Helicobacter Pylori Infection

Used to treat Helicobacter Pylori Infection in combination with Amoxicillin

Zollinger-Ellison Syndrome

Helps manage Zollinger-Ellison Syndrome

Gastric Ulcer

Curling Ulcer

Effectiveness

How Aciphex Affects PatientsRabeprazole stops the stomach from making acid. It is used to reduce symptoms and help prevent damage to the esophagus or stomach in people with gastroesophageal reflux disease (GERD) or ulcers. It can also be used to treat conditions that cause too much stomach acid, like Zollinger-Ellison syndrome, or when taken with antibiotics, to get rid of bacteria that cause some ulcers. Rabeprazole is a type of proton pump inhibitor that works by blocking the final transport of hydrogen ions (with potassium ions) into the stomach, which stops stomach acid from being made.

How Aciphex works in the bodyRabeprazole blocks acid production in the stomach. It does this by inhibiting an enzyme (hydrogen-potassium adenosine triphosphatase) that pumps protons (hydrogen ions) in the gastric parietal cell. When taken, it is changed into an active form and blocks the production of acid.

When to interrupt dosage

The amount of Aciphex is contingent upon the diagnosed disorder, including Zollinger-Ellison Syndrome, Gastric Ulcer and NSAID Associated Gastric Ulcers. The degree of dosage depends on the technique of delivery (e.g. Tablet, coated or Tablet, delayed release - Oral) as specified in the table below.

Condition

Dosage

Administration

NSAID Associated Gastric Ulcers

10.0 mg, , 20.0 mg, 5.0 mg

Tablet, coated, Tablet, delayed release - Oral, Granule, delayed release - Oral, Oral, Tablet, delayed release, , Capsule, delayed release - Oral, Capsule, delayed release, Granule, delayed release, Tablet, coated - Oral

Heartburn

10.0 mg, , 20.0 mg, 5.0 mg

Gastric Ulcer

10.0 mg, , 20.0 mg, 5.0 mg

Prophylaxis of NSAID gastric ulceration

10.0 mg, , 20.0 mg, 5.0 mg

Esophagitis

10.0 mg, , 20.0 mg, 5.0 mg

Nausea and Vomiting

10.0 mg, , 20.0 mg, 5.0 mg

Helicobacter Pylori Infection

10.0 mg, , 20.0 mg, 5.0 mg

Heartburn

10.0 mg, , 20.0 mg, 5.0 mg

Zollinger-Ellison Syndrome

10.0 mg, , 20.0 mg, 5.0 mg

Peptic Esophagitis

10.0 mg, , 20.0 mg, 5.0 mg

Curling Ulcer

10.0 mg, , 20.0 mg, 5.0 mg

Warnings

Aciphex Contraindications

Condition

Risk Level

Notes

Toxoplasma Infections

Do Not Combine

There are 20 known major drug interactions with Aciphex.

Common Aciphex Drug Interactions

Drug Name

Risk Level

Description

Atazanavir

Major

Rabeprazole can cause a decrease in the absorption of Atazanavir resulting in a reduced serum concentration and potentially a decrease in efficacy.

Axitinib

Major

The metabolism of Axitinib can be decreased when combined with Rabeprazole.

Cyclophosphamide

Major

The metabolism of Cyclophosphamide can be decreased when combined with Rabeprazole.

Eliglustat

Major

The metabolism of Eliglustat can be decreased when combined with Rabeprazole.

Fentanyl

Major

The metabolism of Fentanyl can be decreased when combined with Rabeprazole.

image of a doctor in a lab doing drug, clinical research

Aciphex Novel Uses: Which Conditions Have a Clinical Trial Featuring Aciphex?

43 ongoing studies are examining the potential of Aciphex in managing Peptic Esophagitis, Gastric Ulcer and forestalling NSAID-induced Gastric Ulceration.

Condition

Clinical Trials

Trial Phases

Nausea and Vomiting

28 Actively Recruiting

Not Applicable, Phase 3, Phase 2, Phase 4, Phase 1

Heartburn

11 Actively Recruiting

Phase 3, Phase 2, Not Applicable, Phase 4, Early Phase 1

NSAID Associated Gastric Ulcers

0 Actively Recruiting

Heartburn

2 Actively Recruiting

Phase 3, Not Applicable

Curling Ulcer

0 Actively Recruiting

Zollinger-Ellison Syndrome

0 Actively Recruiting

Peptic Esophagitis

0 Actively Recruiting

Helicobacter Pylori Infection

0 Actively Recruiting

Prophylaxis of NSAID gastric ulceration

0 Actively Recruiting

Gastric Ulcer

1 Actively Recruiting

Phase 4

Esophagitis

0 Actively Recruiting

Aciphex Reviews: What are patients saying about Aciphex?

5Patient Review

5/9/2014

Aciphex for Condition in which Stomach Acid is Pushed Into the Esophagus

I've been taking this for a couple of years now and it's the only thing that's still working. I have some side effects listed under the symptoms for this drug, but I can't tell if they're actually side effects or just how things are for me in general. Either way, I like the medication and it does what it's supposed to do.

5Patient Review

6/12/2014

Aciphex for Symptoms Accompanying Esophageal Reflux of Stomach Acid

Unfortunately, I had to stop taking Aciphex after only five weeks because I developed a severe hypersensitivity to the drug. This led to renal failure and a week-long hospital stay. Even after stopping the medication, it took me two years to fully recover.

5Patient Review

3/28/2014

Aciphex for Symptoms Accompanying Esophageal Reflux of Stomach Acid

Aciphex has been the only medication I've tried that's actually worked for me. The generic brand didn't cut it, so make sure you get the real thing. 20mg twice a day does the trick for me!

5Patient Review

11/10/2013

Aciphex for Conditions of Excess Stomach Acid Secretion

ACIPHEX was much more effective for me than over-the-counter drugs. I took it for years, but now the price has gotten too high--even with insurance it's difficult to afford.

5Patient Review

11/18/2013

Aciphex for Heartburn

I've been using this for twelve years and have to be careful of my bone density and magnesium levels. You can get a prescription card from the Aciphex website for $35 maximum.

5Patient Review

2/2/2015

Aciphex for Condition in which Stomach Acid is Pushed Into the Esophagus

I have taken this medication for years with great success, but the latest prescription from a new company does not work at all. I'm beginning to wonder if I am actually receiving name-brand medication or not. Has anyone else experienced this? I need help!

5Patient Review

7/17/2013

Aciphex for Condition in which Stomach Acid is Pushed Into the Esophagus

I've tried other medications, and none of them work as well as Aciphexl.

5Patient Review

10/17/2012

Aciphex for Heartburn

5Patient Review

8/26/2013

Aciphex for Condition in which Stomach Acid is Pushed Into the Esophagus

This medication helped me a lot, but one of the side effects is dry mouth.

5Patient Review

7/7/2018

Aciphex for Condition in which Stomach Acid is Pushed Into the Esophagus

Out of all the treatments I've tried, this is the only one that's been effective for me. I've been taking it for over a decade with great results.

3.7Patient Review

4/30/2014

Aciphex for Excessive Production of Stomach Acid

I've used this medication for a few years now, and it's been pretty effective in managing my H. Pylori. However, the price of the medication has gotten too expensive for me to keep using it. I'm now on the hunt for something new that will be just as effective but won't break the bank.

3.7Patient Review

10/21/2013

Aciphex for Medication Treatment for Healing Gastroesophageal Reflux

I experienced very severe nausea after taking this medication.

2.3Patient Review

7/3/2013

Aciphex for Medication Treatment for Healing Gastroesophageal Reflux

2Patient Review

1/26/2015

Aciphex for Condition in which Stomach Acid is Pushed Into the Esophagus

This medicine gave me joint pain, dry eyes, and terrible heartburn that I couldn't control. My heart also started acting irregularly.

2Patient Review

5/24/2013

Aciphex for Condition in which Stomach Acid is Pushed Into the Esophagus

1.7Patient Review

4/22/2014

Aciphex for Heartburn

I have tried the generic medication rabeprazola and I have found that it gives me nausea, a cough, and diarrhea. Additionally, I get dry heaves.

image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about aciphex

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are side effects of Aciphex?

"You may experience a rash or itching, an upset stomach, diarrhea, gas, a sore throat, a headache, insomnia, or nervousness."

Answered by AI

Is Pepcid the same thing as Aciphex?

"Other medications for heartburn may not last as long or start working as quickly as Pepcid, but Pepcid works well for heartburn. Aciphex is a delayed-release pill that provides relief over 24 hours and is better than over-the-counter medications that have not relieved your acid reflux."

Answered by AI

Is Aciphex the same as omeprazole?

"pylori) infections that cause ulcers.

Are Aciphex and Prilosec the same medication?

Aciphex (rabeprazole sodium) and Prilosec (omeprazole) are both proton pump inhibitors (PPIs) that are used to reduce stomach acid and treat gastroesophageal reflux disease (GERD) and duodenal ulcers. Aciphex can also be used in combination with antibiotics to treat Helicobacter pylori (H. pylori) infections that cause ulcers."

Answered by AI

How long can you take Aciphex?

"AcipHex is intended to be used for short periods of time, typically 4 to 8 weeks. If you require further healing time, your doctor may suggest a second course of treatment. AcipHex Sprinkle should not be given to children under the age of 1."

Answered by AI