Aciphex

Zollinger-Ellison Syndrome, Curling Ulcer, Heartburn + 8 more
Treatment
7 FDA approvals
20 Active Studies for Aciphex

What is Aciphex

RabeprazoleThe Generic name of this drug
Treatment SummaryRabeprazole is a medication used to reduce the production of stomach acid in patients with gastrointestinal disorders. It works by inhibiting the proton pump, the enzyme responsible for making stomach acid. Rabeprazole is in the class of proton pump inhibitors and becomes active when it reacts with the acid in the gastric cells. The drug works to decrease both baseline and stimulated stomach acid production in a dose-dependent manner.
AcipHexis the brand name
image of different drug pills on a surface
Aciphex Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
AcipHex
Rabeprazole
1999
81

Approved as Treatment by the FDA

Rabeprazole, otherwise called AcipHex, is approved by the FDA for 7 uses such as Heartburn and Zollinger-Ellison Syndrome .
Heartburn
Zollinger-Ellison Syndrome
Helps manage Zollinger-Ellison Syndrome
Helicobacter Pylori Infection
Used to treat Helicobacter Pylori Infection in combination with Amoxicillin
Gastric Ulcer
Heartburn
Esophagitis
Curling Ulcer

Effectiveness

How Aciphex Affects PatientsRabeprazole stops the stomach from making acid. It is used to reduce symptoms and help prevent damage to the esophagus or stomach in people with gastroesophageal reflux disease (GERD) or ulcers. It can also be used to treat conditions that cause too much stomach acid, like Zollinger-Ellison syndrome, or when taken with antibiotics, to get rid of bacteria that cause some ulcers. Rabeprazole is a type of proton pump inhibitor that works by blocking the final transport of hydrogen ions (with potassium ions) into the stomach, which stops stomach acid from being made.
How Aciphex works in the bodyRabeprazole blocks acid production in the stomach. It does this by inhibiting an enzyme (hydrogen-potassium adenosine triphosphatase) that pumps protons (hydrogen ions) in the gastric parietal cell. When taken, it is changed into an active form and blocks the production of acid.

When to interrupt dosage

The amount of Aciphex is contingent upon the diagnosed disorder, including Zollinger-Ellison Syndrome, Gastric Ulcer and NSAID Associated Gastric Ulcers. The degree of dosage depends on the technique of delivery (e.g. Tablet, coated or Tablet, delayed release - Oral) as specified in the table below.
Condition
Dosage
Administration
develop NSAID-induced gastric ulcers
, 20.0 mg, 5.0 mg, 10.0 mg
, Oral, Tablet, delayed release, Tablet, delayed release - Oral, Capsule, delayed release, Capsule, delayed release - Oral, Tablet, coated - Oral, Tablet, coated, Granule, delayed release, Granule, delayed release - Oral
Curling Ulcer
, 20.0 mg, 5.0 mg, 10.0 mg
, Oral, Tablet, delayed release, Tablet, delayed release - Oral, Capsule, delayed release, Capsule, delayed release - Oral, Tablet, coated - Oral, Tablet, coated, Granule, delayed release, Granule, delayed release - Oral
Helicobacter Pylori Infection
, 20.0 mg, 5.0 mg, 10.0 mg
, Oral, Tablet, delayed release, Tablet, delayed release - Oral, Capsule, delayed release, Capsule, delayed release - Oral, Tablet, coated - Oral, Tablet, coated, Granule, delayed release, Granule, delayed release - Oral
Heartburn
, 20.0 mg, 5.0 mg, 10.0 mg
, Oral, Tablet, delayed release, Tablet, delayed release - Oral, Capsule, delayed release, Capsule, delayed release - Oral, Tablet, coated - Oral, Tablet, coated, Granule, delayed release, Granule, delayed release - Oral
Nausea and Vomiting
, 20.0 mg, 5.0 mg, 10.0 mg
, Oral, Tablet, delayed release, Tablet, delayed release - Oral, Capsule, delayed release, Capsule, delayed release - Oral, Tablet, coated - Oral, Tablet, coated, Granule, delayed release, Granule, delayed release - Oral
Gastric Ulcer
, 20.0 mg, 5.0 mg, 10.0 mg
, Oral, Tablet, delayed release, Tablet, delayed release - Oral, Capsule, delayed release, Capsule, delayed release - Oral, Tablet, coated - Oral, Tablet, coated, Granule, delayed release, Granule, delayed release - Oral
Zollinger-Ellison Syndrome
, 20.0 mg, 5.0 mg, 10.0 mg
, Oral, Tablet, delayed release, Tablet, delayed release - Oral, Capsule, delayed release, Capsule, delayed release - Oral, Tablet, coated - Oral, Tablet, coated, Granule, delayed release, Granule, delayed release - Oral
Heartburn
, 20.0 mg, 5.0 mg, 10.0 mg
, Oral, Tablet, delayed release, Tablet, delayed release - Oral, Capsule, delayed release, Capsule, delayed release - Oral, Tablet, coated - Oral, Tablet, coated, Granule, delayed release, Granule, delayed release - Oral
Peptic Esophagitis
, 20.0 mg, 5.0 mg, 10.0 mg
, Oral, Tablet, delayed release, Tablet, delayed release - Oral, Capsule, delayed release, Capsule, delayed release - Oral, Tablet, coated - Oral, Tablet, coated, Granule, delayed release, Granule, delayed release - Oral
Esophagitis
, 20.0 mg, 5.0 mg, 10.0 mg
, Oral, Tablet, delayed release, Tablet, delayed release - Oral, Capsule, delayed release, Capsule, delayed release - Oral, Tablet, coated - Oral, Tablet, coated, Granule, delayed release, Granule, delayed release - Oral
Prophylaxis of NSAID gastric ulceration
, 20.0 mg, 5.0 mg, 10.0 mg
, Oral, Tablet, delayed release, Tablet, delayed release - Oral, Capsule, delayed release, Capsule, delayed release - Oral, Tablet, coated - Oral, Tablet, coated, Granule, delayed release, Granule, delayed release - Oral

Warnings

Aciphex Contraindications
Condition
Risk Level
Notes
Pulse Frequency
Do Not Combine
There are 20 known major drug interactions with Aciphex.
Common Aciphex Drug Interactions
Drug Name
Risk Level
Description
Atazanavir
Major
Rabeprazole can cause a decrease in the absorption of Atazanavir resulting in a reduced serum concentration and potentially a decrease in efficacy.
Axitinib
Major
The metabolism of Axitinib can be decreased when combined with Rabeprazole.
Cyclophosphamide
Major
The metabolism of Cyclophosphamide can be decreased when combined with Rabeprazole.
Eliglustat
Major
The metabolism of Eliglustat can be decreased when combined with Rabeprazole.
Fentanyl
Major
The metabolism of Fentanyl can be decreased when combined with Rabeprazole.
image of a doctor in a lab doing drug, clinical research

Aciphex Novel Uses: Which Conditions Have a Clinical Trial Featuring Aciphex?

43 ongoing studies are examining the potential of Aciphex in managing Peptic Esophagitis, Gastric Ulcer and forestalling NSAID-induced Gastric Ulceration.
Condition
Clinical Trials
Trial Phases
Helicobacter Pylori Infection
0 Actively Recruiting
Curling Ulcer
0 Actively Recruiting
Nausea and Vomiting
24 Actively Recruiting
Not Applicable, Phase 3, Phase 2, Phase 4, Phase 1
Heartburn
14 Actively Recruiting
Phase 3, Phase 2, Not Applicable, Phase 4, Phase 1
Heartburn
2 Actively Recruiting
Phase 3, Not Applicable
Peptic Esophagitis
0 Actively Recruiting
Gastric Ulcer
1 Actively Recruiting
Phase 4
develop NSAID-induced gastric ulcers
0 Actively Recruiting
Prophylaxis of NSAID gastric ulceration
0 Actively Recruiting
Zollinger-Ellison Syndrome
0 Actively Recruiting
Esophagitis
0 Actively Recruiting

Aciphex Reviews: What are patients saying about Aciphex?

5Patient Review
5/9/2014
Aciphex for Condition in which Stomach Acid is Pushed Into the Esophagus
I've been taking this for a couple of years now and it's the only thing that's still working. I have some side effects listed under the symptoms for this drug, but I can't tell if they're actually side effects or just how things are for me in general. Either way, I like the medication and it does what it's supposed to do.
5Patient Review
6/12/2014
Aciphex for Symptoms Accompanying Esophageal Reflux of Stomach Acid
Unfortunately, I had to stop taking Aciphex after only five weeks because I developed a severe hypersensitivity to the drug. This led to renal failure and a week-long hospital stay. Even after stopping the medication, it took me two years to fully recover.
5Patient Review
3/28/2014
Aciphex for Symptoms Accompanying Esophageal Reflux of Stomach Acid
Aciphex has been the only medication I've tried that's actually worked for me. The generic brand didn't cut it, so make sure you get the real thing. 20mg twice a day does the trick for me!
5Patient Review
11/10/2013
Aciphex for Conditions of Excess Stomach Acid Secretion
ACIPHEX was much more effective for me than over-the-counter drugs. I took it for years, but now the price has gotten too high--even with insurance it's difficult to afford.
5Patient Review
11/18/2013
Aciphex for Heartburn
I've been using this for twelve years and have to be careful of my bone density and magnesium levels. You can get a prescription card from the Aciphex website for $35 maximum.
5Patient Review
2/2/2015
Aciphex for Condition in which Stomach Acid is Pushed Into the Esophagus
I have taken this medication for years with great success, but the latest prescription from a new company does not work at all. I'm beginning to wonder if I am actually receiving name-brand medication or not. Has anyone else experienced this? I need help!
5Patient Review
7/17/2013
Aciphex for Condition in which Stomach Acid is Pushed Into the Esophagus
I've tried other medications, and none of them work as well as Aciphexl.
5Patient Review
10/17/2012
Aciphex for Heartburn
5Patient Review
8/26/2013
Aciphex for Condition in which Stomach Acid is Pushed Into the Esophagus
This medication helped me a lot, but one of the side effects is dry mouth.
5Patient Review
7/7/2018
Aciphex for Condition in which Stomach Acid is Pushed Into the Esophagus
Out of all the treatments I've tried, this is the only one that's been effective for me. I've been taking it for over a decade with great results.
3.7Patient Review
4/30/2014
Aciphex for Excessive Production of Stomach Acid
I've used this medication for a few years now, and it's been pretty effective in managing my H. Pylori. However, the price of the medication has gotten too expensive for me to keep using it. I'm now on the hunt for something new that will be just as effective but won't break the bank.
3.7Patient Review
10/21/2013
Aciphex for Medication Treatment for Healing Gastroesophageal Reflux
I experienced very severe nausea after taking this medication.
2.3Patient Review
7/3/2013
Aciphex for Medication Treatment for Healing Gastroesophageal Reflux
2Patient Review
1/26/2015
Aciphex for Condition in which Stomach Acid is Pushed Into the Esophagus
This medicine gave me joint pain, dry eyes, and terrible heartburn that I couldn't control. My heart also started acting irregularly.
2Patient Review
5/24/2013
Aciphex for Condition in which Stomach Acid is Pushed Into the Esophagus
1.7Patient Review
4/22/2014
Aciphex for Heartburn
I have tried the generic medication rabeprazola and I have found that it gives me nausea, a cough, and diarrhea. Additionally, I get dry heaves.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about aciphex

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are side effects of Aciphex?

"You may experience a rash or itching, an upset stomach, diarrhea, gas, a sore throat, a headache, insomnia, or nervousness."

Answered by AI

Is Pepcid the same thing as Aciphex?

"Other medications for heartburn may not last as long or start working as quickly as Pepcid, but Pepcid works well for heartburn. Aciphex is a delayed-release pill that provides relief over 24 hours and is better than over-the-counter medications that have not relieved your acid reflux."

Answered by AI

Is Aciphex the same as omeprazole?

"pylori) infections that cause ulcers.

Are Aciphex and Prilosec the same medication?

Aciphex (rabeprazole sodium) and Prilosec (omeprazole) are both proton pump inhibitors (PPIs) that are used to reduce stomach acid and treat gastroesophageal reflux disease (GERD) and duodenal ulcers. Aciphex can also be used in combination with antibiotics to treat Helicobacter pylori (H. pylori) infections that cause ulcers."

Answered by AI

How long can you take Aciphex?

"AcipHex is intended to be used for short periods of time, typically 4 to 8 weeks. If you require further healing time, your doctor may suggest a second course of treatment. AcipHex Sprinkle should not be given to children under the age of 1."

Answered by AI

Clinical Trials for Aciphex

Have you considered Aciphex clinical trials? We made a collection of clinical trials featuring Aciphex, we think they might fit your search criteria.
Have you considered Aciphex clinical trials? We made a collection of clinical trials featuring Aciphex, we think they might fit your search criteria.
Have you considered Aciphex clinical trials? We made a collection of clinical trials featuring Aciphex, we think they might fit your search criteria.