Aciphex

Zollinger-Ellison Syndrome, Curling Ulcer, Heartburn + 8 more
Treatment
12 FDA approvals
20 Active Studies for Aciphex

What is Aciphex

RabeprazoleThe Generic name of this drug
Treatment SummaryRabeprazole is a medication used to reduce the production of stomach acid in patients with gastrointestinal disorders. It works by inhibiting the proton pump, the enzyme responsible for making stomach acid. Rabeprazole is in the class of proton pump inhibitors and becomes active when it reacts with the acid in the gastric cells. The drug works to decrease both baseline and stimulated stomach acid production in a dose-dependent manner.
AcipHexis the brand name
image of different drug pills on a surface
Aciphex Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
AcipHex
Rabeprazole
1999
81

Approved as Treatment by the FDA

Rabeprazole, otherwise called AcipHex, is approved by the FDA for 12 uses such as Duodenal Ulcer and Gastric Ulcer .
Duodenal Ulcer
Gastric Ulcer
Heartburn
Gastro-esophageal Reflux Disease (GERD)
Non-erosive Reflux Esophagitis Disease (NERD)
Esophagitis
Helicobacter Pylori Infection
Used to treat Helicobacter Pylori Infection in combination with Amoxicillin
Heartburn
Zollinger-Ellison Syndrome
Helps manage Zollinger-Ellison Syndrome
Heartburn
Stomach Ulcer
Curling Ulcer

Effectiveness

How Aciphex Affects PatientsRabeprazole stops the stomach from making acid. It is used to reduce symptoms and help prevent damage to the esophagus or stomach in people with gastroesophageal reflux disease (GERD) or ulcers. It can also be used to treat conditions that cause too much stomach acid, like Zollinger-Ellison syndrome, or when taken with antibiotics, to get rid of bacteria that cause some ulcers. Rabeprazole is a type of proton pump inhibitor that works by blocking the final transport of hydrogen ions (with potassium ions) into the stomach, which stops stomach acid from being made.
How Aciphex works in the bodyRabeprazole blocks acid production in the stomach. It does this by inhibiting an enzyme (hydrogen-potassium adenosine triphosphatase) that pumps protons (hydrogen ions) in the gastric parietal cell. When taken, it is changed into an active form and blocks the production of acid.

When to interrupt dosage

The amount of Aciphex is contingent upon the diagnosed disorder, including Zollinger-Ellison Syndrome, Gastric Ulcer and NSAID Associated Gastric Ulcers. The degree of dosage depends on the technique of delivery (e.g. Tablet, coated or Tablet, delayed release - Oral) as specified in the table below.
Condition
Dosage
Administration
Zollinger-Ellison Syndrome
, 20.0 mg, 5.0 mg, 10.0 mg
, Oral, Tablet, delayed release, Tablet, delayed release - Oral, Capsule, delayed release, Capsule, delayed release - Oral, Tablet, coated - Oral, Tablet, coated, Granule, delayed release, Granule, delayed release - Oral
Curling Ulcer
, 20.0 mg, 5.0 mg, 10.0 mg
, Oral, Tablet, delayed release, Tablet, delayed release - Oral, Capsule, delayed release, Capsule, delayed release - Oral, Tablet, coated - Oral, Tablet, coated, Granule, delayed release, Granule, delayed release - Oral
Heartburn
, 20.0 mg, 5.0 mg, 10.0 mg
, Oral, Tablet, delayed release, Tablet, delayed release - Oral, Capsule, delayed release, Capsule, delayed release - Oral, Tablet, coated - Oral, Tablet, coated, Granule, delayed release, Granule, delayed release - Oral
Nausea and Vomiting
, 20.0 mg, 5.0 mg, 10.0 mg
, Oral, Tablet, delayed release, Tablet, delayed release - Oral, Capsule, delayed release, Capsule, delayed release - Oral, Tablet, coated - Oral, Tablet, coated, Granule, delayed release, Granule, delayed release - Oral
Helicobacter Pylori Infection
, 20.0 mg, 5.0 mg, 10.0 mg
, Oral, Tablet, delayed release, Tablet, delayed release - Oral, Capsule, delayed release, Capsule, delayed release - Oral, Tablet, coated - Oral, Tablet, coated, Granule, delayed release, Granule, delayed release - Oral
Stomach Ulcer
, 20.0 mg, 5.0 mg, 10.0 mg
, Oral, Tablet, delayed release, Tablet, delayed release - Oral, Capsule, delayed release, Capsule, delayed release - Oral, Tablet, coated - Oral, Tablet, coated, Granule, delayed release, Granule, delayed release - Oral
Esophagitis
, 20.0 mg, 5.0 mg, 10.0 mg
, Oral, Tablet, delayed release, Tablet, delayed release - Oral, Capsule, delayed release, Capsule, delayed release - Oral, Tablet, coated - Oral, Tablet, coated, Granule, delayed release, Granule, delayed release - Oral
Heartburn
, 20.0 mg, 5.0 mg, 10.0 mg
, Oral, Tablet, delayed release, Tablet, delayed release - Oral, Capsule, delayed release, Capsule, delayed release - Oral, Tablet, coated - Oral, Tablet, coated, Granule, delayed release, Granule, delayed release - Oral
Prophylaxis of NSAID gastric ulceration
, 20.0 mg, 5.0 mg, 10.0 mg
, Oral, Tablet, delayed release, Tablet, delayed release - Oral, Capsule, delayed release, Capsule, delayed release - Oral, Tablet, coated - Oral, Tablet, coated, Granule, delayed release, Granule, delayed release - Oral
Peptic Esophagitis
, 20.0 mg, 5.0 mg, 10.0 mg
, Oral, Tablet, delayed release, Tablet, delayed release - Oral, Capsule, delayed release, Capsule, delayed release - Oral, Tablet, coated - Oral, Tablet, coated, Granule, delayed release, Granule, delayed release - Oral
Stomach Ulcer
, 20.0 mg, 5.0 mg, 10.0 mg
, Oral, Tablet, delayed release, Tablet, delayed release - Oral, Capsule, delayed release, Capsule, delayed release - Oral, Tablet, coated - Oral, Tablet, coated, Granule, delayed release, Granule, delayed release - Oral

Warnings

Aciphex Contraindications
Condition
Risk Level
Notes
Pulse Frequency
Do Not Combine
There are 20 known major drug interactions with Aciphex.
Common Aciphex Drug Interactions
Drug Name
Risk Level
Description
Atazanavir
Major
Rabeprazole can cause a decrease in the absorption of Atazanavir resulting in a reduced serum concentration and potentially a decrease in efficacy.
Axitinib
Major
The metabolism of Axitinib can be decreased when combined with Rabeprazole.
Cyclophosphamide
Major
The metabolism of Cyclophosphamide can be decreased when combined with Rabeprazole.
Eliglustat
Major
The metabolism of Eliglustat can be decreased when combined with Rabeprazole.
Fentanyl
Major
The metabolism of Fentanyl can be decreased when combined with Rabeprazole.
image of a doctor in a lab doing drug, clinical research

Aciphex Novel Uses: Which Conditions Have a Clinical Trial Featuring Aciphex?

43 ongoing studies are examining the potential of Aciphex in managing Peptic Esophagitis, Gastric Ulcer and forestalling NSAID-induced Gastric Ulceration.
Condition
Clinical Trials
Trial Phases
Curling Ulcer
0 Actively Recruiting
Zollinger-Ellison Syndrome
0 Actively Recruiting
Prophylaxis of NSAID gastric ulceration
0 Actively Recruiting
Esophagitis
0 Actively Recruiting
Stomach Ulcer
2 Actively Recruiting
Phase 4, Not Applicable
Heartburn
12 Actively Recruiting
Phase 3, Phase 2, Not Applicable
Heartburn
2 Actively Recruiting
Phase 3, Not Applicable
Peptic Esophagitis
0 Actively Recruiting
Nausea and Vomiting
7 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 4
Stomach Ulcer
0 Actively Recruiting
Helicobacter Pylori Infection
2 Actively Recruiting
Not Applicable, Phase 4

Aciphex Reviews: What are patients saying about Aciphex?

5Patient Review
5/9/2014
Aciphex for Condition in which Stomach Acid is Pushed Into the Esophagus
I've been taking this for a couple of years now and it's the only thing that's still working. I have some side effects listed under the symptoms for this drug, but I can't tell if they're actually side effects or just how things are for me in general. Either way, I like the medication and it does what it's supposed to do.
5Patient Review
6/12/2014
Aciphex for Symptoms Accompanying Esophageal Reflux of Stomach Acid
Unfortunately, I had to stop taking Aciphex after only five weeks because I developed a severe hypersensitivity to the drug. This led to renal failure and a week-long hospital stay. Even after stopping the medication, it took me two years to fully recover.
5Patient Review
3/28/2014
Aciphex for Symptoms Accompanying Esophageal Reflux of Stomach Acid
Aciphex has been the only medication I've tried that's actually worked for me. The generic brand didn't cut it, so make sure you get the real thing. 20mg twice a day does the trick for me!
5Patient Review
11/10/2013
Aciphex for Conditions of Excess Stomach Acid Secretion
ACIPHEX was much more effective for me than over-the-counter drugs. I took it for years, but now the price has gotten too high--even with insurance it's difficult to afford.
5Patient Review
11/18/2013
Aciphex for Heartburn
I've been using this for twelve years and have to be careful of my bone density and magnesium levels. You can get a prescription card from the Aciphex website for $35 maximum.
5Patient Review
2/2/2015
Aciphex for Condition in which Stomach Acid is Pushed Into the Esophagus
I have taken this medication for years with great success, but the latest prescription from a new company does not work at all. I'm beginning to wonder if I am actually receiving name-brand medication or not. Has anyone else experienced this? I need help!
5Patient Review
7/17/2013
Aciphex for Condition in which Stomach Acid is Pushed Into the Esophagus
I've tried other medications, and none of them work as well as Aciphexl.
5Patient Review
10/17/2012
Aciphex for Heartburn
5Patient Review
8/26/2013
Aciphex for Condition in which Stomach Acid is Pushed Into the Esophagus
This medication helped me a lot, but one of the side effects is dry mouth.
5Patient Review
7/7/2018
Aciphex for Condition in which Stomach Acid is Pushed Into the Esophagus
Out of all the treatments I've tried, this is the only one that's been effective for me. I've been taking it for over a decade with great results.
3.7Patient Review
4/30/2014
Aciphex for Excessive Production of Stomach Acid
I've used this medication for a few years now, and it's been pretty effective in managing my H. Pylori. However, the price of the medication has gotten too expensive for me to keep using it. I'm now on the hunt for something new that will be just as effective but won't break the bank.
3.7Patient Review
10/21/2013
Aciphex for Medication Treatment for Healing Gastroesophageal Reflux
I experienced very severe nausea after taking this medication.
2.3Patient Review
7/3/2013
Aciphex for Medication Treatment for Healing Gastroesophageal Reflux
2Patient Review
1/26/2015
Aciphex for Condition in which Stomach Acid is Pushed Into the Esophagus
This medicine gave me joint pain, dry eyes, and terrible heartburn that I couldn't control. My heart also started acting irregularly.
2Patient Review
5/24/2013
Aciphex for Condition in which Stomach Acid is Pushed Into the Esophagus
1.7Patient Review
4/22/2014
Aciphex for Heartburn
I have tried the generic medication rabeprazola and I have found that it gives me nausea, a cough, and diarrhea. Additionally, I get dry heaves.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about aciphex

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are side effects of Aciphex?

"You may experience a rash or itching, an upset stomach, diarrhea, gas, a sore throat, a headache, insomnia, or nervousness."

Answered by AI

Is Pepcid the same thing as Aciphex?

"Other medications for heartburn may not last as long or start working as quickly as Pepcid, but Pepcid works well for heartburn. Aciphex is a delayed-release pill that provides relief over 24 hours and is better than over-the-counter medications that have not relieved your acid reflux."

Answered by AI

Is Aciphex the same as omeprazole?

"pylori) infections that cause ulcers.

Are Aciphex and Prilosec the same medication?

Aciphex (rabeprazole sodium) and Prilosec (omeprazole) are both proton pump inhibitors (PPIs) that are used to reduce stomach acid and treat gastroesophageal reflux disease (GERD) and duodenal ulcers. Aciphex can also be used in combination with antibiotics to treat Helicobacter pylori (H. pylori) infections that cause ulcers."

Answered by AI

How long can you take Aciphex?

"AcipHex is intended to be used for short periods of time, typically 4 to 8 weeks. If you require further healing time, your doctor may suggest a second course of treatment. AcipHex Sprinkle should not be given to children under the age of 1."

Answered by AI

Clinical Trials for Aciphex

Image of University of California, Irvine - UCI Medical Center in Orange, United States.

Sling-Fiber Preservation vs. Conventional POEM for Achalasia

18+
All Sexes
Orange, CA
Peroral endoscopic myotomy (POEM) is an effective, minimally invasive treatment for achalasia, offering excellent rates of symptom relief. However, a significant drawback is the high incidence of gastroesophageal reflux disease (GERD) following the procedure. One proposed technical modification, the selective preservation of the sling fibers during gastric myotomy (SFP-POEM), may reduce this risk without compromising efficacy as compared to a conventional POEM procedure, which includes myotomy of the sling fibers. In this study, adults with achalasia will be randomly assigned to receive one of the two POEM technical approaches. Researchers will monitor whether preserving sling fibers reduces the rates of reflux esophagitis (classified as Los Angeles Grade B or higher) on follow-up endoscopy. Participants will be followed for up to 1 year after the procedure.
Waitlist Available
Has No Placebo
University of California, Irvine - UCI Medical CenterJason Samarasena, MD, MBA
Image of Del Sol Research Management, LLC in Tucson, United States.

Linaprazan Glurate vs Lansoprazole for Acid Reflux

18 - 80
All Sexes
Tucson, AZ
The goal of this clinical trial is to find out how well linaprazan glurate can heal erosive esophagitis (EE) caused by gastroesophageal reflux disease (GERD), compared to lansoprazole, a commonly used medication. Researchers will also evaluate whether linaprazan glurate: * Reduces heartburn symptoms more effectively than lansoprazole * Is safe and well tolerated, based on physical exams, blood tests, and vital signs (heart rate, blood pressure, temperature, and breathing rate) * Causes any side effects during treatment * Has different effects depending on how much of the drug is in the blood * Works differently depending on participants' genes Participants must be between 18 to 80 years old and have EE due to GERD confirmed by an endoscopy. Participants cannot join if they have an active Helicobacter pylori (HP) infection or were treated for HP in the past 6 weeks or have taken antibiotics or bismuth-containing drugs in the past 6 weeks. The study is a randomized, double-blind, active comparator-controlled trial lasting up to 4 months. Randomized means that participants are assigned by chance (like flipping a coin) to one of the treatment groups and double-blind means neither the participants nor the study team will know which treatment is given. Participants will be placed into one of three groups (about 167 people in each group): * Linaprazan glurate 50 mg twice a day * Linaprazan glurate 50 mg once a day * Lansoprazole 30 mg once a day Everyone will take 2 tablets and 1 capsule by mouth daily for 8 weeks. Some tablets or capsules will be placebos (look like medicine but contain no active drug). Participants will: * Undergo an endoscopy in the beginning and after 4 weeks of treatment * If healing is not observed, another endoscopy may be done at 8 weeks * During the procedure, doctors will use a thin, flexible tube with a camera to look at the esophagus and take small tissue samples (biopsies) * Have blood and urine tests at clinic visits to check overall health * Receive electrocardiograms (ECGs) to monitor heart function * Complete daily questionnaires on an electronic device about symptoms and experiences
Phase 3
Waitlist Available
Del Sol Research Management, LLC (+24 Sites)Cinclus Pharma Holding AB
Have you considered Aciphex clinical trials? We made a collection of clinical trials featuring Aciphex, we think they might fit your search criteria.Go to Trials
Image of Montefiore Medical Center in Bronx, United States.

Fosaprepitant vs Metoclopramide for Nausea and Vomiting

18+
All Sexes
Bronx, NY
The study team proposes a double-blind, comparative effectiveness, randomized controlled trial (RCT) to address the following goal: to determine the relative efficacy and adverse event profile of fosaprepitant compared to the standard of care antiemetic metoclopramide. Fosaprepitant and its active metabolite aprepitant are a relatively new class of antiemetic that exclusively acts in the central nervous system by blocking neurokinin (NK-1) which is a key signaling molecule in the centrally mediated aspects of the vomiting reflex. Currently, fosaprepitant and aprepitant both have only two United Stated Food and Drug Administration (USFDA) approved indications for nausea and vomiting: chemotherapy-induced and postoperative. Neurokinin inhibitors are highly effective and generally well-tolerated. Therefore, this class of medication may be a more appropriate medication for the millions of patients with nausea and vomiting that seek care in emergency departments (EDs). Intravenous fosaprepitant is converted to the active metabolite aprepitant on the order of minutes and is significantly cheaper to procure at this time.
Phase 4
Waitlist Available
Montefiore Medical Center (+1 Sites)Benjamin Friedman, MD
Image of Medical College of Wisconsin in Milwaukee, United States.

Fosamprenavir + Sodium Alginate for GERD

18 - 64
All Sexes
Milwaukee, WI
The goal of this clinical trial is to learn if study drug Fosamprenavir-Sodium Alginate (FOS-SA) administered orally improves symptoms for Proton Pump Inhibitor (PPI)-refractory Gastro Esophageal Reflux Disease (GERD). The main questions it aims to answer are: 1. Does FOS-SA significantly improve heartburn severity over the 8-week treatment period 2. Does FOS-SA significantly improve regurgitation frequency over the 8-week treatment period 3. Does FOS-SA significantly improve symptoms of persistent GERD over the 8-week treatment period Researchers will compare FOS-SA to a placebo (a look-alike substance that contains no active drug) to see if FOS-SA works to treat PPI-refractory GERD. Participants will: 1. Take FOS-SA or placebo every day BID (twice a day) for 8 weeks 2. Visit the Adult Translational Research Unit (ATRU) seven times for consenting, screening, and checkups and tests 3. Keep a daily diary of their symptoms of persistent GERD
Phase 2
Waitlist Available
Medical College of WisconsinNikki Johnston, PhD.
Image of Brigham and Women's Hospital in Boston, United States.

Low Thermal Plasma for Marginal Ulcers

18+
All Sexes
Boston, MA
The objective of the study is to investigate the treatment of marginal ulcers with Low Thermal plasma in an endoscopic setting. By a treatment of the ulcerated areas with argon plasma with low power settings (\~ 1 W) we hypothesize that the size of the ulcers will shrink, and the healing is accelerated compared to standard of care alone. Patients will benefit from this minimally invasive approach compared to a much more invasive surgical approach that comes with higher risks and hospital stay length time. From a societal and scientific perspective, this study aims to extend the well-documented clinical benefits of plasma technology - from external wound healing to internal ulcer treatment - within an endoscopic framework. The success of this study could pave the way for broader applications of LTP in the treatment of other endoscopically accessible conditions such as peptic ulcers, duodenal ulcers and esophageal ulcers. This advancement has the potential not only to improve patient outcomes through less invasive methods, but also to position LTP as a cornerstone in the future of gastroenterological wound management strategies.
Recruiting
Has No Placebo
Brigham and Women's HospitalChristopher C. Thompson, MD, MSc
Image of Brigham and Women's Hospital in Boston, United States.

Argon Plasma for Helicobacter Pylori Infection

18+
All Sexes
Boston, MA
The objective of the study is to investigate the efficacy and safety of an argon plasma-based therapy - HEAPE - in treating H. pylori infections during endoscopic procedures. By filling the stomach with sodium chloride solution that is treated with APC (PAL), the Investigators hypothesize a significant reduction in H. pylori. The use of PAL instead of direct application of APC allows for a broader and more homogeneous application throughout the stomach and a faster procedure time, as the fluid bypasses the thermal effects typically associated with higher electrical power settings and focuses on the bactericidal action of PAL. It is a procedure that does not involve thermal ablation of the stomach lining. Thus, side effects should be expected to be as low as possible. Two different PAL generation modalities will be compared in this study: 1. HEAPE direct: This modality is the direct generation of PAL in the stomach. The stomach is filled with sodium chloride solution which is then treated with APC. With HEAPE direct a potential decrease of reactive species is avoided, as the treatment happens directly at the intended location in the H. pylori infected stomach. 2. Pre-HEAPE: This modality features the treatment of sodium chloride with APC outside of the patient in a sterile container. After the APC treatment, the generated PAL is administered into the stomach with a syringe through the working channel of the endoscope. Pre-HEAPE allows an easier handling of the APC probe as the treatment of the sodium chloride solution can be done without an endoscope. To evaluate the immediate effect of this novel treatment approach the metabolic activity of H. pylori will be assessed using a urea breath test (UBT) before and after treatment. A reduction in H. pylori levels can be detected by a reduction in urease activity in the breath test. After the HEAPE procedure, patients are treated with antibiotics (best practice) as they would be under normal circumstances. Four weeks after treatment, another UBT is performed to determine if H. pylori has been eradicated or if additional antibiotic treatment is indicated. This two-arm, randomized, pilot, single-center, prospective clinical study is designed to evaluate the safety, tolerability and proof of concept that PAL has the ability to eradicate or reduce the bacterial load of H. pylori in humans.
Recruiting
Has No Placebo
Brigham and Women's HospitalChristopher C Thompson, MDErbe Elektromedizin GmbH
Have you considered Aciphex clinical trials? We made a collection of clinical trials featuring Aciphex, we think they might fit your search criteria.Go to Trials
Image of Montefiore Medical Center (Montefiore and Weiler EDs) in Bronx, United States.

Fosaprepitant for Nausea and Vomiting

18+
All Sexes
Bronx, NY
The study team proposes a randomized, double-blind, RCT to address the following goal: to determine the relative efficacy and adverse event profile of fosaprepitant compared to the standard of care antiemetic ondansetron. Fosaprepitant and its active metabolite aprepitant are a relatively new class of antiemetic that exclusively acts in the central nervous system by blocking neurokinin (NK-1) which is a key signaling molecule in the centrally mediated aspects of the vomiting reflex. Currently, fosaprepitant and aprepitant both have only two United Stated Food and Drug Administration (USFDA) approved indications for nausea and vomiting: chemotherapy-induced and postoperative. Neurokinin inhibitors are highly effective and generally well-tolerated. Therefore, this class of medication may be a more appropriate medication for the millions of patients with nausea and vomiting that seek care in EDs. Intravenous fosaprepitant is converted to the active metabolite aprepitant on the order of minutes and is significantly cheaper to procure at this time. The outcome for the efficacy analysis will be no need for additional medication to treat nausea and vomiting within 2 hours of investigational medication administration. The primary outcome for the tolerability analysis will be the development of any new symptom within 2 hours of medication administration.
Phase 2 & 3
Recruiting
Montefiore Medical Center (Montefiore and Weiler EDs) (+1 Sites)Benjamin W Friedman, MD MS
Have you considered Aciphex clinical trials? We made a collection of clinical trials featuring Aciphex, we think they might fit your search criteria.Go to Trials
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