Aciphex

Zollinger-Ellison Syndrome, Curling Ulcer, Heartburn + 8 more

Treatment

12 FDA approvals

18 Active Studies for Aciphex

Treatment for

Zollinger-Ellison Syndrome

What is Aciphex

RabeprazoleThe Generic name of this drug

Treatment SummaryRabeprazole is a medication used to reduce the production of stomach acid in patients with gastrointestinal disorders. It works by inhibiting the proton pump, the enzyme responsible for making stomach acid. Rabeprazole is in the class of proton pump inhibitors and becomes active when it reacts with the acid in the gastric cells. The drug works to decrease both baseline and stimulated stomach acid production in a dose-dependent manner.

AcipHexis the brand name

image of different drug pills on a surface

Aciphex Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

AcipHex

Rabeprazole

1999

Approved as Treatment by the FDA

Rabeprazole, otherwise called AcipHex, is approved by the FDA for 12 uses such as Duodenal Ulcer and Gastro-esophageal Reflux Disease (GERD) .

Duodenal Ulcer

Gastro-esophageal Reflux Disease (GERD)

Gastric Ulcer

Heartburn

Non-erosive Reflux Esophagitis Disease (NERD)

Esophagitis

Helicobacter Pylori Infection

Used to treat Helicobacter Pylori Infection in combination with Amoxicillin

Heartburn

Zollinger-Ellison Syndrome

Helps manage Zollinger-Ellison Syndrome

Heartburn

Stomach Ulcer

Curling Ulcer

Effectiveness

How Aciphex Affects PatientsRabeprazole stops the stomach from making acid. It is used to reduce symptoms and help prevent damage to the esophagus or stomach in people with gastroesophageal reflux disease (GERD) or ulcers. It can also be used to treat conditions that cause too much stomach acid, like Zollinger-Ellison syndrome, or when taken with antibiotics, to get rid of bacteria that cause some ulcers. Rabeprazole is a type of proton pump inhibitor that works by blocking the final transport of hydrogen ions (with potassium ions) into the stomach, which stops stomach acid from being made.

How Aciphex works in the bodyRabeprazole blocks acid production in the stomach. It does this by inhibiting an enzyme (hydrogen-potassium adenosine triphosphatase) that pumps protons (hydrogen ions) in the gastric parietal cell. When taken, it is changed into an active form and blocks the production of acid.

When to interrupt dosage

The amount of Aciphex is contingent upon the diagnosed disorder, including Zollinger-Ellison Syndrome, Gastric Ulcer and NSAID Associated Gastric Ulcers. The degree of dosage depends on the technique of delivery (e.g. Tablet, coated or Tablet, delayed release - Oral) as specified in the table below.

Condition

Dosage

Administration

Zollinger-Ellison Syndrome

, 20.0 mg, 5.0 mg, 10.0 mg

, Oral, Tablet, delayed release, Tablet, delayed release - Oral, Capsule, delayed release, Capsule, delayed release - Oral, Tablet, coated - Oral, Tablet, coated, Granule, delayed release, Granule, delayed release - Oral

Curling Ulcer

, 20.0 mg, 5.0 mg, 10.0 mg

Heartburn

, 20.0 mg, 5.0 mg, 10.0 mg

Nausea and Vomiting

, 20.0 mg, 5.0 mg, 10.0 mg

Helicobacter Pylori Infection

, 20.0 mg, 5.0 mg, 10.0 mg

Stomach Ulcer

, 20.0 mg, 5.0 mg, 10.0 mg

Esophagitis

, 20.0 mg, 5.0 mg, 10.0 mg

Heartburn

, 20.0 mg, 5.0 mg, 10.0 mg

Prophylaxis of NSAID gastric ulceration

, 20.0 mg, 5.0 mg, 10.0 mg

Peptic Esophagitis

, 20.0 mg, 5.0 mg, 10.0 mg

Stomach Ulcer

, 20.0 mg, 5.0 mg, 10.0 mg

Warnings

Aciphex Contraindications

Condition

Risk Level

Notes

Pulse Frequency

Do Not Combine

There are 20 known major drug interactions with Aciphex.

Common Aciphex Drug Interactions

Drug Name

Risk Level

Description

Atazanavir

Major

Rabeprazole can cause a decrease in the absorption of Atazanavir resulting in a reduced serum concentration and potentially a decrease in efficacy.

Axitinib

Major

The metabolism of Axitinib can be decreased when combined with Rabeprazole.

Cyclophosphamide

Major

The metabolism of Cyclophosphamide can be decreased when combined with Rabeprazole.

Eliglustat

Major

The metabolism of Eliglustat can be decreased when combined with Rabeprazole.

Fentanyl

Major

The metabolism of Fentanyl can be decreased when combined with Rabeprazole.

image of a doctor in a lab doing drug, clinical research

Aciphex Novel Uses: Which Conditions Have a Clinical Trial Featuring Aciphex?

43 ongoing studies are examining the potential of Aciphex in managing Peptic Esophagitis, Gastric Ulcer and forestalling NSAID-induced Gastric Ulceration.

Condition

Clinical Trials

Trial Phases

Curling Ulcer

0 Actively Recruiting

Esophagitis

0 Actively Recruiting

Prophylaxis of NSAID gastric ulceration

0 Actively Recruiting

Zollinger-Ellison Syndrome

0 Actively Recruiting

Stomach Ulcer

2 Actively Recruiting

Phase 4, Not Applicable

Heartburn

10 Actively Recruiting

Phase 3, Phase 2, Not Applicable, Phase 4

Heartburn

2 Actively Recruiting

Phase 3, Not Applicable

Peptic Esophagitis

0 Actively Recruiting

Nausea and Vomiting

5 Actively Recruiting

Phase 2, Phase 3, Not Applicable

Stomach Ulcer

0 Actively Recruiting

Helicobacter Pylori Infection

1 Actively Recruiting

Not Applicable

Aciphex Reviews: What are patients saying about Aciphex?

5Patient Review

5/9/2014

Aciphex for Condition in which Stomach Acid is Pushed Into the Esophagus

I've been taking this for a couple of years now and it's the only thing that's still working. I have some side effects listed under the symptoms for this drug, but I can't tell if they're actually side effects or just how things are for me in general. Either way, I like the medication and it does what it's supposed to do.

5Patient Review

6/12/2014

Aciphex for Symptoms Accompanying Esophageal Reflux of Stomach Acid

Unfortunately, I had to stop taking Aciphex after only five weeks because I developed a severe hypersensitivity to the drug. This led to renal failure and a week-long hospital stay. Even after stopping the medication, it took me two years to fully recover.

5Patient Review

3/28/2014

Aciphex for Symptoms Accompanying Esophageal Reflux of Stomach Acid

Aciphex has been the only medication I've tried that's actually worked for me. The generic brand didn't cut it, so make sure you get the real thing. 20mg twice a day does the trick for me!

5Patient Review

11/10/2013

Aciphex for Conditions of Excess Stomach Acid Secretion

ACIPHEX was much more effective for me than over-the-counter drugs. I took it for years, but now the price has gotten too high--even with insurance it's difficult to afford.

5Patient Review

11/18/2013

Aciphex for Heartburn

I've been using this for twelve years and have to be careful of my bone density and magnesium levels. You can get a prescription card from the Aciphex website for $35 maximum.

View All Reviews

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Patient Q&A Section about aciphex

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are side effects of Aciphex?

"You may experience a rash or itching, an upset stomach, diarrhea, gas, a sore throat, a headache, insomnia, or nervousness."

Answered by AI

Is Pepcid the same thing as Aciphex?

"Other medications for heartburn may not last as long or start working as quickly as Pepcid, but Pepcid works well for heartburn. Aciphex is a delayed-release pill that provides relief over 24 hours and is better than over-the-counter medications that have not relieved your acid reflux."

Answered by AI

Is Aciphex the same as omeprazole?

"pylori) infections that cause ulcers.

Are Aciphex and Prilosec the same medication?

Aciphex (rabeprazole sodium) and Prilosec (omeprazole) are both proton pump inhibitors (PPIs) that are used to reduce stomach acid and treat gastroesophageal reflux disease (GERD) and duodenal ulcers. Aciphex can also be used in combination with antibiotics to treat Helicobacter pylori (H. pylori) infections that cause ulcers."

Answered by AI

How long can you take Aciphex?

"AcipHex is intended to be used for short periods of time, typically 4 to 8 weeks. If you require further healing time, your doctor may suggest a second course of treatment. AcipHex Sprinkle should not be given to children under the age of 1."

Answered by AI