Metoprolol vs Bystolic Weight Gain

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For patients with hypertension or heart-related conditions, certain medications that control the rate and rhythm of the heartbeat can help manage symptoms. Metoprolol and Bystolic are two such drugs often prescribed for these conditions. They both belong to a class of drugs called beta-blockers, which work by blocking the effects of adrenaline on your body's beta receptors to lower heart rate and blood pressure.

Metoprolol is commonly used to treat high blood pressure (hypertension), chest pain (angina), uneven heartbeats (arrhythmias), and it's also used in prevention after a heart attack.

Bystolic, on the other hand, is primarily used for hypertension treatment alone but has an added advantage over metoprolol because it’s less likely to cause weight gain—a common concern among chronic medication users who need long-term management.

What is Metoprolol?

Metoprolol is a beta blocker that was first approved by the FDA in 1978. It blocks the action of certain chemicals in your body, such as epinephrine on the heart and blood vessels. This effect lowers heart rate, blood pressure, and strain on the heart. Metoprolol has been widely used to treat hypertension (high blood pressure), angina (chest pain), tachycardia (fast heartbeat) and it's also given to people who have had a heart attack.

On the other hand, Bystolic or nebivolol is another kind of beta-blocker which was approved by FDA later in 2007. Compared to metoprolol, Bystolic is considered more cardio-selective because it primarily works on beta-1 receptors located within the heart muscle cells - therefore having fewer side effects related with lungs or smooth muscles found elsewhere in our bodies.

As for weight gain concerns associated with these medications – while both drugs can potentially lead to some weight gain due to water retention or decreased metabolic rate; this side effect seems less common with Bystolic than Metoprolol according to patient reviews and clinical studies.

What conditions is Metoprolol approved to treat?

Metoprolol is approved for the treatment of various cardiovascular conditions:

  • Hypertension, also known as high blood pressure
  • Angina pectoris, a condition characterized by chest pain due to reduced blood flow to the heart
  • Heart failure (for certain types and in combination with other drugs)
  • Acute myocardial infarction (heart attack), used in an early treatment strategy.

Note: Weight gain can be a side effect of Metoprolol. Bystolic, on the other hand, may cause less weight gain than some other beta blockers like Metoprolol.

How does Metoprolol help with these illnesses?

Metoprolol helps to manage high blood pressure by blocking the effects of certain hormones, such as adrenaline (epinephrine), on the heart. It does this by interacting with beta receptors in the heart tissue, reducing both the rate and strength at which your heart beats, thereby decreasing blood pressure. Adrenaline is a hormone that plays an important role in our body's "fight or flight" response, influencing factors like heart rate, blood pressure, and energy usage.

On the other hand, Bystolic (also known as nebivolol) works similarly to Metoprolol but with an added vasodilatory effect due to its unique property of releasing nitric oxide in endothelial cells lining arteries. This contributes further to lowering blood pressure.

Weight gain can be a potential side effect for some patients using either medication; however it seems more commonly reported among those taking Metoprolol than those on Bystolic. Therefore if weight gain is a concern for you when managing hypertension or other cardiovascular conditions requiring these medications, discussing this factor with your doctor may help determine which option will best suit your needs without negatively affecting your health goals.

What is Bystolic Weight Gain?

Bystolic, which is a brand name for Nebivolol, is a beta blocker that helps to decrease the heart rate and blood pressure by blocking the effects of certain natural substances on your heart. It was first approved by the FDA in 2007. As Bystolic does not inhibit norepinephrine like other typical beta blockers such as metoprolol, it has a slightly different side-effect profile. In particular, one of its most notable potential side effects is weight gain. While this isn't an issue with every patient who takes Bystolic, some do report moderate to significant weight gain while using this medication. This could be due to fluid retention or changes in metabolism caused by the drug's impact on cardiovascular function. However, despite these risks associated with weight gain, many people find that Bystolic can be very effective in managing hypertension or reducing their risk of heart attacks — especially those patients who have not responded well to "typical" beta blockers like Metoprolol.

What conditions is Bystolic Weight Gain approved to treat?

Bystolic, also known as nebivolol, is used for the treatment of high blood pressure (hypertension). It belongs to a class of drugs called beta blockers. However, Bystolic may cause weight gain in some people due to its potential effect on slowing metabolism and reducing physical activity levels.

It's important for patients taking this medication or considering it to monitor their weight regularly and report any significant changes to their healthcare provider. Combining regular exercise with a healthy diet can help manage potential weight gain while taking Bystolic for hypertension control.

How does Bystolic Weight Gain help with these illnesses?

Nebivolol, marketed under the brand name Bystolic, is a beta-blocker that functions by blocking the action of certain natural substances in your body, such as adrenaline and noradrenaline on the heart and blood vessels. This effect reduces strain on the heart, decreases heart rate, and lowers blood pressure providing protection against stroke, heart attack and kidney problems. Just like Metoprolol it's commonly used to treat high blood pressure (hypertension). It's worth noting though that weight gain can be one side effect of Bystolic use due to its potential impact on metabolism or fluid retention. However this varies from patient to patient and not everyone experiences this side effect. Its influence on metabolic processes may also result in slower calorie burn leading to weight increment if dietary intake isn't adjusted accordingly. If a patient doesn't respond well or is concerned about possible weight gain with other beta-blockers like Metoprolol they might consider Nebivolol but should always consult their healthcare provider for personalized advice.

How effective are both Metoprolol and Bystolic Weight Gain?

Both metoprolol and nebivolol (Bystolic) are beta-blockers with a long history of use in managing cardiovascular conditions such as hypertension and heart failure. They were approved by the FDA in 1978 and 2007, respectively. Since they act on different subtypes of beta receptors, they may be prescribed under different circumstances.

The effectiveness of metoprolol and nebivolol in controlling blood pressure was directly studied in a double-blind clinical trial in 2011; both drugs exhibited similar efficacy in decreasing systolic blood pressure as well as similar safety profiles. In this study, none of the different metrics to measure efficacy differed between patients receiving metoprolol or nebivolol.

A review from 1992 reported that metoprolol is effective at reducing cardiac workload starting from the first dose due to its selective action on β1-receptors located primarily within cardiac tissue. Metoprolol has been widely used around the world for decades now which indicates its overall tolerability among diverse patient populations.

Nebivolol has shown comparable effectiveness to other common antihypertensives including ACE inhibitors, ARBs and calcium channel blockers according to a review from 2015 but it's still considered relatively new compared to classic beta-blockers like metoprolol. Significant research on its use involves co-prescription with other classes of antihypertensives where data confirms its additive blood-pressure lowering effect.

When comparing weight gain associated with these two medications, both have been linked with modest weight gain although less commonly so than older non-selective beta blockers like propranololand atenelone. However, given individual variations exist when considering side effects such as weight gain it would be advisable for those concerned about this issue discuss their concerns with their healthcare provider before initiating therapy.

abstract image of a researcher studying a bottle of drug.

At what dose is Metoprolol typically prescribed?

Oral dosages of Metoprolol range from 25–200 mg/day, but studies have shown that a starting dosage of 50 mg/day is typically effective for managing hypertension in most adults. For Bystolic, the typical starting dose is lower at 5 mg/day. In both cases, if there’s no sufficient response after two weeks, your doctor may adjust the dosage upwards. However, it's important to note that weight gain can be a side effect with either medication and some patients report more significant weight gain with Bystolic than Metoprolol. The maximum daily dosage for Metoprolol should not exceed 400mg per day and for Bystolic it’s 40mg per day.

At what dose is Bystolic Weight Gain typically prescribed?

Bystolic weight gain is often a concern for patients. Bystolic treatment typically begins at a dosage of 5 mg/day, and this can be increased to a maximum of 20 mg/day if necessary. The dose is usually taken once per day, with or without food. It's important to monitor your weight as you start Bystolic because some people may experience weight gain due to fluid retention or other factors after starting the medication. If there is substantial unexpected weight gain after several weeks of treatment, it would be prudent to consult with your healthcare provider about possible adjustments in your medication regimen.

What are the most common side effects for Metoprolol?

Common side effects of Metoprolol and Bystolic may include:

  • Fatigue, drowsiness or lethargy
  • Dizziness or lightheadedness, especially when standing up suddenly
  • Weight gain
  • Headache
  • Depression or anxiety
  • Nausea, digestive discomfort or heartburn
  • Diarrhea or constipation
  • Dry mouth
  • Decreased sex drive, impotence, difficulty having an orgasm
  • Insomnia (difficulty falling asleep)
    -Mild itching or rash
    -Swelling in hands and feet.

More serious side effects are less common but should prompt immediate medical attention: shortness of breath (even with mild exertion), swelling of the ankles/feet/hands/significant weight gain due to fluid retention, slow heartbeat/extremely low blood pressure/fainting.

Remember that your healthcare provider has prescribed these medications because they judge that the benefit to you is greater than the risk of potential side effects. Always consult a healthcare professional for medical advice.

abstract image of a patient experiencing side effect

Are there any potential serious side effects for Metoprolol?

When comparing Metoprolol and Bystolic, specifically regarding weight gain as a side effect, it's important to be aware of certain potential issues. Both medications can lead to slight weight gain due to water retention or increased appetite in some patients. However, if you notice significant rapid weight gain, especially in the face and midsection, or swelling in your ankles or feet; this may indicate that your body is retaining too much fluid and could signal heart failure. Other serious side effects include:

  • Allergic reactions: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
  • Changes in vision: blurred vision;
  • Heart problems: chest pain or tightness; irregular heartbeat; shortness of breath even at rest.
  • Neurological symptoms: confusion; severe headache (especially sudden); slurred speech.
  • Signs of severe allergic reaction - unexplained rash, itching/swelling (especially of the face/tongue/throat), dizziness.

If you experience any such symptoms while on either medication immediately notify your healthcare provider for advice. Remember these are not common occurrence but rather rare possibilities which you should be aware about when starting new medication like Metoprolol and Bystolic.

What are the most common side effects for Bystolic Weight Gain?

Weight gain associated with Bystolic can present the following possible effects:

  • Increased appetite leading to weight gain
  • Water retention, causing swelling in your hands or ankles
  • Feeling of fatigue and lethargy
  • Possible onset of depression or anxiety due to body image changes
  • Difficulty sleeping due to increased body mass
  • Potential increase in blood pressure from added weight
  • Joint pain due to increased stress on joints
  • Digestive problems such as constipation or bloating.

It's important that you monitor any significant weight changes while taking Bystolic and discuss them with your healthcare provider.

Are there any potential serious side effects for Bystolic Weight Gain?

While Bystolic is generally well-tolerated, one of the potential side effects can be weight gain. While this isn't typically harmful, it can lead to other health concerns if not appropriately managed. If you are taking Bystolic and notice any of the following changes in your body or behaviour, consult with your doctor:

  • Significant increase in weight over a short period
  • Swelling or fluid retention especially around the abdomen and legs
  • Breathing difficulties when lying down or during physical activities
  • Feelings of fatigue or lethargy that weren't present before starting medication
  • Unusual mood swings or behavioral changes
  • Changes in vision such as seeing halos around lights
  • Rapid heartbeat, palpitations, chest pain

Remember that these symptoms could signify different health issues including metabolic changes due to medication use. It's important to keep an open and regular dialogue with your healthcare provider about any physical or emotional changes you experience while on medication.

Contraindications for Metoprolol and Bystolic Weight Gain?

Both Metoprolol and Bystolic, like most beta-blockers, can cause weight gain in some people. If you notice a significant increase in your weight without any changes to your diet or exercise routine after starting these medications, please consult with your healthcare provider.

Neither Metoprolol nor Bystolic should be taken if you are using, or have recently used certain other medications including other beta-blockers or monoamine oxidase (MAO) inhibitors. Always inform your physician about all the medicines you're currently taking; MAOIs for instance may need about 2 weeks to clear from the system to avoid harmful interactions with Metoprolol and Bystolic.

Furthermore, abrupt cessation of either medication can lead to severe heart-related problems. Therefore, it's crucial that both metoprolol and bystolic must not be stopped suddenly without discussing with your doctor.

How much do Metoprolol and Bystolic Weight Gain cost?

For the brand name versions of these drugs:

  • The price of 60 tablets of Metoprolol (50mg) averages around $90, which works out to approximately $1.5/day.
  • The price for a month's supply (30 tablets) of Bystolic (5 mg) is about $155, working out to roughly $5.16/day.

Therefore, if you are on higher dosages for Metoprolol or taking more than one dose per day, it may still be less expensive compared to Bystolic. Remember that cost should not be your primary consideration in determining which drug is right for you.

In terms of generic versions:

  • Generic metoprolol tartrate can range from as low as $4 for a month’s supply up to about $10 depending upon the pharmacy and dosage required. This translates into an approximate daily cost from just over cents up to around 33 cents per day.

  • Currently there is no generic version available for Bystolic (nebivolol), so its costs remain relatively high at this time.

As with any medication decision, it's important that patients consult their healthcare provider who will take into account individual factors such as overall health condition and potential side effects when prescribing medication.

Popularity of Metoprolol and Bystolic Weight Gain

Metoprolol, available in generic form as well as under brand names such as Lopressor and Toprol XL, was prescribed to approximately 18.6 million people in the US in 2020. Metoprolol is a beta-blocker that treats hypertension and angina pectoris (chest pain), and it prevents heart attacks. It belongs to the class of drugs known as beta1-selective adrenergic receptor blockers.

Nebivolol, also known by its brand name Bystolic, was prescribed to about 2.8 million people in the USA during the same period of time. Nebivolol is also a beta blocker used primarily for treating hypertension but has additional vasodilating properties which differentiate it from other drugs within its class.

Patients frequently express concerns regarding weight gain with these medications; however, this side effect isn't directly associated with either drug according to scientific studies. While some patients may experience slight weight changes after starting these medications due to water retention or decreased physical activity levels due to fatigue or lethargy caused by these drugs, any significant weight gain should be reported immediately to your healthcare provider.


Both Metoprolol and Bystolic (nebivolol) are widely recognized for their use in managing conditions such as hypertension and angina. They belong to the beta-blocker class of drugs, which work by reducing heart rate, blood pressure, and strain on the heart. Although both drugs may be used together under certain circumstances, this should only occur under careful medical guidance due to potential interactions.

Metoprolol primarily blocks β1 receptors while Bystolic has additional vasodilating effects due to its interaction with nitric oxide. Hence they might be prescribed under different clinical scenarios based on patient-specific factors. Metoprolol is often first-line therapy in hypertension management whereas Bystolic could be considered when patients have specific indications like a need for increased arterial dilation or if there's intolerance or inadequate response to other beta-blockers.

Both medications are available generically representing significant cost savings especially for patients who must pay out of pocket. Similar to most cardiovascular medications, effects from Metoprolol and Bystolic may not be noticeable immediately as it can take several weeks for them to reach full efficacy.

The side effect profile between these two drugs is fairly similar with fatigue, dizziness, slow heartbeat being common complaints but weight gain seems less prominent with nebivolol compared to metoprolol. It's important that individuals monitor their responses closely when starting treatment; any rapid weight gain or swelling should prompt immediate medical attention.