Menopause

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64 Menopause Trials Near You

Power is an online platform that helps thousands of Menopause patients discover FDA-reviewed trials every day. Every trial we feature meets safety and ethical standards, giving patients an easy way to discover promising new treatments in the research stage.

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No Placebo
Highly Paid
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Pivotal Trials (Near Approval)
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Ovarian Tissue Transplantation for Premature Ovarian Failure

Cleveland, Ohio
Premature ovarian failure, also known as primary ovarian insufficiency (POI), or premature menopause, affects 1-2% of women under 40. The diagnosis is typically made based on high levels of follicle stimulating hormone (FSH) and absent or irregular menstrual periods. It leads to infertility and menopause-like effects (hot flashes and thin bones) due to low estrogen levels. POI can result from various factors such as genetic conditions, autoimmune diseases, or previous medical treatments like chemotherapy. Treatment of POI usually involves hormone replacement therapy and, if pregnancy is desired, assisted reproductive technologies such as in vitro fertilization (IVF) using an egg donor. However, IVF may not be an option for everyone due to personal, religious, ethical or financial reasons. Recent advances in medicine have identified ovarian tissue transplantation (OTT) as a potential solution. OTT involves transplanting either fresh or frozen ovarian tissue into the pelvic area, where it can begin functioning again. Studies in animals and humans have shown success in restoring hormonal function and even achieving pregnancies in some cases. Initial human trials of ovarian tissue transplants from another individual began with identical twins and have since expanded to include non-identical siblings with compatible tissue matches using immunosuppression. Success rates of OTT have been promising, with multiple live births reported between identical twins. Long-term studies indicate that transplanted tissue can remain functional for up to eight years. Ovarian tissue transplantation offers a promising avenue for women with POI to help restore fertility and hormonal function. Continued research and refinement of tissue techniques are essential to improve outcomes and expand access to this innovative treatment option. This study will enroll 10 participants who will undergo ovarian tissue transplantation donated by a non-identical sister using an immunosuppression protocol at University Hospitals.
No Placebo Group

Trial Details

Trial Status:Not Yet Recruiting
Trial Phase:Unphased
Age:21 - 40
Sex:Female

10 Participants Needed

Autologous Ovarian Tissue Transplant for Infertility

Pittsburgh, Pennsylvania
Chemotherapy and radiation for cancer and other conditions can cause infertility. Several centers around the world are cryopreserving ovarian tissue from these patients though an experimental protocol, including the Fertility Preservation Program in Pittsburgh (protocol PRO08050491). The objective of this study is to study the efficacy and safety of autologous tissue transplantation in patients diagnosed with primary ovarian insufficiency after chemotherapy and/or radiation treatments.
No Placebo Group

Trial Details

Trial Status:Recruiting
Trial Phase:Unphased
Age:18 - 45
Sex:Female

5 Participants Needed

Iron Supplementation for Menorrhagia

West Lafayette, Indiana
The goal of this clinical trial is to investigate how iron status and heavy bleeding during the menopausal transition affect women's cognitive function and quality of life. The main questions it aims to answer are: * What is the association between iron status, cognitive function, mood, quality of family relationships, and quality of life in perimenopausal women? * How does iron repletion, via supplementation, affect cognitive function, mood, quality of family relationships, and quality of life in perimenopausal women? The investigators will compare the effect of iron supplements to a placebo (gelatin capsule) to see if iron supplements could improve iron status, cognitive function, mood, quality of family relationships, and quality of life of iron-deficient and/or anemic women undergoing the menopausal transition. Each participant will: * Make 2 visits (about 2 hours each - baseline and endline) to the Clinical Research Center at Purdue * Make a very brief visit at midpoint (about 10 minutes) for a checkup * Take a daily study supplement or placebo for 4 months

Trial Details

Trial Status:Not Yet Recruiting
Trial Phase:Unphased
Sex:Female

240 Participants Needed

Pollen Extracts for Menopause

London, Ontario
The goal of this study is to investigate the effect of pollen extracts on menopausal symptoms in healthy women The main question it aims to answer is: What is the difference in change in severity of menopausal symptoms as assessed by the total Menopause Rating Scale (MRS) score from baseline at Week 36 between Graminex Water Soluble Pollen Extract (WSPE), Lipid Soluble Pollen Extract (LSPE), and Placebo? Participants will be asked to complete the MRS assessment tool to rate their menopausal symptoms while receiving either WSPE, LSPE, or Placebo.

Trial Details

Trial Status:Recruiting
Trial Phase:Phase 2
Age:45 - 65
Sex:Female

120 Participants Needed

Estradiol and Elagolix for Menopause

University Park, Pennsylvania
The frequency and severity of heat waves has increased in the last decades. Older adults (over 65 years) have impaired responses to heat stress making them at increased risk for adverse events. Previous heat waves report that women over 65 experience worse health outcomes than any other age group and age matched men. Aging and reproductive hormones, specifically estrogen, independently alter responses to heat stress. However, the combined effects of low estrogen following menopause and aging on the response to heat stress are unknown. In this study, the investigators will identify the role of estrogen in pre and post menopausal women on thermoregulatory responses to heat stress.

Trial Details

Trial Status:Recruiting
Trial Phase:Phase 4
Age:42 - 64
Sex:Female

24 Participants Needed

Nitrate Supplementation and Exercise for Menopause

Charlottesville, Virginia
Menopause greatly increases cardiovascular disease risk (CVD). Current exercise guidelines are inadequate to ameliorate this risk and higher intensity exercise may be necessary for cardiovascular benefits in postmenopausal females. Oral nitrate supplementation enhances exercise performance and CVD risk profile in several clinical conditions. The investigators recently reported that 3-days of nitrate supplementation in postmenopausal females enhances acute post-exercise vascular function, in an intensity dependent manner. The effects of nitrate supplementation and exercise training over a longer training program remains unexplored. This investigation will examine the impact of exercise training intensity with and without inorganic nitrate supplementation, on CVD and fitness outcomes. Postmenopausal females will be tested for maximal oxygen uptake and lactate threshold before randomization to one of four groups: that inorganic nitrate-rich beetroot juice, or beetroot juice with nitrate extracted; and assigned to one-month of calorie matched high-intensity or moderate-intensity exercise training. Vascular function and fitness will be evaluated before and after training.

Trial Details

Trial Status:Recruiting
Trial Phase:Unphased
Age:45 - 75
Sex:Female

40 Participants Needed

PERI-MIND for Menopause and Dementia Risk

Chicago, Illinois
By age 45, women's lifetime risk of dementia is estimated to be 1 in 5. Two-thirds of people currently living with a dementia diagnosis are women, and-women make up the majority of carers for people with dementia. Because women bear a larger burden of the dementia epidemic, they tend to be more fearful about dementia compared to men. Women may be especially fearful during the menopause transition, which can impact cognition. These fears can cause significant psychological distress, functional impairment, and avoidance of help seeking. Interventions that acknowledge women's fears and promote adaptive coping during the menopause transition are needed to combat dementia-related fear and its negative impacts. This project aims to develop, and pilot test a brief personalized, psychosocial intervention for middle-aged perimenopausal individuals with elevated dementia risk. The investigators will assess the intervention's acceptability and feasibility for use in this population. The project will be completed in three stages. First, the investigators will conduct focus groups to better understand individual fears about dementia, informational and decisional needs, and strategies to promote adaptive coping as they transition through menopause (case-only, single time point). Second, the investigators will develop an intervention to meet the specific needs identified by the focus groups. Intervention components will address multiple areas of women's health in midlife, including aspects of physical and psychological health, as well as functional health outcomes that have important and long-lasting life implications. Finally, the investigators will conduct pilot testing to assess the acceptability and feasibility of the intervention (cohort, 3-week testing period). This project will deliver a novel psychosocial intervention that can provide middle-aged perimenopausal women with the information and practical skills that can help them manage their dementia-related fears and encourage adaptive coping behaviors. Outputs from the project will serve as preliminary data for a fully powered randomized controlled trial.
No Placebo Group

Trial Details

Trial Status:Recruiting
Trial Phase:Unphased
Age:40 - 58
Sex:Female

60 Participants Needed

Duavive for Menopausal Depression

Hamilton, Ontario
This study evaluates the impact of conjugated estrogens/ bazedoxifene (CE/ BZA) on the mood (depression and anxiety) in peri- and early menopausal women.
No Placebo Group

Trial Details

Trial Status:Recruiting
Trial Phase:Phase 1
Age:45 - 60
Sex:Female

30 Participants Needed

Hormone Replacement Therapy for Premature Ovarian Failure

Bethesda, Maryland
Background: Premature ovarian insufficiency (POI) is a condition in which women under the age of 40 years have absent or irregular menstrual cycles. POI can cause infertility, signs of menopause, osteoporosis, and other symptoms. Hormone replacement therapy (HRT) is a treatment that gives women extra hormones, such as estrogen and progesterone. HRT works well in adult women. Researchers want to find the most effective doses and regimens for adolescents. Objective: To monitor the effects of HRT on adolescents with POI. Eligibility: Female adolescents aged 11 to 19 years diagnosed with POI. Healthy volunteers are also needed. Design: All participants will have clinic visits every 6 months for 2 years. Each visit may last 2 days. Each visit may include: Blood and urine tests. A test of their heart function. A test to measure the stiffness of their blood vessels. Participants will lie flat with a blood pressure cuff on a leg and a meter on the neck while the cuff inflates. A test of their grip strength. Participants will squeeze a handheld device as hard as they can. Two scans to measure bone density. For one, participants will lie on a table while a scanner passes along their body. For the other, participants will sit in a chair and insert their forearm, then their lower leg, into a scanner. A test to measure skin pigmentation. Participants skin will be touched lightly with a device. An optional visual exam of the vagina. Some vaginal fluid may also be collected with a cotton swab/cytobrush. Participants with POI will receive HRT. They will be given estrogen patches and progesterone pills.
No Placebo Group

Trial Details

Trial Status:Recruiting
Trial Phase:Early Phase 1
Age:11 - 19
Sex:Female

185 Participants Needed

PRP Injections for Postmenopausal Syndrome

Washington, District of Columbia
Platelet-rich plasma (PRP) is autologous blood which has been centrifuged to separate the supernatant resulting in a solution with high concentration of platelets. Injection of PRP stimulates cell growth and can has been proven safe and effective for uses in orthopedics, dermatology, and gynecology. Despite the relative paucity of data, the use of PRP as a therapy for sexual dysfunction and genitourinary symptoms in the setting of menopause has been patented as the O-Shot and V-Shot. This is a single-blinded randomized control trial to determine if PRP injections into the anterior vaginal wall improve sexual functioning in women diagnosed with the genitourinary syndrome of menopause (GSM) characterized by vaginal dryness/irritation.

Trial Details

Trial Status:Recruiting
Trial Phase:Unphased
Sex:Female

30 Participants Needed

Vegan Diet + Soybeans for Hot Flashes

Washington, District of Columbia
This trial tests if a low-fat, vegan diet with soybeans can reduce menopausal hot flashes. Women experiencing these symptoms will follow this diet for a few months. The soybeans might help lessen hot flashes by acting like estrogen. Soy has been studied for its potential to reduce menopausal hot flashes, with varying degrees of success reported in different studies.
No Placebo Group

Trial Details

Trial Status:Active Not Recruiting
Age:40 - 60
Sex:Female

120 Participants Needed

Estradiol Products for Menopause

Baltimore, Maryland
The purpose is to determine if the two estradiol products can deliver similar amounts of estradiol after single and multiple dosing.
No Placebo Group

Trial Details

Trial Status:Recruiting
Trial Phase:Early Phase 1
Age:45 - 65
Sex:Female

12 Participants Needed

Cognitive Behavioral Therapy for Menopause

Baltimore, Maryland
Women are the fastest-growing group of U.S. Veterans. Over half of those using VA care are 45 or older, with more age-related health concerns than civilian women. The VA urgently needs gender-informed strategies to ensure women Veterans receive tailored care that addresses their intersecting mental, physical, and age related health concerns, as well as gender-linked stressors. One prominent example is menopause, a health transition period that, for many women, can be associated with negative physical and mental health concerns that can worsen their functioning and quality of life. This project will: (1) integrate stakeholder feedback to tailor Cognitive Behavioral Therapy for Menopause (CBT-Meno) for women Veterans with menopause concerns; and (2) refine and evaluate tailored CBT-Meno as a treatment to address these intersecting needs in a clinical trial.
No Placebo Group

Trial Details

Trial Status:Not Yet Recruiting
Trial Phase:Unphased
Age:45+
Sex:Female

48 Participants Needed

Topical Estrogen for Menopause

Baltimore, Maryland
The aim of the present study is to determine if two products can deliver bioequivalent amounts of estrogen (estradiol, estriol, and estrone).
No Placebo Group

Trial Details

Trial Status:Recruiting
Age:45 - 65
Sex:Female

4 Participants Needed

Stress Testing for Heart Disease

Chapel Hill, North Carolina
Depression is a known risk factor for cardiovascular disease (CVD), and this comorbidity contributes significantly to the morbidity and mortality of women. The menopausal transition or perimenopause is a period of vulnerability for both depression and CVD, making it a key time to study this critical public health issue. This research will preliminarily explore whether disruption in two novel stress pathways 1) the renin-angiotensin-aldosterone system (RAAS) and autonomic nervous system (ANS) and their relationship may underlie the link between these illnesses. Findings will provide important insight into potential mechanisms by which depression during perimenopause may increase risk for CVD in midlife women, which will inform potential risk reduction and treatment strategies that can improve health outcomes in this population.
No Placebo Group

Trial Details

Trial Status:Recruiting
Trial Phase:Unphased
Age:44 - 55
Sex:Female

30 Participants Needed

Gel Dressing 7-0940 for Vulvovaginal Atrophy

Fayetteville, North Carolina
This trial is testing a new gel dressing on adult women with specific vulvovaginal skin conditions to see if it is safe and effective over time.
No Placebo Group

Trial Details

Trial Status:Recruiting
Trial Phase:Unphased
Sex:Female

2000 Participants Needed

Silicone Gel vs. Estrogen Cream for Genitourinary Syndrome

Johns Creek, Georgia
This trial is testing a new treatment called StrataMGT for women experiencing Genitourinary Syndrome of Menopause (GSM). It aims to see if StrataMGT can improve their quality of life as well as the standard estrogen vaginal cream. Participants will use either StrataMGT or estrogen cream for a period of time and will be monitored regularly.
No Placebo Group

Trial Details

Trial Status:Recruiting
Trial Phase:Unphased
Sex:Female

100 Participants Needed

Stress Response Study for Heart Issues

Atlanta, Georgia
Coronary Microvascular Dysfunction (CMD) occurs when there are problems in small blood vessels/arteries in the heart and symptoms of persistent chest pain that impact women. There are an estimated 3 million women in the US with CMD and about 100,000 new cases annually. This research will investigate whether the stress response physiology and autonomic function in response to mental stress are different in women with CMD compared to other groups. The autonomic nervous system (ANS) controls normally involuntary activities, such as heart rate, respiration (breathing), body temperature, blood pressure, and urinary function. This study will also examine how chronic and daily life mental stress affects the heart, blood vessels. Participants from this study will be recruited mainly from Emory Healthcare-associated hospitals, the Emory Heart Disease Center for Prevention, and Emory Healthcare outpatient cardiology clinics. Participants will have physical exams, blood tests, stress tests, exercise tests, surveys, questionnaires, and images taken of their hearts and blood vessels. They will be asked to take home devices to monitor their autonomic function, sleep and to track their mood, stress level, and symptoms for one week. Data and specimens will be saved for future research.
No Placebo Group

Trial Details

Trial Status:Recruiting
Trial Phase:Unphased
Age:45 - 100
Sex:Female

150 Participants Needed

NOE-115 for Hot Flashes Due to Menopause

Atlanta, Georgia
The purpose of this study is to determine the safety, tolerability, and preliminary effectiveness of NOE-115 on moderate to severe vasomotor symptoms (hot flashes) due to menopause in women.
No Placebo Group

Trial Details

Trial Status:Active Not Recruiting
Trial Phase:Phase 2
Age:45 - 60
Sex:Female

24 Participants Needed

Intravaginal Device for Genitourinary Syndrome

Warren, New Jersey
This pilot study aims to evaluate the safety and effectiveness of the VITA AV Clinical System over a period of up to three months after the last treatment, compared to a sham device. The study focuses on improving vaginal signs and symptoms of Genitourinary Syndrome of Menopause (GSM) in post-menopausal women who experience moderate to severe pain during intercourse (dyspareunia). Long-term follow-up visits will assess the ongoing effectiveness and durability of the treatment, while also collecting safety data.

Trial Details

Trial Status:Not Yet Recruiting
Trial Phase:Unphased
Sex:Female

60 Participants Needed

Why Other Patients Applied

"I have dealt with voice and vocal fold issues related to paralysis for over 12 years. This problem has negatively impacted virtually every facet of my life. I am an otherwise healthy 48 year old married father of 3 living. My youngest daughter is 12 and has never heard my real voice. I am now having breathing issues related to the paralysis as well as trouble swallowing some liquids. In my research I have seen some recent trials focused on helping people like me."

AG
Paralysis PatientAge: 50

"I was diagnosed with stage 4 pancreatic cancer three months ago, metastatic to my liver, and I have been receiving and responding well to chemotherapy. My blood work revealed that my tumor markers have gone from 2600 in the beginning to 173 as of now, even with the delay in treatment, they are not going up. CT Scans reveal they have been shrinking as well. However, chemo is seriously deteriorating my body. I have 4 more treatments to go in this 12 treatment cycle. I am just interested in learning about my other options, if any are available to me."

ID
Pancreatic Cancer PatientAge: 40

"I changed my diet in 2020 and I’ve lost 95 pounds from my highest weight (283). I am 5’3”, female, and now 188. I still have a 33 BMI. I've been doing research on alternative approaches to continue my progress, which brought me here to consider clinical trials."

WR
Obesity PatientAge: 58

"As a healthy volunteer, I like to participate in as many trials as I'm able to. It's a good way to help research and earn money."

IZ
Healthy Volunteer PatientAge: 38

"I've been struggling with ADHD and anxiety since I was 9 years old. I'm currently 30. I really don't like how numb the medications make me feel. And especially now, that I've lost my grandma and my aunt 8 days apart, my anxiety has been even worse. So I'm trying to find something new."

FF
ADHD PatientAge: 31

PhytoSERM for Menopause-related Cognitive Impairment

New York, New York
This trial tests PhytoSERM, a plant-based supplement that mimics estrogen, in peri- and postmenopausal women. The goal is to see if it helps the brain use glucose better, potentially improving brain function and reducing menopausal symptoms. Participants will take the supplement for several months, with brain scans before and after to measure effects. PhytoSERM is a formulation of genistein, daidzein, and S-equol that may enhance neuron function and estrogenic mechanisms in the brain.

Trial Details

Trial Status:Recruiting
Trial Phase:Phase 2
Age:45 - 60

100 Participants Needed

Ovarian Tissue Cryopreservation for Premature Ovarian Failure

New York, New York
The study hopes to contribute to the development of technologies of ovarian tissue freezing-thawing and in vitro maturation of immature eggs such that a person at risk for premature ovarian failure might be able to conceive a genetically related child.
No Placebo Group

Trial Details

Trial Status:Recruiting
Trial Phase:Unphased
Age:< 45
Sex:Female

300 Participants Needed

Propranolol for Vascular Responses in Menopause

Columbia, Missouri
The purpose of this study is to examine hypoxic vasodilation and the role of beta-adrenergic receptors in younger premenopausal, perimenopausal, and older postmenopausal women.

Trial Details

Trial Status:Recruiting
Trial Phase:Early Phase 1
Sex:Female

75 Participants Needed

PET Scans for Heart Disease Risk Assessment in Women

Ottawa, Ontario
The full HER CROWN will be a prospective cohort study to propose a novel, women-specific cardiovascular risk score/ algorithm in the prediction of hard cardiovascular outcomes (myocardial infarction, unstable angina, coronary revascularization, stroke, total and cardiovascular mortality). This future study will be the first longitudinal cohort study, to our knowledge, that is focused entirely on researching the pathophysiology and natural history of cardiovascular disease in women with known female-specific risk factors. Further, the investigators are aiming to recruit a sample that is representative of the ethnic distribution in Canada. The proposed pilot study is a feasibility study as an essential preparatory step for HER CROWN.
No Placebo Group

Trial Details

Trial Status:Recruiting
Trial Phase:Unphased
Age:25 - 55
Sex:Female

210 Participants Needed

EMMII App for Menopause

Rochester, Minnesota
The purpose of this study is about assessing the utilization of a mobile phone application (app), designed to improve the menopause experience of midlife women experiencing related symptoms and its association with menopause-related health care utilization
No Placebo Group

Trial Details

Trial Status:Enrolling By Invitation
Trial Phase:Unphased
Age:24 - 80

450 Participants Needed

Inspiratory Muscle Training for Menopausal Hot Flashes

Rochester, Minnesota
The purpose of this research is to understand how training the muscles used for breathing (inhalation) affects menopausal hot flashes, sympathetic nerve activity and sleep.
No Placebo Group

Trial Details

Trial Status:Recruiting
Trial Phase:Unphased
Age:45 - 60
Sex:Female

30 Participants Needed

Neurovascular Responses to Hot Flashes

Rochester, Minnesota
Women who experience hot flashes are at greater risk for hypertension and other cardiovascular disease. Neurovascular control mechanisms are likely to play an important role in this relationship. As such, these studies are designed to provide a major step forward in understanding the link between hot flashes and neurovascular dysfunction and, by extension, cardiovascular disease in women.
No Placebo Group

Trial Details

Trial Status:Recruiting
Trial Phase:Unphased
Age:40 - 60
Sex:Female

120 Participants Needed

Choline for Menopause

Burlington, Vermont
This study will use a randomized placebo-controlled trial to examine smaller doses of choline and whether a signal in the brain is detectable using fMRI. This study will examine if an even smaller doses of choline can show these similar brain activation and connectivity patterns to the 1650 mg dose. This will be a dose ranging study of 550 mg and 1100 mg oral choline compared to placebo.

Trial Details

Trial Status:Recruiting
Trial Phase:Unphased
Age:50 - 65
Sex:Female

20 Participants Needed

Aerobic vs Resistance Exercise for Type 1 Diabetes

Montreal, Quebec
Participants will be asked to wear a continuous glucose monitor for at least three days on three separate occasions. One testing session will be a no-exercise resting control session (90 minutes). One will be a moderate aerobic exercise session (30 minutes of exercise, 60 minutes of recovery), and the third will be a moderate weight-lifting session (\~30 minutes of exercise, 60 minutes of recovery).The investigators will measure changes in blood glucose during exercise by drawing blood during and after exercise. Post-exercise glucose trends will be examined using continuous glucose monitoring.
No Placebo Group

Trial Details

Trial Status:Recruiting
Trial Phase:Unphased
Age:45 - 75
Sex:Female

20 Participants Needed

Micronized Progesterone for Turner Syndrome

Kansas City, Missouri
This is a single-site open label non-randomized study comparing effects of sequential versus continuous use of progesterone supplementation amongst Turner Syndrome (TS) patients with primary ovarian insufficiency (POI) prescribed hormone replacement therapy (HRT).
No Placebo Group

Trial Details

Trial Status:Not Yet Recruiting
Trial Phase:Phase 4
Age:12 - 20
Sex:Female

40 Participants Needed

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Learn More About Trials
How Do Clinical Trials Work?Are Clinical Trials Safe?What Can I Expect During a Clinical Trial?

Frequently Asked Questions

How much do Menopause clinical trials pay?

Each trial will compensate patients a different amount, but $50-100 for each visit is a fairly common range for Phase 2–4 trials (Phase 1 trials often pay substantially more). Further, most trials will cover the costs of a travel to-and-from the clinic.

How do Menopause clinical trials work?

After a researcher reviews your profile, they may choose to invite you in to a screening appointment, where they'll determine if you meet 100% of the eligibility requirements. If you do, you'll be sorted into one of the treatment groups, and receive your study drug. For some trials, there is a chance you'll receive a placebo. Across Menopause trials 30% of clinical trials have a placebo. Typically, you'll be required to check-in with the clinic every month or so. The average trial length for Menopause is 12 months.

How do I participate in a study as a "healthy volunteer"?

Not all studies recruit healthy volunteers: usually, Phase 1 studies do. Participating as a healthy volunteer means you will go to a research facility several times over a few days or weeks to receive a dose of either the test treatment or a "placebo," which is a harmless substance that helps researchers compare results. You will have routine tests during these visits, and you'll be compensated for your time and travel, with the number of appointments and details varying by study.

What does the "phase" of a clinical trial mean?

The phase of a trial reveals what stage the drug is in to get approval for a specific condition. Phase 1 trials are the trials to collect safety data in humans. Phase 2 trials are those where the drug has some data showing safety in humans, but where further human data is needed on drug effectiveness. Phase 3 trials are in the final step before approval. The drug already has data showing both safety and effectiveness. As a general rule, Phase 3 trials are more promising than Phase 2, and Phase 2 trials are more promising than phase 1.

Do I need to be insured to participate in a Menopause medical study?

Clinical trials are almost always free to participants, and so do not require insurance. The only exception here are trials focused on cancer, because only a small part of the typical treatment plan is actually experimental. For these cancer trials, participants typically need insurance to cover all the non-experimental components.

What are the newest Menopause clinical trials?

Most recently, we added Cognitive Behavioral Therapy for Menopause, Hot Water Therapy for Menopause-Related Hot Flashes and PROSOMNIA Sleep Therapy for Chronic Insomnia to the Power online platform.

How to reverse menopause naturally?

Natural menopause—the point when ovaries have run out of viable eggs—is biologically irreversible, so no diet, herb, or supplement can make regular periods and fertility reliably return. What you can do is (a) avoid reaching menopause a bit earlier than necessary by not smoking, maintaining a healthy weight, and eating a mostly plant-based, fish-and-legume-rich diet, and (b) lessen hot flashes, sleep trouble, and mood changes with regular exercise, stress-reduction, and cautiously tested aids such as soy foods or short-term black cohosh—checking with your healthcare provider first for interactions or liver concerns. If symptoms are still disruptive, discuss stronger evidence-based options like hormone therapy or newer non-hormonal medications with a clinician.

What stage of menopause is the hardest?

For most women, the toughest stretch is late perimenopause and the first year or two after the final period, when estrogen and progesterone swing unpredictably and then fall, driving hot flashes, sleep loss, and mood changes. Individual experience varies—sudden surgical menopause, smoking, stress, or other health issues can shift when symptoms feel worst—so the “hardest stage” is personal. Track your own pattern and discuss lifestyle tweaks or hormone/non-hormone treatments with a menopause-savvy clinician to ease whatever phase is giving you the most trouble.

Is 46 too early for menopause?

Menopause at 46 is at the younger end of the normal 45-55-year range, so it isn’t considered “too early” (only menopause before 45 is classed as early and before 40 as premature). Let your clinician know so they can rule out other causes, discuss symptom relief, and check bone and heart health, but in most cases menopause at 46 is simply a normal variation.

Which hormone replacement therapy is best for weight loss?

Hormone replacement is only helpful for weight when it corrects a proven deficiency: estrogen/progestin can trim about 1 kg of the usual mid-life gain, levothyroxine stops further gain in true hypothyroidism, and testosterone adds lean tissue but little fat loss in women who are genuinely low. If your hormone levels are normal, none of these therapies will make you slimmer, so treatment choice should focus on relieving deficiency-related symptoms while weight control relies on diet, activity, and (when appropriate) dedicated anti-obesity drugs like semaglutide, which is not HRT.

What are the signs that you need hormone replacement therapy?

Think of hormone replacement as a tool for clearly defined situations, not a catch-all fix. For women, doctors consider systemic estrogen (with or without progestin) when hot flashes, night sweats, or vaginal dryness are moderate-to-severe or when menopause occurs early (<40 yrs) and is putting bones at risk; benefit is greatest if therapy starts within 10 years of the last period and there are no major heart-, clot-, or cancer-related contraindications. For men, testosterone is only offered when typical symptoms such as low libido, erectile problems, or loss of muscle strength coexist with TWO separate morning blood tests showing testosterone below the normal range—other causes must first be ruled out. If these criteria fit you, ask your clinician to review the pros, cons, and any needed screening (breast/prostate, heart, clot risk) before deciding on treatment.

Do you age faster without estrogen?

Time itself doesn’t speed up, but when estrogen drops after menopause the skin, bones and blood vessels start to thin, weaken and stiffen more quickly, so many women “show” aging sooner than before. Hormone therapy (or other bone- and skin-protective measures like exercise, good diet and sun protection) can slow some of these changes, but because estrogen can also raise the risk of blood clots, stroke or certain cancers, the decision to take it should be made with a doctor after weighing personal risks and goals.

What happens to a woman's body after menopause?

Once your periods have been gone for 12 months, estrogen from the ovaries drops to very low levels; in the near term this can cause hot flashes, poor sleep and vaginal dryness, while over the years it speeds up bone loss, shifts cholesterol and belly fat in ways that raise heart-disease risk, and thins skin, hair and pelvic-floor tissues. The good news is that most symptoms can be eased (for example with targeted hormone or non-hormone therapies) and the major risks can be curbed by weight-bearing exercise, calcium/vitamin D, not smoking, heart-healthy eating, and regular check-ups that include bone-density and cholesterol tests—so think in two buckets: manage bothersome symptoms now and adopt long-term habits and screenings to protect bones, heart and pelvic health.

What burns menopausal belly fat?

You can’t “spot-burn” belly fat, but studies show menopausal women shrink it fastest when they pair a slightly calorie-reduced, Mediterranean- or high-protein style diet with both progressive strength training (2-3 times a week) and moderate-to-vigorous or interval cardio (about 150 minutes weekly). Quality sleep, stress control and—if appropriate—discussing hormone therapy with your doctor help curb the hormonal shifts that push fat toward the waistline. Think of it as a three-legged stool: smart food choices, muscle-building plus heart-pumping movement, and restorative habits working together to whittle the mid-section.

What is the monthly injection for menopause?

The “monthly shot” is a long-acting estrogen called estradiol valerate or estradiol cypionate, sold as Delestrogen or Depo-Estradiol and typically injected into a muscle every 3–4 weeks to ease hot flashes and vaginal dryness. It is reserved for women who cannot use or do not absorb pills, patches, or gels; if you still have a uterus you must also take a progestin to protect the lining, and the usual estrogen safety cautions (blood-clot, stroke, breast-cancer risk) still apply, so the decision should be made with your clinician.

Why is HRT no longer recommended?

HRT wasn’t “banned”—practice simply shifted after large studies showed that, in women starting therapy well past menopause, the small benefits were outweighed by higher rates of breast cancer, blood clots, stroke and heart disease. Today, experts still recommend HRT as the most effective treatment for troublesome hot flushes and bone loss when started before age 60 or within 10 years of menopause, but they weigh each woman’s personal risks and stop or adjust it if those risks rise.

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