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Trial Phase
Trial Status
Paid Participation
153 Depression Trials near Manchester, NH
Power is an online platform that helps thousands of Depression patients discover FDA-reviewed trials every day. Every trial we feature meets safety and ethical standards, giving patients an easy way to discover promising new treatments in the research stage.
Learn More About PowerLifestyle Physical Activity for Depression and Alcoholism
Trial Details
Key Eligibility Criteria
214 Participants Needed
mHealth Intervention for Severe Mental Illness
Trial Details
Key Eligibility Criteria
180 Participants Needed
Exercise + TMS for Treatment Resistant Depression
Trial Details
Key Eligibility Criteria
30 Participants Needed
Nurse-Led Phone Support for Heart Failure
Trial Details
Key Eligibility Criteria
100 Participants Needed
ABBT for Mental Health in LGBTQ+ Community
Trial Details
240 Participants Needed
Text Messaging Program for Depression
Trial Details
Key Eligibility Criteria
800 Participants Needed
RE104 for Postpartum Depression
Trial Details
Key Eligibility Criteria
72 Participants Needed
Chronotherapy for Perinatal Depression
Trial Details
Key Eligibility Criteria
158 Participants Needed
Mindfulness Training for Postpartum Depression
Trial Details
Key Eligibility Criteria
100 Participants Needed
Black Cumin Seed Oil for Stress
Trial Details
Key Eligibility Criteria
40 Participants Needed
Cognitive Behavioural Therapy for Suicidal Ideation
Trial Details
Key Eligibility Criteria
150 Participants Needed
App-Based CBT for Postpartum Depression
Trial Details
Key Eligibility Criteria
90 Participants Needed
Behavioral Strategies to Improve Sleep for Expectant Mothers
Trial Details
Key Eligibility Criteria
55 Participants Needed
Baby2Home Mobile Application for Mental Health Wellness
Trial Details
Key Eligibility Criteria
642 Participants Needed
Mindfulness-Based Therapy for Serious Mental Illness
Trial Details
Key Eligibility Criteria
160 Participants Needed
ACT-based Physical Activity Program for Depression
Trial Details
Key Eligibility Criteria
75 Participants Needed
Prism Training for Depression
Trial Details
Key Eligibility Criteria
170 Participants Needed
Centanafadine for Depression
Trial Details
Key Eligibility Criteria
336 Participants Needed
Omega-3 for Depression
Trial Details
Key Eligibility Criteria
80 Participants Needed
Ecopipam for Tourette Syndrome
Trial Details
Key Eligibility Criteria
150 Participants Needed
Why Other Patients Applied
"Dealt with treatment-resistant depression for pretty much my entire life. I would be eternally grateful for something that actually worked for once. I'd just like to feel normal. "
"I've used SSRIs (Lexapro, Celexa) and they helped a bit but also, truthfully, they've had pretty serious sexual side effects. Depression was already hurting my marriage, and now these drugs continue to paralyze my it. I've heard that psilocybin-based treatments typically have no sexual side effects... I think a clinical trial will let me try safely."
"I have struggled with depression since I was a child. I have experienced about more than 6 major depressive episodes lasting at least 4 months since I was 7 years old. I have tried talk therapy, a plethora of medication, and nothing has worked long term. Medication and talk therapy helps me manage and reduce the length of depressive episodes but I am in search for alternative treatments. My depression has made completing a bachelors degree a major challenge."
"I've tried several different SSRIs over the past 23 years with no luck. Some of these new treatments seem interesting... haven't tried anything like them before. I really hope that one could work."
"I’ve had depression for many years and been on a LOT of different medications. They work for awhile and then they just stop working. It’s very frustrating. I am very open to trying something new and different. Just looking to fight this, head on."
Intranasal Oxytocin for Central Diabetes Insipidus
Trial Details
Key Eligibility Criteria
40 Participants Needed
Decision Aid for Gender Dysphoria
Trial Details
Key Eligibility Criteria
140 Participants Needed
Mobile App Support for Opioid Use Disorder
Trial Details
Key Eligibility Criteria
1300 Participants Needed
MRT-2359 for Solid Tumors
Trial Details
Key Eligibility Criteria
174 Participants Needed
Targeted Milk Fortification for Premature Infants
Trial Details
Key Eligibility Criteria
130 Participants Needed
Venetoclax + Chemotherapy for B-Cell Lymphoma
Trial Details
Key Eligibility Criteria
363 Participants Needed
Mirvetuximab + Bevacizumab for Ovarian Cancer
Trial Details
Key Eligibility Criteria
520 Participants Needed
Mirvetuximab Soravtansine + Carboplatin for Ovarian Cancer
Trial Details
Key Eligibility Criteria
125 Participants Needed
Dato-DXd + Rilvegostomig for Non-Small Cell Lung Cancer
Trial Details
Key Eligibility Criteria
675 Participants Needed
Dapagliflozin for Type 2 Diabetes
Trial Details
Key Eligibility Criteria
50 Participants Needed
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Frequently Asked Questions
How much do Depression clinical trials in Manchester, NH pay?
Each trial will compensate patients a different amount, but $50-100 for each visit is a fairly common range for Phase 2–4 trials (Phase 1 trials often pay substantially more). Further, most trials will cover the costs of a travel to-and-from the clinic.
How do Depression clinical trials in Manchester, NH work?
After a researcher reviews your profile, they may choose to invite you in to a screening appointment, where they'll determine if you meet 100% of the eligibility requirements. If you do, you'll be sorted into one of the treatment groups, and receive your study drug. For some trials, there is a chance you'll receive a placebo. Across Depression trials in Manchester, NH 30% of clinical trials have a placebo. Typically, you'll be required to check-in with the clinic every month or so. The average trial length in Manchester, NH for Depression is 12 months.
How do I participate in a study as a "healthy volunteer"?
Not all studies recruit healthy volunteers: usually, Phase 1 studies do. Participating as a healthy volunteer means you will go to a research facility in Manchester, NH several times over a few days or weeks to receive a dose of either the test treatment or a "placebo," which is a harmless substance that helps researchers compare results. You will have routine tests during these visits, and you'll be compensated for your time and travel, with the number of appointments and details varying by study.
What does the "phase" of a clinical trial mean?
The phase of a trial reveals what stage the drug is in to get approval for a specific condition. Phase 1 trials are the trials to collect safety data in humans. Phase 2 trials are those where the drug has some data showing safety in humans, but where further human data is needed on drug effectiveness. Phase 3 trials are in the final step before approval. The drug already has data showing both safety and effectiveness. As a general rule, Phase 3 trials are more promising than Phase 2, and Phase 2 trials are more promising than phase 1.
Do I need to be insured to participate in a Depression medical study in Manchester, NH?
Clinical trials are almost always free to participants, and so do not require insurance. The only exception here are trials focused on cancer, because only a small part of the typical treatment plan is actually experimental. For these cancer trials, participants typically need insurance to cover all the non-experimental components.
What are the newest Depression clinical trials in Manchester, NH?
Most recently, we added Online Intervention for Transgender Young Adults' Alcohol Use, Mindfulness-Based Therapy for Serious Mental Illness and Digital Intervention for Depression and Cannabis Use to the Power online platform.
What do the "Power Preferred" and "SuperSite" badges mean?
We recognize research clinics with these awards when they are especially responsive to patients who apply through the Power online platform. SuperSite clinics are research sites recognized for a high standard of rapid and thorough follow-up with patient applicants. Meanwhile, Power Preferred clinics are the top 20 across the entire Power platform, recognized for their absolute top patient experience.
Which clinics have received Power Preferred and SuperSite awards recruiting for Depression trials in Manchester, NH?
The Depression clinics in Manchester, NH currently recognized as Power Preferred are: Adams Clinical in Watertown, Massachusetts Copley Clinical Research in Boston, Massachusetts Adams Clinical in Watertown, Massachusetts Copley Clinical in Boston, Massachusetts Adams Clinical in Watertown, Massachusetts Boston Clinical Trials in Roslindale, Massachusetts The Depression clinics in Manchester, NH currently recognized as SuperSites are: Massachusetts General Hospital in Boston, Massachusetts
What are the current treatment options for depression?
Doctors use a stepped-care approach. First, most people try evidence-based talk therapy (such as CBT or interpersonal therapy), an antidepressant medicine (SSRIs are typical), or both, while also improving sleep, exercise and diet. If symptoms persist, the next “step” is to add or switch treatments—e.g., combining two medicines, adding lithium or an antipsychotic, or using brain-stimulation methods like transcranial magnetic stimulation or, for severe cases, electroconvulsive therapy; newer options such as esketamine nasal spray are reserved for treatment-resistant depression. Working with a clinician to review progress every few weeks and adjust the plan is key to finding the right mix.
When is depression considered severe?
Doctors call a depressive episode “severe” when almost all of the nine core symptoms are present at high intensity, the person’s daily life has largely shut down (can’t work, study, or manage self-care), or there are high-risk features like active suicidal thoughts, a recent attempt, or hallucinations/false beliefs. On common checklists this usually means a PHQ-9 score of 20 or higher, and it signals the need for urgent, comprehensive care—often a combination of medication, psychotherapy, and sometimes hospitalization. If you or someone you know reaches this point, treat it as an emergency and contact a mental-health professional or call/text 988 (USA) or your local crisis line right away.
Is it possible to never be depressed again?
Some people have a single episode of depression and stay well, but the risk of another episode is higher if you stop treatment too soon, have had several episodes before, or still have mild symptoms. You can greatly lower that risk by continuing the treatment that got you better for at least 6–12 months, learning relapse-prevention skills in CBT or mindfulness therapy, keeping regular sleep, exercise, and social routines, and checking in early with a professional if warning signs return. In short, there is no iron-clad guarantee you’ll never be depressed again, but staying on maintenance care and a healthy lifestyle makes long-term wellness much more likely.
What are the top 3 symptoms of depression?
Doctors look first for three core signs: 1) a low or hopeless mood that hangs around most of the day, nearly every day; 2) a marked loss of interest or pleasure in things you used to enjoy (called anhedonia); and 3) big changes in body energy—feeling drained, sleeping or eating far more or less than usual. If any of these have lasted two weeks or longer, it’s time to talk with a health professional, because other symptoms can pile on and treatment works best when started early.
Is depression a chemical imbalance?
No—depression can’t be pinned on one missing brain chemical. Research shows it arises from a mix of factors: how your brain circuits and several neurotransmitters work, your genes, long-term stress, and life circumstances all interact. Because causes differ from person to person, the most effective care is usually a combination of approaches—medication when needed, talking therapies, and lifestyle changes—worked out with your clinician.
How many people have untreatable depression?
Doctors call “untreatable” depression “treatment-resistant depression,” meaning the person has not improved after trying at least two suitable antidepressants. Large studies show this applies to roughly one-quarter to one-third of people with major depression—about 2–3 % of adults overall, or roughly 5–8 million U.S. adults in any given year. Importantly, many still respond to other options such as medication combinations, ketamine/esketamine, transcranial magnetic stimulation, or electroconvulsive therapy.
How to get out of deep depression?
Think of recovery as two tracks that run side-by-side. Track 1: get professional help right away—if you ever feel unsafe call 988 (or your local hotline), and with a clinician discuss proven treatments such as CBT, antidepressant medicine, and, when needed, newer options like ketamine, transcranial magnetic stimulation or electroconvulsive therapy. Track 2: reinforce the medical plan daily with mood-boosting basics—consistent exercise, regular sleep, balanced meals, limited alcohol or drugs, and time with supportive people—because these habits make the treatments work better and give you small, sustainable lifts while you heal.
Why is depression so hard to treat?
Depression is hard to treat because it isn’t a single disease—each person’s symptoms arise from a unique blend of brain chemistry, genetics, stress, medical issues, and life circumstances—so one-size-fits-all therapies rarely work. Without a blood test to guide choices, clinicians must try treatments sequentially, and roughly one-third of people need several steps or a combination of medication, talk therapy, lifestyle changes, or newer options like ketamine or magnetic stimulation before they feel well. The encouraging news is that persistence with a systematic plan and attention to sleep, exercise, and co-existing conditions allows most patients to eventually reach full recovery.
What are unhealthy coping mechanisms for depression?
Unhealthy coping means doing things that give quick relief but actually deepen depression—common examples include using alcohol or other drugs, overeating or not eating, oversleeping or endless screen-scrolling to avoid feelings, cutting or other self-harm, harsh self-talk and rumination, and withdrawing from friends or lashing out at them. These behaviors worsen mood, relationships, and safety; if you notice yourself relying on them, reach out to a trusted person or mental-health professional (or call your local crisis line) and ask about safer skills such as problem-solving steps, scheduled activity, or therapy.
Is it OK to have clinical depression?
Yes—having clinical depression isn’t a personal failing; it’s a common medical illness, and recognising it is the first step toward feeling better. What isn’t OK is to face it alone, because untreated depression can worsen and raise the risk of other problems, whereas most people improve with timely care such as talk therapy, medication, or a combination. If symptoms last more than two weeks or include thoughts of self-harm, book a visit with a primary-care doctor or mental-health professional and, in crisis, call 988 (U.S.) or your local emergency number—effective help and recovery are the norm when treatment is started.