tDCS for Parkinson's Disease
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial explores a new method to help people with movement issues from Parkinson's disease or chronic stroke. Researchers are testing transcranial direct current stimulation (tDCS), which uses electrical currents to potentially improve motor control. The trial includes two groups: one receives actual tDCS, while the other receives a sham (fake) version for comparison. Individuals with Parkinson's disease or chronic stroke who have previously agreed to be contacted for research studies might be suitable for this trial. As an unphased trial, it offers participants the chance to contribute to groundbreaking research that could lead to new treatment options.
Do I need to stop my current medications for the trial?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.
What prior data suggests that transcranial direct current stimulation (tDCS) is safe for patients with Parkinson's disease?
Research has shown that transcranial direct current stimulation (tDCS) is generally safe for individuals with movement disorders like Parkinson's disease. Studies have found that most people, including older adults who may be more fragile, can tolerate tDCS well. This indicates that it is not overly taxing on the body.
Serious side effects are rare. Some individuals might experience slight tingling or itching where the current is applied, but these sensations are usually mild and resolve quickly.
Overall, studies suggest that tDCS does not cause serious harm and is safe for humans. However, it is important to consider personal health and consult a doctor before deciding to join any trial.12345Why are researchers excited about this trial?
Researchers are excited about these treatments for Parkinson's disease because they explore the innovative use of transcranial direct current stimulation (tDCS), which might offer benefits over current options like medication and deep brain stimulation (DBS). Unlike typical treatments that primarily target symptoms with drugs or require invasive surgery, tDCS provides a non-invasive way to potentially influence brain activity. The method involves applying a mild electrical current to parts of the brain, which could improve motor function and quality of life without the need for surgery. This trial could uncover how combining tDCS with invasive and non-invasive recording techniques might further enhance its effectiveness, paving the way for new treatment strategies for Parkinson’s patients.
What evidence suggests that transcranial direct current stimulation could be an effective treatment for Parkinson's disease?
Research has shown that transcranial direct current stimulation (tDCS) can improve symptoms in people with Parkinson's disease. Studies have found that tDCS can enhance both movement and cognitive skills. For instance, applying tDCS to the brain has been linked to better balance and walking in individuals with Parkinson's. One study found that it can also reduce pain and improve pain management. Although not all studies agree, these findings suggest that tDCS is a promising method for managing Parkinson’s symptoms. This trial will compare different approaches: one group will receive tDCS with invasive recording, another with noninvasive recording, and a third group will receive sham tDCS with noninvasive recording.678910
Who Is on the Research Team?
Nathan C Rowland, MD,PhD
Principal Investigator
Medical University of South Carolina
Are You a Good Fit for This Trial?
This trial is for adults over 18 who have previously agreed to be contacted about research studies at the Medical University of South Carolina. It's not suitable for pregnant individuals, those with scalp issues, a history of seizures, metal implants in the head/neck area, prior brain surgery or radiotherapy, or past intracranial tumors/infections/malformations.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants undergo transcranial direct current stimulation (tDCS) or sham stimulation while performing motor tasks
Follow-up
Participants are monitored for changes in motor cortical beta oscillations after tDCS or sham stimulation
What Are the Treatments Tested in This Trial?
Interventions
- sham transcranial direct current stimulation (noninvasive recording)
- transcranial direct current stimulation (invasive recording)
- transcranial direct current stimulation (noninvasive recording)
Find a Clinic Near You
Who Is Running the Clinical Trial?
Medical University of South Carolina
Lead Sponsor