Hypofractionated Radiation Therapy for Diffuse Midline Glioma

Phase-Based Progress Estimates
Mayo Clinic in Rochester, Rochester, MNDiffuse Midline GliomaHypofractionated Radiation Therapy - Radiation
Any Age
All Sexes
What conditions do you have?

Study Summary

This trial studies a new way of delivering radiation to patients with diffuse midline gliomas, which may improve the outcome of the treatment and the patients' quality of life.

Eligible Conditions
  • Diffuse Midline Glioma, H3 K27M-Mutant

Treatment Effectiveness

Study Objectives

1 Primary · 5 Secondary · Reporting Duration: Up to 3 years

Year 3
Quality of Life Measurement
Year 3
Time to progression
Year 3
Overall survival
Year 3
Progression free survival
Up to 3 years
FACT-General Family/Caregiver Questionnaire
Incidence of adverse events

Trial Safety

Safety Progress

2 of 3
This is further along than 68% of similar trials

Trial Design

1 Treatment Group

Treatment (hypofractionated RT)
1 of 1

Experimental Treatment

18 Total Participants · 1 Treatment Group

Primary Treatment: Hypofractionated Radiation Therapy · No Placebo Group · Phase 2

Treatment (hypofractionated RT)Experimental Group · 3 Interventions: Hypofractionated Radiation Therapy, Quality-of-Life Assessment, Questionnaire Administration · Intervention Types: Radiation, Other, Other
First Studied
Drug Approval Stage
How many patients have taken this drug
Hypofractionated Radiation Therapy
Completed Phase 2

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: up to 3 years

Who is running the clinical trial?

Mayo ClinicLead Sponsor
2,954 Previous Clinical Trials
3,448,099 Total Patients Enrolled
National Cancer Institute (NCI)NIH
13,153 Previous Clinical Trials
41,162,290 Total Patients Enrolled
Danielle A CunninghamPrincipal InvestigatorMayo Clinic in Rochester

Eligibility Criteria

Age Any Age · All Participants · 11 Total Inclusion Criteria

Mark “Yes” if the following statements are true for you:
You are able to have a brain scan called an MRI.
If you meet certain medical and imaging criteria, you may be able to continue with the study even if you do not have a biopsy.

Frequently Asked Questions

Is this research endeavor still accepting participants?

"This clinical trial is currently seeking participants, as per the information found on clinicaltrials.gov. The study first went live on October 6th 2021 and was most recently updated in January of 2022." - Anonymous Online Contributor

Unverified Answer

How many participants are enrolled in the current medical experiment?

"Yes, clinicaltrials.gov attests to this medical study's ongoing recruitment process that began on October 6th 2021 and was last updated on January 31st 2022. A total of 18 patients will be sought from a single location." - Anonymous Online Contributor

Unverified Answer

Has the FDA sanctioned Hypofractionated Radiation Therapy?

"Hypofractionated Radiation Therapy's safety was evaluated at a score of 2 as, while there is limited data to support its security, there are no studies yet that assess the efficacy of this treatment." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.