40 Participants Needed

Aerobic Exercise for Aging Brain Health

JR
MO
Overseen ByMedina O Bello
Age: 65+
Sex: Any
Trial Phase: Phase 2 & 3
Sponsor: VA Office of Research and Development
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)
Prior Safety DataThis treatment has passed at least one previous human trial

What You Need to Know Before You Apply

What is the purpose of this trial?

This proposal will evaluate two brain health measures, cerebrovascular perfusion and cerebrovascular reactivity (CVR), before and after a proven, interval-based, aerobic exercise intervention in older Veterans. The hypothesis is that the 12-week aerobic exercise intervention (Spin) will increase perfusion and improve CVR in brain regions susceptible to age-related decline. This information will inform the impact of exercise on cerebrovascular health which is known to be negatively impacted in aging and implicated in the development of neurogenerative disease. This information will also aid the investigators' continued efforts of clinical implementation of evidence-based exercise interventions in the local Atlanta VA and surround region.

Who Is on the Research Team?

JR

Joe R. Nocera, PhD

Principal Investigator

Atlanta VA Medical and Rehab Center, Decatur, GA

Are You a Good Fit for This Trial?

This trial is for English-speaking older Veterans aged 65-80 with at least a high school education, who exercise minimally and have no major diseases affecting cognition or the ability to do aerobic exercises. They must be free from severe psychiatric disorders, ongoing substance abuse, and not regularly perform skilled manual movements.

Inclusion Criteria

I don't have diseases like heart, liver, or kidney disease that affect my thinking or exercise ability.
Participant will be quantified at or below the "poor" range for cardiovascular fitness as assessed by a volume of oxygen (VO2) test (26.0 ml/kg/min for males, 21.0 ml/kg/min for females)
I am between 65-80 years old and exercise less than 40 minutes a week.
See 3 more

Exclusion Criteria

You have a serious mental health condition, such as psychosis, major depression, or bipolar disorder.
I do not regularly perform skilled manual tasks.
I do not have severe high blood pressure or a current drug or alcohol problem.
See 1 more

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants undergo a 12-week aerobic exercise intervention or a control stretching condition

12 weeks
3 sessions per week

Follow-up

Participants are monitored for changes in cerebrovascular function and performance

4 weeks

What Are the Treatments Tested in This Trial?

Interventions

  • Spin
Trial Overview The study tests how a 12-week Spin class—a type of interval-based aerobic exercise—impacts brain health in aging individuals. It focuses on whether this exercise can improve blood flow and reactivity in parts of the brain that are vulnerable as we get older.
How Is the Trial Designed?
2Treatment groups
Experimental Treatment
Active Control
Group I: SpinExperimental Treatment1 Intervention
Group II: ControlActive Control1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

VA Office of Research and Development

Lead Sponsor

Trials
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Recruited
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