Aerobic Exercise for Aging Brain Health
What You Need to Know Before You Apply
What is the purpose of this trial?
This proposal will evaluate two brain health measures, cerebrovascular perfusion and cerebrovascular reactivity (CVR), before and after a proven, interval-based, aerobic exercise intervention in older Veterans. The hypothesis is that the 12-week aerobic exercise intervention (Spin) will increase perfusion and improve CVR in brain regions susceptible to age-related decline. This information will inform the impact of exercise on cerebrovascular health which is known to be negatively impacted in aging and implicated in the development of neurogenerative disease. This information will also aid the investigators' continued efforts of clinical implementation of evidence-based exercise interventions in the local Atlanta VA and surround region.
Who Is on the Research Team?
Joe R. Nocera, PhD
Principal Investigator
Atlanta VA Medical and Rehab Center, Decatur, GA
Are You a Good Fit for This Trial?
This trial is for English-speaking older Veterans aged 65-80 with at least a high school education, who exercise minimally and have no major diseases affecting cognition or the ability to do aerobic exercises. They must be free from severe psychiatric disorders, ongoing substance abuse, and not regularly perform skilled manual movements.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants undergo a 12-week aerobic exercise intervention or a control stretching condition
Follow-up
Participants are monitored for changes in cerebrovascular function and performance
What Are the Treatments Tested in This Trial?
Interventions
- Spin
Find a Clinic Near You
Who Is Running the Clinical Trial?
VA Office of Research and Development
Lead Sponsor