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Aerobic Exercise for Aging Brain Health
Phase 2 & 3
Waitlist Available
Led By Joe R. Nocera, PhD
Research Sponsored by VA Office of Research and Development
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Adults aged 65-80 who do not regularly exercise, defined as exercising less than 20 minutes twice per week
Free from diseases/injuries directly affecting brain functions - including but not limited to: significant closed head injury, open intracranial wounds, stroke, epilepsy, degenerative diseases of the nervous system
Timeline
Screening 3 weeks
Treatment Varies
Follow Up at the pre-intervention assessment and 12-weeks following at the post intervention assessment
Awards & highlights
Study Summary
This trial will study how a 12-week aerobic exercise intervention affects brain health measures in older Veterans. The hypothesis is that the intervention will increase perfusion and improve CVR in brain regions susceptible to age-related decline.
Who is the study for?
This trial is for English-speaking older Veterans aged 65-80 with at least a high school education, who exercise minimally and have no major diseases affecting cognition or the ability to do aerobic exercises. They must be free from severe psychiatric disorders, ongoing substance abuse, and not regularly perform skilled manual movements.Check my eligibility
What is being tested?
The study tests how a 12-week Spin class—a type of interval-based aerobic exercise—impacts brain health in aging individuals. It focuses on whether this exercise can improve blood flow and reactivity in parts of the brain that are vulnerable as we get older.See study design
What are the potential side effects?
While specific side effects aren't listed for an exercise intervention like Spin classes, participants may experience typical physical activity-related issues such as muscle soreness, fatigue, or increased risk of falls or injuries.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowSelect...
I am between 65-80 years old and exercise less than 40 minutes a week.
Select...
My brain function is not impaired by diseases like stroke, epilepsy, or injuries.
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ at the pre-intervention assessment and 12-weeks following at the post intervention assessment
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~at the pre-intervention assessment and 12-weeks following at the post intervention assessment
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
Arterial Spin Labeling (ASL) to Measure Cerebral Blood Flow Change
Secondary outcome measures
Cerebrovascular reactivity (CVR) using a hypercapnic CO2 response test change
Trial Design
2Treatment groups
Experimental Treatment
Active Control
Group I: SpinExperimental Treatment1 Intervention
The intervention will take place three times a week for 12 weeks and will be led by a qualified instructor (an Exercise Physiologist with five years of experience conducting the intervention). The duration of each session will be increased by 1-2 minutes to a maximum time of 45 minutes per session based on the progression of the participants and the recommendation of the instructor. Because participants are initially sedentary and detrained, exercise intensity will begin at low levels (50% of maximal heart rate reserve, HRR) but will be increased by 5% every week (if deemed necessary by the instructor) to a maximum of 75% maximal HRR.
Group II: ControlActive Control1 Intervention
Participants in the control group will be equalized (frequency and duration) to the Spin group for contact and monitoring. As such they will report to the same facility and interact with the same experienced interventionist; however instead of progressive Spin exercise they will participate in sessions focused on balance and stretching. Similar to the aerobic intervention, these exercises will take place in a group setting and heart rate will be consistently monitored during each session to verify heart rate does not reach 50% HRR.
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Who is running the clinical trial?
VA Office of Research and DevelopmentLead Sponsor
1,609 Previous Clinical Trials
3,306,563 Total Patients Enrolled
23 Trials studying Aging
2,779 Patients Enrolled for Aging
Joe R. Nocera, PhDPrincipal InvestigatorAtlanta VA Medical and Rehab Center, Decatur, GA
4 Previous Clinical Trials
328 Total Patients Enrolled
1 Trials studying Aging
30 Patients Enrolled for Aging
Media Library
Eligibility Criteria:
This trial includes the following eligibility criteria:- You have a serious mental health condition, such as psychosis, major depression, or bipolar disorder.I don't have diseases like heart, liver, or kidney disease that affect my thinking or exercise ability.I do not regularly perform skilled manual tasks.I am between 65-80 years old and exercise less than 40 minutes a week.I do not have severe high blood pressure or a current drug or alcohol problem.I am willing and able to follow through with all required tests and treatments.My brain function is not impaired by diseases like stroke, epilepsy, or injuries.
Research Study Groups:
This trial has the following groups:- Group 1: Spin
- Group 2: Control
Awards:
This trial has 1 awards, including:- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Will this experiment be testing on elderly subjects?
"The age limit for this study are individuals that are over 65 and below 80 years old."
Answered by AI
How many people fit the screening criteria for this clinical trial?
"Yes, the information on clinicaltrials.gov suggests that this study is actively searching for candidates. The trial was first posted on 4/1/2019 and was most recently updated on 5/17/2022. The study is admitting 80 patients between 1 sites"
Answered by AI
Are there any unfilled participant positions in this research?
"Indeed, the clinical trial detailed on clinicaltrials.gov is recruiting patients right now. This specific study was originally posted on April 1st, 2019 and was most recently edited on May 17th, 2022."
Answered by AI
Could I possibly qualify to join this clinical trial?
"This study is open to 80 octogenarians and nonagenarians who meet the following requirements: being sedentary (defined as exercising less than 20 minutes twice per week), 21.0 ml/kg/min for females, suffering from chronic heart or kidney disease, and being willing and able to comply with evaluations and treatment plans."
Answered by AI
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