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What is Zyprexa
OlanzapineThe Generic name of this drug
Treatment SummaryOlanzapine is an antipsychotic medication that belongs to a class of drugs known as atypical or second-generation antipsychotics. It was developed in the 1990s and is known for its effectiveness, low risk of side effects, and reduced risk of drug interactions. It is similar to clozapine but contains two additional methyl groups and does not have a chloride moiety. Olanzapine was approved by the FDA in 1996 and is sold under the brand name Zyprexa.
Zyprexais the brand name
Zyprexa Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Zyprexa
Olanzapine
1996
546
Approved as Treatment by the FDA
Olanzapine, otherwise known as Zyprexa, is approved by the FDA for 8 uses which include Mental Depression and Acute Depressive Episode .Mental Depression
Used to treat Acute Depressive Episode in combination with Fluoxetine
Acute Depressive Episode
Used to treat Acute Depressive Episode in combination with Fluoxetine
Bipolar Disorder With Manic or Mixed Episodes
Used to treat Bipolar Disorder With Manic or Mixed Episodes in combination with Lithium cation
Bipolar Disorder
Used to treat Bipolar 1 Disorder in combination with Fluoxetine
Bipolar 1 Disorder
Used to treat Bipolar 1 Disorder in combination with Fluoxetine
Bipolar Disorder
Used to treat Bipolar Disorder With Manic or Mixed Episodes in combination with Lithium cation
Unipolar Depression
Used to treat Major depressive disorder, recurrent episode in combination with Fluoxetine
Major depressive disorder, recurrent episode
Used to treat Major depressive disorder, recurrent episode in combination with Fluoxetine
Effectiveness
How Zyprexa Affects PatientsOlanzapine is a drug used to treat schizophrenia and bipolar disorder in adults and adolescents. It works by targeting the dopamine D2 receptor and the serotonin 5HT2A receptor, which helps to reduce hallucinations, delusions, disorganized speech and behavior, and anhedonia (loss of pleasure). Olanzapine also has been shown to help control chemotherapy-induced nausea and vomiting. In clinical trials, it was observed that 84% of individuals had a complete response on the delay phase, with over 80% control of emesis.
How Zyprexa works in the bodyOlanzapine works by blocking multiple receptors in the brain, such as dopamine, serotonin, adrenaline and histamine receptors. The blocking of dopamine receptors in the mesolimbic pathway plays a key role in preventing dopamine from having an effect at the post-synaptic receptor. Olanzapine also acts on serotonin 5HT2A receptors in the frontal cortex to reduce unpleasant side effects.
When to interrupt dosage
The prescribed amount of Zyprexa is contingent upon the diagnosed condition, including Schizophrenia, Bipolar Disorder and Delirium. The quantity of dosage is based on the administration process (e.g. Kit - Intramuscular or Tablet, film coated - Oral) elucidated in the table below.Condition
Dosage
Administration
Delirium
2.5 mg, , 5.0 mg, 20.0 mg, 15.0 mg, 10.0 mg, 10.0 mg/mL, 7.5 mg, 3.0 mg, 6.0 mg, 12.0 mg, 210.0 mg, 300.0 mg, 405.0 mg, 405.0 mg/mL, 300.0 mg/mL, 210.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Injection, powder, for solution, Intramuscular, Injection, powder, for solution - Intramuscular, Tablet - Oral, Tablet, Capsule, Capsule - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular, Powder, for solution, Powder, for solution - Intramuscular, Tablet, coated, Tablet, coated - Oral, Injection, powder, for suspension, extended release, Injection, powder, for suspension, extended release - Intramuscular, Kit - Intramuscular, Kit
Schizophrenia
2.5 mg, , 5.0 mg, 20.0 mg, 15.0 mg, 10.0 mg, 10.0 mg/mL, 7.5 mg, 3.0 mg, 6.0 mg, 12.0 mg, 210.0 mg, 300.0 mg, 405.0 mg, 405.0 mg/mL, 300.0 mg/mL, 210.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Injection, powder, for solution, Intramuscular, Injection, powder, for solution - Intramuscular, Tablet - Oral, Tablet, Capsule, Capsule - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular, Powder, for solution, Powder, for solution - Intramuscular, Tablet, coated, Tablet, coated - Oral, Injection, powder, for suspension, extended release, Injection, powder, for suspension, extended release - Intramuscular, Kit - Intramuscular, Kit
Schizophrenia
2.5 mg, , 5.0 mg, 20.0 mg, 15.0 mg, 10.0 mg, 10.0 mg/mL, 7.5 mg, 3.0 mg, 6.0 mg, 12.0 mg, 210.0 mg, 300.0 mg, 405.0 mg, 405.0 mg/mL, 300.0 mg/mL, 210.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Injection, powder, for solution, Intramuscular, Injection, powder, for solution - Intramuscular, Tablet - Oral, Tablet, Capsule, Capsule - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular, Powder, for solution, Powder, for solution - Intramuscular, Tablet, coated, Tablet, coated - Oral, Injection, powder, for suspension, extended release, Injection, powder, for suspension, extended release - Intramuscular, Kit - Intramuscular, Kit
Bipolar Disorder
2.5 mg, , 5.0 mg, 20.0 mg, 15.0 mg, 10.0 mg, 10.0 mg/mL, 7.5 mg, 3.0 mg, 6.0 mg, 12.0 mg, 210.0 mg, 300.0 mg, 405.0 mg, 405.0 mg/mL, 300.0 mg/mL, 210.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Injection, powder, for solution, Intramuscular, Injection, powder, for solution - Intramuscular, Tablet - Oral, Tablet, Capsule, Capsule - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular, Powder, for solution, Powder, for solution - Intramuscular, Tablet, coated, Tablet, coated - Oral, Injection, powder, for suspension, extended release, Injection, powder, for suspension, extended release - Intramuscular, Kit - Intramuscular, Kit
Post Traumatic Stress Disorder
2.5 mg, , 5.0 mg, 20.0 mg, 15.0 mg, 10.0 mg, 10.0 mg/mL, 7.5 mg, 3.0 mg, 6.0 mg, 12.0 mg, 210.0 mg, 300.0 mg, 405.0 mg, 405.0 mg/mL, 300.0 mg/mL, 210.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Injection, powder, for solution, Intramuscular, Injection, powder, for solution - Intramuscular, Tablet - Oral, Tablet, Capsule, Capsule - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular, Powder, for solution, Powder, for solution - Intramuscular, Tablet, coated, Tablet, coated - Oral, Injection, powder, for suspension, extended release, Injection, powder, for suspension, extended release - Intramuscular, Kit - Intramuscular, Kit
Tourette Syndrome
2.5 mg, , 5.0 mg, 20.0 mg, 15.0 mg, 10.0 mg, 10.0 mg/mL, 7.5 mg, 3.0 mg, 6.0 mg, 12.0 mg, 210.0 mg, 300.0 mg, 405.0 mg, 405.0 mg/mL, 300.0 mg/mL, 210.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Injection, powder, for solution, Intramuscular, Injection, powder, for solution - Intramuscular, Tablet - Oral, Tablet, Capsule, Capsule - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular, Powder, for solution, Powder, for solution - Intramuscular, Tablet, coated, Tablet, coated - Oral, Injection, powder, for suspension, extended release, Injection, powder, for suspension, extended release - Intramuscular, Kit - Intramuscular, Kit
Mental Depression
2.5 mg, , 5.0 mg, 20.0 mg, 15.0 mg, 10.0 mg, 10.0 mg/mL, 7.5 mg, 3.0 mg, 6.0 mg, 12.0 mg, 210.0 mg, 300.0 mg, 405.0 mg, 405.0 mg/mL, 300.0 mg/mL, 210.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Injection, powder, for solution, Intramuscular, Injection, powder, for solution - Intramuscular, Tablet - Oral, Tablet, Capsule, Capsule - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular, Powder, for solution, Powder, for solution - Intramuscular, Tablet, coated, Tablet, coated - Oral, Injection, powder, for suspension, extended release, Injection, powder, for suspension, extended release - Intramuscular, Kit - Intramuscular, Kit
Acute Agitation
2.5 mg, , 5.0 mg, 20.0 mg, 15.0 mg, 10.0 mg, 10.0 mg/mL, 7.5 mg, 3.0 mg, 6.0 mg, 12.0 mg, 210.0 mg, 300.0 mg, 405.0 mg, 405.0 mg/mL, 300.0 mg/mL, 210.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Injection, powder, for solution, Intramuscular, Injection, powder, for solution - Intramuscular, Tablet - Oral, Tablet, Capsule, Capsule - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular, Powder, for solution, Powder, for solution - Intramuscular, Tablet, coated, Tablet, coated - Oral, Injection, powder, for suspension, extended release, Injection, powder, for suspension, extended release - Intramuscular, Kit - Intramuscular, Kit
Unipolar Depression
2.5 mg, , 5.0 mg, 20.0 mg, 15.0 mg, 10.0 mg, 10.0 mg/mL, 7.5 mg, 3.0 mg, 6.0 mg, 12.0 mg, 210.0 mg, 300.0 mg, 405.0 mg, 405.0 mg/mL, 300.0 mg/mL, 210.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Injection, powder, for solution, Intramuscular, Injection, powder, for solution - Intramuscular, Tablet - Oral, Tablet, Capsule, Capsule - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular, Powder, for solution, Powder, for solution - Intramuscular, Tablet, coated, Tablet, coated - Oral, Injection, powder, for suspension, extended release, Injection, powder, for suspension, extended release - Intramuscular, Kit - Intramuscular, Kit
Acute Coryza
2.5 mg, , 5.0 mg, 20.0 mg, 15.0 mg, 10.0 mg, 10.0 mg/mL, 7.5 mg, 3.0 mg, 6.0 mg, 12.0 mg, 210.0 mg, 300.0 mg, 405.0 mg, 405.0 mg/mL, 300.0 mg/mL, 210.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Injection, powder, for solution, Intramuscular, Injection, powder, for solution - Intramuscular, Tablet - Oral, Tablet, Capsule, Capsule - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular, Powder, for solution, Powder, for solution - Intramuscular, Tablet, coated, Tablet, coated - Oral, Injection, powder, for suspension, extended release, Injection, powder, for suspension, extended release - Intramuscular, Kit - Intramuscular, Kit
Delusional Parasitosis
2.5 mg, , 5.0 mg, 20.0 mg, 15.0 mg, 10.0 mg, 10.0 mg/mL, 7.5 mg, 3.0 mg, 6.0 mg, 12.0 mg, 210.0 mg, 300.0 mg, 405.0 mg, 405.0 mg/mL, 300.0 mg/mL, 210.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Injection, powder, for solution, Intramuscular, Injection, powder, for solution - Intramuscular, Tablet - Oral, Tablet, Capsule, Capsule - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular, Powder, for solution, Powder, for solution - Intramuscular, Tablet, coated, Tablet, coated - Oral, Injection, powder, for suspension, extended release, Injection, powder, for suspension, extended release - Intramuscular, Kit - Intramuscular, Kit
Bipolar Disorder
2.5 mg, , 5.0 mg, 20.0 mg, 15.0 mg, 10.0 mg, 10.0 mg/mL, 7.5 mg, 3.0 mg, 6.0 mg, 12.0 mg, 210.0 mg, 300.0 mg, 405.0 mg, 405.0 mg/mL, 300.0 mg/mL, 210.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Injection, powder, for solution, Intramuscular, Injection, powder, for solution - Intramuscular, Tablet - Oral, Tablet, Capsule, Capsule - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular, Powder, for solution, Powder, for solution - Intramuscular, Tablet, coated, Tablet, coated - Oral, Injection, powder, for suspension, extended release, Injection, powder, for suspension, extended release - Intramuscular, Kit - Intramuscular, Kit
Alzheimer's Disease
2.5 mg, , 5.0 mg, 20.0 mg, 15.0 mg, 10.0 mg, 10.0 mg/mL, 7.5 mg, 3.0 mg, 6.0 mg, 12.0 mg, 210.0 mg, 300.0 mg, 405.0 mg, 405.0 mg/mL, 300.0 mg/mL, 210.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Injection, powder, for solution, Intramuscular, Injection, powder, for solution - Intramuscular, Tablet - Oral, Tablet, Capsule, Capsule - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular, Powder, for solution, Powder, for solution - Intramuscular, Tablet, coated, Tablet, coated - Oral, Injection, powder, for suspension, extended release, Injection, powder, for suspension, extended release - Intramuscular, Kit - Intramuscular, Kit
Bipolar Disorder
2.5 mg, , 5.0 mg, 20.0 mg, 15.0 mg, 10.0 mg, 10.0 mg/mL, 7.5 mg, 3.0 mg, 6.0 mg, 12.0 mg, 210.0 mg, 300.0 mg, 405.0 mg, 405.0 mg/mL, 300.0 mg/mL, 210.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Injection, powder, for solution, Intramuscular, Injection, powder, for solution - Intramuscular, Tablet - Oral, Tablet, Capsule, Capsule - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular, Powder, for solution, Powder, for solution - Intramuscular, Tablet, coated, Tablet, coated - Oral, Injection, powder, for suspension, extended release, Injection, powder, for suspension, extended release - Intramuscular, Kit - Intramuscular, Kit
Warnings
There are 20 known major drug interactions with Zyprexa.Common Zyprexa Drug Interactions
Drug Name
Risk Level
Description
Acenocoumarol
Major
The metabolism of Acenocoumarol can be decreased when combined with Olanzapine.
Acepromazine
Major
Olanzapine may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Acepromazine.
Aclidinium
Major
The risk or severity of adverse effects can be increased when Olanzapine is combined with Aclidinium.
Alfuzosin
Major
Olanzapine may increase the hypotensive activities of Alfuzosin.
Amisulpride
Major
Olanzapine may increase the antipsychotic activities of Amisulpride.
Zyprexa Toxicity & Overdose RiskSymptoms of olanzapine toxicity include drowsiness, dilated pupils, difficulty breathing, low blood pressure, muscle stiffness, and dry mouth. The maximum recommended dose is 300 mg, although higher doses have been reported to cause agitation, slurred speech, rapid heartbeat, and reduced consciousness. In extreme cases, olanzapine overdose can be fatal. Treatment for olanzapine overdose includes ensuring adequate oxygen and ventilation, as well as administering activated charcoal and laxatives. In animal studies, olanzapine has been linked to an increased risk of liver and breast tumors, as well as decreased fertility in males
Zyprexa Novel Uses: Which Conditions Have a Clinical Trial Featuring Zyprexa?
At present, 578 active trials are being conducted to investigate the potential of Zyprexa in providing relief from Schizophrenia, Post Traumatic Stress Disorder and Delusional Parasitosis.Condition
Clinical Trials
Trial Phases
Bipolar Disorder
0 Actively Recruiting
Schizophrenia
108 Actively Recruiting
Phase 3, Not Applicable, Early Phase 1, Phase 4, Phase 2, Phase 1
Post Traumatic Stress Disorder
233 Actively Recruiting
Early Phase 1, Not Applicable, Phase 2, Phase 4, Phase 3, Phase 1
Schizophrenia
33 Actively Recruiting
Early Phase 1, Not Applicable, Phase 4
Mental Depression
1 Actively Recruiting
Not Applicable
Delirium
30 Actively Recruiting
Not Applicable, Phase 2, Phase 3, Phase 4, Early Phase 1
Unipolar Depression
51 Actively Recruiting
Not Applicable, Phase 4, Early Phase 1, Phase 3, Phase 2, Phase 1
Bipolar Disorder
0 Actively Recruiting
Bipolar Disorder
0 Actively Recruiting
Delusional Parasitosis
0 Actively Recruiting
Alzheimer's Disease
35 Actively Recruiting
Phase 4, Phase 2, Phase 3, Not Applicable, Phase 1
Acute Coryza
1 Actively Recruiting
Not Applicable
Acute Agitation
0 Actively Recruiting
Tourette Syndrome
0 Actively Recruiting
Zyprexa Reviews: What are patients saying about Zyprexa?
5Patient Review
12/28/2020 I've been on this medication for a couple of months now, and it has really helped me to manage my anxiety. It's made a world of difference for me, and I would recommend it to anyone struggling with similar issues.
5Patient Review
5/21/2022 If you're struggling with depression and anxiety, I would highly recommend this medication. In addition to my antidepressant, it's really helped me with managing my anxiety levels and getting better sleep. Just be aware that you may see some weight gain as a side effect.
4.3Patient Review
1/15/2021 Zyprexa was an absolute lifesaver for me. I had been struggling with suicidal thoughts for months, and they disappeared the very next day after taking this medication. It's not intended to be a long-term solution, but it definitely helped me in the short term. The main downside is that it made me feel incredibly drowsy and gave me a voracious appetite; however, I believe that the pros outweigh the cons in this case.
4Patient Review
5/23/2021 I've been taking this medication on and off for years, and it does a great job of curbing the paranoia and psychosis. However, it can make you feel exhausted and coming off of it is really tough - expect severe depression and suicidal thoughts. I hate that I may need to be on this medication for the rest of my life just to have any sense of normalcy.
3.7Patient Review
8/14/2022 I started on 5mg, which made me sleepy for a few months. But it stopped the crazy thoughts and I didn't gain any weight. I'm a very fussy eater and hit the gym 5 days a week so I decided to see if I could get away with microdosing. So far, 0.625 mg is still working for me.
Patient Q&A Section about zyprexa
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What are side effects of Zyprexa?
",increased sweating or urination, diarrhea, or constipation; and, very rare side effects (occurring in less than 1 in 1,000 people), coma and death.
The following are potential side effects of the medication, which are more likely to occur in teenagers: weight gain, increased appetite, headache, dizziness, drowsiness, feeling tired or restless, problems with speech or memory, tremors or shaking, numbness or tingly feeling, changes in personality, dry mouth, or increased salivation. Increased sweating or urination, diarrhea, or constipation are also potential side effects, though they are less common. Very rare side effects, which occur in less than 1 in 1,000 people, include coma and death."
Answered by AI
Is Zyprexa a mood stabilizer?
"Olanzapine is a mood stabilizer that is similar to lithium, certain anticonvulsants, and some other antipsychotics. Olanzapine can also help to treat depression when combined with fluoxetine."
Answered by AI
What is the drug Zyprexa used for?
"Olanzapine is a medication that is used to treat schizophrenia by working on the brain. It is classified as a second generation antipsychotic (SGA) or atypical antipsychotic. Olanzapine balances the levels of dopamine and serotonin in order to improve thinking, mood, and behavior."
Answered by AI
Is Zyprexa for anxiety or depression?
"Lithium is a medication that is taken for long periods of time in order to treat episodes of mania and depression. It is often prescribed for a minimum of six months. Lithium works as a mood stabilizer by helping to even out moods and control symptoms of both mania and depression. Olanzapine is another medication that can help with symptoms of mania."
Answered by AI
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