Zyflo Cr

Asthma, Asthma

Treatment

4 FDA approvals

20 Active Studies for Zyflo Cr

Treatment for

Asthma

What is Zyflo Cr

ZileutonThe Generic name of this drug

Treatment SummaryZileuton is a medication used to relieve asthma symptoms. It works by blocking the production of leukotrienes, which are substances that can cause inflammation, swelling, mucus production, and narrowing of the airways in asthmatic patients. Zileuton inhibits the enzyme 5-lipoxygenase and stops the formation of leukotrienes LTB4, LTC4, LTD4, and LTE4. Both the R(+) and S(-) enantiomers have been shown to be effective at blocking the enzyme in laboratory tests. The immediate release tablet version of Zileuton is no longer available in

Zyflois the brand name

Zyflo Cr Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Zyflo

Zileuton

1996

Approved as Treatment by the FDA

Zileuton, also known as Zyflo, is approved by the FDA for 4 uses such as Asthma and Chronic Asthma .

Asthma

Chronic Asthma

Helps manage Chronic Asthma

Asthma

Helps manage Chronic Asthma

Asthma

Effectiveness

How Zyflo Cr Affects PatientsZileuton is a drug that helps with asthma. It prevents the production of a substance called leukotrienes which can lead to inflammation in the airways. In people with asthma, this drug has been shown to reduce the constricting of airways caused by cold air.

How Zyflo Cr works in the bodyZileuton reduces inflammation and bronchoconstriction in people with asthma. It works by blocking an enzyme called 5-lipoxygenase, which is responsible for producing leukotrienes, molecules that cause inflammation and other symptoms of asthma. Zileuton prevents the production of these molecules, reducing asthma symptoms. Both the left and right versions of the drug are equally effective. By stopping the production of leukotrienes, Zileuton helps to control asthma and reduce airway symptoms.

When to interrupt dosage

The proposed dosage of Zyflo Cr is contingent upon the diagnosed condition. The sum of dosage changes, subject to the administration technique (e.g. Tablet - Oral or Tablet, extended release) listed in the table below.

Condition

Dosage

Administration

Asthma

, 600.0 mg

, Tablet, extended release - Oral, Tablet, extended release, Oral, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral

Asthma

, 600.0 mg

Warnings

Zyflo Cr has two contraindications and should be avoided when dealing with the conditions in the table below.Zyflo Cr Contraindications

Condition

Risk Level

Notes

Liver Failure, Acute

Do Not Combine

Pulse Frequency

Do Not Combine

There are 20 known major drug interactions with Zyflo Cr.

Common Zyflo Cr Drug Interactions

Drug Name

Risk Level

Description

Aminophylline

Major

The metabolism of Aminophylline can be decreased when combined with Zileuton.

Anagrelide

Major

The metabolism of Anagrelide can be decreased when combined with Zileuton.

Axitinib

Major

The metabolism of Axitinib can be decreased when combined with Zileuton.

Bendamustine

Major

The metabolism of Bendamustine can be decreased when combined with Zileuton.

Clomipramine

Major

The metabolism of Clomipramine can be decreased when combined with Zileuton.

Zyflo Cr Toxicity & Overdose RiskThe lowest toxic dose of zileuton in mice is 500mg/kg and 300mg/kg in rats, which is 3 to 9 times the amount of exposure that humans would get from the recommended daily dose.

image of a doctor in a lab doing drug, clinical research

Zyflo Cr Novel Uses: Which Conditions Have a Clinical Trial Featuring Zyflo Cr?

147 active trials are currently assessing the potential of Zyflo Cr in ameliorating Asthma symptoms.

Condition

Clinical Trials

Trial Phases

Asthma

88 Actively Recruiting

Phase 4, Early Phase 1, Phase 2, Not Applicable, Phase 1, Phase 3

Asthma

2 Actively Recruiting

Not Applicable, Phase 2

Zyflo Cr Reviews: What are patients saying about Zyflo Cr?

5Patient Review

11/6/2015

Zyflo Cr for Asthma Prevention

Zyflo was a game-changer for me back in the '90s. I'm glad they eventually released an extended-release version, but it's getting harder and harder to find nowadays.

5Patient Review

6/9/2009

Zyflo Cr for Allergic Asthma

Allergic symptoms like increased mucus production and sinus pressure seem to be improving, as well as less irritation in my eyes.

5Patient Review

4/13/2017

Zyflo Cr for Controller Medication for Asthma

This treatment was a life-saver for me. I had been having repeated exacerbations of my asthma, and was almost placed on a ventilator several times. But then my pulmonologist prescribed this medication for me, and it has been a miracle drug. It's the only leukotriene inhibitor available, and it has helped me immensely with no complications or side effects.

4.7Patient Review

5/31/2013

Zyflo Cr for Allergic Asthma

Zyflo is a great medication for asthma and sinus problems. I think it's under prescribed because of the cost, but it's worth it. This medication goes a step further than Singulair and the results are amazing. I don't even need inhalers with Zyflo CR. If you have difficulty breathing from allergies, I recommend you try this medication.

4.7Patient Review

1/30/2013

Zyflo Cr for Allergic Asthma

I've been on this medication for nearly a year now, and it has finally allowed me to live without the constant fear of asthma attacks. However, I am concerned about the long-term effects of taking this drug.

View All Reviews

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Patient Q&A Section about zyflo cr

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are the side effects of Zyflo?

"The following are possible side-effects: feeling nauseous, having an upset stomach, suffering from diarrhea, trouble sleeping, cold symptoms (blocked nose, pain in the sinuses, sneezing, sore throat), headaches, feeling weak, or muscle pain."

Answered by AI

What is Zyflo used for?

"Zileuton is a medication used to treat asthma by controlling and preventing symptoms such as wheezing and shortness of breath. This medication is effective when used regularly and can help people with asthma to maintain their normal activities and avoid time lost from work or school."

Answered by AI

Why was Zyflo taken off the market?

"The FDA issued a warning to Cornerstone over the marketing of Zyflo CR, stating that some of the materials used violated the Food, Drug, and Cosmetic Act. Specifically, the FDA noted that some of the materials used outdated labeling and suggested that Zyflo CR is more effective than competing drugs like Singulair."

Answered by AI

Is there a generic for Zyflo?

"There is no equivalent to Zyflo available in the United States. There may be counterfeit versions of this medication being sold by fraudulent online pharmacies. These versions of the medication may be unsafe."

Answered by AI

Clinical Trials for Zyflo Cr

Have you considered Zyflo Cr clinical trials? We made a collection of clinical trials featuring Zyflo Cr, we think they might fit your search criteria.

Have you considered Zyflo Cr clinical trials? We made a collection of clinical trials featuring Zyflo Cr, we think they might fit your search criteria.