Zofran

Pruritus, Hyperemesis Gravidarum, Nausea + 8 more
Treatment
7 Active Studies for Zofran

What is Zofran

OndansetronThe Generic name of this drug
Treatment SummaryOndansetron is a medication developed in the 1980s to prevent nausea and vomiting caused by chemotherapy. It is also used to treat anxiety and has been approved by the US FDA since 1991. It is available in the form of oral tablets, orally disintegrating tablets and injections, and can also be found as generic products. Recently, orally soluble films have been developed which make taking the drug easier, especially when a person is vomiting.
Zofranis the brand name
image of different drug pills on a surface
Zofran Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Zofran
Ondansetron
1991
583

Effectiveness

How Zofran Affects PatientsOndansetron is a medicine that blocks the serotonin 5-HT3 receptors in the body, which are responsible for causing nausea and vomiting. It has no effect on other serotonin receptors or dopamine receptors. Ondansetron can be given as an intravenous infusion, but a single dose of 8 mg orally is generally considered safe with minimal effects on the QTc interval. When taken over multiple days, it has been shown to slow down colonic transit. Ondansetron also does not affect plasma prolactin concentrations.
How Zofran works in the bodyOndansetron works by blocking the body's natural reaction to vomiting, which is triggered by serotonin. Serotonin is released when a person receives chemotherapy or radiation therapy, which causes the body to vomit. Ondansetron stops this reaction by blocking the serotonin receptor, 5-HT3. This prevents the body from sending the signal to vomit. It is not yet exactly known how Ondansetron works to prevent nausea and vomiting from opiates, but it likely works through similar pathways.

When to interrupt dosage

The recommended dosage of Zofran is contingent upon the diagnosed condition, such as Uremia, radiation therapy induced nausea and vomiting and Pharmacotherapy. The quantity of dosage is contingent upon the technique of delivery specified in the table below.
Condition
Dosage
Administration
Pharmacotherapy
3.2 mg/mL, , 2.0 mg/mL, 8.0 mg, 4.0 mg, 24.0 mg, 4.0 mg/mL, 0.4 mg, 16.0 mg, 2.0 mg, 8.0 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Solution, Solution - Oral, Tablet, coated, Tablet, coated - Oral, Injection - Intravenous, Intramuscular, Injection, solution - Intramuscular, Film, soluble, Film, soluble - Oral, Solution - Intramuscular; Intravenous, Solution - Intravenous, Liquid, Liquid - Intravenous, Film, Film - Oral, Troche - Sublingual, Sublingual, Troche
Nausea
3.2 mg/mL, , 2.0 mg/mL, 8.0 mg, 4.0 mg, 24.0 mg, 4.0 mg/mL, 0.4 mg, 16.0 mg, 2.0 mg, 8.0 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Solution, Solution - Oral, Tablet, coated, Tablet, coated - Oral, Injection - Intravenous, Intramuscular, Injection, solution - Intramuscular, Film, soluble, Film, soluble - Oral, Solution - Intramuscular; Intravenous, Solution - Intravenous, Liquid, Liquid - Intravenous, Film, Film - Oral, Troche - Sublingual, Sublingual, Troche
Uremia
3.2 mg/mL, , 2.0 mg/mL, 8.0 mg, 4.0 mg, 24.0 mg, 4.0 mg/mL, 0.4 mg, 16.0 mg, 2.0 mg, 8.0 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Solution, Solution - Oral, Tablet, coated, Tablet, coated - Oral, Injection - Intravenous, Intramuscular, Injection, solution - Intramuscular, Film, soluble, Film, soluble - Oral, Solution - Intramuscular; Intravenous, Solution - Intravenous, Liquid, Liquid - Intravenous, Film, Film - Oral, Troche - Sublingual, Sublingual, Troche
Pharmacotherapy
3.2 mg/mL, , 2.0 mg/mL, 8.0 mg, 4.0 mg, 24.0 mg, 4.0 mg/mL, 0.4 mg, 16.0 mg, 2.0 mg, 8.0 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Solution, Solution - Oral, Tablet, coated, Tablet, coated - Oral, Injection - Intravenous, Intramuscular, Injection, solution - Intramuscular, Film, soluble, Film, soluble - Oral, Solution - Intramuscular; Intravenous, Solution - Intravenous, Liquid, Liquid - Intravenous, Film, Film - Oral, Troche - Sublingual, Sublingual, Troche
Malignant Neoplasms
3.2 mg/mL, , 2.0 mg/mL, 8.0 mg, 4.0 mg, 24.0 mg, 4.0 mg/mL, 0.4 mg, 16.0 mg, 2.0 mg, 8.0 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Solution, Solution - Oral, Tablet, coated, Tablet, coated - Oral, Injection - Intravenous, Intramuscular, Injection, solution - Intramuscular, Film, soluble, Film, soluble - Oral, Solution - Intramuscular; Intravenous, Solution - Intravenous, Liquid, Liquid - Intravenous, Film, Film - Oral, Troche - Sublingual, Sublingual, Troche
Pruritus
3.2 mg/mL, , 2.0 mg/mL, 8.0 mg, 4.0 mg, 24.0 mg, 4.0 mg/mL, 0.4 mg, 16.0 mg, 2.0 mg, 8.0 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Solution, Solution - Oral, Tablet, coated, Tablet, coated - Oral, Injection - Intravenous, Intramuscular, Injection, solution - Intramuscular, Film, soluble, Film, soluble - Oral, Solution - Intramuscular; Intravenous, Solution - Intravenous, Liquid, Liquid - Intravenous, Film, Film - Oral, Troche - Sublingual, Sublingual, Troche
Hyperemesis Gravidarum
3.2 mg/mL, , 2.0 mg/mL, 8.0 mg, 4.0 mg, 24.0 mg, 4.0 mg/mL, 0.4 mg, 16.0 mg, 2.0 mg, 8.0 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Solution, Solution - Oral, Tablet, coated, Tablet, coated - Oral, Injection - Intravenous, Intramuscular, Injection, solution - Intramuscular, Film, soluble, Film, soluble - Oral, Solution - Intramuscular; Intravenous, Solution - Intravenous, Liquid, Liquid - Intravenous, Film, Film - Oral, Troche - Sublingual, Sublingual, Troche
Nausea
3.2 mg/mL, , 2.0 mg/mL, 8.0 mg, 4.0 mg, 24.0 mg, 4.0 mg/mL, 0.4 mg, 16.0 mg, 2.0 mg, 8.0 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Solution, Solution - Oral, Tablet, coated, Tablet, coated - Oral, Injection - Intravenous, Intramuscular, Injection, solution - Intramuscular, Film, soluble, Film, soluble - Oral, Solution - Intramuscular; Intravenous, Solution - Intravenous, Liquid, Liquid - Intravenous, Film, Film - Oral, Troche - Sublingual, Sublingual, Troche
radiation therapy induced nausea and vomiting
3.2 mg/mL, , 2.0 mg/mL, 8.0 mg, 4.0 mg, 24.0 mg, 4.0 mg/mL, 0.4 mg, 16.0 mg, 2.0 mg, 8.0 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Solution, Solution - Oral, Tablet, coated, Tablet, coated - Oral, Injection - Intravenous, Intramuscular, Injection, solution - Intramuscular, Film, soluble, Film, soluble - Oral, Solution - Intramuscular; Intravenous, Solution - Intravenous, Liquid, Liquid - Intravenous, Film, Film - Oral, Troche - Sublingual, Sublingual, Troche
Nausea
3.2 mg/mL, , 2.0 mg/mL, 8.0 mg, 4.0 mg, 24.0 mg, 4.0 mg/mL, 0.4 mg, 16.0 mg, 2.0 mg, 8.0 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Solution, Solution - Oral, Tablet, coated, Tablet, coated - Oral, Injection - Intravenous, Intramuscular, Injection, solution - Intramuscular, Film, soluble, Film, soluble - Oral, Solution - Intramuscular; Intravenous, Solution - Intravenous, Liquid, Liquid - Intravenous, Film, Film - Oral, Troche - Sublingual, Sublingual, Troche
Malignant Neoplasms
3.2 mg/mL, , 2.0 mg/mL, 8.0 mg, 4.0 mg, 24.0 mg, 4.0 mg/mL, 0.4 mg, 16.0 mg, 2.0 mg, 8.0 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Solution, Solution - Oral, Tablet, coated, Tablet, coated - Oral, Injection - Intravenous, Intramuscular, Injection, solution - Intramuscular, Film, soluble, Film, soluble - Oral, Solution - Intramuscular; Intravenous, Solution - Intravenous, Liquid, Liquid - Intravenous, Film, Film - Oral, Troche - Sublingual, Sublingual, Troche

Warnings

Zofran Contraindications
Condition
Risk Level
Notes
Pulse Frequency
Do Not Combine
There are 20 known major drug interactions with Zofran.
Common Zofran Drug Interactions
Drug Name
Risk Level
Description
Amitriptyline
Major
The metabolism of Amitriptyline can be decreased when combined with Ondansetron.
Amoxapine
Major
The metabolism of Amoxapine can be decreased when combined with Ondansetron.
Anagrelide
Major
The risk or severity of QTc prolongation can be increased when Ondansetron is combined with Anagrelide.
Apomorphine
Major
The risk or severity of adverse effects can be increased when Ondansetron is combined with Apomorphine.
Arsenic trioxide
Major
The risk or severity of QTc prolongation can be increased when Ondansetron is combined with Arsenic trioxide.
Zofran Toxicity & Overdose RiskThere is limited information on overdosing on ondansetron. However, some cases have reported sudden blindness, low blood pressure, or abnormal heart rhythm with large doses. It is also not recommended to take ondansetron while pregnant or while breastfeeding. Additionally, there is not enough information to recommend a dosage for children under the age of 3.
image of a doctor in a lab doing drug, clinical research

Zofran Novel Uses: Which Conditions Have a Clinical Trial Featuring Zofran?

Two ongoing clinical trials are examining the potential of Zofran to reduce Nausea, Uremia and Radiation Therapy induced Nausea and Vomiting.
Condition
Clinical Trials
Trial Phases
Hyperemesis Gravidarum
0 Actively Recruiting
Nausea
0 Actively Recruiting
radiation therapy induced nausea and vomiting
0 Actively Recruiting
Malignant Neoplasms
0 Actively Recruiting
Nausea
5 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 4
Nausea
0 Actively Recruiting
Pruritus
0 Actively Recruiting
Pharmacotherapy
0 Actively Recruiting
Uremia
0 Actively Recruiting
Pharmacotherapy
2 Actively Recruiting
Phase 4, Not Applicable
Malignant Neoplasms
0 Actively Recruiting

Zofran Reviews: What are patients saying about Zofran?

5Patient Review
12/28/2018
Zofran for Nausea and Vomiting
I'd rather have a headache than feel nauseous any day.
5Patient Review
8/16/2022
Zofran for Nausea and Vomiting
The medication completely curbed my nausea and allowed me to eat again, which was amazing. I didn't have any issues with headaches, but other people have mentioned that as a potential side effect.
4.3Patient Review
12/19/2016
Zofran for Nausea and Vomiting
Zofran is a great alternative to Phenergan for those who are looking for something that will still work quickly, but without the drowsiness. I did experience a headache once from it, but not every time.
4Patient Review
4/10/2022
Zofran for Nausea and Vomiting
After getting sick from the Norovirus, this worked quickly and effectively. Just remember NOT to drink water whilst it dissolves under your tongue or you end up with a wicked headache. The relief is a godsend.
3.7Patient Review
3/17/2019
Zofran for Nausea and Vomiting
This medication helped me a lot with the nausea and vomiting I was experiencing from my other pain medications. However, it did cause constipation as a side effect.
View All Reviews
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Patient Q&A Section about zofran

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is Zofran an opioid?

"Zofran does not belong to the class of medications that are classified as narcotics. Instead, it belongs to a class of medications called 5-HT3 (serotonin) receptor antagonists."

Answered by AI

Who should not take Zofran?

"You should not use Zofran if you are allergic to it or to similar medicines such as dolasetron (Anzemet), granisetron (Kytril), or palonosetron (Aloxi). Zofran may contain phenylalanine. Tell your doctor if you have phenylketonuria (PKU)."

Answered by AI

What is the drug Zofran used for?

"Ondansetron is a medication used to prevent nausea and vomiting. It is typically used in cancer patients undergoing chemotherapy, radiation therapy, or surgery."

Answered by AI

Does Zofran make one sleepy?

"You may experience headaches, lightheadedness, dizziness, drowsiness, or fatigue, as well as constipation. If you have any of these symptoms, let your doctor know."

Answered by AI

Clinical Trials for Zofran

Have you considered Zofran clinical trials? We made a collection of clinical trials featuring Zofran, we think they might fit your search criteria.
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