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What is Zaroxolyn
MetolazoneThe Generic name of this drug
Treatment SummaryAcetazolamide is a long-acting diuretic that is used to treat chronic kidney failure. It can reduce blood pressure and increase the amount of potassium lost in the urine. Acetazolamide belongs to a group of drugs called quinazoline-sulfonamides, which are similar to thiazide diuretics.
Metolazoneis the brand name
Zaroxolyn Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Metolazone
Metolazone
1973
81
Approved as Treatment by the FDA
Metolazone, also known as Metolazone, is approved by the FDA for 2 uses which include Hypertensive disease and Hypertensive disease .Hypertensive disease
Used in combination with Hydrochlorothiazide / Losartan to help manage High Blood Pressure (Hypertension)
Hypertensive disease
Helps manage moderate Hypertension
Effectiveness
How Zaroxolyn Affects PatientsMetolazone is a type of diuretic that works similarly to thiazide diuretics. It has been seen to increase the amount of sodium, magnesium and phosphate that is passed out of the body in humans with a weak kidney filtering system. This has also been confirmed through experiments on animals.
How Zaroxolyn works in the bodyMetolazone makes your kidneys work harder to remove salt and water from the body. This helps reduce blood pressure. Metolazone stops sodium from being reabsorbed, meaning it gets removed from the body instead. It also causes potassium to be removed. These effects are caused by changes that happen in the renal tubules, but the exact mechanism of action is not known.
When to interrupt dosage
The prescribed measure of Zaroxolyn is contingent upon the diagnosed condition, for instance Mild Hypertension, Hypertensive affliction and Hypertensive disease. The amount of dosage similarly relies upon the administration approach featured in the table beneath.Condition
Dosage
Administration
Hypertensive disease
5.0 mg, , 2.5 mg, 10.0 mg, 0.5 mg
, Oral, Tablet, Tablet - Oral
Swollen feet or ankles
5.0 mg, , 2.5 mg, 10.0 mg, 0.5 mg
, Oral, Tablet, Tablet - Oral
Chronic Kidney Disease (CKD)
5.0 mg, , 2.5 mg, 10.0 mg, 0.5 mg
, Oral, Tablet, Tablet - Oral
Congestive Heart Failure
5.0 mg, , 2.5 mg, 10.0 mg, 0.5 mg
, Oral, Tablet, Tablet - Oral
Mild Hypertension
5.0 mg, , 2.5 mg, 10.0 mg, 0.5 mg
, Oral, Tablet, Tablet - Oral
Hypertensive disease
5.0 mg, , 2.5 mg, 10.0 mg, 0.5 mg
, Oral, Tablet, Tablet - Oral
Warnings
Zaroxolyn has three known contraindications and should not be taken when confronting conditions listed in the below table.Zaroxolyn ContraindicationsCondition
Risk Level
Notes
Anuria
Do Not Combine
Hepatic coma
Do Not Combine
precoma
Do Not Combine
Common Zaroxolyn Drug Interactions
Drug Name
Risk Level
Description
Amifostine
Major
Metolazone may increase the hypotensive activities of Amifostine.
Cyclopentamine
Major
The risk or severity of adverse effects can be increased when Metolazone is combined with Cyclopentamine.
Dofetilide
Major
The risk or severity of QTc prolongation can be increased when Metolazone is combined with Dofetilide.
Hexamethonium
Major
The risk or severity of adverse effects can be increased when Metolazone is combined with Hexamethonium.
Lithium carbonate
Major
Metolazone may decrease the excretion rate of Lithium carbonate which could result in a higher serum level.
Zaroxolyn Toxicity & Overdose RiskOverdosing on Metronidazole can lead to difficulty breathing, dizziness, lightheadedness when standing, drowsiness, stomach and intestine irritation, and extreme fatigue that may result in unconsciousness.
Zaroxolyn Novel Uses: Which Conditions Have a Clinical Trial Featuring Zaroxolyn?
314 active trials are currently assessing the utility of Zaroxolyn in treating Congestive Heart Failure, Hypertension and Edema.Condition
Clinical Trials
Trial Phases
Swollen feet or ankles
40 Actively Recruiting
Phase 1, Phase 2, Not Applicable, Early Phase 1, Phase 3, Phase 4
Chronic Kidney Disease (CKD)
246 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 1, Phase 4, Early Phase 1
Mild Hypertension
0 Actively Recruiting
Hypertensive disease
0 Actively Recruiting
Congestive Heart Failure
24 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 1
Hypertensive disease
19 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Zaroxolyn Reviews: What are patients saying about Zaroxolyn?
5Patient Review
11/29/2008 Worked very quickly and efficiently to rid my body of excess fluid. I also took potassium at the same time, which I think made a big difference. Within 24 hours, my breathing was much better and coughing almost stopped altogether.
5Patient Review
3/22/2009 This medication was completely effective at removing the fluid in my body.
4.3Patient Review
7/25/2012 This diuretic really helped when I was taking it with other fluid pills. In just two days, I lost over five pounds!
3.3Patient Review
8/13/2008 The drug helped to reduce the fluid retention in my legs, but I struggled with maintaining healthy levels of potassium and magnesium. This led to muscle cramps, dizziness, and weakness. Even after taking extra magnesium and potassium supplements, I still had problems.
3Patient Review
2/3/2010 I saw a significant reduction in fluid retention within two weeks of starting this treatment. I'm not sure yet what the best maintenance plan is, but so far so good.
2.3Patient Review
3/6/2010 I didn't notice any difference after taking this medication.
Patient Q&A Section about zaroxolyn
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What type of diuretic is Zaroxolyn?
"Zaroxolyn is a quinazoline diuretic. Its properties are similar to those of the thiazide diuretics."
Answered by AI
What is the drug Zaroxolyn used for?
"This medication is used to lower blood pressure in order to prevent strokes, heart attacks, and kidney problems. It may also be used to reduce swelling caused by conditions such as congestive heart failure or kidney disease."
Answered by AI
What is the difference between Lasix and Zaroxolyn?
"Lasix prevents the filtered fluid in the kidney tubules from being absorbed into the body, causing the body to get rid of it through urine (diuresis). Zaroxolyn is a diuretic ("water pill") used in the treatment of high blood pressure and fluid accumulation."
Answered by AI
How long does it take for Zaroxolyn to work?
"If you're taking Zaroxolyn for excess fluid retention, you may start urinating more within an hour after taking it. This increased urination can continue throughout the day. If you're taking Zaroxolyn to treat high blood pressure, it may take 3 to 4 days to 3 to 6 weeks for it to start working."
Answered by AI