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What is Vfend
VoriconazoleThe Generic name of this drug
Treatment SummaryEthanol is a type of alcohol that is rapidly absorbed from the stomach and distributed around the body. It has powerful germ-killing properties, so it is often used as a disinfectant. It also has other uses in medicines and as the main ingredient in alcoholic drinks.
Voriconazoleis the brand name
Vfend Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Voriconazole
Voriconazole
2002
85
Approved as Treatment by the FDA
Voriconazole, also known as Voriconazole, is approved by the FDA for 10 uses like Esophageal Candidiasis and Scedosporium Infection .Esophageal Candidiasis
Scedosporium Infection
prophylaxis of moderate Pneumocystis pneumonia
Hematopoietic stem cells
Invasive Aspergillosis
refractory Fungal Infections
Neutropenia
Candida (fungus)
Fusariosis
Candidemia
Effectiveness
How Vfend Affects PatientsAlcohol can damage cells by drying them out and breaking down their inner structures. This is why it can kill bacteria and fungi. When alcohol comes in contact with nerve tissue, it can cause inflammation and damage to the nerves. Most of the ethanol that enters the body is broken down and oxidized. It is also used in small amounts to dissolve medicines and create a mild sedative effect in some drugs. Ethanol also binds to certain receptors in the body, like GABA and glycine, and affects how they work. The body also breaks down ethanol using a special enzyme in the liver called alcohol dehydrogenase.
How Vfend works in the bodyEthanol affects the brain by changing the structure and activity of neurons. It binds directly to receptors for acetylcholine, serotonin, GABA, and glutamate. Ethanol also has calming effects by binding to GABA and glycine receptors. It can also act as an anti-infective by disrupting the balance of fluids across cell membranes.
When to interrupt dosage
The encouraged measure of Vfend is dependent upon the diagnosed condition, including Urinary Tract Infection (UTI), Hand Hygiene and ethylene glycol. The quantity of dosage fluctuates, in line with the administration technique (e.g. Topical or Solution, gel forming / drops) provided in the following table.Condition
Dosage
Administration
Immunosuppression
10.0 mg/mL, , 50.0 mg, 200.0 mg, 40.0 mg/mL, 200.0 mg/mL
, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Powder, for solution, Powder, for solution - Intravenous, Powder, for suspension - Oral, Powder, for suspension, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Suspension, Suspension - Oral, Tablet, coated, Tablet, coated - Oral, Powder - Intravenous, Powder, Nasal, Tablet, film coated - Nasal
Penicillium marneffei infection
10.0 mg/mL, , 50.0 mg, 200.0 mg, 40.0 mg/mL, 200.0 mg/mL
, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Powder, for solution, Powder, for solution - Intravenous, Powder, for suspension - Oral, Powder, for suspension, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Suspension, Suspension - Oral, Tablet, coated, Tablet, coated - Oral, Powder - Intravenous, Powder, Nasal, Tablet, film coated - Nasal
Aspergillosis
10.0 mg/mL, , 50.0 mg, 200.0 mg, 40.0 mg/mL, 200.0 mg/mL
, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Powder, for solution, Powder, for solution - Intravenous, Powder, for suspension - Oral, Powder, for suspension, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Suspension, Suspension - Oral, Tablet, coated, Tablet, coated - Oral, Powder - Intravenous, Powder, Nasal, Tablet, film coated - Nasal
Aspergillosis
10.0 mg/mL, , 50.0 mg, 200.0 mg, 40.0 mg/mL, 200.0 mg/mL
, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Powder, for solution, Powder, for solution - Intravenous, Powder, for suspension - Oral, Powder, for suspension, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Suspension, Suspension - Oral, Tablet, coated, Tablet, coated - Oral, Powder - Intravenous, Powder, Nasal, Tablet, film coated - Nasal
Yeast Infection
10.0 mg/mL, , 50.0 mg, 200.0 mg, 40.0 mg/mL, 200.0 mg/mL
, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Powder, for solution, Powder, for solution - Intravenous, Powder, for suspension - Oral, Powder, for suspension, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Suspension, Suspension - Oral, Tablet, coated, Tablet, coated - Oral, Powder - Intravenous, Powder, Nasal, Tablet, film coated - Nasal
Esophageal Candidiasis
10.0 mg/mL, , 50.0 mg, 200.0 mg, 40.0 mg/mL, 200.0 mg/mL
, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Powder, for solution, Powder, for solution - Intravenous, Powder, for suspension - Oral, Powder, for suspension, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Suspension, Suspension - Oral, Tablet, coated, Tablet, coated - Oral, Powder - Intravenous, Powder, Nasal, Tablet, film coated - Nasal
Histoplasmosis
10.0 mg/mL, , 50.0 mg, 200.0 mg, 40.0 mg/mL, 200.0 mg/mL
, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Powder, for solution, Powder, for solution - Intravenous, Powder, for suspension - Oral, Powder, for suspension, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Suspension, Suspension - Oral, Tablet, coated, Tablet, coated - Oral, Powder - Intravenous, Powder, Nasal, Tablet, film coated - Nasal
Osteomyelitis
10.0 mg/mL, , 50.0 mg, 200.0 mg, 40.0 mg/mL, 200.0 mg/mL
, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Powder, for solution, Powder, for solution - Intravenous, Powder, for suspension - Oral, Powder, for suspension, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Suspension, Suspension - Oral, Tablet, coated, Tablet, coated - Oral, Powder - Intravenous, Powder, Nasal, Tablet, film coated - Nasal
Candidemia
10.0 mg/mL, , 50.0 mg, 200.0 mg, 40.0 mg/mL, 200.0 mg/mL
, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Powder, for solution, Powder, for solution - Intravenous, Powder, for suspension - Oral, Powder, for suspension, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Suspension, Suspension - Oral, Tablet, coated, Tablet, coated - Oral, Powder - Intravenous, Powder, Nasal, Tablet, film coated - Nasal
Neutropenia
10.0 mg/mL, , 50.0 mg, 200.0 mg, 40.0 mg/mL, 200.0 mg/mL
, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Powder, for solution, Powder, for solution - Intravenous, Powder, for suspension - Oral, Powder, for suspension, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Suspension, Suspension - Oral, Tablet, coated, Tablet, coated - Oral, Powder - Intravenous, Powder, Nasal, Tablet, film coated - Nasal
Invasive Aspergillosis
10.0 mg/mL, , 50.0 mg, 200.0 mg, 40.0 mg/mL, 200.0 mg/mL
, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Powder, for solution, Powder, for solution - Intravenous, Powder, for suspension - Oral, Powder, for suspension, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Suspension, Suspension - Oral, Tablet, coated, Tablet, coated - Oral, Powder - Intravenous, Powder, Nasal, Tablet, film coated - Nasal
Aspergillosis
10.0 mg/mL, , 50.0 mg, 200.0 mg, 40.0 mg/mL, 200.0 mg/mL
, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Powder, for solution, Powder, for solution - Intravenous, Powder, for suspension - Oral, Powder, for suspension, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Suspension, Suspension - Oral, Tablet, coated, Tablet, coated - Oral, Powder - Intravenous, Powder, Nasal, Tablet, film coated - Nasal
Candida (fungus)
10.0 mg/mL, , 50.0 mg, 200.0 mg, 40.0 mg/mL, 200.0 mg/mL
, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Powder, for solution, Powder, for solution - Intravenous, Powder, for suspension - Oral, Powder, for suspension, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Suspension, Suspension - Oral, Tablet, coated, Tablet, coated - Oral, Powder - Intravenous, Powder, Nasal, Tablet, film coated - Nasal
refractory Fungal Infections
10.0 mg/mL, , 50.0 mg, 200.0 mg, 40.0 mg/mL, 200.0 mg/mL
, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Powder, for solution, Powder, for solution - Intravenous, Powder, for suspension - Oral, Powder, for suspension, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Suspension, Suspension - Oral, Tablet, coated, Tablet, coated - Oral, Powder - Intravenous, Powder, Nasal, Tablet, film coated - Nasal
Hematopoietic stem cells
10.0 mg/mL, , 50.0 mg, 200.0 mg, 40.0 mg/mL, 200.0 mg/mL
, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Powder, for solution, Powder, for solution - Intravenous, Powder, for suspension - Oral, Powder, for suspension, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Suspension, Suspension - Oral, Tablet, coated, Tablet, coated - Oral, Powder - Intravenous, Powder, Nasal, Tablet, film coated - Nasal
Fusariosis
10.0 mg/mL, , 50.0 mg, 200.0 mg, 40.0 mg/mL, 200.0 mg/mL
, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Powder, for solution, Powder, for solution - Intravenous, Powder, for suspension - Oral, Powder, for suspension, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Suspension, Suspension - Oral, Tablet, coated, Tablet, coated - Oral, Powder - Intravenous, Powder, Nasal, Tablet, film coated - Nasal
Peritonitis
10.0 mg/mL, , 50.0 mg, 200.0 mg, 40.0 mg/mL, 200.0 mg/mL
, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Powder, for solution, Powder, for solution - Intravenous, Powder, for suspension - Oral, Powder, for suspension, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Suspension, Suspension - Oral, Tablet, coated, Tablet, coated - Oral, Powder - Intravenous, Powder, Nasal, Tablet, film coated - Nasal
prophylaxis of moderate Pneumocystis pneumonia
10.0 mg/mL, , 50.0 mg, 200.0 mg, 40.0 mg/mL, 200.0 mg/mL
, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Powder, for solution, Powder, for solution - Intravenous, Powder, for suspension - Oral, Powder, for suspension, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Suspension, Suspension - Oral, Tablet, coated, Tablet, coated - Oral, Powder - Intravenous, Powder, Nasal, Tablet, film coated - Nasal
Lung Transplant
10.0 mg/mL, , 50.0 mg, 200.0 mg, 40.0 mg/mL, 200.0 mg/mL
, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Powder, for solution, Powder, for solution - Intravenous, Powder, for suspension - Oral, Powder, for suspension, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Suspension, Suspension - Oral, Tablet, coated, Tablet, coated - Oral, Powder - Intravenous, Powder, Nasal, Tablet, film coated - Nasal
Debridement
10.0 mg/mL, , 50.0 mg, 200.0 mg, 40.0 mg/mL, 200.0 mg/mL
, Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Powder, for solution, Powder, for solution - Intravenous, Powder, for suspension - Oral, Powder, for suspension, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Suspension, Suspension - Oral, Tablet, coated, Tablet, coated - Oral, Powder - Intravenous, Powder, Nasal, Tablet, film coated - Nasal
Warnings
Vfend ContraindicationsCondition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Voriconazole may interact with Pulse Frequency
Common Vfend Drug Interactions
Drug Name
Risk Level
Description
(R)-warfarin
Major
The metabolism of (R)-warfarin can be decreased when combined with Voriconazole.
(S)-Warfarin
Major
The metabolism of (S)-Warfarin can be decreased when combined with Voriconazole.
1,2-Benzodiazepine
Major
The metabolism of 1,2-Benzodiazepine can be decreased when combined with Voriconazole.
3,5-diiodothyropropionic acid
Major
The metabolism of 3,5-diiodothyropropionic acid can be decreased when combined with Voriconazole.
5-androstenedione
Major
The metabolism of 5-androstenedione can be decreased when combined with Voriconazole.
Vfend Toxicity & Overdose RiskThe lowest toxic dose of this drug in rats has been found to be 5628mg/kg. Overdosing on this drug can cause nausea, vomiting, reduced brain activity, respiratory failure, or death. Those who take this drug over a long period of time may also experience severe health problems such as liver or brain damage.
Vfend Novel Uses: Which Conditions Have a Clinical Trial Featuring Vfend?
32 active clinical trials are presently assessing the potential of Vfend in providing relief from Obstructive Hypertrophic Cardiomyopathy, Urinary Tract Infection (UTI) and Disinfection.Condition
Clinical Trials
Trial Phases
Penicillium marneffei infection
0 Actively Recruiting
Neutropenia
14 Actively Recruiting
Phase 3, Phase 1, Phase 2, Not Applicable, Phase 4
Lung Transplant
15 Actively Recruiting
Not Applicable, Early Phase 1, Phase 2
refractory Fungal Infections
0 Actively Recruiting
Immunosuppression
6 Actively Recruiting
Phase 2, Phase 4, Not Applicable
Histoplasmosis
1 Actively Recruiting
Phase 1, Phase 2
prophylaxis of moderate Pneumocystis pneumonia
0 Actively Recruiting
Valve Replacement
0 Actively Recruiting
Scedosporium Infection
0 Actively Recruiting
Peritonitis
0 Actively Recruiting
Aspergillosis
0 Actively Recruiting
Coccidioidomycosis
1 Actively Recruiting
Phase 2
Aspergillosis
0 Actively Recruiting
Fusariosis
0 Actively Recruiting
Debridement
0 Actively Recruiting
Osteomyelitis
0 Actively Recruiting
Candidemia
3 Actively Recruiting
Phase 3, Phase 2, Not Applicable
Hematopoietic stem cells
4 Actively Recruiting
Early Phase 1, Phase 1, Phase 2
Invasive Aspergillosis
1 Actively Recruiting
Phase 3
aspergillus endophthalmitis
0 Actively Recruiting
Vfend Reviews: What are patients saying about Vfend?
4.7Patient Review
2/15/2008 I used this after Diflucan for Coccidioidomyhcosis (Valley Fever). Unfortunately, I had severe vomiting, hallucinations, and woke up in middle of night to searing pain in foot then numbness on that entire side of body. This was after 3 - 200mg doses.
4.7Patient Review
3/30/2011 I've been struggling with chronic candidiasis for over a decade now, and this is the first medication I've tried that's actually been effective at killing it.
4.3Patient Review
12/29/20074Patient Review
12/10/2010 I found that taking two pills a day led to an increase in my blurry vision and dizziness. These side effects were amplified when I used antibiotics alongside the medication. After a couple months, I went down to one pill per day and experienced minimal side effects. However, upon stopping the treatment altogether, my aspergillosis came back relatively quickly.
3.7Patient Review
12/27/2013 The biggest issue I've had is loss of appetite; I went back on a feeding tube five months after my double lung transplant. This medication saps all my energy and makes my stomach churn constantly, but it's working. I'm doing 200mg twice a day.
3.7Patient Review
2/3/20083.7Patient Review
8/10/2009 I have skin cancer and it keeps coming back as squamous cell carcinomas. I've had a lot of the listed side effects from this medication, but my transplant doctor put me on it as a precautionary measure in 2004.
2.3Patient Review
10/12/2008 Nausea and blurred vision were my initial side effects when starting this medication; however, they have since subsided. I've been on the drug for 2 1/2 years now and it's kept me alive without any negative impact on my transplant.
2.3Patient Review
4/25/2021 VFend was honestly just too tough for me to handle long-term. The side effects were really bad and even after I stopped taking it, I felt the consequences for months afterwards. If my infection comes back...I don't know what I'll do, but this medication is not an option for me anymore.
1.7Patient Review
3/22/2012 I have aspergillus and was treated with IV Vfend before and after a double lung transplant. I experienced terrifying hallucinations for days both times, although docs suspected the pain medication was potentiating this effect. I am getting ready to start again, 200mg twice daily oral, and I am not looking forward to it. The drug is horrible but sadly there are few options.
Patient Q&A Section about vfend
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Is VFEND an antibiotic?
"Vfend is an antifungal medicine used to treat infections caused by yeast or other types of fungus."
Answered by AI
What is the generic name for VFEND?
"This is the oral form of voriconazole, a drug used to treat certain types of fungal infections.
This drug is used to treat certain types of fungal infections. It is available in an oral form."
Answered by AI
What is voriconazole used to treat?
"Voriconazole is used to treat serious fungal or yeast infections, such as aspergillosis (fungal infection in the lungs), candidemia (fungal infection in the blood), esophageal candidiasis (candida esophagitis), or other fungal infections (infections in the skin, stomach, kidney, bladder, or wounds)."
Answered by AI
How long can I take voriconazole?
"The usual length of treatment with Vfend (voriconazole) is at least 2 weeks, but this may be longer or shorter depending on the severity of the infection. In some cases, treatment may last for several months."
Answered by AI