Ventavis

Pulmonary Arterial Hypertension, Pulmonary Arterial Hypertension

Treatment

4 FDA approvals

0 Active Studies for Ventavis

Treatment for

Pulmonary Arterial Hypertension

What is Ventavis

IloprostThe Generic name of this drug

Treatment SummaryIloprost is a drug used to treat pulmonary arterial hypertension (PAH). It works by widening the blood vessels in the lungs, allowing for easier blood flow and reducing pressure in the vessels. Iloprost is a synthetic version of a substance called prostacyclin PGI2.

Ventavisis the brand name

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Ventavis Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Ventavis

Iloprost

2005

Approved as Treatment by the FDA

Iloprost, also known as Ventavis, is approved by the FDA for 4 uses like NYHA class IV Pulmonary arterial hypertension and NYHA class III Pulmonary arterial hypertension .

NYHA class IV Pulmonary arterial hypertension

Helps manage NYHA class IV Pulmonary arterial hypertension

NYHA class III Pulmonary arterial hypertension

Helps manage NYHA class III Pulmonary arterial hypertension

Pulmonary Arterial Hypertension

Helps manage NYHA class IV Pulmonary arterial hypertension

Pulmonary Arterial Hypertension

Helps manage NYHA class III Pulmonary arterial hypertension

Effectiveness

How Ventavis Affects PatientsIloprost is a drug that helps to widen the blood vessels in the lungs and other parts of the body. It is a man-made version of prostacyclin PGI2 and can also affect how platelets stick together, although it is unclear if this contributes to its ability to widen blood vessels. Iloprost comes in two forms, the 4S isomer and the 4R isomer. The 4S isomer is more effective in widening blood vessels than the 4R isomer.

How Ventavis works in the bodyIloprost is a stronger version of prostacyclin, a molecule that works to reduce inflammation and constrict smooth muscles. Iloprost binds to prostacyclin and prostaglandin receptors, and it helps reduce the clumping of platelets. In the body, it acts as a vasodilator, meaning it widens blood vessels, lowers blood pressure, and reduces the amount of urine produced. Iloprost also increases the amount of time it takes for bleeding to stop. All of these benefits can help reduce the symptoms of pulmonary hypertension.

When to interrupt dosage

The recommended dosage of Ventavis depends on the diagnosed ailment. The amount of dosage is contingent upon the mode of delivery (e.g. Respiratory (inhalation) or Solution) enumerated in the table below.

Condition

Dosage

Administration

Pulmonary Arterial Hypertension

, 0.01 mg/mL, 0.02 mg/mL

, Solution, Solution - Respiratory (inhalation), Respiratory (inhalation)

Pulmonary Arterial Hypertension

, 0.01 mg/mL, 0.02 mg/mL

, Solution, Solution - Respiratory (inhalation), Respiratory (inhalation)

Warnings

Ventavis has one contraindication and should not be employed while experiencing any of the conditions demonstrated in the following table.Ventavis Contraindications

Condition

Risk Level

Notes

Pulse Frequency

Do Not Combine

There are 20 known major drug interactions with Ventavis.

Common Ventavis Drug Interactions

Drug Name

Risk Level

Description

Abrocitinib

Major

The risk or severity of bleeding and thrombocytopenia can be increased when Iloprost is combined with Abrocitinib.

Alemtuzumab

Minor

The risk or severity of bleeding can be increased when Iloprost is combined with Alemtuzumab.

Altretamine

Minor

The risk or severity of bleeding can be increased when Iloprost is combined with Altretamine.

Amifostine

Minor

The risk or severity of adverse effects can be increased when Iloprost is combined with Amifostine.

Amsacrine

Minor

The risk or severity of bleeding can be increased when Iloprost is combined with Amsacrine.

Ventavis Toxicity & Overdose RiskTaking too much of this drug can cause low blood pressure, headaches, redness, feeling sick, throwing up, and diarrhea.

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Ventavis Novel Uses: Which Conditions Have a Clinical Trial Featuring Ventavis?

There are currently 5 active trials assessing the potential of Ventavis to mitigate Pulmonary Arterial Hypertension.

Condition

Clinical Trials

Trial Phases

Pulmonary Arterial Hypertension

0 Actively Recruiting

Pulmonary Arterial Hypertension

0 Actively Recruiting

Ventavis Reviews: What are patients saying about Ventavis?

4.3Patient Review

5/15/2010

Ventavis for Pulmonary Arterial Hypertension

Though this medicine requires multiple treatments throughout the day, I feel much better now and those things do not matter.

3.7Patient Review

12/29/2007

Ventavis for Pulmonary Arterial Hypertension

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Patient Q&A Section about ventavis

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How is Ventavis administered?

"Subsequent doses should be increased by 2.5 mcg increments at 6 to 24 hour intervals until a single daily dose that improves exercise tolerance is achieved.

The recommended dose for Ventavis is 2.5 mcg, to be inhaled using either the I-neb™ AAD® System or the Prodose® AAD® System. The dose may be increased by 2.5 mcg increments at 6 to 24 hour intervals, as needed, until a single daily dose that improves exercise tolerance is achieved."

Answered by AI

What is iloprost used for?

"Iloprost is a medication used to treat pulmonary arterial hypertension (PAH). PAH is a condition that causes high blood pressure in the vessels carrying blood to the lungs, resulting in shortness of breath, dizziness, and fatigue. Iloprost may improve patients' ability to exercise and slow the progression of symptoms in PAH."

Answered by AI

What is Ventavis used for?

"VENTAVIS is a prescription medicine that is used to treat adults with a certain type of severe pulmonary arterial hypertension. This is a condition in which the blood pressure is too high in the blood vessels between the heart and lungs."

Answered by AI

What type of drug is bosentan?

"Bosentan belongs to a class of medications called endothelin receptor antagonists. By inhibiting the action of endothelin, a natural substance that constricts blood vessels and impairs blood flow in people with PAH, bosentan facilitates normal blood flow."

Answered by AI