Ventavis
Pulmonary Arterial Hypertension, Pulmonary Arterial Hypertension
Treatment
4 FDA approvals
0 Active Studies for Ventavis
Treatment for
Pulmonary Arterial Hypertension
What is Ventavis
Iloprost
The Generic name of this drug
Treatment Summary
Iloprost is a drug used to treat pulmonary arterial hypertension (PAH). It works by widening the blood vessels in the lungs, allowing for easier blood flow and reducing pressure in the vessels. Iloprost is a synthetic version of a substance called prostacyclin PGI2.
Ventavis
is the brand name
Ventavis Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Ventavis
Iloprost
2005
3
Approved as Treatment by the FDA
Iloprost, also known as Ventavis, is approved by the FDA for 4 uses like NYHA class III Pulmonary arterial hypertension and NYHA class IV Pulmonary arterial hypertension .
NYHA class III Pulmonary arterial hypertension
Helps manage NYHA class III Pulmonary arterial hypertension
NYHA class IV Pulmonary arterial hypertension
Helps manage NYHA class IV Pulmonary arterial hypertension
Pulmonary Arterial Hypertension
Helps manage NYHA class IV Pulmonary arterial hypertension
Pulmonary Arterial Hypertension
Helps manage NYHA class III Pulmonary arterial hypertension
Effectiveness
How Ventavis Affects Patients
Iloprost is a drug that helps to widen the blood vessels in the lungs and other parts of the body. It is a man-made version of prostacyclin PGI2 and can also affect how platelets stick together, although it is unclear if this contributes to its ability to widen blood vessels. Iloprost comes in two forms, the 4S isomer and the 4R isomer. The 4S isomer is more effective in widening blood vessels than the 4R isomer.
How Ventavis works in the body
Iloprost is a stronger version of prostacyclin, a molecule that works to reduce inflammation and constrict smooth muscles. Iloprost binds to prostacyclin and prostaglandin receptors, and it helps reduce the clumping of platelets. In the body, it acts as a vasodilator, meaning it widens blood vessels, lowers blood pressure, and reduces the amount of urine produced. Iloprost also increases the amount of time it takes for bleeding to stop. All of these benefits can help reduce the symptoms of pulmonary hypertension.
When to interrupt dosage
The recommended dosage of Ventavis depends on the diagnosed ailment. The amount of dosage is contingent upon the mode of delivery (e.g. Respiratory (inhalation) or Solution) enumerated in the table below.
Condition
Dosage
Administration
Pulmonary Arterial Hypertension
, 0.01 mg/mL, 0.02 mg/mL
, Solution, Solution - Respiratory (inhalation), Respiratory (inhalation)
Pulmonary Arterial Hypertension
, 0.01 mg/mL, 0.02 mg/mL
, Solution, Solution - Respiratory (inhalation), Respiratory (inhalation)
Warnings
Ventavis has one contraindication and should not be employed while experiencing any of the conditions demonstrated in the following table.
Ventavis Contraindications
Condition
Risk Level
Notes
Pulse Frequency
Do Not Combine
There are 20 known major drug interactions with Ventavis.
Common Ventavis Drug Interactions
Drug Name
Risk Level
Description
Abrocitinib
Major
The risk or severity of bleeding and thrombocytopenia can be increased when Iloprost is combined with Abrocitinib.
Alemtuzumab
Minor
The risk or severity of bleeding can be increased when Iloprost is combined with Alemtuzumab.
Altretamine
Minor
The risk or severity of bleeding can be increased when Iloprost is combined with Altretamine.
Amifostine
Minor
The risk or severity of adverse effects can be increased when Iloprost is combined with Amifostine.
Amsacrine
Minor
The risk or severity of bleeding can be increased when Iloprost is combined with Amsacrine.
Ventavis Toxicity & Overdose Risk
Taking too much of this drug can cause low blood pressure, headaches, redness, feeling sick, throwing up, and diarrhea.
Ventavis Novel Uses: Which Conditions Have a Clinical Trial Featuring Ventavis?
There are currently 5 active trials assessing the potential of Ventavis to mitigate Pulmonary Arterial Hypertension.
Condition
Clinical Trials
Trial Phases
Pulmonary Arterial Hypertension
0 Actively Recruiting
Pulmonary Arterial Hypertension
0 Actively Recruiting
Ventavis Reviews: What are patients saying about Ventavis?
4.3
Patient Review
5/15/2010
Ventavis for Pulmonary Arterial Hypertension
3.7
Patient Review
12/29/2007
Ventavis for Pulmonary Arterial Hypertension
Patient Q&A Section about ventavis
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
How is Ventavis administered?
"Subsequent doses should be increased by 2.5 mcg increments at 6 to 24 hour intervals until a single daily dose that improves exercise tolerance is achieved.
The recommended dose for Ventavis is 2.5 mcg, to be inhaled using either the I-neb™ AAD® System or the Prodose® AAD® System. The dose may be increased by 2.5 mcg increments at 6 to 24 hour intervals, as needed, until a single daily dose that improves exercise tolerance is achieved."
Answered by AI
What is iloprost used for?
"Iloprost is a medication used to treat pulmonary arterial hypertension (PAH). PAH is a condition that causes high blood pressure in the vessels carrying blood to the lungs, resulting in shortness of breath, dizziness, and fatigue. Iloprost may improve patients' ability to exercise and slow the progression of symptoms in PAH."
Answered by AI
What is Ventavis used for?
"VENTAVIS is a prescription medicine that is used to treat adults with a certain type of severe pulmonary arterial hypertension. This is a condition in which the blood pressure is too high in the blood vessels between the heart and lungs."
Answered by AI
What type of drug is bosentan?
"Bosentan belongs to a class of medications called endothelin receptor antagonists. By inhibiting the action of endothelin, a natural substance that constricts blood vessels and impairs blood flow in people with PAH, bosentan facilitates normal blood flow."
Answered by AI