Vectical

Hypoparathyroidism, Osteodystrophy, Hemodialysis + 4 more

Treatment

7 Active Studies for Vectical

What is Vectical

Calcitriol

The Generic name of this drug

Treatment Summary

Calcitriol is a form of vitamin D that is produced in the body after it is exposed to UV light. It helps to regulate calcium levels and fatty acid synthesis in the body, and is used to treat secondary hyperparathyroidism, hypocalcemia, and osteoporosis. It can be taken orally or intravenously, and also comes in topical form to treat psoriasis. Calcitriol is sold under the brand names Rocaltrol, Calcijex, and Decostriol.

Calcitriol

is the brand name

image of different drug pills on a surface

Vectical Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Calcitriol

Calcitriol

2001

85

Effectiveness

How Vectical Affects Patients

Calcitriol is a hormone made from vitamin D that helps regulate calcium levels in the body. It helps the body absorb more calcium from the intestines, and also helps the kidneys reabsorb more calcium. The effects of a single dose usually last 3-5 days. Calcitriol has also been studied for its ability to reduce the growth of cancer cells and help fight tuberculosis. Results from some trials have shown that taking calcitriol can reduce the risk of prostate cancer, although it can cause side effects like high levels of calcium in the blood. It can also be used in combination with other drugs to treat autoimmune diseases like

How Vectical works in the body

Calcitriol works to reduce inflammation and cell growth in psoriasis. It does this by binding to vitamin D receptors on the cell's surface and activating certain genes that help the cells control the growth and inflammation. Calcitriol also affects the immune system by suppressing certain immune cells, like Th9 cells, and increasing the activity of certain vitamin D-receptor positive immune cells. It also reduces the production of certain cytokines that can cause inflammation.

When to interrupt dosage

The proposed measure of Vectical is contingent upon the diagnosed condition, including Plaque Psoriasis, Vitamin D Resistant Rickets and Chronic Kidney Disease. The quantity of dosage fluctuates, contingent upon the technique of delivery outlined in the table underneath.

Condition

Dosage

Administration

Osteodystrophy

0.001 mg/mL, , 0.0005 mg, 0.00025 mg, 0.000003 mg/mg, 0.002 mg/mL, 1.0 mg/mL, 2.0 mg/mg

Injection, solution, , Injection, solution - Intravenous, Ointment, Ointment - Topical, Topical, Injection - Intravenous, Injection, Oral, Solution - Oral, Solution, Capsule - Oral, Capsule, Intravenous, Capsule, liquid filled - Oral, Capsule, liquid filled, Kit, Solution - Intravenous, Capsule, gelatin coated - Oral, Capsule, gelatin coated

Hemodialysis

0.001 mg/mL, , 0.0005 mg, 0.00025 mg, 0.000003 mg/mg, 0.002 mg/mL, 1.0 mg/mL, 2.0 mg/mg

Injection, solution, , Injection, solution - Intravenous, Ointment, Ointment - Topical, Topical, Injection - Intravenous, Injection, Oral, Solution - Oral, Solution, Capsule - Oral, Capsule, Intravenous, Capsule, liquid filled - Oral, Capsule, liquid filled, Kit, Solution - Intravenous, Capsule, gelatin coated - Oral, Capsule, gelatin coated

Hyperparathyroidism, Secondary

0.001 mg/mL, , 0.0005 mg, 0.00025 mg, 0.000003 mg/mg, 0.002 mg/mL, 1.0 mg/mL, 2.0 mg/mg

Injection, solution, , Injection, solution - Intravenous, Ointment, Ointment - Topical, Topical, Injection - Intravenous, Injection, Oral, Solution - Oral, Solution, Capsule - Oral, Capsule, Intravenous, Capsule, liquid filled - Oral, Capsule, liquid filled, Kit, Solution - Intravenous, Capsule, gelatin coated - Oral, Capsule, gelatin coated

Hypoparathyroidism

0.001 mg/mL, , 0.0005 mg, 0.00025 mg, 0.000003 mg/mg, 0.002 mg/mL, 1.0 mg/mL, 2.0 mg/mg

Injection, solution, , Injection, solution - Intravenous, Ointment, Ointment - Topical, Topical, Injection - Intravenous, Injection, Oral, Solution - Oral, Solution, Capsule - Oral, Capsule, Intravenous, Capsule, liquid filled - Oral, Capsule, liquid filled, Kit, Solution - Intravenous, Capsule, gelatin coated - Oral, Capsule, gelatin coated

Hypocalcemia

0.001 mg/mL, , 0.0005 mg, 0.00025 mg, 0.000003 mg/mg, 0.002 mg/mL, 1.0 mg/mL, 2.0 mg/mg

Injection, solution, , Injection, solution - Intravenous, Ointment, Ointment - Topical, Topical, Injection - Intravenous, Injection, Oral, Solution - Oral, Solution, Capsule - Oral, Capsule, Intravenous, Capsule, liquid filled - Oral, Capsule, liquid filled, Kit, Solution - Intravenous, Capsule, gelatin coated - Oral, Capsule, gelatin coated

Chronic Kidney Disease

0.001 mg/mL, , 0.0005 mg, 0.00025 mg, 0.000003 mg/mg, 0.002 mg/mL, 1.0 mg/mL, 2.0 mg/mg

Injection, solution, , Injection, solution - Intravenous, Ointment, Ointment - Topical, Topical, Injection - Intravenous, Injection, Oral, Solution - Oral, Solution, Capsule - Oral, Capsule, Intravenous, Capsule, liquid filled - Oral, Capsule, liquid filled, Kit, Solution - Intravenous, Capsule, gelatin coated - Oral, Capsule, gelatin coated

Rickets

0.001 mg/mL, , 0.0005 mg, 0.00025 mg, 0.000003 mg/mg, 0.002 mg/mL, 1.0 mg/mL, 2.0 mg/mg

Injection, solution, , Injection, solution - Intravenous, Ointment, Ointment - Topical, Topical, Injection - Intravenous, Injection, Oral, Solution - Oral, Solution, Capsule - Oral, Capsule, Intravenous, Capsule, liquid filled - Oral, Capsule, liquid filled, Kit, Solution - Intravenous, Capsule, gelatin coated - Oral, Capsule, gelatin coated

Warnings

Vectical has two contraindications and should not be utilized while enduring the conditions listed in the table below.

Vectical Contraindications

Condition

Risk Level

Notes

evidence of vitamin D toxicity

Do Not Combine

Hypercalcemia

Do Not Combine

There are 20 known major drug interactions with Vectical.

Common Vectical Drug Interactions

Drug Name

Risk Level

Description

Abemaciclib

Major

The metabolism of Abemaciclib can be increased when combined with Calcitriol.

Acalabrutinib

Major

The metabolism of Acalabrutinib can be increased when combined with Calcitriol.

Alectinib

Major

The metabolism of Alectinib can be increased when combined with Calcitriol.

Alpelisib

Major

The metabolism of Alpelisib can be increased when combined with Calcitriol.

Aminophylline

Major

The metabolism of Aminophylline can be increased when combined with Calcitriol.

Vectical Toxicity & Overdose Risk

The lowest toxic dose of calcitriol in rats has been found to be 620 micrograms per kg. Symptoms of calcitriol toxicity may include weakness, headache, drowsiness, nausea, vomiting, dry mouth, constipation, muscle pain, bone pain, metallic taste, excessive thirst and urination, loss of appetite, weight loss, increased cholesterol, elevated liver enzymes, and in rare cases, psychosis.

image of a doctor in a lab doing drug, clinical research

Vectical Novel Uses: Which Conditions Have a Clinical Trial Featuring Vectical?

Currently, there are 30 active trials assessing the potential of Vectical for Hemodialysis, Hypocalcemia and Plaque Psoriasis alleviation.

Condition

Clinical Trials

Trial Phases

Osteodystrophy

0 Actively Recruiting

Rickets

2 Actively Recruiting

Early Phase 1, Not Applicable

Chronic Kidney Disease

0 Actively Recruiting

Hyperparathyroidism, Secondary

2 Actively Recruiting

Phase 3, Not Applicable

Hypoparathyroidism

3 Actively Recruiting

Not Applicable, Phase 2, Phase 1

Hemodialysis

0 Actively Recruiting

Hypocalcemia

0 Actively Recruiting

Vectical Reviews: What are patients saying about Vectical?

4.3

Patient Review

4/4/2010

Vectical for Plaque Psoriasis

I have both fibromyalgia and RA, so my hands are deformed and quite crooked. Despite that, I've been able to use this product for about a month now without any discomfort. The cotton swab applicator allows me to target the areas that need it without any pain or difficulty. All in all, I'd say this medication has been working well for me.

3.3

Patient Review

12/21/2009

Vectical for Plaque Psoriasis

Vectical ointment is a great in-between maintenance drug to use with Clobex lotion. The combination of the two has really helped to slow my psoriasis flareups. My only complaint is that the ointment can be messy and difficult to apply.

3.3

Patient Review

9/16/2009

Vectical for Plaque Psoriasis

The itchiness is unfortunately really bad, and it often wakes me up at night. By morning, my foot is usually bleeding.

2.7

Patient Review

3/5/2016

Vectical for Plaque Psoriasis

I think this would work better as a cream. The ointment is tough to apply evenly.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about vectical

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Can I use vectical ointment on face?

"VECTICAL Ointment should not be used on the eyes, lips, or facial skin. It should be applied to the affected areas twice a day, once in the morning and once in the evening. The maximum amount that should be used in a week should not exceed 200 grams. VECTICAL Ointment is not meant to be taken orally, used in the eyes, or used vaginally."

Answered by AI

What is calcitriol ointment used for?

"Calcitriol topical ointment can be used to help reduce the symptoms of mild to moderate plaque psoriasis. This includes treating the red patches and white scales that are often characteristic of the disease. Calcitriol is a form of vitamin d, making it a natural and potentially effective treatment option for psoriasis sufferers."

Answered by AI

Is vectical a steroid?

"Although calcitriol (Vectical) is not classified as a steroid medication, it is a form of Vitamin d. Medications classified as steroids work by reducing the activity of the immune system and lowering inflammation, while calcitriol (Vectical) has a different mechanism of action."

Answered by AI

What is vectical ointment used for?

"Calcitriol is a medication used to treat psoriasis by slowing the growth of cells. It is a form of vitamin d."

Answered by AI

Clinical Trials for Vectical

Image of Madigan Army Medical Center in Tacoma, United States.

Vitamin D3 + K2 for Vitamin Deficiency

18 - 69
All Sexes
Tacoma, WA

The main purpose of this research study is to learn about the effects of supplemental vitamin D3 and vitamin K2 on blood levels and the gut microbial community, called the gut microbiome. There are many influences on blood levels of vitamin D and K to include your dietary intake, lifestyle behaviors (physical activity, sleep), genetic alterations in metabolism of these vitamins, and the gut microbial abundance and diversity. You will be asked to take one capsule containing vitamin D3 (125 mcg), vitamin K2 (180 mcg), a combination of vitamins D3 and K2 (same doses as previous), or a placebo powder for 90 days. You will also be asked to complete questionnaires, undergo body composition and blood pressure measurements, provide blood samples and a stool swab, all on 2 occasions about 3 - 4 months apart. By conducting this study, we aim to identify the frequency of common genetic alterations in vitamins D and K metabolism and establish the impact on the gut microbiome for the first time. Your participation in this study will last about 4 - 6 months and include up to 3 visits.

Recruiting
Paid Trial

Madigan Army Medical Center

Mary S McCarthy, PhD

Image of St Joseph's Hospital in Hamilton, Canada.

Hormone Monitoring for Hyperparathyroidism

18+
All Sexes
Hamilton, Canada

The goal of this pilot clinical is to determine the feasibility of a fully powered clinical trial to determine the effectiveness of intraoperative parathyroid hormone (IOPTH) criteria in guiding surgery for secondary and tertiary hyperparathyroidism. The main question it aims to answer is: Is a fully powered trial investigating the role for IOPTH criteria in secondary and tertiary hyperparathyroidism feasible? The comparison group is surgery not guided by IOPTH. Participants will be randomized to undergo parathyroid surgery with one of four IOPTH criteria or a control arm that does not use IOPTH. All recruited patients are asked to complete quality of life and cognitive questionnaires, in addition to bloodwork during the study period.

Waitlist Available
Has No Placebo

St Joseph's Hospital

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