Vectical
Hypoparathyroidism, Osteodystrophy, Hemodialysis + 4 more
Treatment
7 Active Studies for Vectical
Treatment for
Hypoparathyroidism
What is Vectical
Calcitriol
The Generic name of this drug
Treatment Summary
Calcitriol is a form of vitamin D that is produced in the body after it is exposed to UV light. It helps to regulate calcium levels and fatty acid synthesis in the body, and is used to treat secondary hyperparathyroidism, hypocalcemia, and osteoporosis. It can be taken orally or intravenously, and also comes in topical form to treat psoriasis. Calcitriol is sold under the brand names Rocaltrol, Calcijex, and Decostriol.
Calcitriol
is the brand name
Vectical Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Calcitriol
Calcitriol
2001
85
Effectiveness
How Vectical Affects Patients
Calcitriol is a hormone made from vitamin D that helps regulate calcium levels in the body. It helps the body absorb more calcium from the intestines, and also helps the kidneys reabsorb more calcium. The effects of a single dose usually last 3-5 days. Calcitriol has also been studied for its ability to reduce the growth of cancer cells and help fight tuberculosis. Results from some trials have shown that taking calcitriol can reduce the risk of prostate cancer, although it can cause side effects like high levels of calcium in the blood. It can also be used in combination with other drugs to treat autoimmune diseases like
How Vectical works in the body
Calcitriol works to reduce inflammation and cell growth in psoriasis. It does this by binding to vitamin D receptors on the cell's surface and activating certain genes that help the cells control the growth and inflammation. Calcitriol also affects the immune system by suppressing certain immune cells, like Th9 cells, and increasing the activity of certain vitamin D-receptor positive immune cells. It also reduces the production of certain cytokines that can cause inflammation.
When to interrupt dosage
The proposed measure of Vectical is contingent upon the diagnosed condition, including Plaque Psoriasis, Vitamin D Resistant Rickets and Chronic Kidney Disease. The quantity of dosage fluctuates, contingent upon the technique of delivery outlined in the table underneath.
Condition
Dosage
Administration
Osteodystrophy
0.001 mg/mL, , 0.0005 mg, 0.00025 mg, 0.000003 mg/mg, 0.002 mg/mL, 1.0 mg/mL, 2.0 mg/mg
Injection, solution, , Injection, solution - Intravenous, Capsule, gelatin coated, Oral, Capsule, gelatin coated - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Ointment, Ointment - Topical, Topical, Injection - Intravenous, Injection, Solution, Capsule - Oral, Capsule, Intravenous, Solution - Intravenous, Kit, Solution - Oral
Hemodialysis
0.001 mg/mL, , 0.0005 mg, 0.00025 mg, 0.000003 mg/mg, 0.002 mg/mL, 1.0 mg/mL, 2.0 mg/mg
Injection, solution, , Injection, solution - Intravenous, Capsule, gelatin coated, Oral, Capsule, gelatin coated - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Ointment, Ointment - Topical, Topical, Injection - Intravenous, Injection, Solution, Capsule - Oral, Capsule, Intravenous, Solution - Intravenous, Kit, Solution - Oral
Hyperparathyroidism, Secondary
0.001 mg/mL, , 0.0005 mg, 0.00025 mg, 0.000003 mg/mg, 0.002 mg/mL, 1.0 mg/mL, 2.0 mg/mg
Injection, solution, , Injection, solution - Intravenous, Capsule, gelatin coated, Oral, Capsule, gelatin coated - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Ointment, Ointment - Topical, Topical, Injection - Intravenous, Injection, Solution, Capsule - Oral, Capsule, Intravenous, Solution - Intravenous, Kit, Solution - Oral
Hypoparathyroidism
0.001 mg/mL, , 0.0005 mg, 0.00025 mg, 0.000003 mg/mg, 0.002 mg/mL, 1.0 mg/mL, 2.0 mg/mg
Injection, solution, , Injection, solution - Intravenous, Capsule, gelatin coated, Oral, Capsule, gelatin coated - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Ointment, Ointment - Topical, Topical, Injection - Intravenous, Injection, Solution, Capsule - Oral, Capsule, Intravenous, Solution - Intravenous, Kit, Solution - Oral
Hypocalcemia
0.001 mg/mL, , 0.0005 mg, 0.00025 mg, 0.000003 mg/mg, 0.002 mg/mL, 1.0 mg/mL, 2.0 mg/mg
Injection, solution, , Injection, solution - Intravenous, Capsule, gelatin coated, Oral, Capsule, gelatin coated - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Ointment, Ointment - Topical, Topical, Injection - Intravenous, Injection, Solution, Capsule - Oral, Capsule, Intravenous, Solution - Intravenous, Kit, Solution - Oral
Chronic Kidney Disease
0.001 mg/mL, , 0.0005 mg, 0.00025 mg, 0.000003 mg/mg, 0.002 mg/mL, 1.0 mg/mL, 2.0 mg/mg
Injection, solution, , Injection, solution - Intravenous, Capsule, gelatin coated, Oral, Capsule, gelatin coated - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Ointment, Ointment - Topical, Topical, Injection - Intravenous, Injection, Solution, Capsule - Oral, Capsule, Intravenous, Solution - Intravenous, Kit, Solution - Oral
Rickets
0.001 mg/mL, , 0.0005 mg, 0.00025 mg, 0.000003 mg/mg, 0.002 mg/mL, 1.0 mg/mL, 2.0 mg/mg
Injection, solution, , Injection, solution - Intravenous, Capsule, gelatin coated, Oral, Capsule, gelatin coated - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Ointment, Ointment - Topical, Topical, Injection - Intravenous, Injection, Solution, Capsule - Oral, Capsule, Intravenous, Solution - Intravenous, Kit, Solution - Oral
Warnings
Vectical has two contraindications and should not be utilized while enduring the conditions listed in the table below.
Vectical Contraindications
Condition
Risk Level
Notes
evidence of vitamin D toxicity
Do Not Combine
Hypercalcemia
Do Not Combine
There are 20 known major drug interactions with Vectical.
Common Vectical Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The metabolism of Abemaciclib can be increased when combined with Calcitriol.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be increased when combined with Calcitriol.
Alectinib
Major
The metabolism of Alectinib can be increased when combined with Calcitriol.
Alpelisib
Major
The metabolism of Alpelisib can be increased when combined with Calcitriol.
Aminophylline
Major
The metabolism of Aminophylline can be increased when combined with Calcitriol.
Vectical Toxicity & Overdose Risk
The lowest toxic dose of calcitriol in rats has been found to be 620 micrograms per kg. Symptoms of calcitriol toxicity may include weakness, headache, drowsiness, nausea, vomiting, dry mouth, constipation, muscle pain, bone pain, metallic taste, excessive thirst and urination, loss of appetite, weight loss, increased cholesterol, elevated liver enzymes, and in rare cases, psychosis.
Vectical Novel Uses: Which Conditions Have a Clinical Trial Featuring Vectical?
Currently, there are 30 active trials assessing the potential of Vectical for Hemodialysis, Hypocalcemia and Plaque Psoriasis alleviation.
Condition
Clinical Trials
Trial Phases
Osteodystrophy
0 Actively Recruiting
Rickets
1 Actively Recruiting
Early Phase 1
Chronic Kidney Disease
1 Actively Recruiting
Early Phase 1
Hyperparathyroidism, Secondary
2 Actively Recruiting
Phase 3, Not Applicable
Hypoparathyroidism
3 Actively Recruiting
Not Applicable, Phase 2, Phase 1
Hemodialysis
0 Actively Recruiting
Hypocalcemia
0 Actively Recruiting
Vectical Reviews: What are patients saying about Vectical?
4.3
Patient Review
4/4/2010
Vectical for Plaque Psoriasis
3.3
Patient Review
12/21/2009
Vectical for Plaque Psoriasis
3.3
Patient Review
9/16/2009
Vectical for Plaque Psoriasis
2.7
Patient Review
3/5/2016
Vectical for Plaque Psoriasis
Patient Q&A Section about vectical
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Can I use vectical ointment on face?
"VECTICAL Ointment should not be used on the eyes, lips, or facial skin. It should be applied to the affected areas twice a day, once in the morning and once in the evening. The maximum amount that should be used in a week should not exceed 200 grams. VECTICAL Ointment is not meant to be taken orally, used in the eyes, or used vaginally."
Answered by AI
What is calcitriol ointment used for?
"Calcitriol topical ointment can be used to help reduce the symptoms of mild to moderate plaque psoriasis. This includes treating the red patches and white scales that are often characteristic of the disease. Calcitriol is a form of vitamin d, making it a natural and potentially effective treatment option for psoriasis sufferers."
Answered by AI
Is vectical a steroid?
"Although calcitriol (Vectical) is not classified as a steroid medication, it is a form of Vitamin d. Medications classified as steroids work by reducing the activity of the immune system and lowering inflammation, while calcitriol (Vectical) has a different mechanism of action."
Answered by AI