Urecholine
acute post-operative Urinary retention, Urinary Retention, Urinary Bladder, Neurogenic
Treatment
3 FDA approvals
0 Active Studies for Urecholine
Treatment for
acute post-operative Urinary retention
What is Urecholine
Bethanechol
The Generic name of this drug
Treatment Summary
Bethanechol is a synthetic chemical that mimics the effects of acetylcholine, an important neurotransmitter in the parasympathetic nervous system. It is primarily used to treat urinary retention after childbirth or surgery. Bethanechol is more long-lasting than acetylcholine, because it is not broken down by cholinesterase enzymes.
Bethanechol Chloride
is the brand name
Urecholine Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Bethanechol Chloride
Bethanechol
1990
100
Approved as Treatment by the FDA
Bethanechol, also called Bethanechol Chloride, is approved by the FDA for 3 uses which include Urinary Bladder, Neurogenic and Urinary Retention .
Urinary Bladder, Neurogenic
Urinary Retention
acute post-operative Urinary retention
Effectiveness
How Urecholine Affects Patients
Bethanechol works by targeting only muscarinic receptors. The special structure of the drug prevents it from entering the brain, so it does not cause any side effects related to the central nervous system.
How Urecholine works in the body
Bethanechol is a drug that stimulates the parasympathetic nervous system. It does this by connecting to specific receptors in the body, known as M3 receptors. These receptors are found in the bladder and intestines, and when activated, they can help to empty the bladder and restore normal digestion. Bethanechol specifically targets M3 receptors, without having an effect on other types of receptors, so it has minimal side effects.
When to interrupt dosage
The recommended dosage of Urecholine is contingent upon the diagnosed condition, such as non-obstructive postpartum urinary retention, acute post-operative Urinary retention and neurogenic atony of the urinary bladder. The measure of dosage shifts as per the administration mode noted in the accompanying table.
Condition
Dosage
Administration
acute post-operative Urinary retention
, 5.0 mg, 10.0 mg, 25.0 mg, 50.0 mg, 5.0 mg/mL
Oral, , Tablet, Tablet - Oral, Liquid, Liquid - Subcutaneous, Subcutaneous
Urinary Retention
, 5.0 mg, 10.0 mg, 25.0 mg, 50.0 mg, 5.0 mg/mL
Oral, , Tablet, Tablet - Oral, Liquid, Liquid - Subcutaneous, Subcutaneous
Urinary Bladder, Neurogenic
, 5.0 mg, 10.0 mg, 25.0 mg, 50.0 mg, 5.0 mg/mL
Oral, , Tablet, Tablet - Oral, Liquid, Liquid - Subcutaneous, Subcutaneous
Warnings
Urecholine Contraindications
Condition
Risk Level
Notes
Urinary Bladder Neck Obstruction
Do Not Combine
Peptic Ulcer
Do Not Combine
Vagotonia
Do Not Combine
Asthma
Do Not Combine
Bradycardia
Do Not Combine
Gastrointestinal Diseases
Do Not Combine
Mechanical Intestinal Obstruction
Do Not Combine
unknown bladder wall integrity
Do Not Combine
Urinary Bladder
Do Not Combine
Gastrointestinal tract structure
Do Not Combine
Urinary Bladder
Do Not Combine
Spastic gastrointestinal disturbances
Do Not Combine
Coronary Disease
Do Not Combine
Hypotension
Do Not Combine
Hyperthyroidism
Do Not Combine
Parkinson Disease
Do Not Combine
Asthma
Do Not Combine
Epilepsy
Do Not Combine
Peritonitis
Do Not Combine
There are 1 known major drug interactions with Urecholine.
Common Urecholine Drug Interactions
Drug Name
Risk Level
Description
Cimetropium
Moderate
Bethanechol may decrease the anticholinergic activities of Cimetropium.
Urecholine Toxicity & Overdose Risk
Symptoms of an overdose of bethanechol include nausea, vomiting, stomach pain, drooling, excessive sweating, and redness of the skin. In case of an overdose, atropine sulfate can be used as an antidote. For adults, a dose of 0.6 mg is recommended, while for children up to 12 years of age, a dose of 0.01 mg/kg is recommended (maximum single dose = 0.4 mg). The lethal dose of bethanechol in mice is 1510 mg/kg.
Urecholine Novel Uses: Which Conditions Have a Clinical Trial Featuring Urecholine?
Zero active clinical trials are currently assessing the potential of Urecholine to mitigate neurogenic atony of the urinary bladder, non-obstructive postpartum urinary retention and acute post-operative Urinary retention.
Condition
Clinical Trials
Trial Phases
Urinary Bladder, Neurogenic
0 Actively Recruiting
acute post-operative Urinary retention
0 Actively Recruiting
Urinary Retention
0 Actively Recruiting
Urecholine Reviews: What are patients saying about Urecholine?
5
Patient Review
3/22/2009
Urecholine for Cannot Empty Bladder
5
Patient Review
3/7/2011
Urecholine for Stomach Muscle Paralysis and Decreased Function
5
Patient Review
5/19/2012
Urecholine for Cannot Empty Bladder
5
Patient Review
11/14/2013
Urecholine for Cannot Empty Bladder
4
Patient Review
12/18/2010
Urecholine for Cannot Empty Bladder
4
Patient Review
9/12/2010
Urecholine for Cannot Empty Bladder
3.3
Patient Review
7/20/2013
Urecholine for Stomach Muscle Paralysis and Decreased Function
2.3
Patient Review
11/25/2008
Urecholine for Cannot Empty Bladder
2
Patient Review
10/19/2008
Urecholine for Cannot Empty Bladder
1.7
Patient Review
9/29/2008
Urecholine for Cannot Empty Bladder
1.3
Patient Review
1/10/2009
Urecholine for Cannot Empty Bladder
Patient Q&A Section about urecholine
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
What is the generic name for Urecholine?
"Urecholine is a medication used to treat urinary retention and bladder issues. It works by increasing the activity of a certain neurotransmitter in the body, which helps to improve muscle function in the bladder. This can help to relieve the symptoms of urinary retention and improve the overall function of the bladder."
Answered by AI
What drug class is Urecholine?
"Urecholine is a cholinergic agent, which helps muscles work to empty urine from the bladder."
Answered by AI
What is Urecholine used for?
"The medication is used to treat bladder problems, such as the inability to urinate or to empty the bladder completely. The medication works by improving the ability of the bladder muscle to squeeze, thereby improving the individual's ability to urinate."
Answered by AI
How long does it take for Urecholine to work?
"Give this medication on an empty stomach, unless vomiting occurs. If vomiting does occur, give future doses of the medication with food. Be careful when measuring liquid forms of the medication. The medication will take effect quickly, in about 1 to 2 hours. After taking the medication, you should see an improvement in clinical signs."
Answered by AI