Tropicamide

Cycloplegia, Induced Hyperthermia, diagnostic procedures + 6 more
Treatment
2 Active Studies for Tropicamide

What is Tropicamide

TropicamideThe Generic name of this drug
Treatment SummaryTropicamide is a medication used to dilate the pupil of the eye and temporarily paralyze the focusing muscles. It is used to help doctors or eye surgeons examine or treat the eye. Tropicamide can also be taken orally to help reduce excessive saliva in people with Parkinson's Disease.
Mydriacylis the brand name
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Tropicamide Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Mydriacyl
Tropicamide
1959
16

Effectiveness

How Tropicamide Affects PatientsTropicamide is a drug that helps with dilation of the pupil and relaxation of the eye muscles. It takes 10-15 minutes to start working, and its effects can last up to 24 hours. It can also raise the pressure inside the eye, but this is usually not associated with serious side effects. Tropicamide has been used to reduce symptoms of excessive saliva (sialorrhea) in people with Parkinson's Disease, and can be used to reduce tremulous jaw movements in rodent models.
How Tropicamide works in the bodyTropicamide is a drug that relaxes the muscles that control the pupil size and lens shape of the eye. It works by blocking muscarinic receptors in the eye, which are responsible for pupil constriction and accommodation. It also blocks salivary gland receptors, reducing saliva production. By blocking these receptors, tropicamide helps to reduce sialorrhea.

When to interrupt dosage

The quantity of Tropicamide is contingent upon the diagnosed affliction, including diagnostic tests, induction of Cycloplegia and Cycloplegia. The portion furthermore fluctuates as per the means of delivery (e.g. Solution or Solution - Ophthalmic) provided in the table below.
Condition
Dosage
Administration
diagnostic procedures
, 10.0 mg/mL, 5.0 mg/mL, 2.5 mg/mL, 0.8 %, 1.0 %, 0.5 %
, Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Solution, Solution - Ophthalmic, Liquid, Liquid - Ophthalmic
induction of partial cycloplegia
, 10.0 mg/mL, 5.0 mg/mL, 2.5 mg/mL, 0.8 %, 1.0 %, 0.5 %
, Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Solution, Solution - Ophthalmic, Liquid, Liquid - Ophthalmic
Epilepsies, Partial
, 10.0 mg/mL, 5.0 mg/mL, 2.5 mg/mL, 0.8 %, 1.0 %, 0.5 %
, Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Solution, Solution - Ophthalmic, Liquid, Liquid - Ophthalmic
Induced Hyperthermia
, 10.0 mg/mL, 5.0 mg/mL, 2.5 mg/mL, 0.8 %, 1.0 %, 0.5 %
, Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Solution, Solution - Ophthalmic, Liquid, Liquid - Ophthalmic
induction of Cycloplegia
, 10.0 mg/mL, 5.0 mg/mL, 2.5 mg/mL, 0.8 %, 1.0 %, 0.5 %
, Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Solution, Solution - Ophthalmic, Liquid, Liquid - Ophthalmic
Ocular Anesthesia
, 10.0 mg/mL, 5.0 mg/mL, 2.5 mg/mL, 0.8 %, 1.0 %, 0.5 %
, Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Solution, Solution - Ophthalmic, Liquid, Liquid - Ophthalmic
Pupil
, 10.0 mg/mL, 5.0 mg/mL, 2.5 mg/mL, 0.8 %, 1.0 %, 0.5 %
, Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Solution, Solution - Ophthalmic, Liquid, Liquid - Ophthalmic
Cycloplegia
, 10.0 mg/mL, 5.0 mg/mL, 2.5 mg/mL, 0.8 %, 1.0 %, 0.5 %
, Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Solution, Solution - Ophthalmic, Liquid, Liquid - Ophthalmic
Cataract Surgery
, 10.0 mg/mL, 5.0 mg/mL, 2.5 mg/mL, 0.8 %, 1.0 %, 0.5 %
, Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Solution, Solution - Ophthalmic, Liquid, Liquid - Ophthalmic

Warnings

Tropicamide has one contraindication and should not be utilized when dealing with the circumstances listed in the table below.Tropicamide Contraindications
Condition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Tropicamide may interact with Pulse Frequency
There are 20 known major drug interactions with Tropicamide.
Common Tropicamide Drug Interactions
Drug Name
Risk Level
Description
Aclidinium
Minor
The risk or severity of adverse effects can be increased when Tropicamide is combined with Aclidinium.
Agmatine
Minor
The risk or severity of adverse effects can be increased when Tropicamide is combined with Agmatine.
Alcuronium
Minor
The risk or severity of adverse effects can be increased when Tropicamide is combined with Alcuronium.
Alloin
Minor
The therapeutic efficacy of Alloin can be decreased when used in combination with Tropicamide.
Amantadine
Minor
The risk or severity of adverse effects can be increased when Tropicamide is combined with Amantadine.
Tropicamide Toxicity & Overdose RiskThe lowest toxic dose of tropicamide in rats is 865mg/kg when taken orally, and 1210mg/kg when taken intraperitoneally. In mice, the lowest toxic dose is 565mg/kg when taken orally, and 695mg/kg when taken intraperitoneally. In the case of an overdose, side effects such as rapid heartbeat, confusion, muscle stiffness, and breathing problems have been observed in both adults and children.
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Tropicamide Novel Uses: Which Conditions Have a Clinical Trial Featuring Tropicamide?

A single study is being conducted to assess the potential of Tropicamide to induce partial cycloplegia, Ocular Anesthesia and Pupillary dilation for the treatment of certain conditions.
Condition
Clinical Trials
Trial Phases
Cycloplegia
0 Actively Recruiting
Ocular Anesthesia
0 Actively Recruiting
Pupil
0 Actively Recruiting
induction of Cycloplegia
0 Actively Recruiting
Epilepsies, Partial
0 Actively Recruiting
diagnostic procedures
0 Actively Recruiting
Cataract Surgery
2 Actively Recruiting
Not Applicable, Phase 4
Induced Hyperthermia
0 Actively Recruiting
induction of partial cycloplegia
0 Actively Recruiting

Tropicamide Reviews: What are patients saying about Tropicamide?

4.7Patient Review
6/21/2017
Tropicamide for Dilated Pupil
This is an excellent way to dilate your pupils with no other known side effects. It's both safe and effective, which makes it a great option overall.
2Patient Review
11/11/2022
Tropicamide for Dilated Pupil
These eye drops caused an intense burning sensation that made it difficult to open my eyes for some time. Even days later, my eyes were still sensitive to light. This has never happened before during my annual eye examinations, so I'm not sure if the medicine has changed or if it was just too strong this time around.
2Patient Review
2/19/2022
Tropicamide for Dilated Pupil
After using this medication, my eyes stayed dilated for six to eight hours. This was a problem because it made bright light intolerable. Additionally, my eyes were sensitive to light for two to three days following useage; it seems like the drug's effects and side-effects last too long.
1.3Patient Review
7/29/2010
Tropicamide for Dilated Pupil
I was having bad seizures.
1Patient Review
11/13/2018
Tropicamide for Dilated Pupil
After using this eye drops, I experienced an intense burning and stinging sensation. Not only that, but the whites of my eyes became red and bloodshot. A week later and these problems persist.
View All Reviews
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Patient Q&A Section about tropicamide

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How does tropicamide work in the eye?

"Tropicamide is a non-selective muscarinic antagonist that prevents the pupil from constricting by binding to muscarinic receptors, as well as prevents the eye from focusing by blocking the muscarinic receptors of the ciliary body."

Answered by AI

Is tropicamide eye drops safe?

"Tropicamide ophthalmic may cause blurred vision or make your eyes very sensitive to light. Be careful if driving or doing anything that requires clear vision. This effect may last up to 24 hours. Protect eyes from bright light while pupils are dilated."

Answered by AI

What type of drug is tropicamide?

"Tropicamide is a medication that is used to widen the pupil in preparation for certain eye examinations. It is an anticholinergic that works by relaxing the eye muscles."

Answered by AI

What is tropicamide used for?

"Tropicamide is used in order to increase the size of the pupil so that the doctor can clearly see the back of the eye. It is commonly used before examinations such as cycloplegic refraction and examination of the fundus of the eye. In some cases, tropicamide may also be used before and after eye surgery."

Answered by AI

Clinical Trials for Tropicamide

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