Curcumin for Tinnitus
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial tests whether a special form of curcumin can reduce tinnitus, the ringing in the ears. Participants will receive either capsules containing curcumin and another compound or a placebo, taken twice daily for a month. The trial aims to determine if curcumin can significantly decrease tinnitus impact, based on surveys conducted before and after treatment. It suits adults with tinnitus due to hearing loss confirmed by a hearing test and who are not using other treatments for tinnitus. As an unphased trial, this study offers participants the chance to contribute to groundbreaking research that could lead to new treatment options for tinnitus.
Will I have to stop taking my current medications?
The trial does not specify if you need to stop taking your current medications, but you cannot participate if you are using medications specifically for tinnitus or taking anticoagulants.
Is there any evidence suggesting that highly bioavailable curcumin is likely to be safe for humans?
Research has shown that curcumin, when easily absorbed by the body, is generally safe. In one study, participants took up to 8,000 mg daily for three months without major health problems. Another study found no harmful effects with a daily intake of 1,000 mg for 90 days. These findings indicate that the curcumin used in the trial is well-tolerated. Participants can feel reassured knowing that this treatment has a good safety record in previous research.12345
Why are researchers excited about this trial's treatment for tinnitus?
Unlike traditional treatments for tinnitus, which often involve sound therapy or medications like antidepressants and anticonvulsants, the treatment being studied uses a natural compound: curcumin. Researchers are excited about this treatment because curcumin, especially in its highly bioavailable form combined with phosphatidylcholine, may offer anti-inflammatory benefits that directly target the underlying mechanisms of tinnitus. Additionally, the inclusion of boswellia, another anti-inflammatory agent, distinguishes this approach by potentially reducing inflammation more effectively than current options. This natural, dual-action strategy could provide a safer alternative with fewer side effects, offering hope to those seeking relief from tinnitus.
What evidence suggests that highly bioavailable curcumin might be an effective treatment for tinnitus?
Research has shown that curcumin, a natural compound, possesses strong antioxidant properties that can protect the ears from damage. Some studies have found that it reduces discomfort in people with tinnitus, indicating a positive effect. In animal studies, curcumin effectively prevented hearing loss caused by loud noise, suggesting it might help treat tinnitus. Although limited data exist from human studies, these early findings suggest that curcumin could help manage tinnitus symptoms. Participants in this trial will receive either a highly bioavailable form of curcumin or a placebo to evaluate its effectiveness in managing tinnitus symptoms.13678
Who Is on the Research Team?
Seilish Babu, MD
Principal Investigator
Michigan Ear Institute
Are You a Good Fit for This Trial?
This trial is for adults who have ringing in their ears (tinnitus) because of hearing loss from nerve damage. They must not be allergic to the test compounds, pregnant, using other tinnitus treatments like certain medications or counseling, or taking blood thinners.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive either the active compound or placebo for 30 days
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Highly Bioavailable Curcumin
Trial Overview
The study is testing if a form of curcumin that's easy for the body to use can help with tinnitus. Participants will either get this special curcumin or a placebo and answer surveys about their tinnitus before and after treatment.
How Is the Trial Designed?
2
Treatment groups
Experimental Treatment
Placebo Group
Subjects will be provided with a supply of capsules containing 500 mg of curcumin-phosphatidylcholine combined with 250 mg of boswellia-phosphatidyl. Subjects will take 1 capsule by mouth twice daily for 30 days.
Subjects will be provided with a placebo compound with instructions to take 1 capsule by mouth twice daily for 30 days.
Find a Clinic Near You
Who Is Running the Clinical Trial?
Henry Ford Health System
Lead Sponsor
Ascension South East Michigan
Lead Sponsor
Published Research Related to This Trial
Citations
Effect of Highly Bioavailable Curcumin on Subjective Tinnitus
This study will assess the effectiveness of highly bioavailable curcumin in suppressing subjective tinnitus based on pre- and post-treatment evaluations using ...
Curcumin for Tinnitus · Info for Participants
Research shows that curcumin, known for its antioxidant properties, can protect against ear damage in animal studies and reduce discomfort in tinnitus patients ...
Trial | NCT04800107
This study will assess the effectiveness of highly bioavailable curcumin in suppressing subjective tinnitus based on pre- and post-treatment evaluations ...
Preventive effect of curcumin and its highly bioavailable ...
Together, these data suggest that curcumin exerts a preventive effect on noise-induced hearing loss and is therefore a good therapeutic ...
Effect of Highly Bioavailable Curcumin on Subjective Tinnitus
This study will assess the effectiveness of highly bioavailable curcumin in suppressing subjective tinnitus based on pre- and post-treatment evaluations ...
Safety assessment of a highly bioavailable curcumin ...
In summary, CGM was found not to cause any toxic manifestations or adverse events when consumed for 90 days at 1000 mg/day dosage (∼380 mg ...
Evidence Supporting the Hypothesis That Inflammation ...
It is therefore not surprising that oral curcumin in a highly bioavailable preparation has been shown to reduce noise-induced SNHL in a murine ...
(PDF) The effectiveness of curcumin as a safe agent on ...
This study aimed to investigate the protective effects and possible mechanisms of curcumin as a therapeutic agent on hearing impairment in ...
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