Reducing Antibiotic Use for Dementia
(TRAIN-AD 2 Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
The goal of this pragmatic cluster randomized clinical trial is to compare management of suspected infection in nursing home residents with dementia The main questions it aims to answer whether residents with dementia in nursing homes randomized to use a multicomponent intervention to optimize suspected infection management ( versus usual care) use less antibiotics and fewer burdensome interventions.
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications. It is best to discuss this with the trial coordinators or your doctor.
Is the treatment in the clinical trial generally safe for humans?
How is the TRAIN AD 2.0 treatment different from other treatments for reducing antibiotic use in dementia patients?
What data supports the effectiveness of the treatment TRAIN AD 2.0 for reducing antibiotic use in dementia patients?
Who Is on the Research Team?
Susan Mitchell, MD, MPH
Principal Investigator
Hebrew SeniorLife
Are You a Good Fit for This Trial?
This trial is for nursing home residents over 60 years old with a diagnosis of any type of dementia, who have lived in the facility for more than 90 days. They must have moderate to severe cognitive impairment. It's not suitable for those without or with only mild cognitive issues.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Preparation
Preparation phase for setting up the trial, including randomization and program roll out at the facility level
Startup
Initial startup period for the trial in all nursing homes
Resident Enrollment
Enrollment of eligible residents with dementia using the EHR and Minimum DataSet (MDS)
Intervention Implementation
Implementation of the multicomponent intervention in the experimental arm nursing homes
Data Collection
Data collection period for all nursing homes
Follow-up
Participants are monitored for safety and effectiveness after the intervention
Data Analysis and Manuscript Preparation
Analysis of collected data and preparation of manuscripts
What Are the Treatments Tested in This Trial?
Interventions
- TRAIN AD 2.0
Find a Clinic Near You
Who Is Running the Clinical Trial?
Hebrew SeniorLife
Lead Sponsor
Brown University
Collaborator