Tolcapone

Parkinson Disease
Treatment
1 FDA approval
7 Active Studies for Tolcapone

What is Tolcapone

TolcaponeThe Generic name of this drug
Treatment SummaryTolcapone is a medication used to treat Parkinson’s disease when taken with other medications. It works by blocking an enzyme in the body called catechol-O-methyl transferase (COMT). The drug is yellow, odorless, and crystalline in form. However, it can cause liver damage, so it should be taken with caution.
Tasmaris the brand name
image of different drug pills on a surface
Tolcapone Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Tasmar
Tolcapone
2004
5

Approved as Treatment by the FDA

Tolcapone, also known as Tasmar, is approved by the FDA for 1 uses such as Parkinson Disease .
Parkinson Disease
Used in combination with other therapies

Effectiveness

How Tolcapone Affects PatientsTolcapone is a drug used to help people with Parkinson's disease. It works by blocking an enzyme called catechol-O-methyltransferase (COMT). This enzyme breaks down substances like dopamine, which is important for controlling movement. When taken with other drugs, such as levodopa, tolcapone can help keep the levels of dopamine in the body more steady, leading to better control of movement and fewer side effects from the other drugs.
How Tolcapone works in the bodyTolcapone works by preventing an enzyme called COMT from breaking down levodopa. This allows levodopa to stay in the bloodstream longer, increasing the amount that reaches the brain. By increasing the amount of levodopa in the brain, it can help reduce the symptoms of Parkinson's disease.

When to interrupt dosage

The advised measure of Tolcapone is contingent upon the diagnosed state of health. The amount of dosage is dependent upon the mode of administration (e.g. Tablet, coated - Oral or Tablet, film coated) described in the following table.
Condition
Dosage
Administration
Parkinson Disease
100.0 mg, , 200.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral

Warnings

Tolcapone has four contraindications and should not be consumed while experiencing the conditions detailed in the subsequent table.Tolcapone Contraindications
Condition
Risk Level
Notes
prior drug-related confusion
Do Not Combine
Rhabdomyolysis
Do Not Combine
Hyperthermia
Do Not Combine
prior drug-related hepatocellular injury
Do Not Combine
There are 20 known major drug interactions with Tolcapone.
Common Tolcapone Drug Interactions
Drug Name
Risk Level
Description
Azelastine
Major
Tolcapone may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
Ethanol
Major
Tolcapone may increase the central nervous system depressant (CNS depressant) activities of Ethanol.
Oliceridine
Major
The risk or severity of hypotension, sedation, death, somnolence, and respiratory depression can be increased when Tolcapone is combined with Oliceridine.
Thalidomide
Major
Tolcapone may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
2-Hydroxyestradiol
Minor
The metabolism of 2-Hydroxyestradiol can be decreased when combined with Tolcapone.
Tolcapone Toxicity & Overdose RiskThe LD50 for the drug when taken orally by rats is 1600mg/kg.

Tolcapone Novel Uses: Which Conditions Have a Clinical Trial Featuring Tolcapone?

There are 6 ongoing trials assessing the potential of Tolcapone to mitigate the symptoms of Parkinson Disease.
Condition
Clinical Trials
Trial Phases
Parkinson Disease
7 Actively Recruiting
Early Phase 1, Not Applicable, Phase 2

Tolcapone Reviews: What are patients saying about Tolcapone?

5Patient Review
4/21/2009
Tolcapone for Parkinson's Disease
This treatment really helped to supercharge the effectiveness of my carb/levo medications.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about tolcapone

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is tolcapone used to treat?

"Tolcapone is a medication used in combination with levodopa and carbidopa to treat the symptoms of Parkinson's disease. It is only available with a doctor's prescription."

Answered by AI

Why was tolcapone withdrawn?

"Tolcapone is a drug that was approved for use in the United States in 1998 to help treat symptoms of Parkinson's disease. The drug was soon withdrawn after it was linked to several cases of acute liver failure."

Answered by AI

What drug class is tolcapone?

"Tolcapone is a catechol-O-methyl transferase inhibitor used to manage and treat Parkinson disease."

Answered by AI

Does tolcapone increase dopamine?

"Tolcapone is a drug that inhibits the catechol-O-methyl transferase (COMT) enzyme, which is responsible for breaking down the neurotransmitter dopamine. This leads to increased levels of dopamine in the brain, which has a variety of effects on mood and behavior."

Answered by AI

Clinical Trials for Tolcapone

Have you considered Tolcapone clinical trials? We made a collection of clinical trials featuring Tolcapone, we think they might fit your search criteria.