Tolcapone

Parkinson Disease

Treatment

2 FDA approvals

7 Active Studies for Tolcapone

Treatment for

Parkinson Disease

What is Tolcapone

TolcaponeThe Generic name of this drug

Treatment SummaryTolcapone is a medication used to treat Parkinson’s disease when taken with other medications. It works by blocking an enzyme in the body called catechol-O-methyl transferase (COMT). The drug is yellow, odorless, and crystalline in form. However, it can cause liver damage, so it should be taken with caution.

Tasmaris the brand name

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Tolcapone Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Tasmar

Tolcapone

2004

Approved as Treatment by the FDA

Tolcapone, also known as Tasmar, is approved by the FDA for 2 uses such as Idiopathic Parkinson's Disease and Parkinson Disease .

Idiopathic Parkinson's Disease

Used in combination with other therapies

Parkinson Disease

Used in combination with other therapies

Effectiveness

How Tolcapone Affects PatientsTolcapone is a drug used to help people with Parkinson's disease. It works by blocking an enzyme called catechol-O-methyltransferase (COMT). This enzyme breaks down substances like dopamine, which is important for controlling movement. When taken with other drugs, such as levodopa, tolcapone can help keep the levels of dopamine in the body more steady, leading to better control of movement and fewer side effects from the other drugs.

How Tolcapone works in the bodyTolcapone works by preventing an enzyme called COMT from breaking down levodopa. This allows levodopa to stay in the bloodstream longer, increasing the amount that reaches the brain. By increasing the amount of levodopa in the brain, it can help reduce the symptoms of Parkinson's disease.

When to interrupt dosage

The advised measure of Tolcapone is contingent upon the diagnosed state of health. The amount of dosage is dependent upon the mode of administration (e.g. Tablet, coated - Oral or Tablet, film coated) described in the following table.

Condition

Dosage

Administration

Parkinson Disease

100.0 mg, , 200.0 mg

, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral

Warnings

Tolcapone has four contraindications and should not be consumed while experiencing the conditions detailed in the subsequent table.Tolcapone Contraindications

Condition

Risk Level

Notes

Confusion

Do Not Combine

Rhabdomyolysis

Do Not Combine

Hyperthermia

Do Not Combine

prior drug-related hepatocellular injury

Do Not Combine

There are 20 known major drug interactions with Tolcapone.

Common Tolcapone Drug Interactions

Drug Name

Risk Level

Description

Azelastine

Major

Tolcapone may increase the central nervous system depressant (CNS depressant) activities of Azelastine.

Ethanol

Major

Tolcapone may increase the central nervous system depressant (CNS depressant) activities of Ethanol.

Oliceridine

Major

The risk or severity of hypotension, sedation, death, somnolence, and respiratory depression can be increased when Tolcapone is combined with Oliceridine.

Thalidomide

Major

Tolcapone may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.

2-Hydroxyestradiol

Minor

The metabolism of 2-Hydroxyestradiol can be decreased when combined with Tolcapone.

Tolcapone Toxicity & Overdose RiskThe LD50 for the drug when taken orally by rats is 1600mg/kg.

Tolcapone Novel Uses: Which Conditions Have a Clinical Trial Featuring Tolcapone?

There are 6 ongoing trials assessing the potential of Tolcapone to mitigate the symptoms of Parkinson Disease.

Condition

Clinical Trials

Trial Phases

Parkinson Disease

7 Actively Recruiting

Early Phase 1, Phase 2, Not Applicable

Tolcapone Reviews: What are patients saying about Tolcapone?

5Patient Review

4/21/2009

Tolcapone for Parkinson's Disease

This treatment really helped to supercharge the effectiveness of my carb/levo medications.

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Patient Q&A Section about tolcapone

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is tolcapone used to treat?

"Tolcapone is a medication used in combination with levodopa and carbidopa to treat the symptoms of Parkinson's disease. It is only available with a doctor's prescription."

Answered by AI

Why was tolcapone withdrawn?

"Tolcapone is a drug that was approved for use in the United States in 1998 to help treat symptoms of Parkinson's disease. The drug was soon withdrawn after it was linked to several cases of acute liver failure."

Answered by AI

What drug class is tolcapone?

"Tolcapone is a catechol-O-methyl transferase inhibitor used to manage and treat Parkinson disease."

Answered by AI

Does tolcapone increase dopamine?

"Tolcapone is a drug that inhibits the catechol-O-methyl transferase (COMT) enzyme, which is responsible for breaking down the neurotransmitter dopamine. This leads to increased levels of dopamine in the brain, which has a variety of effects on mood and behavior."

Answered by AI

Clinical Trials for Tolcapone

Have you considered Tolcapone clinical trials? We made a collection of clinical trials featuring Tolcapone, we think they might fit your search criteria.