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What is Tivicay
DolutegravirThe Generic name of this drug
Treatment SummaryDolutegravir is a medication used to treat HIV-1. It works by blocking the activity of an enzyme used by the virus to insert its genetic material into human cells. This makes it easier for the immune system to fight off the virus. Dolutegravir was developed by ViiV Healthcare and approved by the FDA in 2013. In 2017, it was approved in combination with another drug, rilpivirine, as part of the first two-drug regimen for adults with HIV-1, called Juluca.
Tivicayis the brand name
Tivicay Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Tivicay
Dolutegravir
2013
16
Approved as Treatment by the FDA
Dolutegravir, otherwise called Tivicay, is approved by the FDA for 3 uses including HIV and Anti-Retroviral Agents .HIV
Used to treat Human Immunodeficiency Virus Type 1 (HIV-1) Infection in combination with Rilpivirine
Anti-Retroviral Agents
Used to treat stable antiretroviral regimen in combination with Rilpivirine
treatment failure
Used to treat no history of treatment failure in combination with Rilpivirine
Effectiveness
How Tivicay Affects PatientsDolutegravir is a drug used to fight HIV-1 infections. It works quickly and the effects last for several days. Studies have shown that dolutegravir has a strong bond to HIV-1 and is difficult to build up resistance to. When taken with the drug ripivirine, it has been found to be just as effective as three-drug therapies, without causing HIV-1 mutations or resistance to ripivirine.
How Tivicay works in the bodyDolutegravir is an HIV-1 antiviral drug. It works by preventing HIV from copying itself and spreading inside the body. It does this by stopping a key step of the replication process called strand transfer. Dolutegravir is very effective, with an average success rate of 0.5 to 2.1 nanomoles per milliliter in cells.
When to interrupt dosage
The measure of Tivicay is predicated upon the identified affliction. The quantity of dosage is determined by the technique of delivery (e.g. Tablet, film coated or Tablet) as detailed in the table below.Condition
Dosage
Administration
HIV
, 50.0 mg, 10.0 mg, 25.0 mg, 5.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, for suspension, Tablet, for suspension - Oral
treatment failure
, 50.0 mg, 10.0 mg, 25.0 mg, 5.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, for suspension, Tablet, for suspension - Oral
Antiretroviral Therapy
, 50.0 mg, 10.0 mg, 25.0 mg, 5.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, for suspension, Tablet, for suspension - Oral
treatment experienced
, 50.0 mg, 10.0 mg, 25.0 mg, 5.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, for suspension, Tablet, for suspension - Oral
Treatment Naive
, 50.0 mg, 10.0 mg, 25.0 mg, 5.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, for suspension, Tablet, for suspension - Oral
Anti-Retroviral Agents
, 50.0 mg, 10.0 mg, 25.0 mg, 5.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, for suspension, Tablet, for suspension - Oral
Warnings
Tivicay has two contraindications and should not be administered with the circumstances given in the following table.Tivicay ContraindicationsCondition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Dolutegravir may interact with Pulse Frequency
Common Tivicay Drug Interactions
Drug Name
Risk Level
Description
Cisplatin
Major
The serum concentration of Cisplatin can be increased when it is combined with Dolutegravir.
Clofarabine
Major
The serum concentration of Clofarabine can be increased when it is combined with Dolutegravir.
Dalfampridine
Major
The serum concentration of Dalfampridine can be increased when it is combined with Dolutegravir.
Dofetilide
Major
The serum concentration of Dofetilide can be increased when it is combined with Dolutegravir.
Gentamicin
Major
The serum concentration of Gentamicin can be increased when it is combined with Dolutegravir.
Tivicay Toxicity & Overdose RiskTaking dolutegravir around the time of conception or during the first trimester of pregnancy may increase the risk of neural tube defects in unborn babies. Doctors should carefully consider the risks and benefits of taking this drug during these times, and may advise switching to an alternative treatment. Animal studies have not shown any effects on development, but there is not enough information from human studies to know for sure. If you take too much dolutegravir, you should be monitored and given the necessary supportive treatment. Dialysis probably won't remove a lot of the drug from your body since it is tightly bound to proteins in the blood.
Tivicay Novel Uses: Which Conditions Have a Clinical Trial Featuring Tivicay?
There are currently 43 active studies examining the use of Tivicay in managing HIV (Human Immunodeficiency Virus) infections.Condition
Clinical Trials
Trial Phases
Treatment Naive
0 Actively Recruiting
Anti-Retroviral Agents
0 Actively Recruiting
treatment failure
0 Actively Recruiting
treatment experienced
0 Actively Recruiting
Antiretroviral Therapy
2 Actively Recruiting
Phase 3, Phase 1
HIV
42 Actively Recruiting
Phase 2, Phase 3, Phase 1, Phase 4, Not Applicable, Early Phase 1
Tivicay Reviews: What are patients saying about Tivicay?
5Patient Review
9/22/2014 So far, I really like this medication. No negative side effects that I've noticed, and it appears to be working well (two months in).
5Patient Review
11/1/2014 My CD4 count increased from 31 to 232 after just two months of taking this medication. I also didn't experience any negative side effects, which was great.
Patient Q&A Section about tivicay
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Is Tivicay used for PEP?
"Tivicay (dolutegravir) is a medication that can be used for post-exposure prophylaxis (PEP). PEP is a method of preventing HIV infection in people who do not have HIV, but may have been exposed to it. PEP involves taking Tivicay (dolutegravir) once daily, in combination with Truvada, for 28 days."
Answered by AI
What are the side effects of Tivicay?
"anxiety, irritability
If you experience any of the following side effects, you should contact your doctor immediately: trouble sleeping (insomnia), tiredness, headache, allergic reactions such as rash, changes in liver tests, changes in body fat (especially in your back, neck, and trunk), changes in your immune system, depression, anxiety, irritability."
Answered by AI
What is the drug Tivicay used for?
"TIVICAY and TIVICAY PD are prescription antiviral medications used in the treatment of human immunodeficiency virus (HIV-1) infection. They are typically used in conjunction with other HIV-1 medications in adults who have not previously received treatment for their infection, or to replace their current HIV-1 medications in cases where the virus has developed resistance to those medications."
Answered by AI