Temsirolimus

Kidney Neoplasms

Treatment

2 FDA approvals

16 Active Studies for Temsirolimus

Treatment for

Kidney Neoplasms

What is Temsirolimus

TemsirolimusThe Generic name of this drug

Treatment SummaryTemsirolimus, also known as Torisel, is a medication used to treat renal cell carcinoma (RCC). It was developed by Wyeth Pharmaceuticals and approved by the FDA in 2007 and the European Medicines Agency (EMEA) in November of the same year.

Toriselis the brand name

image of different drug pills on a surface

Temsirolimus Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Torisel

Temsirolimus

2007

Approved as Treatment by the FDA

Temsirolimus, otherwise called Torisel, is approved by the FDA for 2 uses including Advanced Renal Cell Carcinoma (aRCC) and Kidney Neoplasms .

Advanced Renal Cell Carcinoma (aRCC)

Kidney Neoplasms

Effectiveness

How Temsirolimus works in the bodyTemsirolimus stops cell division by targeting an intracellular protein called mTOR. When it binds to the protein FKBP-12, it prevents mTOR from activating the pathways needed for cell division. This stops tumor cells from growing. In vitro studies on renal cell cancer also showed that temsirolimus blocked the production of factors that contribute to blood vessel growth, which could be beneficial for cancer patients.

When to interrupt dosage

The suggested dosage of Temsirolimus is contingent upon the diagnosed affliction. The quantity of dosage varies, as indicated by the method of delivery featured in the table beneath.

Condition

Dosage

Administration

Kidney Neoplasms

, 30.0 mg, 25.0 mg/mL

Intravenous, , Solution, Solution - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Kit, Kit - Intravenous

Warnings

Temsirolimus Contraindications

Condition

Risk Level

Notes

Pulse Frequency

Do Not Combine

There are 20 known major drug interactions with Temsirolimus.

Common Temsirolimus Drug Interactions

Drug Name

Risk Level

Description

9-(N-methyl-L-isoleucine)-cyclosporin A

Major

The risk or severity of adverse effects can be increased when Temsirolimus is combined with 9-(N-methyl-L-isoleucine)-cyclosporin A.

Abemaciclib

Major

The serum concentration of Abemaciclib can be increased when it is combined with Temsirolimus.

Abetimus

Major

The risk or severity of adverse effects can be increased when Temsirolimus is combined with Abetimus.

Acteoside

Major

The risk or severity of adverse effects can be increased when Temsirolimus is combined with Acteoside.

Amoxapine

Major

The metabolism of Amoxapine can be decreased when combined with Temsirolimus.

Temsirolimus Toxicity & Overdose RiskTemsirolimus has been tested on cancer patients in early trials with doses as high as 220 mg/m2. Taking doses greater than 25 mg can increase the risk of serious problems such as blood clots, holes in the intestine, lung disease, seizures, and mental health issues.

image of a doctor in a lab doing drug, clinical research

Temsirolimus Novel Uses: Which Conditions Have a Clinical Trial Featuring Temsirolimus?

Fifteen studies are being conducted to evaluate the potential of Temsirolimus to treat Advanced Renal Cell Carcinoma (aRCC).

Condition

Clinical Trials

Trial Phases

Kidney Neoplasms

16 Actively Recruiting

Phase 3, Not Applicable, Phase 2, Phase 1

Temsirolimus Reviews: What are patients saying about Temsirolimus?

5Patient Review

9/4/2010

Temsirolimus for Cancer Involving the Kidney Cells

I was diagnosed with kidney cancer in 2004 and have had surgeries on both kidneys. I have been on IL-2, Sutent, Trial Clinic. I have been on Torisel for 30 months with stable results every 3-4 under a CT/MRI.

3Patient Review

6/23/2008

Temsirolimus for Cancer Involving the Kidney Cells

I contracted pneumonia

image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about temsirolimus

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is temsirolimus an immunotherapy?

"The mTOR inhibitors are also immunosuppressants and are used clinically to prevent rejection following solid-organ transplant. However, researchers are also working on developing new immunotherapies that could be used to treat immunoresponsive tumours, such as RCC and melanoma."

Answered by AI

Is temsirolimus the same as sirolimus?

"Temsirolimus and sirolimus are both drugs that inhibit mammalian target of rapamycin. Temsirolimus is a prodrug of sirolimus, meaning that it is converted into sirolimus once it is inside the body."

Answered by AI

Is temsirolimus a chemotherapy?

"The drug Temsirolimus is sold under the trade name Torisel. In some cases, doctors and other health care professionals may refer to the drug by its generic name, Temsirolimus, instead of its trade name, Torisel."

Answered by AI

What is Temsirolimus used for?

"Temsirolimus is a medication used to treat advanced renal cell carcinoma, a type of cancer that begins in the kidney. Temsirolimus works by blocking the action of the abnormal protein that tells the cancer cells to multiply, which may help slow the growth of tumors."

Answered by AI

Clinical Trials for Temsirolimus

Have you considered Temsirolimus clinical trials? We made a collection of clinical trials featuring Temsirolimus, we think they might fit your search criteria.

Have you considered Temsirolimus clinical trials? We made a collection of clinical trials featuring Temsirolimus, we think they might fit your search criteria.