Temsirolimus

Advanced Renal Cell Carcinoma (aRCC)
Treatment
1 FDA approval
17 Active Studies for Temsirolimus

What is Temsirolimus

TemsirolimusThe Generic name of this drug
Treatment SummaryTemsirolimus, also known as Torisel, is a medication used to treat renal cell carcinoma (RCC). It was developed by Wyeth Pharmaceuticals and approved by the FDA in 2007 and the European Medicines Agency (EMEA) in November of the same year.
Toriselis the brand name
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Temsirolimus Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Torisel
Temsirolimus
2007
5

Approved as Treatment by the FDA

Temsirolimus, otherwise called Torisel, is approved by the FDA for 1 uses including Advanced Renal Cell Carcinoma (aRCC) .
Advanced Renal Cell Carcinoma (aRCC)

Effectiveness

How Temsirolimus works in the bodyTemsirolimus stops cell division by targeting an intracellular protein called mTOR. When it binds to the protein FKBP-12, it prevents mTOR from activating the pathways needed for cell division. This stops tumor cells from growing. In vitro studies on renal cell cancer also showed that temsirolimus blocked the production of factors that contribute to blood vessel growth, which could be beneficial for cancer patients.

When to interrupt dosage

The suggested dosage of Temsirolimus is contingent upon the diagnosed affliction. The quantity of dosage varies, as indicated by the method of delivery featured in the table beneath.
Condition
Dosage
Administration
Advanced Renal Cell Carcinoma (aRCC)
, 30.0 mg, 25.0 mg/mL
Intravenous, , Solution, Solution - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Kit, Kit - Intravenous

Warnings

Temsirolimus Contraindications
Condition
Risk Level
Notes
Pulse Frequency
Do Not Combine
There are 20 known major drug interactions with Temsirolimus.
Common Temsirolimus Drug Interactions
Drug Name
Risk Level
Description
9-(N-methyl-L-isoleucine)-cyclosporin A
Major
The risk or severity of adverse effects can be increased when Temsirolimus is combined with 9-(N-methyl-L-isoleucine)-cyclosporin A.
Abemaciclib
Major
The serum concentration of Abemaciclib can be increased when it is combined with Temsirolimus.
Abetimus
Major
The risk or severity of adverse effects can be increased when Temsirolimus is combined with Abetimus.
Acteoside
Major
The risk or severity of adverse effects can be increased when Temsirolimus is combined with Acteoside.
Amoxapine
Major
The metabolism of Amoxapine can be decreased when combined with Temsirolimus.
Temsirolimus Toxicity & Overdose RiskTemsirolimus has been tested on cancer patients in early trials with doses as high as 220 mg/m2. Taking doses greater than 25 mg can increase the risk of serious problems such as blood clots, holes in the intestine, lung disease, seizures, and mental health issues.
image of a doctor in a lab doing drug, clinical research

Temsirolimus Novel Uses: Which Conditions Have a Clinical Trial Featuring Temsirolimus?

Fifteen studies are being conducted to evaluate the potential of Temsirolimus to treat Advanced Renal Cell Carcinoma (aRCC).
Condition
Clinical Trials
Trial Phases
Advanced Renal Cell Carcinoma (aRCC)
17 Actively Recruiting
Phase 3, Not Applicable, Phase 1, Phase 2

Temsirolimus Reviews: What are patients saying about Temsirolimus?

5Patient Review
9/4/2010
Temsirolimus for Cancer Involving the Kidney Cells
I was diagnosed with kidney cancer in 2004 and have had surgeries on both kidneys. I have been on IL-2, Sutent, Trial Clinic. I have been on Torisel for 30 months with stable results every 3-4 under a CT/MRI.
3Patient Review
6/23/2008
Temsirolimus for Cancer Involving the Kidney Cells
I contracted pneumonia
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Patient Q&A Section about temsirolimus

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is temsirolimus an immunotherapy?

"The mTOR inhibitors are also immunosuppressants and are used clinically to prevent rejection following solid-organ transplant. However, researchers are also working on developing new immunotherapies that could be used to treat immunoresponsive tumours, such as RCC and melanoma."

Answered by AI

Is temsirolimus the same as sirolimus?

"Temsirolimus and sirolimus are both drugs that inhibit mammalian target of rapamycin. Temsirolimus is a prodrug of sirolimus, meaning that it is converted into sirolimus once it is inside the body."

Answered by AI

Is temsirolimus a chemotherapy?

"The drug Temsirolimus is sold under the trade name Torisel. In some cases, doctors and other health care professionals may refer to the drug by its generic name, Temsirolimus, instead of its trade name, Torisel."

Answered by AI

What is Temsirolimus used for?

"Temsirolimus is a medication used to treat advanced renal cell carcinoma, a type of cancer that begins in the kidney. Temsirolimus works by blocking the action of the abnormal protein that tells the cancer cells to multiply, which may help slow the growth of tumors."

Answered by AI

Clinical Trials for Temsirolimus

Have you considered Temsirolimus clinical trials? We made a collection of clinical trials featuring Temsirolimus, we think they might fit your search criteria.
Have you considered Temsirolimus clinical trials? We made a collection of clinical trials featuring Temsirolimus, we think they might fit your search criteria.
Have you considered Temsirolimus clinical trials? We made a collection of clinical trials featuring Temsirolimus, we think they might fit your search criteria.