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What is Tasigna
NilotinibThe Generic name of this drug
Treatment SummaryNilotinib, also known as AMN107, is a drug being studied as a possible treatment for chronic myelogenous leukemia (CML). In a clinical trial in 2006, it was found to be safe and effective in cases of CML that had become resistant to the current first-line treatment, imatinib (Gleevec).
Tasignais the brand name
Tasigna Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Tasigna
Nilotinib
2007
3
Effectiveness
How Tasigna Affects PatientsNilotinib is a drug that stops certain proteins from working, which can help treat different types of leukemia, including chronic myeloid leukemia (CML).
How Tasigna works in the bodyNilotinib stops the BCR-ABL protein from causing Chronic Myelogenous Leukaemia (CML). It is able to do this by fitting into the ATP-binding site of the BCR-ABL protein with greater affinity than other drugs. It can also treat other types of leukaemia, mastocytosis, and gastrointestinal stromal tumours by inhibiting the c-Kit receptor kinase.
When to interrupt dosage
The recommended dose of Tasigna is contingent upon the diagnosed state, including refractory, accelerated phase Chronic myeloid leukemia, Gastrointestinal Stromal Tumors and Myeloid Leukemia, Chronic, Chronic Phase. The degree of dosage fluctuates as per the delivery approach featured in the table below.Condition
Dosage
Administration
imatinib
, 200.0 mg, 150.0 mg, 50.0 mg
, Oral, Capsule, Capsule - Oral
imatinib
, 200.0 mg, 150.0 mg, 50.0 mg
, Oral, Capsule, Capsule - Oral
newly diagnosed, chronic phase Chronic myeloid leukemia
, 200.0 mg, 150.0 mg, 50.0 mg
, Oral, Capsule, Capsule - Oral
Leukemia, Myeloid, Accelerated Phase
, 200.0 mg, 150.0 mg, 50.0 mg
, Oral, Capsule, Capsule - Oral
Gastrointestinal Stromal Tumors
, 200.0 mg, 150.0 mg, 50.0 mg
, Oral, Capsule, Capsule - Oral
Myeloid Leukemia, Chronic, Chronic Phase
, 200.0 mg, 150.0 mg, 50.0 mg
, Oral, Capsule, Capsule - Oral
resistant to tyrosine kinase inhibitors
, 200.0 mg, 150.0 mg, 50.0 mg
, Oral, Capsule, Capsule - Oral
Warnings
Tasigna ContraindicationsCondition
Risk Level
Notes
Hypokalemia
Do Not Combine
Long QT Syndrome
Do Not Combine
Hypomagnesemia
Do Not Combine
Common Tasigna Drug Interactions
Drug Name
Risk Level
Description
(R)-warfarin
Major
The metabolism of (R)-warfarin can be decreased when combined with Nilotinib.
(S)-Warfarin
Major
The metabolism of (S)-Warfarin can be decreased when combined with Nilotinib.
1,2-Benzodiazepine
Major
The metabolism of 1,2-Benzodiazepine can be decreased when combined with Nilotinib.
3,5-diiodothyropropionic acid
Major
The metabolism of 3,5-diiodothyropropionic acid can be decreased when combined with Nilotinib.
5-androstenedione
Major
The metabolism of 5-androstenedione can be decreased when combined with Nilotinib.
Tasigna Novel Uses: Which Conditions Have a Clinical Trial Featuring Tasigna?
4 studies are presently being conducted to evaluate the effectiveness of Tasigna in treating Chronic Myeloid Leukemia, Chronic Phase, Gastrointestinal Stromal Tumors and Refractory, Accelerated Phase Chronic Myeloid Leukemia.Condition
Clinical Trials
Trial Phases
Leukemia, Myeloid, Accelerated Phase
1 Actively Recruiting
Phase 1, Phase 2
newly diagnosed, chronic phase Chronic myeloid leukemia
0 Actively Recruiting
resistant to tyrosine kinase inhibitors
0 Actively Recruiting
Myeloid Leukemia, Chronic, Chronic Phase
4 Actively Recruiting
Phase 2, Phase 1
imatinib
0 Actively Recruiting
Gastrointestinal Stromal Tumors
0 Actively Recruiting
imatinib
0 Actively Recruiting
Tasigna Reviews: What are patients saying about Tasigna?
5Patient Review
3/7/2011 I experienced minimal side effects when starting this medication, which is incredible considering how effective it was. I had some nausea and headaches at first, but those quickly faded away.
5Patient Review
6/5/2015 Within weeks of starting this treatment, I began to experience several uncomfortable side effects. My nipples became itchy and then painfully sore to the touch. Additionally, I started feeling tired all the time and my erections weakened. After some testing, it was determined that my testosterone levels were low so I started hormone therapy. However, even with increased dosages, my testosterone levels have continued to drop.
5Patient Review
5/1/2010 This drug is very effective, but you have to be careful to follow the directions exactly. I made the mistake of consuming grapefruit products while on the second day and had a 8 hour blackout. After being on the drug for just 1 month, my H&H, RBC, & WBC are all in the normal range. I was previously on Gleevec for 9 years, but the cml grew resistant to it. I am feeling very positive about the results so far. You just need to get your body accustomed to it, then you are set.
5Patient Review
2/19/2013 I was on Gleevac for eight years before I started seeing any signs that it might not be working as well. Tasigna had no negative side effects for me and I'm now in complete remission.
4.7Patient Review
11/30/2014 I've been taking this drug for over 5 years. It's been an adjustment, but I'm grateful to be alive and in remission after 32 years with CML.
4.7Patient Review
2/15/2013 I'm thankful for this medication, especially after difficulties with gleevec. The only side effect I notice that my doctor dismisses is a loss of sense of smell; however, this began occurring when the only new medication I started taking was tasigna. They need to address this-- but regardless, I would still use the tasigna.
4.3Patient Review
11/14/2011 I've been on this medication for three months and, unfortunately, have experienced more irregular heartbeats. This is especially scary for me because heart disease runs in my family. I was originally told to take the medicine an hour before or after eating, but now I'm reading that it should be the opposite. That may explain why going to sleep has been so frightening! Taking the medicine correctly would be a game changer for me.
4.3Patient Review
5/20/2010 Tasigna has been a much better experience than my previous two medications. However, I recently began having many health issues and only just realized that they were due to the listed side effects of this drug. Now, I'm facing an uphill battle to recover from these complications.
4Patient Review
6/29/2011 Tasigna has been an absolute godsend and has put me into remission. However, I am experiencing some nasty side effects that my doctors claim are unrelated to the medication. These include stomach pain, thrush, fatigue, and more. It's really hard to deal with all of this without any support.
4Patient Review
6/14/2013 I've been on this medication for nearly four years as part of a research project, and the side effects have been manageable. The main issue is that you have to take it on an empty stomach twelve hours apart, which can be difficult to work around meal times.
4Patient Review
11/25/2009 The nausea can be tough to deal with at times, but zofran helps me a lot.
3.7Patient Review
1/18/2009 I felt lightheaded and nauseous after taking this medication, and also experienced fatigue.
3Patient Review
12/23/2011 The diet is tough to stick to.
1.3Patient Review
2/25/2013 This pill was tough to keep track of- I had to make sure I took it 12 hours apart and on an empty stomach. 29 days after starting the medication, I ended up in the hospital with pneumonia. The doctors think it might have been caused by the drug.
Patient Q&A Section about tasigna
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What are the side effects of Tasigna?
"Low blood cell counts can cause decreased blood flow to the legs, heart, or brain. Pancreas inflammation (pancreatitis) can cause liver problems. Tumor lysis syndrome can cause bleeding problems. Fluid retention can cause abnormal growth or development in children."
Answered by AI
Can Tasigna cure CML?
"CML-CP is a type of leukemia that is characterized by the presence of the Philadelphia chromosome. TASIGNA is a TKI that has been used to treat approximately 28,000 people with this condition in the United States since it was approved in 2007. Some people may refer to this condition as a "good cancer," but in reality, there is no such thing."
Answered by AI