Sulfanilamide
Candidiasis, Vulvovaginal
Treatment
2 FDA approvals
1 Active Study for Sulfanilamide
Treatment for
Candidiasis, Vulvovaginal
What is Sulfanilamide
Sulfanilamide
The Generic name of this drug
Treatment Summary
Sulfanilamide is a synthetic chemical compound made up of a sulfonamide group connected to an aniline.
AVC Vaginal
is the brand name
Sulfanilamide Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
AVC Vaginal
Sulfanilamide
1965
3
Approved as Treatment by the FDA
Sulfanilamide, otherwise known as AVC Vaginal, is approved by the FDA for 2 uses like Vulvovaginal Candidiasis and Candidiasis, Vulvovaginal .
Vulvovaginal Candidiasis
Candidiasis, Vulvovaginal
Effectiveness
How Sulfanilamide Affects Patients
Sulfanilamide is an antibiotic that works against a variety of bacteria. It stops bacteria from multiplying by blocking an important part of their metabolism. It is usually taken orally, but can be difficult to administer using other methods because of its alkaline and irritating properties. This drug is found in many body tissues and fluids, including the fluid around the brain and spinal cord. It is not as effective against infections with pus.
How Sulfanilamide works in the body
Sulfanilamide prevents bacteria from reproducing by blocking their ability to make folic acid. It does this by competing with para-aminobenzoic acid (PABA) to bind with an enzyme called dihydropteroate synthetase. When the enzyme is blocked, bacteria cannot make the folic acid they need to replicate.
When to interrupt dosage
The advocated dose of Sulfanilamide is contingent upon the diagnosed situation. The amount of dosage will vary, as indicated by the technique of delivery outlined in the table below.
Condition
Dosage
Administration
Candidiasis, Vulvovaginal
, 0.15 mg/mg, 15.0 %, 1050.0 mg
Cream, , Vaginal, Cream - Vaginal, Suppository - Vaginal
Warnings
There are 20 known major drug interactions with Sulfanilamide.
Common Sulfanilamide Drug Interactions
Drug Name
Risk Level
Description
Vibrio cholerae CVD 103-HgR strain live antigen
Major
The therapeutic efficacy of Vibrio cholerae CVD 103-HgR strain live antigen can be decreased when used in combination with Sulfanilamide.
Belzutifan
Moderate
The serum concentration of Belzutifan can be increased when it is combined with Sulfanilamide.
Benzylpenicillin
Moderate
Sulfanilamide may decrease the excretion rate of Benzylpenicillin which could result in a higher serum level.
Estetrol
Moderate
The therapeutic efficacy of Estetrol can be decreased when used in combination with Sulfanilamide.
Finerenone
Moderate
The serum concentration of Finerenone can be increased when it is combined with Sulfanilamide.
Sulfanilamide Toxicity & Overdose Risk
The toxic dose of sulfonamides in mice when taken orally is 3700mg/kg and 621mg/kg when taken intravenously. The toxic dose in rabbits is 1300 mg/kg. Side effects may include skin irritation, itching, burning, rash, redness, or swelling. Over a long period of time, sulfonamides may increase the risk of thyroid cancer.
Sulfanilamide Novel Uses: Which Conditions Have a Clinical Trial Featuring Sulfanilamide?
A single clinical trial is presently assessing the utility of Sulfanilamide in ameliorating Vulvovaginal Candidiasis.
Condition
Clinical Trials
Trial Phases
Candidiasis, Vulvovaginal
1 Actively Recruiting
Phase 3
Patient Q&A Section about sulfanilamide
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Is sulfanilamide an antibiotic?
"Sulfanilamide is a sulfonamide antibiotic that inhibits the growth of bacteria. It has a wide spectrum against most gram-positive and many gram-negative organisms."
Answered by AI
Is sulfanilamide still used?
"Although sulfonamides are not as widely used as they once were, they are still employed for treating urinary tract infections and preventing infection of burns."
Answered by AI
What happened in the 1937 sulfanilamide disaster?
"In 1938, the United States saw 107 people killed by the drug elixir sulfanilamide, which was manufactured and marketed by the S. E. Massengill Company. The company used a poisonous antifreeze solvent, diethylene glycol, in the drug, which led to the fatalities. This disasters led to the realization that it was a priority to prove that a medicine was safe before marketing it."
Answered by AI
Is sulfonamide an antibiotic?
"The term "sulfonamides" refers to synthetic anti-microbial drugs, as opposed to antibiotics, which are naturally-occurring substances produced by bacteria or fungi."
Answered by AI