Sulfadiazine

Trachoma, Chancroid, Conjunctivitis, Inclusion + 16 more
Treatment
7 FDA approvals
14 Active Studies for Sulfadiazine

What is Sulfadiazine

SulfadiazineThe Generic name of this drug
Treatment SummarySilver sulfadiazine is an antibacterial medication applied directly to the skin to treat second or third degree burns. It is a derivative of sulfa drugs.
Sulfadiazineis the brand name
image of different drug pills on a surface
Sulfadiazine Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Sulfadiazine
Sulfadiazine
1994
3

Approved as Treatment by the FDA

Sulfadiazine, otherwise called Sulfadiazine, is approved by the FDA for 7 uses which include Toxoplasmosis and Acquired Immunodeficiency Syndrome .
Toxoplasmosis
Acquired Immunodeficiency Syndrome
LGI1 protein, human
Toxoplasmosis
Acquired Immune Deficiency Syndrome (AIDS)
Acute Otitis Media caused by Haemophilus Influenzae
Encephalitis

Effectiveness

How Sulfadiazine Affects PatientsSilver sulfadiazine is effective against a wide range of bacteria, including both gram-negative and gram-positive bacteria, as well as yeast. It has no effect on carbonic anhydrase, so it can be used when such agents are not recommended.
How Sulfadiazine works in the bodySilver sulfadiazine works differently than silver nitrate and sodium sulfadiazine. It only affects the cell walls and membranes of bacteria, and there's no one specific mechanism that we know of. Silver binds to different parts of the bacteria, like proteins and amino acids, and it changes their structure. It also makes tiny holes in the surface membrane, which eventually leads to the death of the cell. Sulfadiazine blocks the production of folic acid in bacteria, which is necessary for their survival.

When to interrupt dosage

The amount of Sulfadiazine relies upon the acknowledged illness, including Septicemia, Second Degree Burns and Third Degree Burns. The dosage likewise shifts according to the mode of delivery outlined in the provided table.
Condition
Dosage
Administration
Toxoplasmosis
, 500.0 mg, 410.0 mg, 500.5 mg, 167.0 mg, 400.0 mg, 8.0 %, 41.0 mg/mL, 167.0 mg/mL
, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Vaginal, Suppository - Vaginal, Suppository, Cream, Cream - Vaginal
Encephalitis
, 500.0 mg, 410.0 mg, 500.5 mg, 167.0 mg, 400.0 mg, 8.0 %, 41.0 mg/mL, 167.0 mg/mL
, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Vaginal, Suppository - Vaginal, Suppository, Cream, Cream - Vaginal
Wound Infection
, 500.0 mg, 410.0 mg, 500.5 mg, 167.0 mg, 400.0 mg, 8.0 %, 41.0 mg/mL, 167.0 mg/mL
, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Vaginal, Suppository - Vaginal, Suppository, Cream, Cream - Vaginal
Meningitis caused by Haemophilus influenzae
, 500.0 mg, 410.0 mg, 500.5 mg, 167.0 mg, 400.0 mg, 8.0 %, 41.0 mg/mL, 167.0 mg/mL
, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Vaginal, Suppository - Vaginal, Suppository, Cream, Cream - Vaginal
Haemophilus influenzae
, 500.0 mg, 410.0 mg, 500.5 mg, 167.0 mg, 400.0 mg, 8.0 %, 41.0 mg/mL, 167.0 mg/mL
, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Vaginal, Suppository - Vaginal, Suppository, Cream, Cream - Vaginal
recurrent prophylaxis of Rheumatic fever
, 500.0 mg, 410.0 mg, 500.5 mg, 167.0 mg, 400.0 mg, 8.0 %, 41.0 mg/mL, 167.0 mg/mL
, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Vaginal, Suppository - Vaginal, Suppository, Cream, Cream - Vaginal
Malaria
, 500.0 mg, 410.0 mg, 500.5 mg, 167.0 mg, 400.0 mg, 8.0 %, 41.0 mg/mL, 167.0 mg/mL
, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Vaginal, Suppository - Vaginal, Suppository, Cream, Cream - Vaginal
Chancroid
, 500.0 mg, 410.0 mg, 500.5 mg, 167.0 mg, 400.0 mg, 8.0 %, 41.0 mg/mL, 167.0 mg/mL
, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Vaginal, Suppository - Vaginal, Suppository, Cream, Cream - Vaginal
Conjunctivitis, Inclusion
, 500.0 mg, 410.0 mg, 500.5 mg, 167.0 mg, 400.0 mg, 8.0 %, 41.0 mg/mL, 167.0 mg/mL
, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Vaginal, Suppository - Vaginal, Suppository, Cream, Cream - Vaginal
Alopecia
, 500.0 mg, 410.0 mg, 500.5 mg, 167.0 mg, 400.0 mg, 8.0 %, 41.0 mg/mL, 167.0 mg/mL
, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Vaginal, Suppository - Vaginal, Suppository, Cream, Cream - Vaginal
Nocardiosis
, 500.0 mg, 410.0 mg, 500.5 mg, 167.0 mg, 400.0 mg, 8.0 %, 41.0 mg/mL, 167.0 mg/mL
, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Vaginal, Suppository - Vaginal, Suppository, Cream, Cream - Vaginal
prophylaxis of Meningococcal meningitis
, 500.0 mg, 410.0 mg, 500.5 mg, 167.0 mg, 400.0 mg, 8.0 %, 41.0 mg/mL, 167.0 mg/mL
, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Vaginal, Suppository - Vaginal, Suppository, Cream, Cream - Vaginal
Acquired Immunodeficiency Syndrome
, 500.0 mg, 410.0 mg, 500.5 mg, 167.0 mg, 400.0 mg, 8.0 %, 41.0 mg/mL, 167.0 mg/mL
, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Vaginal, Suppository - Vaginal, Suppository, Cream, Cream - Vaginal
Urinary Tract Infections
, 500.0 mg, 410.0 mg, 500.5 mg, 167.0 mg, 400.0 mg, 8.0 %, 41.0 mg/mL, 167.0 mg/mL
, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Vaginal, Suppository - Vaginal, Suppository, Cream, Cream - Vaginal
Trachoma
, 500.0 mg, 410.0 mg, 500.5 mg, 167.0 mg, 400.0 mg, 8.0 %, 41.0 mg/mL, 167.0 mg/mL
, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Vaginal, Suppository - Vaginal, Suppository, Cream, Cream - Vaginal
Rheumatic Fever
, 500.0 mg, 410.0 mg, 500.5 mg, 167.0 mg, 400.0 mg, 8.0 %, 41.0 mg/mL, 167.0 mg/mL
, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Vaginal, Suppository - Vaginal, Suppository, Cream, Cream - Vaginal
Burns
, 500.0 mg, 410.0 mg, 500.5 mg, 167.0 mg, 400.0 mg, 8.0 %, 41.0 mg/mL, 167.0 mg/mL
, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Vaginal, Suppository - Vaginal, Suppository, Cream, Cream - Vaginal
Meningitis, Meningococcal
, 500.0 mg, 410.0 mg, 500.5 mg, 167.0 mg, 400.0 mg, 8.0 %, 41.0 mg/mL, 167.0 mg/mL
, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Vaginal, Suppository - Vaginal, Suppository, Cream, Cream - Vaginal
Acute Otitis Media caused by Haemophilus Influenzae
, 500.0 mg, 410.0 mg, 500.5 mg, 167.0 mg, 400.0 mg, 8.0 %, 41.0 mg/mL, 167.0 mg/mL
, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Vaginal, Suppository - Vaginal, Suppository, Cream, Cream - Vaginal

Warnings

Sulfadiazine Contraindications
Condition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
There are 20 known major drug interactions with Sulfadiazine.
Common Sulfadiazine Drug Interactions
Drug Name
Risk Level
Description
Acenocoumarol
Major
The metabolism of Acenocoumarol can be decreased when combined with Sulfadiazine.
Brigatinib
Major
The metabolism of Brigatinib can be decreased when combined with Sulfadiazine.
Cabazitaxel
Major
The metabolism of Cabazitaxel can be decreased when combined with Sulfadiazine.
Cabozantinib
Major
The metabolism of Cabozantinib can be decreased when combined with Sulfadiazine.
Capecitabine
Major
The metabolism of Capecitabine can be decreased when combined with Sulfadiazine.
Sulfadiazine Toxicity & Overdose RiskThe lowest amount of a drug that will cause toxic effects in rats is 10001mg/kg.
image of a doctor in a lab doing drug, clinical research

Sulfadiazine Novel Uses: Which Conditions Have a Clinical Trial Featuring Sulfadiazine?

Two active studies are investigating the potential of Sulfadiazine to alleviate Third Degree Burns, Second Degree Burns and Wound Infections.
Condition
Clinical Trials
Trial Phases
Urinary Tract Infections
4 Actively Recruiting
Not Applicable, Phase 4
Meningitis caused by Haemophilus influenzae
0 Actively Recruiting
Encephalitis
2 Actively Recruiting
Phase 2
Acute Otitis Media caused by Haemophilus Influenzae
0 Actively Recruiting
Nocardiosis
0 Actively Recruiting
Burns
3 Actively Recruiting
Phase 2, Phase 3
Wound Infection
0 Actively Recruiting
Meningitis, Meningococcal
0 Actively Recruiting
Rheumatic Fever
0 Actively Recruiting
prophylaxis of Meningococcal meningitis
0 Actively Recruiting
Trachoma
1 Actively Recruiting
Phase 4
Toxoplasmosis
1 Actively Recruiting
Phase 4
Acquired Immunodeficiency Syndrome
3 Actively Recruiting
Phase 1, Phase 2, Not Applicable
Alopecia
0 Actively Recruiting
Conjunctivitis, Inclusion
0 Actively Recruiting
Chancroid
0 Actively Recruiting
Haemophilus influenzae
0 Actively Recruiting
recurrent prophylaxis of Rheumatic fever
0 Actively Recruiting
Malaria
0 Actively Recruiting

Sulfadiazine Reviews: What are patients saying about Sulfadiazine?

3Patient Review
2/4/2010
Sulfadiazine for Encephalitis due to the Parasite Toxoplasma Gondii
I experienced dry mouth and cough while taking sulfadiazine, but I found the benefits of the drug outweighed these minor inconveniences.
1.3Patient Review
9/27/2007
Sulfadiazine for Inflammation of the Choroid and Retina of the Eye
This caused me acute renal failure.
1Patient Review
2/11/2011
Sulfadiazine for Infection From Birth due to Toxoplasma Gondii Parasite
I was on this medication from November 1992 - March 1993. When Diagnosed with Hydrocephalus, I was taken off this drug Immediately. Inflamation in my eyes were worse than before starting the medication also.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about sulfadiazine

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What drug class is sulfadiazine?

"It will not work for colds, flu, or other viral infections.

Sulfadiazine is an antibiotic in the sulfa class that works by preventing the growth of bacteria and other organisms. It is effective only against certain types of infections and cannot be used to treat colds, flu, or other viral infections."

Answered by AI

What is the other name for sulfadiazine?

"This drug is sold under the brand names Lantrisul, Neotrizine, Sulfa-Triple #2, Sulfadiazine, Sulfaloid, Sulfonamides Duplex, Sulfose, Terfonyl, Triple Sulfa, Triple Sulfas, and Triple Sulfoid."

Answered by AI

What type of antibiotic is sulfadiazine?

"Sulfadiazine is an antibiotic that belongs to a class of drugs called sulfonamides. It's used to treat various bacterial infections, such as those of the brain, ears, and urinary tract. It can also be used to prevent infections in people who are at risk."

Answered by AI

What is sulfadiazine used for?

"Sulfadiazine is an antibiotic used to treat or prevent bacterial infections. It is a sulfonamide antibiotic, which means it works by preventing the growth of bacteria. However, this medicine will not work against viruses, such as the cold or flu."

Answered by AI

Clinical Trials for Sulfadiazine

Have you considered Sulfadiazine clinical trials? We made a collection of clinical trials featuring Sulfadiazine, we think they might fit your search criteria.
Have you considered Sulfadiazine clinical trials? We made a collection of clinical trials featuring Sulfadiazine, we think they might fit your search criteria.
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