Sulfadiazine

Trachoma, Chancroid, Conjunctivitis, Inclusion + 16 more

Treatment

4 FDA approvals

20 Active Studies for Sulfadiazine

Treatment for

Trachoma

What is Sulfadiazine

SulfadiazineThe Generic name of this drug

Treatment SummarySilver sulfadiazine is an antibacterial medication applied directly to the skin to treat second or third degree burns. It is a derivative of sulfa drugs.

Sulfadiazineis the brand name

image of different drug pills on a surface

Sulfadiazine Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Sulfadiazine

Sulfadiazine

1994

3

Approved as Treatment by the FDA

Sulfadiazine, otherwise called Sulfadiazine, is approved by the FDA for 4 uses which include Toxoplasmosis and Acute Otitis Media caused by Haemophilus Influenzae .

Toxoplasmosis

Acute Otitis Media caused by Haemophilus Influenzae

Acquired Immunodeficiency Syndrome

Encephalitis

Effectiveness

How Sulfadiazine Affects PatientsSilver sulfadiazine is effective against a wide range of bacteria, including both gram-negative and gram-positive bacteria, as well as yeast. It has no effect on carbonic anhydrase, so it can be used when such agents are not recommended.

How Sulfadiazine works in the bodySilver sulfadiazine works differently than silver nitrate and sodium sulfadiazine. It only affects the cell walls and membranes of bacteria, and there's no one specific mechanism that we know of. Silver binds to different parts of the bacteria, like proteins and amino acids, and it changes their structure. It also makes tiny holes in the surface membrane, which eventually leads to the death of the cell. Sulfadiazine blocks the production of folic acid in bacteria, which is necessary for their survival.

When to interrupt dosage

The amount of Sulfadiazine relies upon the acknowledged illness, including Septicemia, Second Degree Burns and Third Degree Burns. The dosage likewise shifts according to the mode of delivery outlined in the provided table.

Condition

Dosage

Administration

Alopecia

, 500.0 mg, 410.0 mg, 500.5 mg, 167.0 mg, 400.0 mg, 8.0 %, 41.0 mg/mL, 167.0 mg/mL

, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Vaginal, Suppository - Vaginal, Suppository, Cream, Cream - Vaginal

Haemophilus influenzae

, 500.0 mg, 410.0 mg, 500.5 mg, 167.0 mg, 400.0 mg, 8.0 %, 41.0 mg/mL, 167.0 mg/mL

, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Vaginal, Suppository - Vaginal, Suppository, Cream, Cream - Vaginal

recurrent prophylaxis of Rheumatic fever

, 500.0 mg, 410.0 mg, 500.5 mg, 167.0 mg, 400.0 mg, 8.0 %, 41.0 mg/mL, 167.0 mg/mL

, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Vaginal, Suppository - Vaginal, Suppository, Cream, Cream - Vaginal

prophylaxis of Meningococcal meningitis

, 500.0 mg, 410.0 mg, 500.5 mg, 167.0 mg, 400.0 mg, 8.0 %, 41.0 mg/mL, 167.0 mg/mL

, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Vaginal, Suppository - Vaginal, Suppository, Cream, Cream - Vaginal

Nocardiosis

, 500.0 mg, 410.0 mg, 500.5 mg, 167.0 mg, 400.0 mg, 8.0 %, 41.0 mg/mL, 167.0 mg/mL

, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Vaginal, Suppository - Vaginal, Suppository, Cream, Cream - Vaginal

Conjunctivitis, Inclusion

, 500.0 mg, 410.0 mg, 500.5 mg, 167.0 mg, 400.0 mg, 8.0 %, 41.0 mg/mL, 167.0 mg/mL

, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Vaginal, Suppository - Vaginal, Suppository, Cream, Cream - Vaginal

Meningococcal Meningitis

, 500.0 mg, 410.0 mg, 500.5 mg, 167.0 mg, 400.0 mg, 8.0 %, 41.0 mg/mL, 167.0 mg/mL

, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Vaginal, Suppository - Vaginal, Suppository, Cream, Cream - Vaginal

Toxoplasmosis

, 500.0 mg, 410.0 mg, 500.5 mg, 167.0 mg, 400.0 mg, 8.0 %, 41.0 mg/mL, 167.0 mg/mL

, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Vaginal, Suppository - Vaginal, Suppository, Cream, Cream - Vaginal

Malaria

, 500.0 mg, 410.0 mg, 500.5 mg, 167.0 mg, 400.0 mg, 8.0 %, 41.0 mg/mL, 167.0 mg/mL

, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Vaginal, Suppository - Vaginal, Suppository, Cream, Cream - Vaginal

Meningitis caused by Haemophilus influenzae

, 500.0 mg, 410.0 mg, 500.5 mg, 167.0 mg, 400.0 mg, 8.0 %, 41.0 mg/mL, 167.0 mg/mL

, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Vaginal, Suppository - Vaginal, Suppository, Cream, Cream - Vaginal

Urinary Tract Infection

, 500.0 mg, 410.0 mg, 500.5 mg, 167.0 mg, 400.0 mg, 8.0 %, 41.0 mg/mL, 167.0 mg/mL

, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Vaginal, Suppository - Vaginal, Suppository, Cream, Cream - Vaginal

Acute Otitis Media caused by Haemophilus Influenzae

, 500.0 mg, 410.0 mg, 500.5 mg, 167.0 mg, 400.0 mg, 8.0 %, 41.0 mg/mL, 167.0 mg/mL

, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Vaginal, Suppository - Vaginal, Suppository, Cream, Cream - Vaginal

Trachoma

, 500.0 mg, 410.0 mg, 500.5 mg, 167.0 mg, 400.0 mg, 8.0 %, 41.0 mg/mL, 167.0 mg/mL

, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Vaginal, Suppository - Vaginal, Suppository, Cream, Cream - Vaginal

Chancroid

, 500.0 mg, 410.0 mg, 500.5 mg, 167.0 mg, 400.0 mg, 8.0 %, 41.0 mg/mL, 167.0 mg/mL

, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Vaginal, Suppository - Vaginal, Suppository, Cream, Cream - Vaginal

Wound Infections

, 500.0 mg, 410.0 mg, 500.5 mg, 167.0 mg, 400.0 mg, 8.0 %, 41.0 mg/mL, 167.0 mg/mL

, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Vaginal, Suppository - Vaginal, Suppository, Cream, Cream - Vaginal

Second Degree Burns

, 500.0 mg, 410.0 mg, 500.5 mg, 167.0 mg, 400.0 mg, 8.0 %, 41.0 mg/mL, 167.0 mg/mL

, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Vaginal, Suppository - Vaginal, Suppository, Cream, Cream - Vaginal

Acquired Immunodeficiency Syndrome

, 500.0 mg, 410.0 mg, 500.5 mg, 167.0 mg, 400.0 mg, 8.0 %, 41.0 mg/mL, 167.0 mg/mL

, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Vaginal, Suppository - Vaginal, Suppository, Cream, Cream - Vaginal

Rheumatic Fever

, 500.0 mg, 410.0 mg, 500.5 mg, 167.0 mg, 400.0 mg, 8.0 %, 41.0 mg/mL, 167.0 mg/mL

, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Vaginal, Suppository - Vaginal, Suppository, Cream, Cream - Vaginal

Encephalitis

, 500.0 mg, 410.0 mg, 500.5 mg, 167.0 mg, 400.0 mg, 8.0 %, 41.0 mg/mL, 167.0 mg/mL

, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Vaginal, Suppository - Vaginal, Suppository, Cream, Cream - Vaginal

Warnings

Sulfadiazine Contraindications

Condition

Risk Level

Notes

Pulse Frequency

Do Not Combine

Pulse Frequency

Do Not Combine

There are 20 known major drug interactions with Sulfadiazine.

Common Sulfadiazine Drug Interactions

Drug Name

Risk Level

Description

Acenocoumarol

Major

The metabolism of Acenocoumarol can be decreased when combined with Sulfadiazine.

Brigatinib

Major

The metabolism of Brigatinib can be decreased when combined with Sulfadiazine.

Cabazitaxel

Major

The metabolism of Cabazitaxel can be decreased when combined with Sulfadiazine.

Cabozantinib

Major

The metabolism of Cabozantinib can be decreased when combined with Sulfadiazine.

Capecitabine

Major

The metabolism of Capecitabine can be decreased when combined with Sulfadiazine.

Sulfadiazine Toxicity & Overdose RiskThe lowest amount of a drug that will cause toxic effects in rats is 10001mg/kg.

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Sulfadiazine Novel Uses: Which Conditions Have a Clinical Trial Featuring Sulfadiazine?

Two active studies are investigating the potential of Sulfadiazine to alleviate Third Degree Burns, Second Degree Burns and Wound Infections.

Condition

Clinical Trials

Trial Phases

Meningitis caused by Haemophilus influenzae

0 Actively Recruiting

Trachoma

1 Actively Recruiting

Phase 4

Wound Infections

0 Actively Recruiting

recurrent prophylaxis of Rheumatic fever

0 Actively Recruiting

Rheumatic Fever

0 Actively Recruiting

Second Degree Burns

2 Actively Recruiting

Phase 2, Phase 3

Nocardiosis

0 Actively Recruiting

prophylaxis of Meningococcal meningitis

0 Actively Recruiting

Chancroid

0 Actively Recruiting

Conjunctivitis, Inclusion

0 Actively Recruiting

Acute Otitis Media caused by Haemophilus Influenzae

0 Actively Recruiting

Haemophilus influenzae

0 Actively Recruiting

Toxoplasmosis

1 Actively Recruiting

Phase 4

Malaria

0 Actively Recruiting

Encephalitis

10 Actively Recruiting

Phase 2, Not Applicable, Phase 3, Phase 1

Acquired Immunodeficiency Syndrome

5 Actively Recruiting

Phase 2, Phase 3, Phase 1, Not Applicable

Meningococcal Meningitis

0 Actively Recruiting

Alopecia

0 Actively Recruiting

Urinary Tract Infection

8 Actively Recruiting

Not Applicable, Phase 4, Phase 3

Sulfadiazine Reviews: What are patients saying about Sulfadiazine?

3Patient Review

2/4/2010

Sulfadiazine for Encephalitis due to the Parasite Toxoplasma Gondii

I experienced dry mouth and cough while taking sulfadiazine, but I found the benefits of the drug outweighed these minor inconveniences.

1.3Patient Review

9/27/2007

Sulfadiazine for Inflammation of the Choroid and Retina of the Eye

This caused me acute renal failure.

1Patient Review

2/11/2011

Sulfadiazine for Infection From Birth due to Toxoplasma Gondii Parasite

I was on this medication from November 1992 - March 1993. When Diagnosed with Hydrocephalus, I was taken off this drug Immediately. Inflamation in my eyes were worse than before starting the medication also.

image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about sulfadiazine

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What drug class is sulfadiazine?

"It will not work for colds, flu, or other viral infections.

Sulfadiazine is an antibiotic in the sulfa class that works by preventing the growth of bacteria and other organisms. It is effective only against certain types of infections and cannot be used to treat colds, flu, or other viral infections."

Answered by AI

What is the other name for sulfadiazine?

"This drug is sold under the brand names Lantrisul, Neotrizine, Sulfa-Triple #2, Sulfadiazine, Sulfaloid, Sulfonamides Duplex, Sulfose, Terfonyl, Triple Sulfa, Triple Sulfas, and Triple Sulfoid."

Answered by AI

What type of antibiotic is sulfadiazine?

"Sulfadiazine is an antibiotic that belongs to a class of drugs called sulfonamides. It's used to treat various bacterial infections, such as those of the brain, ears, and urinary tract. It can also be used to prevent infections in people who are at risk."

Answered by AI

What is sulfadiazine used for?

"Sulfadiazine is an antibiotic used to treat or prevent bacterial infections. It is a sulfonamide antibiotic, which means it works by preventing the growth of bacteria. However, this medicine will not work against viruses, such as the cold or flu."

Answered by AI

Clinical Trials for Sulfadiazine

Image of Arizona Burn Center Valleywise Health in Phoenix, United States.

realSKIN® for Wound Healing

This trial will test the safety and effectiveness of realSKIN® in treating deep burns. It aims to see if realSKIN® can fully close the wounds without the need for autografting

Waitlist Available

Arizona Burn Center Valleywise Health (+3 Sites)Bounthavy Homsombath, MD

Image of University of Central Florida in Orlando, United States.

ENTRUST for AIDS

This trial aims to test the idea that helping transgender women with financial stability and counseling will make it more likely for them to use substance abuse and HIV prevention services. Additionally, it will see if transgender women

University of Central FloridaElena Cyrus, PhD

Image of University of Utah in Salt Lake City, United States.

Antibiotic Stewardship at Discharge for Pneumonia

Salt Lake City, UT

This trial will test if an antibiotic stewardship approach tailored to a hospital's needs can reduce antibiotic overuse at discharge in hospitalized patients with CAP or UTI.

Waitlist Available

University of UtahValerie M Vaughn, MD

Image of Medical facility in Miami, United States.

Tebipenem Pivoxil Hydrobromide +1 More for Urinary Tract Infection

This trial aims to compare how well an oral medication called TBP-PI-HBr works against a standard intravenous medication called imipenem-cilastatin in treating urinary tract or abdominal infections

Medical facilityKamal Hamed, MDGlaxoSmithKline

Have you considered Sulfadiazine clinical trials? We made a collection of clinical trials featuring Sulfadiazine, we think they might fit your search criteria.

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Image of National Institute of Neurological Disorders and Stroke (NINDS) in Bethesda, United States.

Motor Memory Assessment for Post-COVID Syndrome

This trial looks at motor memory in people with long COVID vs. healthy adults, by having them complete typing and questionnaire tasks online.

National Institute of Neurological Disorders and Stroke (NINDS)Leonardo G Cohen, M.D.

Image of Magee Women's Hospital of UPMC in Pittsburgh, United States.

Culture-Directed vs Empiric Antibiotics for Urinary Tract Infections

This trial will assess if a culture-based or empiric antibiotic strategy is best for treating UTI symptoms in older women, and their ability to follow the study plan.

Magee Women's Hospital of UPMC

Image of Yale School of Medicne, Neuro ID Research Program in New Haven, United States.

SV2A & TSPO PET Imaging for HIV Neurocognitive Disorders

This trial will study how HIV affects the brain's synaptic density using advanced brain scans and clinical tests.

Yale School of Medicne, Neuro ID Research ProgramSerena Spudich, MD

Image of Swedish Neuroscience Institute in Seattle, United States.

Satralizumab for Autoimmune Encephalitis

This trial will test a new drug to treat two types of brain inflammation: NMDAR and LGI1 encephalitis.

Swedish Neuroscience Institute (+12 Sites)Clinical TrialsHoffmann-La Roche

Have you considered Sulfadiazine clinical trials? We made a collection of clinical trials featuring Sulfadiazine, we think they might fit your search criteria.

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Image of Aie001 50243 in Boston, United States.

Rozanolixizumab for Autoimmune Encephalitis

This trial will test if the drug rozanolixizumab is effective in reducing seizures, cognitive decline, and the need for rescue medication, as well as being safe and tolerable.

Waitlist Available

Aie001 50243 (+9 Sites)UCB CaresUCB Biopharma SRL

Image of University of Alberta Hospital in Edmonton, Canada.

Nefopam Cream for Burns

Edmonton, Canada

This trial is testing the effectiveness of a cream called Nefopam in preventing and treating abnormal scars after burns. Nefopam is a drug that has been found to have anti-scarring properties in rats and pigs, and has been tested in healthy people and found to be well tolerated and safe. The trial will involve making a scratch wound on the skin of the hip of 60 adult burn patients at two burn unit sites, and treating one side with the drug and the other with a control or placebo. Measurements will be taken once per month for four months, and patients will be asked to answer a scar assessment form.

University of Alberta HospitalEdward E Tredget, MD

Image of Roswell Park Cancer Institute in Buffalo, United States.

Antibiotics for Urinary Tract Infections After Bladder Surgery

This trial is testing whether a month of antibiotics can help reduce urinary infections after surgery to remove the bladder.

Roswell Park Cancer InstituteKhurshid A Guru

Image of University of Utah in Salt Lake City, United States.

Inebilizumab for NMDAR Encephalitis

Salt Lake City, UT

This trial will test whether the investigational agent inebilizumab is better than placebo at treating NMDAR encephalitis.

University of Utah (+25 Sites)Stacey L Clardy, MD, PhD

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