Sprycel

Leukemia, Myeloid, Accelerated Phase, Acute Lymphoblastic Leukemia, Chemotherapy + 4 more
Treatment
12 FDA approvals
20 Active Studies for Sprycel

What is Sprycel

DasatinibThe Generic name of this drug
Treatment SummaryDasatinib is a drug used to treat chronic myelogenous leukemia (CML). It works by inhibiting four different types of enzymes: BCRABL, SRC, Ephrins, and GFR. It is taken orally and is approved for use in patients with CML.
Sprycelis the brand name
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Sprycel Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Sprycel
Dasatinib
2006
7

Approved as Treatment by the FDA

Dasatinib, also called Sprycel, is approved by the FDA for 12 uses like Accelerated phase chronic myologenic leukemia and blast phase Chronic myelocytic leukemia .
Accelerated phase chronic myologenic leukemia
blast phase Chronic myelocytic leukemia
Myeloid Leukemia, Chronic, Chronic Phase
Chronic Myeloid Leukemia (CML)
Acute Lymphoblastic Leukemia (ALL)
Newly Diagnosed
Leukemia, Myeloid, Chronic-Phase
Leukemia, Myeloid, Accelerated Phase
Therapeutic procedure
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Chemotherapy
Acute Lymphoblastic Leukemia

Effectiveness

How Sprycel Affects PatientsDasatinib is an oral medication that helps to stop two types of proteins (BCR/ABL and Src family tyrosine kinase) from growing in the body.
How Sprycel works in the bodyDasatinib is a drug that works by stopping certain proteins from functioning. It specifically targets the proteins in the BCR-ABL, SRC family, c-KIT, EPHA2, and PDGFRβ groups. Studies have shown that dasatinib can stop the growth of leukemia cells that overexpress BCR-ABL, and can also overcome resistance caused by mutations and other drug resistance genes.

When to interrupt dosage

The suggested dosage of Sprycel is reliant upon the diagnosed condition. The amount of dosage is contingent upon the method of delivery (e.g. Powder, for suspension or Oral) as described in the table beneath.
Condition
Dosage
Administration
Leukemia, Myeloid, Accelerated Phase
70.0 mg, , 20.0 mg, 50.0 mg, 100.0 mg, 80.0 mg, 140.0 mg, 10.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Powder, for suspension, Powder, for suspension - Oral
Acute Lymphoblastic Leukemia
70.0 mg, , 20.0 mg, 50.0 mg, 100.0 mg, 80.0 mg, 140.0 mg, 10.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Powder, for suspension, Powder, for suspension - Oral
Chemotherapy
70.0 mg, , 20.0 mg, 50.0 mg, 100.0 mg, 80.0 mg, 140.0 mg, 10.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Powder, for suspension, Powder, for suspension - Oral
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
70.0 mg, , 20.0 mg, 50.0 mg, 100.0 mg, 80.0 mg, 140.0 mg, 10.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Powder, for suspension, Powder, for suspension - Oral
Newly Diagnosed
70.0 mg, , 20.0 mg, 50.0 mg, 100.0 mg, 80.0 mg, 140.0 mg, 10.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Powder, for suspension, Powder, for suspension - Oral
Leukemia, Myeloid, Chronic-Phase
70.0 mg, , 20.0 mg, 50.0 mg, 100.0 mg, 80.0 mg, 140.0 mg, 10.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Powder, for suspension, Powder, for suspension - Oral
Therapeutic procedure
70.0 mg, , 20.0 mg, 50.0 mg, 100.0 mg, 80.0 mg, 140.0 mg, 10.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Powder, for suspension, Powder, for suspension - Oral

Warnings

There are 20 known major drug interactions with Sprycel.
Common Sprycel Drug Interactions
Drug Name
Risk Level
Description
2-Methoxyethanol
Major
The risk or severity of adverse effects can be increased when Dasatinib is combined with 2-Methoxyethanol.
9-(N-methyl-L-isoleucine)-cyclosporin A
Major
The risk or severity of adverse effects can be increased when Dasatinib is combined with 9-(N-methyl-L-isoleucine)-cyclosporin A.
Abemaciclib
Major
The metabolism of Abemaciclib can be decreased when combined with Dasatinib.
Abetimus
Major
The risk or severity of adverse effects can be increased when Dasatinib is combined with Abetimus.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be decreased when combined with Dasatinib.
Sprycel Toxicity & Overdose RiskAnimals who take too much of this drug at once may experience heart damage.
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Sprycel Novel Uses: Which Conditions Have a Clinical Trial Featuring Sprycel?

177 active clinical trials are investigating the potential of Sprycel as a novel therapeutic strategy for Acute Lymphoblastic Leukemia treatment.
Condition
Clinical Trials
Trial Phases
Acute Lymphoblastic Leukemia
120 Actively Recruiting
Phase 1, Phase 2, Phase 3, Not Applicable, Early Phase 1, Phase 4
Chemotherapy
3 Actively Recruiting
Phase 1, Phase 3, Not Applicable
Leukemia, Myeloid, Chronic-Phase
3 Actively Recruiting
Phase 2, Phase 1
Newly Diagnosed
3 Actively Recruiting
Phase 3, Phase 1
Leukemia, Myeloid, Accelerated Phase
0 Actively Recruiting
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
0 Actively Recruiting
Therapeutic procedure
0 Actively Recruiting

Sprycel Reviews: What are patients saying about Sprycel?

5Patient Review
2/15/2014
Sprycel for Type of Leukemia - Chronic Myelogenous Leukemia
I'm in remission and this drug definitely played a role in that. Sure, there are some not-so-great side effects like diarrhea and bone pain, but it's worth it to me. I'll have to take this medication for the rest of my life, but that's a small price to pay.
5Patient Review
7/4/2016
Sprycel for Philadelphia Chromosome Positive Chronic Myelocytic Leukemia
I had a pounding headache and pain in my ear that felt like worms boring into it.
5Patient Review
6/2/2013
Sprycel for Chronic Phase Chronic Myeloid Leukemia
I've been on Sprycel for a little over a year now and I'm feeling pretty good. My blast cell count has decreased significantly, which is great news. The only downside is that I sometimes get tired and my arms will ache if I carry anything heavy.
4.7Patient Review
10/21/2015
Sprycel for Chronic Phase Chronic Myeloid Leukemia
I've been on the medication for about 2 months and have had chronic gastrointestinal issues since then. Dairy products make it worse, has anyone else experienced this?
4.7Patient Review
1/2/2018
Sprycel for Chronic Phase Chronic Myeloid Leukemia
After six weeks, I had a bad reaction in the form of itchy red welts on my arms and legs.
View All Reviews
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Patient Q&A Section about sprycel

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is sprycel a chemotherapy?

"Sprycel is not a chemotherapy drug, but is used to treat certain types of leukemia. Chemotherapy drugs work by killing cells that grow and multiply rapidly, including cancer cells."

Answered by AI

How long do you take Sprycel for CML?

"Typically, Sprycel is taken long-term, as clinical trials have proven its efficacy for up to five years. You and your doctor will decide how long to continue treatment based on how well your tests show the drug is working."

Answered by AI

What are the side effects of the drug Sprycel?

"Although not everyone experiences them, the following side effects are considered the most common in people taking SPRYCEL: diarrhea, headache, skin rash, shortness of breath, fatigue, nausea, and muscle pain."

Answered by AI

What is the drug Sprycel used for?

"SPRYCEL® is a prescription medicine used to treat: Adults with newly diagnosed Philadelphia chromosome–positive (Ph+) chronic myeloid leukemia (CML) in chronic phase (CP) Adults with Ph+ CML who no longer benefit from, or did not tolerate, other treatment, including imatinib."

Answered by AI

Clinical Trials for Sprycel

Have you considered Sprycel clinical trials? We made a collection of clinical trials featuring Sprycel, we think they might fit your search criteria.
Have you considered Sprycel clinical trials? We made a collection of clinical trials featuring Sprycel, we think they might fit your search criteria.
Have you considered Sprycel clinical trials? We made a collection of clinical trials featuring Sprycel, we think they might fit your search criteria.
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