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What is Sprycel
DasatinibThe Generic name of this drug
Treatment SummaryDasatinib is a drug used to treat chronic myelogenous leukemia (CML). It works by inhibiting four different types of enzymes: BCRABL, SRC, Ephrins, and GFR. It is taken orally and is approved for use in patients with CML.
Sprycelis the brand name
Sprycel Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Sprycel
Dasatinib
2006
7
Approved as Treatment by the FDA
Dasatinib, also called Sprycel, is approved by the FDA for 7 uses like Myeloid Leukemia, Chronic, Chronic Phase and Chemotherapy .Myeloid Leukemia, Chronic, Chronic Phase
Chemotherapy
blast phase Chronic myelocytic leukemia
Newly Diagnosed
Acute Lymphoblastic Leukemia
Therapeutic procedure
Leukemia, Myeloid, Accelerated Phase
Effectiveness
How Sprycel Affects PatientsDasatinib is an oral medication that helps to stop two types of proteins (BCR/ABL and Src family tyrosine kinase) from growing in the body.
How Sprycel works in the bodyDasatinib is a drug that works by stopping certain proteins from functioning. It specifically targets the proteins in the BCR-ABL, SRC family, c-KIT, EPHA2, and PDGFRβ groups. Studies have shown that dasatinib can stop the growth of leukemia cells that overexpress BCR-ABL, and can also overcome resistance caused by mutations and other drug resistance genes.
When to interrupt dosage
The suggested dosage of Sprycel is reliant upon the diagnosed condition. The amount of dosage is contingent upon the method of delivery (e.g. Powder, for suspension or Oral) as described in the table beneath.Condition
Dosage
Administration
Myeloid Leukemia, Chronic, Chronic Phase
70.0 mg, , 20.0 mg, 50.0 mg, 100.0 mg, 80.0 mg, 140.0 mg, 10.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Powder, for suspension, Powder, for suspension - Oral
Leukemia, Myeloid, Accelerated Phase
70.0 mg, , 20.0 mg, 50.0 mg, 100.0 mg, 80.0 mg, 140.0 mg, 10.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Powder, for suspension, Powder, for suspension - Oral
Newly Diagnosed
70.0 mg, , 20.0 mg, 50.0 mg, 100.0 mg, 80.0 mg, 140.0 mg, 10.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Powder, for suspension, Powder, for suspension - Oral
Chemotherapy
70.0 mg, , 20.0 mg, 50.0 mg, 100.0 mg, 80.0 mg, 140.0 mg, 10.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Powder, for suspension, Powder, for suspension - Oral
blast phase Chronic myelocytic leukemia
70.0 mg, , 20.0 mg, 50.0 mg, 100.0 mg, 80.0 mg, 140.0 mg, 10.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Powder, for suspension, Powder, for suspension - Oral
Acute Lymphoblastic Leukemia
70.0 mg, , 20.0 mg, 50.0 mg, 100.0 mg, 80.0 mg, 140.0 mg, 10.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Powder, for suspension, Powder, for suspension - Oral
Therapeutic procedure
70.0 mg, , 20.0 mg, 50.0 mg, 100.0 mg, 80.0 mg, 140.0 mg, 10.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Powder, for suspension, Powder, for suspension - Oral
Warnings
There are 20 known major drug interactions with Sprycel.Common Sprycel Drug Interactions
Drug Name
Risk Level
Description
2-Methoxyethanol
Major
The risk or severity of adverse effects can be increased when Dasatinib is combined with 2-Methoxyethanol.
9-(N-methyl-L-isoleucine)-cyclosporin A
Major
The risk or severity of adverse effects can be increased when Dasatinib is combined with 9-(N-methyl-L-isoleucine)-cyclosporin A.
Abemaciclib
Major
The metabolism of Abemaciclib can be decreased when combined with Dasatinib.
Abetimus
Major
The risk or severity of adverse effects can be increased when Dasatinib is combined with Abetimus.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be decreased when combined with Dasatinib.
Sprycel Toxicity & Overdose RiskAnimals who take too much of this drug at once may experience heart damage.
Sprycel Novel Uses: Which Conditions Have a Clinical Trial Featuring Sprycel?
177 active clinical trials are investigating the potential of Sprycel as a novel therapeutic strategy for Acute Lymphoblastic Leukemia treatment.Condition
Clinical Trials
Trial Phases
Acute Lymphoblastic Leukemia
146 Actively Recruiting
Phase 2, Phase 3, Phase 1, Not Applicable, Early Phase 1, Phase 4
Leukemia, Myeloid, Accelerated Phase
1 Actively Recruiting
Phase 1, Phase 2
Chemotherapy
2 Actively Recruiting
Not Applicable
Myeloid Leukemia, Chronic, Chronic Phase
4 Actively Recruiting
Phase 2, Phase 1
Newly Diagnosed
3 Actively Recruiting
Phase 3, Phase 1
Therapeutic procedure
0 Actively Recruiting
blast phase Chronic myelocytic leukemia
0 Actively Recruiting
Sprycel Reviews: What are patients saying about Sprycel?
5Patient Review
2/15/2014 I'm in remission and this drug definitely played a role in that. Sure, there are some not-so-great side effects like diarrhea and bone pain, but it's worth it to me. I'll have to take this medication for the rest of my life, but that's a small price to pay.
5Patient Review
7/4/2016 I had a pounding headache and pain in my ear that felt like worms boring into it.
5Patient Review
6/2/2013 I've been on Sprycel for a little over a year now and I'm feeling pretty good. My blast cell count has decreased significantly, which is great news. The only downside is that I sometimes get tired and my arms will ache if I carry anything heavy.
4.7Patient Review
10/21/2015 I've been on the medication for about 2 months and have had chronic gastrointestinal issues since then. Dairy products make it worse, has anyone else experienced this?
4.7Patient Review
1/2/2018 After six weeks, I had a bad reaction in the form of itchy red welts on my arms and legs.
4.7Patient Review
8/6/2014 The worst side effect I experienced was mouth sores, but I also had headaches and joint pain at first. However, they both went away after a month or so. I stopped responding to the treatment after 10 months.
4.7Patient Review
4/27/2013 Great results, but unfortunately I experienced some fatigue, confusion, and depression.
4.3Patient Review
2/2/2013 I began treatment with Gleevec, but unfortunately it only caused me more pain. I was eventually switched to Sprycel, which has helped me enter remission; however, the 50mg dose causes a lot of other issues like fatigue and bone pain.
4.3Patient Review
7/21/2015 Sprycel was effective for me in remissioning my CML within about a year of starting treatment. I had some moderate side effects at first including skin rashes, adult acne, nausea, muscle aches and extreme fatigue; however, these lessened as my dosage was reduced by my doctor. The only issue I'm having now is with blood pressure.
4.3Patient Review
4/18/2019 I was diagnosed with CML 2.5 years ago and have experienced nearly every side effect imaginable: joint pain, nausea, serious fatigue, very high blood pressure, painful acne, constipation. If there's a side effect out there, I've probably had it. I wish I could take a break from the medication but my doctor won't allow it. I've been in remission for almost a year now and am grateful that the treatment has been successful. But at the end of the day, cancer sucks!
4.3Patient Review
1/8/2016 I've encountered some chronic fatigue while using sprycel, which has made it tough to get my insurance company to foot the bill. I'm curious how others have fared in this department.
4Patient Review
2/2/2013 I've experienced some pretty intense bone pain as a result of both the Gleevec and Sprycel treatments. Unfortunately, Gleevec stopped working for me and Sprycel has caused a number of other problems in addition to the bone pain. I'm now disabled because of the side effects from both the disease and the medication
4Patient Review
5/25/2021 I was diagnosed in 2004 at age 46. I started on Gleevic 400 mg and saw great results with only minor side effects. However, after eight years it stopped being effective. So, then I switched to Sprycel 100 mg but experienced terrible fever and acne breakouts as a result. My doctor didn't want to reduce the dosage, but I eventually convinced him/her too lower it to 50 mg. It's still working now, 17 years later; however, I have developed shortness of breath from the Sprycel which is concerning.
3.7Patient Review
10/8/2014 Sprycel has been helping me since 2010, though it comes with some nasty side effects like nausea and vomiting. My heart rate increased and I had to start taking blood pressure medication. In 2014, I started experiencing severe joint and back pain. Thankfully, we have these pills to help us out, even if they come with a price.
2.7Patient Review
3/25/2014 I started taking the medication in January 2014 and experienced a drastic reduction in platelet count. I then stopped taking the medication for over one month, but when I began again, the side effects were worse. I experienced reductions in RBC count and platelet count, weight gain, headaches, tiredness, depression, and chest pain.
Patient Q&A Section about sprycel
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.How long do you take Sprycel for CML?
"Typically, Sprycel is taken long-term, as clinical trials have proven its efficacy for up to five years. You and your doctor will decide how long to continue treatment based on how well your tests show the drug is working."
Answered by AI
What are the side effects of the drug Sprycel?
"Although not everyone experiences them, the following side effects are considered the most common in people taking SPRYCEL: diarrhea, headache, skin rash, shortness of breath, fatigue, nausea, and muscle pain."
Answered by AI
What is the drug Sprycel used for?
"SPRYCEL® is a prescription medicine used to treat: Adults with newly diagnosed Philadelphia chromosome–positive (Ph+) chronic myeloid leukemia (CML) in chronic phase (CP) Adults with Ph+ CML who no longer benefit from, or did not tolerate, other treatment, including imatinib."
Answered by AI