Sotradecol

Gastrointestinal Hemorrhage, Varicosity, Esophageal and Gastric Varices
Treatment
4 FDA approvals
1 Active Study for Sotradecol

What is Sotradecol

Tetradecyl hydrogen sulfate (ester)The Generic name of this drug
Treatment SummarySodium tetradecyl sulfate is a chemical compound used in the medical field to irritate and seal off blood vessels. It has been used since the 1950s, and was first successfully used to treat spider angiomas in 1978. It can cause epidermal necrosis, but this does not have long-term effects. Some patients may experience post-sclerosis pigmentation, but this should resolve within a few months.
Sotradecolis the brand name
image of different drug pills on a surface
Sotradecol Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Sotradecol
Tetradecyl hydrogen sulfate (ester)
2004
8

Approved as Treatment by the FDA

Tetradecyl hydrogen sulfate (ester), also known as Sotradecol, is approved by the FDA for 4 uses including Varices, Esophageal and Esophageal and Gastric Varices .
Varices, Esophageal
Esophageal and Gastric Varices
Gastrointestinal Hemorrhage
Varicosity

Effectiveness

How Sotradecol Affects PatientsTelangiectasias or varicose veins are common, affecting about 33% of adult women and 15% of adult men. Sotradecol is an injection that is used to help treat these veins. It is a sclerosing agent, meaning it causes inflammation in the blood vessel walls and forms a clot, which blocks the vein. This leads to the formation of fibrous tissue which can cause the vein to be blocked off completely or temporarily.
How Sotradecol works in the bodySodium tetradecyl sulfate is injected directly into a vein to create inflammation and clots, which can block the vein. This blockage can be temporary or permanent and also helps to stop active bleeding. The drug is believed to work by creating swelling in the vein, which presses against the walls and helps to close it off. Additionally, it may cause muscle spasms in the vein, making it harder for blood to pass through.

When to interrupt dosage

The suggested measure of Sotradecol is subject to the diagnosed condition, such as Varicosity, Varices, Esophageal and Gastrointestinal Bleeding. The quantity of dosage is contingent upon the approach of delivery featured in the table below.
Condition
Dosage
Administration
Esophageal and Gastric Varices
, 30.0 mg/mL, 10.0 mg/mL
Intravenous, , Injection, solution - Intravenous, Injection, solution
Gastrointestinal Hemorrhage
, 30.0 mg/mL, 10.0 mg/mL
Intravenous, , Injection, solution - Intravenous, Injection, solution
Varicosity
, 30.0 mg/mL, 10.0 mg/mL
Intravenous, , Injection, solution - Intravenous, Injection, solution

Warnings

There are 20 known major drug interactions with Sotradecol.
Common Sotradecol Drug Interactions
Drug Name
Risk Level
Description
Albutrepenonacog alfa
Minor
Tetradecyl hydrogen sulfate (ester) may decrease the excretion rate of Albutrepenonacog alfa which could result in a higher serum level.
Almasilate
Minor
Tetradecyl hydrogen sulfate (ester) may decrease the excretion rate of Almasilate which could result in a higher serum level.
Antithrombin III human
Minor
Tetradecyl hydrogen sulfate (ester) may decrease the excretion rate of Antithrombin III human which could result in a higher serum level.
Apalutamide
Minor
Tetradecyl hydrogen sulfate (ester) may decrease the excretion rate of Apalutamide which could result in a higher serum level.
Baricitinib
Minor
Tetradecyl hydrogen sulfate (ester) may decrease the excretion rate of Baricitinib which could result in a higher serum level.
Sotradecol Toxicity & Overdose RiskSodium Tetradecyl Sulfate can be toxic, with an LD50 of 90 ± 5 mg/kg in mice and 72 mg/kg to 108 mg/kg in rats. Possible side effects include deep vein thrombosis, air embolism, local reactions such as pain, itching, and ulceration at the injection site, allergic reactions, mild systemic reactions such as headache and nausea, and in rare cases, death. Patients should be evaluated for valvular competency and deep venous patency before treatment and should be monitored post-treatment for potential risks.
image of a doctor in a lab doing drug, clinical research

Sotradecol Novel Uses: Which Conditions Have a Clinical Trial Featuring Sotradecol?

Nine active trials are assessing the potential of Sotradecol to alleviate Varicosity, Gastrointestinal Bleeding and Esophageal Varices.
Condition
Clinical Trials
Trial Phases
Varicosity
0 Actively Recruiting
Gastrointestinal Hemorrhage
1 Actively Recruiting
Phase 2
Esophageal and Gastric Varices
0 Actively Recruiting

Sotradecol Reviews: What are patients saying about Sotradecol?

4.7Patient Review
2/22/2008
Sotradecol for Enlarged Superficial Veins
4Patient Review
6/16/2011
Sotradecol for Enlarged Superficial Veins
Though this treatment successfully removed my superficial green veins, I unfortunately had a reaction in the form of hives all over my body. My doctor says it'll take weeks to get rid of them completely.
3.7Patient Review
9/20/2010
Sotradecol for Enlarged Superficial Veins
After receiving multiple injections of this drug in both legs at the same time, I have had difficulty sleeping. The night of the injections, I did not sleep at all and have been struggling to get and stay asleep since then.
3Patient Review
2/13/2010
Sotradecol for Enlarged Superficial Veins
You can purchase Sotradecol online or at most pharmacies.
2Patient Review
11/4/2007
Sotradecol for Enlarged Superficial Veins
View All Reviews

Patient Q&A Section about sotradecol

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What does a sclerosing agent do?

"Sclerosing agents are chemicals that cause inflammation and are used to treat varicose veins."

Answered by AI

What is the mechanism of action of sodium tetradecyl sulfate?

"The injection of sodium tetradecyl sulfate is a mechanism that causes the inflammation of the intima and the formation of clots. This usually leads to the blockage of the injected vein. The formation of fibrous tissue after this usually results in the partial or complete obliteration of the vein, which may be temporary or permanent."

Answered by AI

What is Sotradecol used for?

"If you have small, uncomplicated varicose veins that are simply dilated and have good valves, Sotradecol® (sodium tetradecyl) can help."

Answered by AI

What is the best sclerotherapy agent?

"Hypertonic saline was once the most widely used solution for spider veins. It is a saline (salt) concentrate solution that irritates the tiny veins and subsequently closes them. Hypertonic saline is still used widely and is very effective."

Answered by AI

Clinical Trials for Sotradecol

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