Sildenafil Citrate

Premature Ejaculation, Pulmonary Arterial Hypertension, Impotence + 1 more
Treatment
4 FDA approvals
20 Active Studies for Sildenafil Citrate

What is Sildenafil Citrate

SildenafilThe Generic name of this drug
Treatment SummarySildenafil is a medication used to treat erectile dysfunction, pulmonary arterial hypertension, and chest pain. It works by preventing the breakdown of a chemical called cyclic guanosine monophosphate (cGMP), which helps relax the muscles in the penis and lungs and increases blood flow. It was first researched as a potential treatment for chest pain, but was later discovered to be useful in treating erectile dysfunction. It is available under the brand name Viagra and as a generic medication with or without a prescription in some countries.
Viagrais the brand name
image of different drug pills on a surface
Sildenafil Citrate Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Viagra
Sildenafil
1998
292

Approved as Treatment by the FDA

Sildenafil, also known as Viagra, is approved by the FDA for 4 uses like NYHA Functional Class II-III Pulmonary arterial hypertension and Erectile dysfunction .
NYHA Functional Class II-III Pulmonary arterial hypertension
Helps manage NYHA Functional Class II-III Pulmonary arterial hypertension
Erectile dysfunction
Helps manage Erectile Dysfunction
Pulmonary Arterial Hypertension
Helps manage NYHA Functional Class II-III Pulmonary arterial hypertension
Impotence
Helps manage Erectile Dysfunction

Effectiveness

How Sildenafil Citrate Affects PatientsSildenafil is a drug that primarily affects the phosphodiesterase-5 enzyme (PDE5) and has been shown to be effective in treating erectile dysfunction. In studies, patients taking the drug experienced improved erections within 60 minutes of taking it. Its effects can last up to 4 hours, though they are weaker after that time. Sildenafil can also cause a mild and temporary decrease in blood pressure, with greater decreases seen in those with cardiovascular disease. It does not affect the heart rhythm, and can even reduce pulmonary systolic blood pressure in those with pulmonary arterial hypertension. Mild and temporary
How Sildenafil Citrate works in the bodySildenafil is a medication used to treat erectile dysfunction. It works by increasing blood flow to the penis. This is done by activating a chain reaction that starts with sexual stimulation. This stimulation releases nitric oxide, which activates an enzyme called guanylate cyclase. The enzyme then increases levels of cyclic guanosine monophosphate, which causes the blood vessels in the penis to relax and allow more blood to flow in. Sildenafil also helps to reduce pulmonary arterial hypertension by increasing the levels of cyclic guanosine monophosphate in the pulmonary vascular smooth muscle cells, causing them

When to interrupt dosage

The suggested dosage of Sildenafil Citrate is contingent upon the diagnosed condition, including Premature Ejaculation, Pulmonary Arterial Hypertension and NYHA Functional Class II-III Pulmonary arterial hypertension. The quantity of dosage is determined by the method of delivery (e.g. Tablet or Oral) as represented in the table underneath.
Condition
Dosage
Administration
Premature Ejaculation
, 10.0 mg/mL, 0.8 mg/mL, 20.0 mg, 25.0 mg, 50.0 mg, 100.0 mg, 1.0 mg/mL
, Powder, for suspension, Oral, Powder, for suspension - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, film coated, Tablet, film coated - Oral, Tablet - Oral, Tablet, Solution - Intravenous, Solution, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, For suspension, For suspension - Oral
Impotence
, 10.0 mg/mL, 0.8 mg/mL, 20.0 mg, 25.0 mg, 50.0 mg, 100.0 mg, 1.0 mg/mL
, Powder, for suspension, Oral, Powder, for suspension - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, film coated, Tablet, film coated - Oral, Tablet - Oral, Tablet, Solution - Intravenous, Solution, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, For suspension, For suspension - Oral
Pulmonary Arterial Hypertension
, 10.0 mg/mL, 0.8 mg/mL, 20.0 mg, 25.0 mg, 50.0 mg, 100.0 mg, 1.0 mg/mL
, Powder, for suspension, Oral, Powder, for suspension - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, film coated, Tablet, film coated - Oral, Tablet - Oral, Tablet, Solution - Intravenous, Solution, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, For suspension, For suspension - Oral
Pulmonary Arterial Hypertension
, 10.0 mg/mL, 0.8 mg/mL, 20.0 mg, 25.0 mg, 50.0 mg, 100.0 mg, 1.0 mg/mL
, Powder, for suspension, Oral, Powder, for suspension - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, film coated, Tablet, film coated - Oral, Tablet - Oral, Tablet, Solution - Intravenous, Solution, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, For suspension, For suspension - Oral

Warnings

Sildenafil Citrate Contraindications
Condition
Risk Level
Notes
Severe Hepatic Impairment
Do Not Combine
Erectile Dysfunction
Do Not Combine
Pulse Frequency
Do Not Combine
Hypotension
Do Not Combine
Optic Neuropathy, Ischemic
Do Not Combine
Stroke
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
There are 20 known major drug interactions with Sildenafil Citrate.
Common Sildenafil Citrate Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The serum concentration of Abemaciclib can be increased when it is combined with Sildenafil.
Alprostadil
Major
The risk or severity of hypotension and priapism can be increased when Sildenafil is combined with Alprostadil.
Aminophylline
Major
The metabolism of Aminophylline can be decreased when combined with Sildenafil.
Amitriptyline
Major
The metabolism of Amitriptyline can be decreased when combined with Sildenafil.
Amoxapine
Major
The metabolism of Amoxapine can be decreased when combined with Sildenafil.
Sildenafil Citrate Toxicity & Overdose RiskTaking too much sildenafil can cause side effects such as headaches, flushing, dizziness, indigestion, a stuffy or runny nose, and changes in vision. Women of childbearing potential should not take sildenafil without using appropriate contraceptive measures. It is also not recommended for women during labor and delivery or for nursing mothers due to a lack of data. Sildenafil has not been studied in children under 1 year of age. Elderly patients may have different reactions to this drug than younger patients and should be cautious when taking it. Sildenafil was not
image of a doctor in a lab doing drug, clinical research

Sildenafil Citrate Novel Uses: Which Conditions Have a Clinical Trial Featuring Sildenafil Citrate?

74 active clinical trials are currently assessing the potential of Sildenafil Citrate to treat Pulmonary Arterial Hypertension, Premature Ejaculation and NYHA Functional Class II-III Pulmonary arterial hypertension.
Condition
Clinical Trials
Trial Phases
Pulmonary Arterial Hypertension
3 Actively Recruiting
Phase 1, Not Applicable, Phase 4
Impotence
19 Actively Recruiting
Not Applicable, Phase 4, Early Phase 1, Phase 3, Phase 1, Phase 2
Pulmonary Arterial Hypertension
0 Actively Recruiting
Premature Ejaculation
0 Actively Recruiting

Sildenafil Citrate Reviews: What are patients saying about Sildenafil Citrate?

5Patient Review
8/28/2021
Sildenafil Citrate for Inability to have an Erection
I'm an 80 year old man with no health problems. I was having trouble maintaining an erection during intercourse but after taking 50mg of sildenafil, I felt like my old self again.
5Patient Review
4/7/2022
Sildenafil Citrate for Inability to have an Erection
I'm 38 years old and have been married for 12 years. I noticed that I wasn't able to stay erect, which caused a lot of problems in my relationship. My doctor prescribed this medication and it worked really well with no side effects. Now, I take one almost every night. This has allowed me to enjoy sex much more than before.
5Patient Review
2/11/2022
Sildenafil Citrate for Inability to have an Erection
This is some potent stuff. I can take it as often as I want and be up for hours without issue. The only downside is that my wife says it's almost too much for her. She's petite, so we have to be careful with the dosage.
5Patient Review
11/7/2021
Sildenafil Citrate for Inability to have an Erection
I found that this medication helped me to get and maintain erections better than I could on my own. It was a little bit of a wait (about 45 minutes), but well worth it in the end. The next day I experienced some heartburn, but nothing too serious or bothersome.
5Patient Review
12/17/2021
Sildenafil Citrate for Inability to have an Erection
This not only helped me get harder erections, but also increased my stamina. I'm amazed at how well it works!
5Patient Review
8/28/2021
Sildenafil Citrate for Inability to have an Erection
I'm an 80 year old man with no health problems. Recently, I was struggling to maintain an erection during intercourse and my doctor prescribed sildenafil. Just 40 minutes after taking a 50mg dose, I felt like my old self again.
5Patient Review
2/11/2022
Sildenafil Citrate for Inability to have an Erection
My wife and I both love this stuff. It's great for when you need to be up and alert for extended periods of time. The only downside is that my wife is quite petite, so the dosage is almost too much for her.
5Patient Review
4/7/2022
Sildenafil Citrate for Inability to have an Erection
I've been noticing some issues with my erections recently, so I talked to my doctor. We tried this treatment and it worked great! Now I take it almost every night, although I don't always need it. It's nice to be able to enjoy sex again without worrying about whether or not I'm going to be able to perform.
5Patient Review
11/7/2021
Sildenafil Citrate for Inability to have an Erection
I found this treatment to be effective in about 45 minutes. I was very pleased with the results, as it helped me get back to my old self. There were no major side effects, just a little heartburn the next day.
5Patient Review
12/17/2021
Sildenafil Citrate for Inability to have an Erection
Not only did this treatment give me harder erections, but it helped with my lasting power as well. I used to only last a few minutes, but now I can go for as long as I want!
4.7Patient Review
1/7/2022
Sildenafil Citrate for Inability to have an Erection
I've been using this for years and it's always worked great for me. My last prescription was more than six months after the expiration date, and I still had no issues. Just be sure not to drink alcohol before use.
4.7Patient Review
1/7/2022
Sildenafil Citrate for Inability to have an Erection
I've used this for years and it's always been effective. My last prescription was well over six months expired, and I only just now needed to get a new one.Tip: don't drink alcohol before using.
4.3Patient Review
8/31/2021
Sildenafil Citrate for Inability to have an Erection
This pill definitely helps me last longer during sex, but I always get a pretty severe headache and runny nose afterwards. Paracetamol usually does the trick for me, though.
4.3Patient Review
6/11/2022
Sildenafil Citrate for Inability to have an Erection
I went to my primary care physician and described the issues I was having with maintaining an erection. After a prostate exam, he agreed that medication would help and prescribed me sindafel. It took some adjusting to find the right dosage (half a pill), but it really helped. My wife was also a big help in getting aroused. Overall, this is a good medication for me at my age (80) and I still enjoy sex regularly.
4.3Patient Review
10/28/2022
Sildenafil Citrate for Inability to have an Erection
I had a great experience with this drug, but unfortunately began feeling dizzy and nauseous the day after. I'm hesitant to try it again, but would love to hear if anyone else has had a similar reaction.
4.3Patient Review
10/28/2022
Sildenafil Citrate for Inability to have an Erection
I'm a 75-year-old man who tried 20mg sildenafil 45 minutes before sex. It worked great and I was able to maintain the erection throughout, but the next day I began feeling dizzy and unsteady. The vertigo has mostly passed now, but I'm still hesitant about trying another dose. Has anyone else had a similar experience?
4.3Patient Review
8/31/2021
Sildenafil Citrate for Inability to have an Erection
I find that this pill really helps me extend my sexual performances; however, I often get a strong headache afterwards (though Paracetamol does help) as well as a running nose.
4.3Patient Review
6/11/2022
Sildenafil Citrate for Inability to have an Erection
I talked to my primary care physician about my difficulty maintaining an erection. After a prostate exam, he agreed that medication would help and prescribed me sildenafil. It worked great after some trial and error with dosage; now I only need half a pill when needed. My wife's help in getting aroused is also key. I'm nearly 80 and still enjoy sex thanks to this medication!
2Patient Review
9/14/2021
Sildenafil Citrate for Increased Pressure of Pulmonary Circulation
Unfortunately, this medication not only failed to provide the intended results, but actually had the opposite effect. On top of that, it also gave me terrible diarrhea. I'm not allergic to anything as far as I know, but I will definitely be avoiding this medication in the future.
2Patient Review
9/14/2021
Sildenafil Citrate for Increased Pressure of Pulmonary Circulation
Unfortunately, this medication not only failed to achieve the intended results, but it also gave me terrible diarrhea. I won't be taking it again.
1.3Patient Review
6/14/2022
Sildenafil Citrate for Inability to have an Erection
Viagra worked great for me, but I decided to try sildenafil because it was cheaper. Big mistake! This had zero effect on me. Save your money and just buy Viagra.
1.3Patient Review
6/14/2022
Sildenafil Citrate for Inability to have an Erection
Viagra worked great for me, but when I tried to switch to the cheaper sildenafil option, it was a complete flop. Save your money and just get Viagra.
1Patient Review
5/20/2022
Sildenafil Citrate for Inability to have an Erection
I'm 37 years old, and I can say with certainty that this treatment didn't work for me. Save your money.
1Patient Review
5/20/2022
Sildenafil Citrate for Inability to have an Erection
I'm 37 years old and I didn't see any benefits from this treatment. Don't bother wasting your money.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about sildenafil citrate

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Does sildenafil keep you hard after coming?

"Does Viagra allow you to maintain an erection after ejaculation? Yes, there is a chance that Viagra will enable you to do so. But if your erection lasts for more than 4 hours, you should see a doctor as soon as possible. This could be indicative of a serious medical condition and can lead to damage to your penis."

Answered by AI

Is sildenafil citrate as effective as Viagra?

"Generic Viagra (sildenafil citrate) works the same way as Viagra, but is cheaper. Although Pfizer still manufactures Viagra, other companies both in the United States and globally also make sildenafil. It may look different from Viagra, but it is still an effective treatment for erectile dysfunction."

Answered by AI

What is Sildenafil citrate use for?

"Sildenafil is a medication that is used to treat erectile dysfunction. It works by increasing blood flow to the penis during sexual stimulation. This increased blood flow can cause an erection."

Answered by AI

How long does sildenafil citrate take to work?

"This medicine typically starts working for erectile dysfunction within 30 minutes after taking it. Its effects usually last for up to 4 hours, although it may be less effective after 2 hours. Be sure to use only the brand of this medicine prescribed by your doctor, as different brands may not work in the same way."

Answered by AI

Clinical Trials for Sildenafil Citrate

Image of Clinical Physiology Laboratory in Edmonton, Canada.

Sotatercept for Pulmonary Arterial Hypertension

18+
All Sexes
Edmonton, Canada
The goal of this clinical trial is to determine whether sotatercept is effective in improving diffusing capacity in patients with pulmonary arterial hypertension. Participants will be asked to: * Take Sotatercept every 21 days (±3 days) * Each participant will be enrolled in the study for 29 Weeks * Visit the clinic 18 times * Have a physical exam * Perform assessments of lung function and exercise tests * Have an ultrasound of their heart * Have blood draws done at regular intervals The main objectives of the study are: Primary objective: To assess whether sotatercept will improve recruitment of diffusing membrane capacity (DM) with exercise. Secondary objective: To identify components of the diffusing capacity that respond to treatment with sotatercept in pulmonary arterial hypertension.
Phase 4
Recruiting
Clinical Physiology LaboratoryMichael Stickland, PhDMerck Canada Inc.
Image of Mount Sinai Hospital in New York, United States.

SAFE Technique for Erectile Dysfunction

18+
Male
New York, NY
Robotic-assisted radical prostatectomy (RALP) has become the standard of care in the management of localized prostate cancer. However, post-prostatectomy erectile dysfunction (ED) and urinary incontinence still pose a challenge that adversely affects the patient's quality of life. Hydrodissection (HD) was introduced in 1987 in the medical field and it was tested for the first time during a retropubic radical prostatectomy back in 2005. Since then, research has indicated an improvement in erectile function results, presumably because of a less traumatic neural dissection and a decreased risk of neuropraxia. In an effort to achieve a balance between oncological excision and functional preservation, prostate surgery is evolving to incorporate intraoperative real-time evaluation of extracapsular extension. Recently, a micro-ultrasound operating at 29 MHz has been introduced. It provides a resolution down to 70 μ to assess the glandular pattern and cellular density of the prostatic tissue. Given the experience in more than a thousand cases with this technology, and the growing literature showing promising results in the detection and staging of prostate cancer; the researchers decided to implement this tool as guidance for hydrodissection of the layers of the lateral prostatic fascia. Robotic-Assisted Laparoscopic Prostatectomy and SAFE (Saline assisted fascial engorgement) nerve preservation guided by Microultrasound (MUS) is a prospective randomized controlled trial designed to evaluate the impact of normal saline solution hydrodissection (HD) on erectile function outcomes after RALP. This innovative approach consists of a transrectal ultrasound-guided HD using a high-resolution Microultrasound (MUS) (ExactVu micro-ultrasound, Exact Imaging, Markham, Canada). The technique will be applied to those patients who undergo grade 1, 2, or 3 NS approach taking into account the grading system proposed by Tewari et al. The hypothesis is that the SAFE technique could minimize the risk of a traumatic neurovascular bundle dissection while assessing the prostatic capsule integrity with a high-resolution MUS. The researchers also hypothesize that the use of SAFE along with RALP will optimize the post-surgery recovery of erectile function.
Phase 3
Recruiting
Mount Sinai HospitalAshutosh Kumar Tewari, MBBS, MCh, FRCS (Hon.)
Have you considered Sildenafil Citrate clinical trials? We made a collection of clinical trials featuring Sildenafil Citrate, we think they might fit your search criteria.Go to Trials
Have you considered Sildenafil Citrate clinical trials? We made a collection of clinical trials featuring Sildenafil Citrate, we think they might fit your search criteria.Go to Trials
Have you considered Sildenafil Citrate clinical trials? We made a collection of clinical trials featuring Sildenafil Citrate, we think they might fit your search criteria.Go to Trials
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