Sildenafil Citrate

Premature Ejaculation, Pulmonary Arterial Hypertension, Impotence + 1 more

Treatment

4 FDA approvals

20 Active Studies for Sildenafil Citrate

Treatment for

Premature Ejaculation

What is Sildenafil Citrate

SildenafilThe Generic name of this drug

Treatment SummarySildenafil is a medication used to treat erectile dysfunction, pulmonary arterial hypertension, and chest pain. It works by preventing the breakdown of a chemical called cyclic guanosine monophosphate (cGMP), which helps relax the muscles in the penis and lungs and increases blood flow. It was first researched as a potential treatment for chest pain, but was later discovered to be useful in treating erectile dysfunction. It is available under the brand name Viagra and as a generic medication with or without a prescription in some countries.

Viagrais the brand name

image of different drug pills on a surface

Sildenafil Citrate Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Viagra

Sildenafil

1998

292

Approved as Treatment by the FDA

Sildenafil, also known as Viagra, is approved by the FDA for 4 uses like NYHA Functional Class II-III Pulmonary arterial hypertension and Erectile dysfunction .

NYHA Functional Class II-III Pulmonary arterial hypertension

Helps manage NYHA Functional Class II-III Pulmonary arterial hypertension

Erectile dysfunction

Helps manage Erectile Dysfunction

Pulmonary Arterial Hypertension

Helps manage NYHA Functional Class II-III Pulmonary arterial hypertension

Impotence

Helps manage Erectile Dysfunction

Effectiveness

How Sildenafil Citrate Affects PatientsSildenafil is a drug that primarily affects the phosphodiesterase-5 enzyme (PDE5) and has been shown to be effective in treating erectile dysfunction. In studies, patients taking the drug experienced improved erections within 60 minutes of taking it. Its effects can last up to 4 hours, though they are weaker after that time. Sildenafil can also cause a mild and temporary decrease in blood pressure, with greater decreases seen in those with cardiovascular disease. It does not affect the heart rhythm, and can even reduce pulmonary systolic blood pressure in those with pulmonary arterial hypertension. Mild and temporary

How Sildenafil Citrate works in the bodySildenafil is a medication used to treat erectile dysfunction. It works by increasing blood flow to the penis. This is done by activating a chain reaction that starts with sexual stimulation. This stimulation releases nitric oxide, which activates an enzyme called guanylate cyclase. The enzyme then increases levels of cyclic guanosine monophosphate, which causes the blood vessels in the penis to relax and allow more blood to flow in. Sildenafil also helps to reduce pulmonary arterial hypertension by increasing the levels of cyclic guanosine monophosphate in the pulmonary vascular smooth muscle cells, causing them

When to interrupt dosage

The suggested dosage of Sildenafil Citrate is contingent upon the diagnosed condition, including Premature Ejaculation, Pulmonary Arterial Hypertension and NYHA Functional Class II-III Pulmonary arterial hypertension. The quantity of dosage is determined by the method of delivery (e.g. Tablet or Oral) as represented in the table underneath.

Condition

Dosage

Administration

Premature Ejaculation

, 10.0 mg/mL, 0.8 mg/mL, 20.0 mg, 25.0 mg, 50.0 mg, 100.0 mg, 1.0 mg/mL

, Powder, for suspension, Oral, Powder, for suspension - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, film coated, Tablet, film coated - Oral, Tablet - Oral, Tablet, Solution - Intravenous, Solution, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, For suspension, For suspension - Oral

Impotence

, 10.0 mg/mL, 0.8 mg/mL, 20.0 mg, 25.0 mg, 50.0 mg, 100.0 mg, 1.0 mg/mL

Pulmonary Arterial Hypertension

, 10.0 mg/mL, 0.8 mg/mL, 20.0 mg, 25.0 mg, 50.0 mg, 100.0 mg, 1.0 mg/mL

Pulmonary Arterial Hypertension

, 10.0 mg/mL, 0.8 mg/mL, 20.0 mg, 25.0 mg, 50.0 mg, 100.0 mg, 1.0 mg/mL

Warnings

Sildenafil Citrate Contraindications

Condition

Risk Level

Notes

Severe Hepatic Impairment

Do Not Combine

Erectile Dysfunction

Do Not Combine

Pulse Frequency

Do Not Combine

Hypotension

Do Not Combine

Optic Neuropathy, Ischemic

Do Not Combine

Stroke

Do Not Combine

Pulse Frequency

Do Not Combine

Pulse Frequency

Do Not Combine

There are 20 known major drug interactions with Sildenafil Citrate.

Common Sildenafil Citrate Drug Interactions

Drug Name

Risk Level

Description

Abemaciclib

Major

The serum concentration of Abemaciclib can be increased when it is combined with Sildenafil.

Alprostadil

Major

The risk or severity of hypotension and priapism can be increased when Sildenafil is combined with Alprostadil.

Aminophylline

Major

The metabolism of Aminophylline can be decreased when combined with Sildenafil.

Amitriptyline

Major

The metabolism of Amitriptyline can be decreased when combined with Sildenafil.

Amoxapine

Major

The metabolism of Amoxapine can be decreased when combined with Sildenafil.

Sildenafil Citrate Toxicity & Overdose RiskTaking too much sildenafil can cause side effects such as headaches, flushing, dizziness, indigestion, a stuffy or runny nose, and changes in vision. Women of childbearing potential should not take sildenafil without using appropriate contraceptive measures. It is also not recommended for women during labor and delivery or for nursing mothers due to a lack of data. Sildenafil has not been studied in children under 1 year of age. Elderly patients may have different reactions to this drug than younger patients and should be cautious when taking it. Sildenafil was not