Sabril

Seizures, Focal, Spasms, Infantile, Therapeutic procedure

Treatment

3 Active Studies for Sabril

Treatment for

Seizures, Focal

What is Sabril

VigabatrinThe Generic name of this drug

Treatment SummaryVigabatrin is a medication used to treat difficult-to-control seizures and infantile spasms, which are seizures that occur in babies. It works by increasing the amount of GABA, an inhibitory neurotransmitter in the brain, which helps to reduce seizures. Vigabatrin can have serious side effects, including vision loss, so it is usually only used in cases where other treatments have not been successful. The FDA approved the use of Vigabatrin in 2009, but with the requirement that a drug registry be created to monitor patients for visual deficits.

Sabrilis the brand name

image of different drug pills on a surface

Sabril Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Sabril

Vigabatrin

2009

Effectiveness

How Sabril Affects PatientsVigabatrin is a medication used to treat epilepsy that works differently than other anticonvulsants. It blocks an enzyme called GABA transaminase (GABA-T) which prevents the breakdown of a brain chemical called GABA. Its effects last longer than most medicines, because it takes time for the body to replace the blocked enzyme.

How Sabril works in the bodyVigabatrin works by stopping the enzymes in your body from breaking down the neurotransmitter GABA. GABA is an inhibitory transmitter in the central nervous system, and increased concentrations can help to reduce the excitatory signals that are seen in epilepsy.

When to interrupt dosage

The suggested dosage of Sabril is contingent upon the recognized condition, such as Infantile Spasms (IS), Treatment regimen and Seizures, Focal. The measure of dosage can be found in the table below, in respect to the method of administration.

Condition

Dosage

Administration

Spasms, Infantile

, 500.0 mg, 3000.0 mg, 2000.0 mg, 1000.0 mg, 50.0 mg/mL, 500.0 mg/mL, 100.0 mg

, Tablet, Oral, Tablet - Oral, Powder - Oral, Powder, Tablet, film coated, Tablet, film coated - Oral, Powder, for solution, Powder, for solution - Oral, For solution, For solution - Oral

Seizures, Focal

, 500.0 mg, 3000.0 mg, 2000.0 mg, 1000.0 mg, 50.0 mg/mL, 500.0 mg/mL, 100.0 mg

, Tablet, Oral, Tablet - Oral, Powder - Oral, Powder, Tablet, film coated, Tablet, film coated - Oral, Powder, for solution, Powder, for solution - Oral, For solution, For solution - Oral

Therapeutic procedure

, 500.0 mg, 3000.0 mg, 2000.0 mg, 1000.0 mg, 50.0 mg/mL, 500.0 mg/mL, 100.0 mg

, Tablet, Oral, Tablet - Oral, Powder - Oral, Powder, Tablet, film coated, Tablet, film coated - Oral, Powder, for solution, Powder, for solution - Oral, For solution, For solution - Oral

Warnings

There are 20 known major drug interactions with Sabril.

Common Sabril Drug Interactions

Drug Name

Risk Level

Description

Azelastine

Major

Vigabatrin may increase the central nervous system depressant (CNS depressant) activities of Azelastine.

Ethanol

Major

Vigabatrin may increase the central nervous system depressant (CNS depressant) activities of Ethanol.

Oliceridine

Major

The risk or severity of hypotension, sedation, death, somnolence, and respiratory depression can be increased when Vigabatrin is combined with Oliceridine.

Thalidomide

Major

Vigabatrin may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.

Clonazepam

Minor

The serum concentration of Clonazepam can be increased when it is combined with Vigabatrin.

Sabril Toxicity & Overdose RiskThe toxic dose of vigabatrin for mice and rats is 2830mg/kg and 3100mg/kg, respectively. Overdosing on vigabatrin can cause symptoms such as unconsciousness, drowsiness, seizures, speech disorder, psychosis, agitation, abnormal behavior, and confusion. Treatment for overdose typically involves providing supportive care and removing unabsorbed drug from the system through methods such as gastric lavage. Although vigabatrin is not protein-bound, the effectiveness of hemodialysis for drug removal during overdose is unknown.

image of a doctor in a lab doing drug, clinical research

Sabril Novel Uses: Which Conditions Have a Clinical Trial Featuring Sabril?

At present, there are no active clinical trials researching the novel applications of Sabril in providing relief from Seizures, Focal, Infantile Spasms (IS) and Therapeutic procedures.

Condition

Clinical Trials

Trial Phases

Therapeutic procedure

0 Actively Recruiting

Seizures, Focal

0 Actively Recruiting

Spasms, Infantile

3 Actively Recruiting

Phase 2, Phase 1

Sabril Reviews: What are patients saying about Sabril?

4.3Patient Review

1/8/2014

Sabril for Convulsive Seizures

I have lannox gastat syndrome and didn't experience any benefit from using sabril.

3.3Patient Review

9/16/2011

Sabril for Convulsive Seizures

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Patient Q&A Section about sabril

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is Sabril used to treat?

"Sabril is a prescription medicine used in adults and children 2 years of age or older with refractory complex partial seizures that have not responded well enough to several other treatments, if the possible benefits outweigh the risk of vision loss."

Answered by AI

What class of drug is Sabril?

"A prescription medicine called Sabril is used to treat the symptoms of Partial Seizures. Sabril may be used by itself or with other medications. It belongs to a class of drugs called Anticonvulsants, Other. The safety and effectiveness of Sabril has not been determined in children younger than 2 years of age."

Answered by AI

Does Sabril make you sleepy?

"SABRIL may result in severe adverse effects, e.g. anaemia, somnolence and fatigue, neuropathy, weight increase, and oedema. As SABRIL can cause somnolence and fatigue, avoid driving, operating machinery, or performing any potentially dangerous tasks unless it is confirmed that it can be done safely."

Answered by AI