Sabril
Seizures, Focal, Spasms, Infantile, Therapeutic procedure
Treatment
3 Active Studies for Sabril
Treatment for
Seizures, Focal
What is Sabril
Vigabatrin
The Generic name of this drug
Treatment Summary
Vigabatrin is a medication used to treat difficult-to-control seizures and infantile spasms, which are seizures that occur in babies. It works by increasing the amount of GABA, an inhibitory neurotransmitter in the brain, which helps to reduce seizures. Vigabatrin can have serious side effects, including vision loss, so it is usually only used in cases where other treatments have not been successful. The FDA approved the use of Vigabatrin in 2009, but with the requirement that a drug registry be created to monitor patients for visual deficits.
Sabril
is the brand name
Sabril Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Sabril
Vigabatrin
2009
31
Effectiveness
How Sabril Affects Patients
Vigabatrin is a medication used to treat epilepsy that works differently than other anticonvulsants. It blocks an enzyme called GABA transaminase (GABA-T) which prevents the breakdown of a brain chemical called GABA. Its effects last longer than most medicines, because it takes time for the body to replace the blocked enzyme.
How Sabril works in the body
Vigabatrin works by stopping the enzymes in your body from breaking down the neurotransmitter GABA. GABA is an inhibitory transmitter in the central nervous system, and increased concentrations can help to reduce the excitatory signals that are seen in epilepsy.
When to interrupt dosage
The suggested dosage of Sabril is contingent upon the recognized condition, such as Infantile Spasms (IS), Treatment regimen and Seizures, Focal. The measure of dosage can be found in the table below, in respect to the method of administration.
Condition
Dosage
Administration
Spasms, Infantile
, 500.0 mg, 3000.0 mg, 2000.0 mg, 1000.0 mg, 50.0 mg/mL, 500.0 mg/mL, 100.0 mg
, Oral, Tablet, Tablet - Oral, Powder, Powder - Oral, Tablet, film coated - Oral, Powder, for solution, Powder, for solution - Oral, Tablet, film coated, For solution - Oral, For solution
Seizures, Focal
, 500.0 mg, 3000.0 mg, 2000.0 mg, 1000.0 mg, 50.0 mg/mL, 500.0 mg/mL, 100.0 mg
, Oral, Tablet, Tablet - Oral, Powder, Powder - Oral, Tablet, film coated - Oral, Powder, for solution, Powder, for solution - Oral, Tablet, film coated, For solution - Oral, For solution
Therapeutic procedure
, 500.0 mg, 3000.0 mg, 2000.0 mg, 1000.0 mg, 50.0 mg/mL, 500.0 mg/mL, 100.0 mg
, Oral, Tablet, Tablet - Oral, Powder, Powder - Oral, Tablet, film coated - Oral, Powder, for solution, Powder, for solution - Oral, Tablet, film coated, For solution - Oral, For solution
Warnings
There are 20 known major drug interactions with Sabril.
Common Sabril Drug Interactions
Drug Name
Risk Level
Description
Azelastine
Major
Vigabatrin may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
Ethanol
Major
Vigabatrin may increase the central nervous system depressant (CNS depressant) activities of Ethanol.
Oliceridine
Major
The risk or severity of hypotension, sedation, death, somnolence, and respiratory depression can be increased when Vigabatrin is combined with Oliceridine.
Thalidomide
Major
Vigabatrin may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
Clonazepam
Minor
The serum concentration of Clonazepam can be increased when it is combined with Vigabatrin.
Sabril Toxicity & Overdose Risk
The toxic dose of vigabatrin for mice and rats is 2830mg/kg and 3100mg/kg, respectively. Overdosing on vigabatrin can cause symptoms such as unconsciousness, drowsiness, seizures, speech disorder, psychosis, agitation, abnormal behavior, and confusion. Treatment for overdose typically involves providing supportive care and removing unabsorbed drug from the system through methods such as gastric lavage. Although vigabatrin is not protein-bound, the effectiveness of hemodialysis for drug removal during overdose is unknown.
Sabril Novel Uses: Which Conditions Have a Clinical Trial Featuring Sabril?
At present, there are no active clinical trials researching the novel applications of Sabril in providing relief from Seizures, Focal, Infantile Spasms (IS) and Therapeutic procedures.
Condition
Clinical Trials
Trial Phases
Therapeutic procedure
0 Actively Recruiting
Seizures, Focal
0 Actively Recruiting
Spasms, Infantile
4 Actively Recruiting
Phase 2, Phase 3, Phase 1
Sabril Reviews: What are patients saying about Sabril?
4.3
Patient Review
1/8/2014
Sabril for Convulsive Seizures
3.3
Patient Review
9/16/2011
Sabril for Convulsive Seizures
Patient Q&A Section about sabril
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
What is Sabril used to treat?
"Sabril is a prescription medicine used in adults and children 2 years of age or older with refractory complex partial seizures that have not responded well enough to several other treatments, if the possible benefits outweigh the risk of vision loss."
Answered by AI
What class of drug is Sabril?
"A prescription medicine called Sabril is used to treat the symptoms of Partial Seizures. Sabril may be used by itself or with other medications. It belongs to a class of drugs called Anticonvulsants, Other. The safety and effectiveness of Sabril has not been determined in children younger than 2 years of age."
Answered by AI
Does Sabril make you sleepy?
"SABRIL may result in severe adverse effects, e.g. anaemia, somnolence and fatigue, neuropathy, weight increase, and oedema. As SABRIL can cause somnolence and fatigue, avoid driving, operating machinery, or performing any potentially dangerous tasks unless it is confirmed that it can be done safely."
Answered by AI
How long does it take for Sabril to work?
"Blood levels of Sabril will peak 1-2.5 hours after taking the drug, and it's effects will likely last for several days."
Answered by AI