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What is Rosiglitazone Maleate
RosiglitazoneThe Generic name of this drug
Treatment SummaryRosiglitazone is a diabetes medication that belongs to the thiazolidinedione family. It is sold under the brand names Avandia, Avandamet, or Avandaryl and is used to treat type 2 diabetes. The drug works by activating a receptor in the body called peroxisome proliferator-activated receptor gamma (PPARγ). Rosiglitazone has anti-inflammatory properties, decreasing levels of nuclear factor kappa-B (NFκB) and increasing levels of inhibitor (IκB). Recent research suggests that it may also be beneficial for some patients with Alzheimer's disease who do
Avandiais the brand name
Rosiglitazone Maleate Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Avandia
Rosiglitazone
1999
51
Effectiveness
How Rosiglitazone Maleate Affects PatientsWhen taken alone, rosiglitazone can raise the amount of cholesterol in the body, including the bad cholesterol (LDL) and the good cholesterol (HDL). Free fatty acids also drop. The bad cholesterol levels will rise within the first two months of taking it and stay high, while the good cholesterol will keep increasing over time. This means that the bad to good cholesterol ratio will be highest after two months and then begin to go down.
How Rosiglitazone Maleate works in the bodyRosiglitazone helps your cells respond more effectively to insulin. It does this by stimulating certain proteins in your cells, called peroxisome proliferator activated receptors, which help regulate how your body processes sugar. This increases the sensitivity of your tissues to insulin, allowing them to better control glucose production, transport, and use.
When to interrupt dosage
The suggested dosage of Rosiglitazone Maleate is reliant upon the diagnosed state, for example Diet, Physical Activity and Type 2 Diabetes. The quantity of dosage is contingent upon the method of administration (e.g. Tablet - Oral or Oral) featured in the table beneath.Condition
Dosage
Administration
Diet
, 2.0 mg, 8.0 mg, 4.0 mg, 1.0 mg
, Oral, Tablet, film coated - Oral, Tablet, film coated, Tablet, Tablet - Oral
Type 2 Diabetes
, 2.0 mg, 8.0 mg, 4.0 mg, 1.0 mg
, Oral, Tablet, film coated - Oral, Tablet, film coated, Tablet, Tablet - Oral
Physical Activity
, 2.0 mg, 8.0 mg, 4.0 mg, 1.0 mg
, Oral, Tablet, film coated - Oral, Tablet, film coated, Tablet, Tablet - Oral
Warnings
Rosiglitazone Maleate ContraindicationsCondition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Rosiglitazone may interact with Pulse Frequency
Hypesthesia
Do Not Combine
Hypesthesia
Do Not Combine
Common Rosiglitazone Maleate Drug Interactions
Drug Name
Risk Level
Description
Aminophylline
Major
The metabolism of Aminophylline can be decreased when combined with Rosiglitazone.
Brigatinib
Major
The metabolism of Brigatinib can be decreased when combined with Rosiglitazone.
Cabazitaxel
Major
The metabolism of Cabazitaxel can be decreased when combined with Rosiglitazone.
Enasidenib
Major
The metabolism of Enasidenib can be decreased when combined with Rosiglitazone.
Erlotinib
Major
The metabolism of Erlotinib can be decreased when combined with Rosiglitazone.
Rosiglitazone Maleate Toxicity & Overdose RiskSide effects of taking this drug include retaining extra fluids, increased risk of CHF, and liver damage.
Rosiglitazone Maleate Novel Uses: Which Conditions Have a Clinical Trial Featuring Rosiglitazone Maleate?
196 active clinical trials are currently underway to assess the potential of Rosiglitazone Maleate in ameliorating the symptoms of Type 2 Diabetes through Physical Activity and Diet modification.Condition
Clinical Trials
Trial Phases
Physical Activity
38 Actively Recruiting
Not Applicable, Phase 2, Phase 1, Early Phase 1
Type 2 Diabetes
193 Actively Recruiting
Phase 2, Not Applicable, Early Phase 1, Phase 1, Phase 4, Phase 3
Diet
5 Actively Recruiting
Not Applicable
Rosiglitazone Maleate Reviews: What are patients saying about Rosiglitazone Maleate?
5Patient Review
3/28/2008 I made the mistake of taking a whole tab instead of just a half, and as a result I ran out much more quickly than anticipated. My glucose levels were all over the place in that time period (not disastrously so, but still not good). Once I got more pills from the VA though, everything normalized pretty quickly.
5Patient Review
3/31/2021 This medication is really effective at lowering insulin resistance.
5Patient Review
5/24/2011 I would like to know more about the chemical structure of rosiglitazone.
Patient Q&A Section about rosiglitazone maleate
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What drug class is rosiglitazone in?
"Rosiglitazone is a type of medication known as a thiazolidinedione. It helps to control blood sugar levels by increasing the body's sensitivity to insulin, a natural substance."
Answered by AI
Why was rosiglitazone removed from the market?
"Meta-analyses done in the past of both trials and observational studies suggested that there was an increased risk of heart attack and other adverse cardiovascular events when taking rosiglitazone. Therefore, the FDA required a REMS in order to restrict the use of the drug."
Answered by AI
What is rosiglitazone maleate used for?
"The prescription drug Avandia is used to help treat the symptoms of Type 2 diabetes Mellitus. It can be used by itself or with other medications. Avandia is part of a class of drugs referred to as Antidiabetics, Thiazolidinediones."
Answered by AI
Is rosiglitazone still on the market?
"Although rosiglitazone is no longer available in most countries, it can still be bought in the US. Use of the drug has decreased rapidly since warnings were issued in 2007."
Answered by AI