Your session is about to expire
What is Ranexa
Tranexamic acidThe Generic name of this drug
Treatment SummaryTranexamic acid is a synthetic medication used to prevent and reduce major bleeding. It works by blocking a natural body enzyme, making it about 10 times more effective than a similar drug, Aminocaproic acid. Tranexamic acid was first patented in 1957 and was approved for use in the US in 1986.
Cyklokapronis the brand name
Ranexa Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Cyklokapron
Tranexamic acid
1986
57
Effectiveness
How Ranexa Affects PatientsTranexamic acid is a drug used to prevent excessive blood loss. It works by blocking the breakdown of blood clots. People with hereditary angioedema may have fewer attacks when taking tranexamic acid because it stops plasmin from activating the first complement protein (C1). Taking too much tranexamic acid or taking it during cardiovascular surgery can lead to convulsions or excessive excitement, so people with a history of seizures should be monitored with an EEG.
How Ranexa works in the bodyTranexamic acid helps to stop bleeding by preventing plasminogen from binding to fibrin. It does this by taking up space on the binding sites that plasminogen needs to attach to fibrin. This occupation of the sites stops the breakdown of fibrin, so the clot remains stable and the bleeding stops.
When to interrupt dosage
The prescribed quantity of Ranexa is contingent upon the determined condition, such as Tooth Extractions, Angioedemas, Hereditary and Hemophilia. The measure of dosage changes, in line with the procedure of delivery (e.g. Cream - Topical or Injection, solution - Intravenous) featured in the following table.Condition
Dosage
Administration
Hyperfibrinolysis
100.0 mg/mL, , 650.0 mg, 0.005 mg/mL, 500.0 mg, 2.0 mg/mL, 5.0 mg/mL, 0.1 mg/mL, 10.0 mg/mL, 500.0 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, Tablet - Oral, Oral, Tablet, film coated, Tablet, film coated - Oral, Topical, Cream, Cream - Topical, Solution, Solution - Intravenous, Injection, Injection - Intravenous, Liquid, Liquid - Topical
Angioedemas, Hereditary
100.0 mg/mL, , 650.0 mg, 0.005 mg/mL, 500.0 mg, 2.0 mg/mL, 5.0 mg/mL, 0.1 mg/mL, 10.0 mg/mL, 500.0 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, Tablet - Oral, Oral, Tablet, film coated, Tablet, film coated - Oral, Topical, Cream, Cream - Topical, Solution, Solution - Intravenous, Injection, Injection - Intravenous, Liquid, Liquid - Topical
Hemophilia
100.0 mg/mL, , 650.0 mg, 0.005 mg/mL, 500.0 mg, 2.0 mg/mL, 5.0 mg/mL, 0.1 mg/mL, 10.0 mg/mL, 500.0 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, Tablet - Oral, Oral, Tablet, film coated, Tablet, film coated - Oral, Topical, Cream, Cream - Topical, Solution, Solution - Intravenous, Injection, Injection - Intravenous, Liquid, Liquid - Topical
Hemorrhage
100.0 mg/mL, , 650.0 mg, 0.005 mg/mL, 500.0 mg, 2.0 mg/mL, 5.0 mg/mL, 0.1 mg/mL, 10.0 mg/mL, 500.0 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, Tablet - Oral, Oral, Tablet, film coated, Tablet, film coated - Oral, Topical, Cream, Cream - Topical, Solution, Solution - Intravenous, Injection, Injection - Intravenous, Liquid, Liquid - Topical
Menorrhagia
100.0 mg/mL, , 650.0 mg, 0.005 mg/mL, 500.0 mg, 2.0 mg/mL, 5.0 mg/mL, 0.1 mg/mL, 10.0 mg/mL, 500.0 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, Tablet - Oral, Oral, Tablet, film coated, Tablet, film coated - Oral, Topical, Cream, Cream - Topical, Solution, Solution - Intravenous, Injection, Injection - Intravenous, Liquid, Liquid - Topical
Tooth Extractions
100.0 mg/mL, , 650.0 mg, 0.005 mg/mL, 500.0 mg, 2.0 mg/mL, 5.0 mg/mL, 0.1 mg/mL, 10.0 mg/mL, 500.0 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Tablet, Tablet - Oral, Oral, Tablet, film coated, Tablet, film coated - Oral, Topical, Cream, Cream - Topical, Solution, Solution - Intravenous, Injection, Injection - Intravenous, Liquid, Liquid - Topical
Warnings
Ranexa has six contraindications and should not be taken in combination with the conditions given in the following table.Ranexa ContraindicationsCondition
Risk Level
Notes
NF1 gene
Do Not Combine
active intravascular clotting
Do Not Combine
history of thromboembolism
Do Not Combine
Pulse Frequency
Do Not Combine
Subarachnoid Hemorrhage
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Tranexamic Acid may interact with Pulse Frequency
Common Ranexa Drug Interactions
Drug Name
Risk Level
Description
Albutrepenonacog alfa
Major
Tranexamic acid may increase the thrombogenic activities of Albutrepenonacog alfa.
Aminocaproic acid
Major
Tranexamic acid may increase the thrombogenic activities of Aminocaproic acid.
Aminomethylbenzoic acid
Major
Tranexamic acid may increase the thrombogenic activities of Aminomethylbenzoic acid.
Andexanet alfa
Major
Tranexamic acid may increase the thrombogenic activities of Andexanet alfa.
Anti-inhibitor coagulant complex
Major
Tranexamic acid may increase the thrombogenic activities of Anti-inhibitor coagulant complex.
Ranexa Toxicity & Overdose RiskTaking too much tranexamic acid can lead to severe stomach issues, low blood pressure, blood clots, vision problems, seizures, changes in mental state, and skin rash.
Ranexa Novel Uses: Which Conditions Have a Clinical Trial Featuring Ranexa?
34 active clinical trials are examining the potential of Ranexa in managing Hemophilia, Hereditary Hemorrhage and Angioedemas.Condition
Clinical Trials
Trial Phases
Tooth Extractions
3 Actively Recruiting
Not Applicable
Hyperfibrinolysis
0 Actively Recruiting
Hemorrhage
13 Actively Recruiting
Phase 4, Phase 3, Not Applicable, Phase 1, Phase 2
Menorrhagia
3 Actively Recruiting
Phase 3, Phase 4, Not Applicable
Hemophilia
4 Actively Recruiting
Phase 3
Angioedemas, Hereditary
13 Actively Recruiting
Phase 2, Phase 3, Phase 1
Ranexa Reviews: What are patients saying about Ranexa?
5Patient Review
5/7/2018 This treatment really improved my life. I take MiraLax every day and occasionally get dizzy, but it's worth it because I've lost 20 pounds and my heart is healthier as a result. The quality of my life is excellent now. I exercise regularly and have no trouble taking Ranolazine (1000mg 2x daily). Dr Gary Murray is a pioneer in the field of diastolic dysfunction, also known as stiff heart, and his research has been extremely helpful to me. If you can get Ranolazine from Canada, it's much more affordable than it is in the USA.
5Patient Review
4/15/2014 I've been on Ranexa for a little over a year now, and it's been really helpful. I take 1000mg in the morning and 1000mg at night, and whenever I start to feel pain, I know it's time to take my medication. Some people have reported experiencing irrational anger while taking Ranexa, but my doctor put me on valium for a month and that took care of the problem. Since starting Ranexa, I've had 3 heart attacks and 1 minor stroke, but other than those hospital stays, the medication has been doing its job well.
5Patient Review
9/17/2016 I've been using ranexa for a while now and it's been great. The cost was initially an issue, but I found an online pharmacy that helped me out. Now I'm only paying less than a dollar per day as opposed to over nine dollars.
5Patient Review
9/24/2014 After years of taking 1000mg of Ranexa daily, I asked my doctor if I could lower the dosage. They agreed and let me know what to expect in terms of side effects or other changes.
5Patient Review
5/15/2014 This medication worked for me. I was prescribed two doses per day but found that only one was necessary. Additionally, their website offers a discount card which is definitely worth taking advantage of.
5Patient Review
1/31/2016 After a heart attack, I tried many different angina medications. Ranexa was the only one that worked for me.
5Patient Review
11/4/2015 I feel great since taking this medication. Prior to surgery, I was in a lot of pain constantly. This really helped me and I hope that more people will be able to access it through Medicare tier 2 or 3.
5Patient Review
2/21/2016 I'm on a fixed income with Medicare, so I was very disappointed to see how expensive this treatment is. My doctor even had a coupon for $5.00, but it couldn't be used because of Medicare. If they're willing to sell it for such a low price, why are seniors being charged so much?
4.7Patient Review
2/3/2015 I've been taking this for a few years now, and it's really helped. It's expensive, but thankfully my insurance covers a good chunk of it.
4.7Patient Review
8/17/2014 This treatment has alleviated my chest pain.
4.3Patient Review
10/20/2014 I had a quadruple bypass and six stents put in. I was struggling to function until my doctor prescribed Ranexa. It's not perfect, but it's essential for me. Now, neither the VA nor my insurance will cover the cost. So expensive. Time to die I suppose.
4Patient Review
12/2/2016 I've been taking Ranexa for about three years now with no issues. I was offered a higher dosage by my doctor, but found that the lower dose works just fine for me. In combination with Isosorbmono nitrate, which I take in the morning, it's been an effective treatment regimen for me.
4Patient Review
4/23/2021 I'm curious if anyone else has experienced hair loss while taking Ranexa.
3.7Patient Review
9/9/2016 I had to stop taking this treatment because my doctor said that the simvastatin was more important.
2.3Patient Review
8/5/2016 Since taking this medication, I've been feeling really off. Lightheaded, always tired, and just generally weird. I requested to come off the medication because I don't have chronic angina attacks; however, I've had three episodes since starting this medication.
1Patient Review
10/12/2016 I tried this medication for three months, taking two 500mg pills every day. I saw zero results from it and thought it was way too overpriced.
Patient Q&A Section about ranexa
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Does Ranexa lower your blood pressure?
"Will taking ranolazine (Ranexa) impact my blood pressure? Ranolazine (Ranexa) generally does not have the same effect on blood pressure as other anti-angina medications. In rare cases, it may cause low blood pressure."
Answered by AI
Does Ranexa prevent heart attacks?
"Although it was unclear whether ranolazine 1000 mg twice daily affected the likelihood of dying from any cause, quality of life, or the likelihood of having a heart attack or experiencing angina attacks, ranolazine did modestly reduce the number of angina attacks per week when taken..."
Answered by AI
What exactly does Ranexa do?
"RANEXA is a prescription medicine that is used to treat individuals who suffer from chronic angina. With this medicine, angina episodes should become less frequent. RANEXA can be used in conjunction with other heart medications. The safety and effectiveness of RANEXA has not been tested in children."
Answered by AI
What are side effects of Ranexa?
"These are some of the side effects that may occur when taking this medication. If any of these effects last or get worse, notify your doctor or pharmacist. To reduce the risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position."
Answered by AI