Qternmet Xr

Hypesthesia, Hypesthesia, Hypesthesia + 13 more
Treatment
6 FDA approvals
20 Active Studies for Qternmet Xr

What is Qternmet Xr

DapagliflozinThe Generic name of this drug
Treatment SummarySaxagliptin is an oral medication used to treat diabetes. It belongs to a class of drugs called DPP-4 inhibitors, which work by helping the body produce more insulin and controlling blood sugar levels. Saxagliptin was approved by the FDA in 2009.
Farxigais the brand name
Qternmet Xr Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Farxiga
Dapagliflozin
2008
19

Approved as Treatment by the FDA

Dapagliflozin, also known as Farxiga, is approved by the FDA for 6 uses such as Type 2 Diabetes Mellitus and Physical Activity .
Type 2 Diabetes Mellitus
Used to treat Type 2 Diabetes Mellitus in combination with Metformin
Physical Activity
Used to treat Exercise in combination with Metformin
Diet
Used to treat Diet in combination with Metformin
Type 2 Diabetes
Used to treat Type 2 Diabetes Mellitus in combination with Metformin
Pharmaceutical Preparations
Used to treat previously treated with drugs in combination with Saxagliptin
inadequate response to monotherapy
Used to treat inadequate response to monotherapy in combination with Saxagliptin

Effectiveness

How Qternmet Xr Affects PatientsSaxagliptin boosts the body's natural hormones GLP-1 and GIP by up to three times their normal levels. It specifically targets the DPP-4 enzyme, making it less likely to cause side effects. Saxagliptin works for 24 hours and helps insulin production from the pancreas. It has an IC50 of 0.5 nmol/L, meaning it won't have a serious effect on the heart's rhythm.
How Qternmet Xr works in the bodySaxagliptin is a medicine used to treat type 2 diabetes. It works by increasing the body's natural hormones, called incretins. These hormones help the body use sugar more efficiently by increasing the amount of insulin in the pancreas and decreasing the amount of sugar released by the liver. Saxagliptin blocks an enzyme called DPP-4, which helps the body make a hormone called GLP-1. GLP-1 helps the pancreas produce more insulin and reduces the amount of sugar from the liver. This helps to lower blood sugar levels and manage type 2 diabetes.

When to interrupt dosage

The amount of Qternmet Xr is contingent upon the recognized condition, including dapagliflozin, Diet and Type 2 Diabetes. The degree of dosage also depends on the approach of administration specified in the table below.
Condition
Dosage
Administration
Chronic Kidney Disease
, 5.0 mg, 10.0 mg, 2.5 mg
Tablet, film coated - Oral, Tablet, film coated, Oral, , Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral
Kidney Failure
, 5.0 mg, 10.0 mg, 2.5 mg
Tablet, film coated - Oral, Tablet, film coated, Oral, , Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral
Physical Activity
, 5.0 mg, 10.0 mg, 2.5 mg
Tablet, film coated - Oral, Tablet, film coated, Oral, , Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral
Congestive Heart Failure
, 5.0 mg, 10.0 mg, 2.5 mg
Tablet, film coated - Oral, Tablet, film coated, Oral, , Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral
Hypesthesia
, 5.0 mg, 10.0 mg, 2.5 mg
Tablet, film coated - Oral, Tablet, film coated, Oral, , Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral
Hypesthesia
, 5.0 mg, 10.0 mg, 2.5 mg
Tablet, film coated - Oral, Tablet, film coated, Oral, , Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral
Hypesthesia
, 5.0 mg, 10.0 mg, 2.5 mg
Tablet, film coated - Oral, Tablet, film coated, Oral, , Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral
Diet
, 5.0 mg, 10.0 mg, 2.5 mg
Tablet, film coated - Oral, Tablet, film coated, Oral, , Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral
Cardiovascular Mortality
, 5.0 mg, 10.0 mg, 2.5 mg
Tablet, film coated - Oral, Tablet, film coated, Oral, , Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral
Heart Failure
, 5.0 mg, 10.0 mg, 2.5 mg
Tablet, film coated - Oral, Tablet, film coated, Oral, , Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral
decrease in the glomerular filtration rate
, 5.0 mg, 10.0 mg, 2.5 mg
Tablet, film coated - Oral, Tablet, film coated, Oral, , Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral
Hospitalizations
, 5.0 mg, 10.0 mg, 2.5 mg
Tablet, film coated - Oral, Tablet, film coated, Oral, , Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral
Pharmaceutical Preparations
, 5.0 mg, 10.0 mg, 2.5 mg
Tablet, film coated - Oral, Tablet, film coated, Oral, , Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral
inadequate response to monotherapy
, 5.0 mg, 10.0 mg, 2.5 mg
Tablet, film coated - Oral, Tablet, film coated, Oral, , Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral
Cardiovascular Diseases
, 5.0 mg, 10.0 mg, 2.5 mg
Tablet, film coated - Oral, Tablet, film coated, Oral, , Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral
Type 2 Diabetes
, 5.0 mg, 10.0 mg, 2.5 mg
Tablet, film coated - Oral, Tablet, film coated, Oral, , Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral

Warnings

Qternmet Xr Contraindications
Condition
Risk Level
Notes
Kidney Failure
Do Not Combine
Renal Insufficiency
Do Not Combine
Acidosis
Do Not Combine
Diabetic Ketoacidosis
Do Not Combine
Kidney Failure
Do Not Combine
Dialysis therapy
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Dapagliflozin may interact with Pulse Frequency
There are 20 known major drug interactions with Qternmet Xr.
Common Qternmet Xr Drug Interactions
Drug Name
Risk Level
Description
Acenocoumarol
Major
The metabolism of Acenocoumarol can be decreased when combined with Dapagliflozin.
Aminophylline
Major
The metabolism of Aminophylline can be decreased when combined with Dapagliflozin.
Amitriptyline
Major
The metabolism of Amitriptyline can be decreased when combined with Dapagliflozin.
Amoxapine
Major
The metabolism of Amoxapine can be decreased when combined with Dapagliflozin.
Anagrelide
Major
The metabolism of Anagrelide can be decreased when combined with Dapagliflozin.
Qternmet Xr Toxicity & Overdose RiskSaxagliptin use can lead to more frequent upper respiratory infection, urinary tract infection, and headaches than patients using a placebo.
image of a doctor in a lab doing drug, clinical research

Qternmet Xr Novel Uses: Which Conditions Have a Clinical Trial Featuring Qternmet Xr?

Currently, there are 197 active studies investigating the potential of Qternmet Xr with Saxagliptin to ameliorate Type 2 Diabetes and improve response to Exercise.
Condition
Clinical Trials
Trial Phases
decrease in the glomerular filtration rate
0 Actively Recruiting
Congestive Heart Failure
175 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 4, Phase 3, Early Phase 1
Chronic Kidney Disease
105 Actively Recruiting
Not Applicable, Phase 1, Phase 3, Phase 2, Phase 4, Early Phase 1
Cardiovascular Mortality
0 Actively Recruiting
Cardiovascular Diseases
0 Actively Recruiting
Type 2 Diabetes
175 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3, Phase 4, Early Phase 1
Pharmaceutical Preparations
0 Actively Recruiting
Diet
5 Actively Recruiting
Not Applicable, Phase 1
Hospitalizations
4 Actively Recruiting
Not Applicable
Kidney Failure
45 Actively Recruiting
Phase 4, Phase 2, Phase 3, Not Applicable, Phase 1, Early Phase 1
Heart Failure
0 Actively Recruiting
Hypesthesia
7 Actively Recruiting
Not Applicable, Early Phase 1, Phase 1
Hypesthesia
10 Actively Recruiting
Not Applicable, Phase 1
Hypesthesia
2 Actively Recruiting
Not Applicable
Physical Activity
35 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Early Phase 1
inadequate response to monotherapy
0 Actively Recruiting

Qternmet Xr Reviews: What are patients saying about Qternmet Xr?

5Patient Review
10/17/2015
Qternmet Xr for Type 2 Diabetes Mellitus
I recently found out that I have diabetes. In the month since my diagnosis, I've been taking this medication and it has helped to keep my sugar levels consistent. The only downside is that it makes me sweat a lot. Otherwise, I'm very happy with it.
5Patient Review
5/16/2017
Qternmet Xr for Type 2 Diabetes Mellitus
Xigduo is a really convenient treatment; only having to take one pill per day. The one downside is that it can make you have to urinate frequently, which can be disruptive if it happens in the middle of the night. But other than that, it's been great for reducing my blood sugar with no noticeable side effects.
5Patient Review
12/1/2021
Qternmet Xr for Type 2 Diabetes Mellitus
I took Xigduo XR 5mg/500mg once a day for about 2years. I had no side effects at all. I was able to loss 90lbs and lowered my A1C to 4.9 at which point my Doc told me to stop taking this drug.
5Patient Review
4/30/2018
Qternmet Xr for Type 2 Diabetes Mellitus
I've only been on Xigduo for a month, but I've already lost 15lbs. My blood sugar levels have lowered and I feel great! The only downside is that I sweat a lot more, but that's a small price to pay for the benefits I've seen so far.
5Patient Review
1/30/2018
Qternmet Xr for Type 2 Diabetes Mellitus
This drug has been extremely effective for me. It's helped me lose a lot of weight and I no longer need to take insulin.
View All Reviews
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about qternmet xr

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Why was Qternmet XR discontinued?

"The reason for the discontinuation of Qternmet XR by the manufacturer is unclear. It is possible that the medication was not popular enough, given the cost."

Answered by AI

What is Xigduo XR used for?

"This medication is made of two drugs, dapagliflozin and metformin. It is used to help regulate blood sugar levels in people who have type 2 diabetes, when combined with a healthy diet and exercise routine. High blood sugar levels can cause a range of problems, including kidney damage, blindness, nerve damage, loss of limbs, and sexual dysfunction."

Answered by AI

What is Qternmet?

"Qternmet XR is a once-daily, oral medicine that consists of the selective sodium-glucose cotransporter-2 (SGLT-2) inhibitor dapagliflozin, the dipeptidyl peptidase-4 (DPP-4) inhibitor saxagliptin, and metformin hydrochloride extended release."

Answered by AI

What is Kombiglyze XR used for?

"KOMBIGLYZE XR is a prescription medicine that contains saxagliptin and metformin hydrochloride. KOMBIGLYZE XR is used with diet and exercise to help control high blood sugar (hyperglycemia) in adults with type 2 diabetes. Your doctor will decide if treatment with both saxagliptin and metformin is right for you."

Answered by AI

Clinical Trials for Qternmet Xr

Have you considered Qternmet Xr clinical trials? We made a collection of clinical trials featuring Qternmet Xr, we think they might fit your search criteria.
Have you considered Qternmet Xr clinical trials? We made a collection of clinical trials featuring Qternmet Xr, we think they might fit your search criteria.
Have you considered Qternmet Xr clinical trials? We made a collection of clinical trials featuring Qternmet Xr, we think they might fit your search criteria.
Unbiased ResultsWe believe in providing patients with all the options.
Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.
Back to top