Qternmet Xr

Hypesthesia, Hypesthesia, Hypesthesia + 13 more
Treatment
5 FDA approvals
20 Active Studies for Qternmet Xr

What is Qternmet Xr

DapagliflozinThe Generic name of this drug
Treatment SummarySaxagliptin is an oral medication used to treat diabetes. It belongs to a class of drugs called DPP-4 inhibitors, which work by helping the body produce more insulin and controlling blood sugar levels. Saxagliptin was approved by the FDA in 2009.
Farxigais the brand name
Qternmet Xr Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Farxiga
Dapagliflozin
2008
19

Approved as Treatment by the FDA

Dapagliflozin, also known as Farxiga, is approved by the FDA for 5 uses such as Type 2 Diabetes and Diet .
Type 2 Diabetes
Used to treat Type 2 Diabetes Mellitus in combination with Metformin
Diet
Used to treat Diet in combination with Metformin
Pharmaceutical Preparations
Used to treat previously treated with drugs in combination with Saxagliptin
inadequate response to monotherapy
Used to treat inadequate response to monotherapy in combination with Saxagliptin
Physical Activity
Used to treat Exercise in combination with Metformin

Effectiveness

How Qternmet Xr Affects PatientsSaxagliptin boosts the body's natural hormones GLP-1 and GIP by up to three times their normal levels. It specifically targets the DPP-4 enzyme, making it less likely to cause side effects. Saxagliptin works for 24 hours and helps insulin production from the pancreas. It has an IC50 of 0.5 nmol/L, meaning it won't have a serious effect on the heart's rhythm.
How Qternmet Xr works in the bodySaxagliptin is a medicine used to treat type 2 diabetes. It works by increasing the body's natural hormones, called incretins. These hormones help the body use sugar more efficiently by increasing the amount of insulin in the pancreas and decreasing the amount of sugar released by the liver. Saxagliptin blocks an enzyme called DPP-4, which helps the body make a hormone called GLP-1. GLP-1 helps the pancreas produce more insulin and reduces the amount of sugar from the liver. This helps to lower blood sugar levels and manage type 2 diabetes.

When to interrupt dosage

The amount of Qternmet Xr is contingent upon the recognized condition, including dapagliflozin, Diet and Type 2 Diabetes. The degree of dosage also depends on the approach of administration specified in the table below.
Condition
Dosage
Administration
Hospitalizations
, 5.0 mg, 10.0 mg, 2.5 mg
Tablet, film coated - Oral, Tablet, film coated, Oral, , Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral
Congestive Heart Failure
, 5.0 mg, 10.0 mg, 2.5 mg
Tablet, film coated - Oral, Tablet, film coated, Oral, , Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral
Chronic Kidney Disease
, 5.0 mg, 10.0 mg, 2.5 mg
Tablet, film coated - Oral, Tablet, film coated, Oral, , Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral
Cardiovascular Mortality
, 5.0 mg, 10.0 mg, 2.5 mg
Tablet, film coated - Oral, Tablet, film coated, Oral, , Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral
inadequate response to monotherapy
, 5.0 mg, 10.0 mg, 2.5 mg
Tablet, film coated - Oral, Tablet, film coated, Oral, , Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral
Hypesthesia
, 5.0 mg, 10.0 mg, 2.5 mg
Tablet, film coated - Oral, Tablet, film coated, Oral, , Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral
Diet
, 5.0 mg, 10.0 mg, 2.5 mg
Tablet, film coated - Oral, Tablet, film coated, Oral, , Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral
decrease in the glomerular filtration rate
, 5.0 mg, 10.0 mg, 2.5 mg
Tablet, film coated - Oral, Tablet, film coated, Oral, , Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral
Hypesthesia
, 5.0 mg, 10.0 mg, 2.5 mg
Tablet, film coated - Oral, Tablet, film coated, Oral, , Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral
Pharmaceutical Preparations
, 5.0 mg, 10.0 mg, 2.5 mg
Tablet, film coated - Oral, Tablet, film coated, Oral, , Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral
Hypesthesia
, 5.0 mg, 10.0 mg, 2.5 mg
Tablet, film coated - Oral, Tablet, film coated, Oral, , Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral
Kidney Failure
, 5.0 mg, 10.0 mg, 2.5 mg
Tablet, film coated - Oral, Tablet, film coated, Oral, , Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral
Cardiovascular Diseases
, 5.0 mg, 10.0 mg, 2.5 mg
Tablet, film coated - Oral, Tablet, film coated, Oral, , Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral
Type 2 Diabetes
, 5.0 mg, 10.0 mg, 2.5 mg
Tablet, film coated - Oral, Tablet, film coated, Oral, , Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral
Physical Activity
, 5.0 mg, 10.0 mg, 2.5 mg
Tablet, film coated - Oral, Tablet, film coated, Oral, , Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral
hospitalization due to cardiac failure
, 5.0 mg, 10.0 mg, 2.5 mg
Tablet, film coated - Oral, Tablet, film coated, Oral, , Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral

Warnings

Qternmet Xr Contraindications
Condition
Risk Level
Notes
Kidney Failure
Do Not Combine
moderate to severe renal dysfunction
Do Not Combine
Acute or chronic metabolic acidosis
Do Not Combine
Diabetic Ketoacidosis
Do Not Combine
Kidney Failure
Do Not Combine
Dialysis therapy
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Dapagliflozin may interact with Pulse Frequency
There are 20 known major drug interactions with Qternmet Xr.
Common Qternmet Xr Drug Interactions
Drug Name
Risk Level
Description
Acenocoumarol
Major
The metabolism of Acenocoumarol can be decreased when combined with Dapagliflozin.
Aminophylline
Major
The metabolism of Aminophylline can be decreased when combined with Dapagliflozin.
Amitriptyline
Major
The metabolism of Amitriptyline can be decreased when combined with Dapagliflozin.
Amoxapine
Major
The metabolism of Amoxapine can be decreased when combined with Dapagliflozin.
Anagrelide
Major
The metabolism of Anagrelide can be decreased when combined with Dapagliflozin.
Qternmet Xr Toxicity & Overdose RiskSaxagliptin use can lead to more frequent upper respiratory infection, urinary tract infection, and headaches than patients using a placebo.
image of a doctor in a lab doing drug, clinical research

Qternmet Xr Novel Uses: Which Conditions Have a Clinical Trial Featuring Qternmet Xr?

Currently, there are 197 active studies investigating the potential of Qternmet Xr with Saxagliptin to ameliorate Type 2 Diabetes and improve response to Exercise.
Condition
Clinical Trials
Trial Phases
Hypesthesia
5 Actively Recruiting
Not Applicable, Early Phase 1, Phase 1
Pharmaceutical Preparations
0 Actively Recruiting
Chronic Kidney Disease
109 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 4, Phase 3, Early Phase 1
Type 2 Diabetes
191 Actively Recruiting
Phase 2, Not Applicable, Early Phase 1, Phase 1, Phase 4, Phase 3
inadequate response to monotherapy
0 Actively Recruiting
hospitalization due to cardiac failure
0 Actively Recruiting
Cardiovascular Diseases
0 Actively Recruiting
Hospitalizations
2 Actively Recruiting
Not Applicable
Cardiovascular Mortality
0 Actively Recruiting
decrease in the glomerular filtration rate
0 Actively Recruiting
Congestive Heart Failure
315 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 1, Early Phase 1, Phase 4
Hypesthesia
4 Actively Recruiting
Not Applicable
Hypesthesia
8 Actively Recruiting
Not Applicable, Phase 1
Physical Activity
38 Actively Recruiting
Not Applicable, Phase 2, Phase 1, Early Phase 1
Diet
4 Actively Recruiting
Not Applicable
Kidney Failure
56 Actively Recruiting
Phase 3, Phase 4, Phase 2, Not Applicable, Phase 1

Qternmet Xr Reviews: What are patients saying about Qternmet Xr?

5Patient Review
10/17/2015
Qternmet Xr for Type 2 Diabetes Mellitus
I recently found out that I have diabetes. In the month since my diagnosis, I've been taking this medication and it has helped to keep my sugar levels consistent. The only downside is that it makes me sweat a lot. Otherwise, I'm very happy with it.
5Patient Review
5/16/2017
Qternmet Xr for Type 2 Diabetes Mellitus
Xigduo is a really convenient treatment; only having to take one pill per day. The one downside is that it can make you have to urinate frequently, which can be disruptive if it happens in the middle of the night. But other than that, it's been great for reducing my blood sugar with no noticeable side effects.
5Patient Review
12/1/2021
Qternmet Xr for Type 2 Diabetes Mellitus
I took Xigduo XR 5mg/500mg once a day for about 2years. I had no side effects at all. I was able to loss 90lbs and lowered my A1C to 4.9 at which point my Doc told me to stop taking this drug.
5Patient Review
4/30/2018
Qternmet Xr for Type 2 Diabetes Mellitus
I've only been on Xigduo for a month, but I've already lost 15lbs. My blood sugar levels have lowered and I feel great! The only downside is that I sweat a lot more, but that's a small price to pay for the benefits I've seen so far.
5Patient Review
1/30/2018
Qternmet Xr for Type 2 Diabetes Mellitus
This drug has been extremely effective for me. It's helped me lose a lot of weight and I no longer need to take insulin.
5Patient Review
1/30/2018
Qternmet Xr for Type 2 Diabetes Mellitus
I am so pleased with this drug- it got me off of insulin and I've lost a ton of weight. It's easy to take and really works for me!
5Patient Review
10/17/2015
Qternmet Xr for Type 2 Diabetes Mellitus
This medication has been great for me since I was diagnosed with diabetes. My sugar levels are now much more consistent, and I've even lost weight (15lbs in the first two weeks!). The only downside is that it makes me sweat a lot, but that's a small price to pay for such good results otherwise.
5Patient Review
10/27/2016
Qternmet Xr for Type 2 Diabetes Mellitus
I was really pleased with this medication. It helped me lose weight and lower my A1C without making any other changes to my lifestyle.
5Patient Review
5/16/2017
Qternmet Xr for Type 2 Diabetes Mellitus
Xigduo was easy to take just one tablet/day. The main ingredient is a diuretic, which can be inconvenient in the middle of the night. Otherwise, it is very helpful in reducing blood sugar with literally no side effects except for the frequent urination.
5Patient Review
4/30/2018
Qternmet Xr for Type 2 Diabetes Mellitus
I've only been on Xigduo for a month, and I've already lost 15lbs. My sugars have lowered and I feel great! The only negative is that I sweat quite a lot, but it's worth it for the results.
5Patient Review
12/1/2021
Qternmet Xr for Type 2 Diabetes Mellitus
I took Xigduo XR 5mg/500mg once a day for about 2years. I had no side effects at all. I was able to loss 90lbs and lowered my A1C to 4.9 at which point my Doc told me to stop taking this drug.
5Patient Review
10/27/2016
Qternmet Xr for Type 2 Diabetes Mellitus
I was pleasantly surprised by how well this drug worked. I lost 50 pounds without making any other changes to my lifestyle.
4.7Patient Review
5/18/2017
Qternmet Xr for Type 2 Diabetes Mellitus
I've been taking Xigduo for just over two years now. At first, it was really tough on my stomach; however, after a few weeks my body adjusted and I haven't had any problems since. Not to mention, I've lost over 75lbs and no longer have to inject insulin every day. Plus, my AC1 has been consistently under 5.9. It's a win-win!
4.7Patient Review
5/18/2017
Qternmet Xr for Type 2 Diabetes Mellitus
I've been on Xigduo for a little over two years now. At first, it was really hard on my stomach, but after a few weeks my body adjusted and I stopped having any problems. In that time, I've lost over 75lbs and no longer have to inject insulin every day. Plus, my AC1 has stayed under 5.9 the whole time!
4Patient Review
10/26/2018
Qternmet Xr for Type 2 Diabetes Mellitus
I've only been taking this medication for a few days, so I can't speak to its long-term effects yet. However, I have already noticed some positive changes. My fasting blood sugar was 114 this morning, which is a significant improvement from my average of 205-225. I also experienced some hunger and woke up in the middle of the night last night, but I'm hoping that was just due to adjusting to the new medication and that will go away with time.
4Patient Review
10/26/2018
Qternmet Xr for Type 2 Diabetes Mellitus
I've only been taking this medication for a few days, but I'm already seeing improvements in my fasting sugar levels. I was averaging 205-225 before starting this drug, and now I'm down to 114. Hopefully this trend continues!
3Patient Review
9/11/2022
Qternmet Xr for Type 2 Diabetes Mellitus
While this treatment effectively lowers blood sugar levels, the chronic diarrhea it causes is incredibly disruptive to my quality of life. I'm stopping the medication in hopes of finding something that works better for me.
3Patient Review
9/11/2022
Qternmet Xr for Type 2 Diabetes Mellitus
While this medication does lower blood sugar levels, the trade-off is not worth it for me. I've been dealing with diarrhea every day for over a year now, and it's really taken a toll on my quality of life. I'm going to stop taking it and see if things improve.
2.3Patient Review
6/26/2018
Qternmet Xr for Type 2 Diabetes Mellitus
My muscles always feel so sore and achy. I can't seem to get any relief from this pain.
2.3Patient Review
5/3/2020
Qternmet Xr for Type 2 Diabetes Mellitus
I unfortunately got two different infections after using this treatment for just two weeks.
2.3Patient Review
6/26/2018
Qternmet Xr for Type 2 Diabetes Mellitus
I experienced a lot of muscle pain while taking this medication. It was uncomfortable and at times, debilitating.
2.3Patient Review
5/3/2020
Qternmet Xr for Type 2 Diabetes Mellitus
I got a yeast infection within two weeks of starting this treatment, and then shortly after curing that, I got a urinary tract infection. Now I'm urinating every two hours.
2Patient Review
7/18/2021
Qternmet Xr for Type 2 Diabetes Mellitus
Unfortunately, I had to go to the hospital emergency room three days after taking this drug. I experienced severe constipation and abdominal pain. This drug also suppressed my appetite and lowered my blood sugar levels. Overall, I was very unhappy with the severe adverse side effects and discontinued use of the drug.
2Patient Review
7/18/2021
Qternmet Xr for Type 2 Diabetes Mellitus
Unfortunately, I had to go to the hospital emergency room due to a heart event just three days after taking this drug. I also experienced severe constipation and abdominal pain. This drug suppresses your appetite and lowers blood sugar levels, but the adverse side effects were too much for me so I stopped taking it.
1Patient Review
12/14/2014
Qternmet Xr for Type 2 Diabetes Mellitus
I tried this medication twice and both times had an allergic reaction in the form of a rash. I would not recommend it to anyone.
1Patient Review
4/27/2022
Qternmet Xr for Type 2 Diabetes Mellitus
I experienced such significant hair loss after just two months of use that my hairdresser recommended I speak to a doctor. As a result, I started taking Ozempic instead, which has helped with both the hair loss and other side effects like palpitations and nausea.
1Patient Review
12/14/2014
Qternmet Xr for Type 2 Diabetes Mellitus
I was really disappointed with this medication. I had an allergic reaction to it both times I tried it, even when I wasn't taking any other drugs.
1Patient Review
4/27/2022
Qternmet Xr for Type 2 Diabetes Mellitus
After just two months of using this medication, I experienced such significant hair loss that my hairdresser recommended consulting my doctor. As a result, I was put on Ozempic to combat the side effects I was experiencing, like hair loss, palpitations, and nausea.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about qternmet xr

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Why was Qternmet XR discontinued?

"The reason for the discontinuation of Qternmet XR by the manufacturer is unclear. It is possible that the medication was not popular enough, given the cost."

Answered by AI

What is Xigduo XR used for?

"This medication is made of two drugs, dapagliflozin and metformin. It is used to help regulate blood sugar levels in people who have type 2 diabetes, when combined with a healthy diet and exercise routine. High blood sugar levels can cause a range of problems, including kidney damage, blindness, nerve damage, loss of limbs, and sexual dysfunction."

Answered by AI

What is Qternmet?

"Qternmet XR is a once-daily, oral medicine that consists of the selective sodium-glucose cotransporter-2 (SGLT-2) inhibitor dapagliflozin, the dipeptidyl peptidase-4 (DPP-4) inhibitor saxagliptin, and metformin hydrochloride extended release."

Answered by AI

What is Kombiglyze XR used for?

"KOMBIGLYZE XR is a prescription medicine that contains saxagliptin and metformin hydrochloride. KOMBIGLYZE XR is used with diet and exercise to help control high blood sugar (hyperglycemia) in adults with type 2 diabetes. Your doctor will decide if treatment with both saxagliptin and metformin is right for you."

Answered by AI

Clinical Trials for Qternmet Xr

Have you considered Qternmet Xr clinical trials? We made a collection of clinical trials featuring Qternmet Xr, we think they might fit your search criteria.
Have you considered Qternmet Xr clinical trials? We made a collection of clinical trials featuring Qternmet Xr, we think they might fit your search criteria.
Have you considered Qternmet Xr clinical trials? We made a collection of clinical trials featuring Qternmet Xr, we think they might fit your search criteria.