Prozac

Premature Ejaculation, Cataplexy, Bulimia Nervosa + 11 more
Treatment
6 FDA approvals
20 Active Studies for Prozac

What is Prozac

FluoxetineThe Generic name of this drug
Treatment SummaryFluoxetine is an antidepressant medication that was approved by the FDA in 1987. It belongs to a class of drugs called selective serotonin reuptake inhibitors (SSRIs) and is used to treat depression. It has since been used to treat other mental health conditions as well.
Prozacis the brand name
image of different drug pills on a surface
Prozac Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Prozac
Fluoxetine
1987
490

Approved as Treatment by the FDA

Fluoxetine, also known as Prozac, is approved by the FDA for 6 uses such as Bipolar 1 Disorder and Premenstrual Dysphoric Disorder (PMDD) .
Bipolar 1 Disorder
Used to treat Bipolar 1 Disorder in combination with Olanzapine
Premenstrual Dysphoric Disorder (PMDD)
Major depressive disorder, recurrent episode
Used to treat Major depressive disorder, recurrent episode in combination with Olanzapine
Bipolar Disorder
Used to treat Bipolar 1 Disorder in combination with Olanzapine
Depression
Used to treat Depression in combination with Olanzapine
Unipolar Depression
Used to treat Major depressive disorder, recurrent episode in combination with Olanzapine

Effectiveness

How Prozac Affects PatientsFluoxetine works by keeping serotonin levels high in certain parts of the brain. It has a milder effect on other receptors like dopamine, adrenaline, and histamine compared to other types of antidepressants, which makes it have fewer side effects.
How Prozac works in the bodyThe monoaminergic hypothesis of depression suggests that low levels of serotonin are linked to depression. Fluoxetine is a drug designed to help treat this type of depression. It works by increasing the amount of serotonin available in the brain. It does this by blocking the reuptake of serotonin, which essentially traps it in the brain. Fluoxetine has a strong affinity for serotonin, but only a weak affinity for noradrenaline and no affinity for dopamine. Additionally, it interacts with the 5-HT2C receptor, which increases noradrenaline and dopamine levels in the prefrontal cortex.

When to interrupt dosage

The recommended dosage of Prozac is contingent upon the diagnosed condition, such as Myoclonus, Bipolar Disorder and Unipolar Depression. The dosage amount is dependent upon the administration technique (e.g. Tablet, coated or Oral) detailed in the table below.
Condition
Dosage
Administration
Premature Ejaculation
, 90.0 mg, 40.0 mg, 20.0 mg, 10.0 mg, 25.0 mg, 50.0 mg, 60.0 mg, 20.0 mg/mL, 15.0 mg
, Capsule, delayed release, Capsule, delayed release - Oral, Oral, Capsule, Capsule - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Kit, Solution, Solution - Oral, Liquid, Liquid - Oral, Tablet, coated, Tablet, coated - Oral
Cataplexy
, 90.0 mg, 40.0 mg, 20.0 mg, 10.0 mg, 25.0 mg, 50.0 mg, 60.0 mg, 20.0 mg/mL, 15.0 mg
, Capsule, delayed release, Capsule, delayed release - Oral, Oral, Capsule, Capsule - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Kit, Solution, Solution - Oral, Liquid, Liquid - Oral, Tablet, coated, Tablet, coated - Oral
Bulimia Nervosa
, 90.0 mg, 40.0 mg, 20.0 mg, 10.0 mg, 25.0 mg, 50.0 mg, 60.0 mg, 20.0 mg/mL, 15.0 mg
, Capsule, delayed release, Capsule, delayed release - Oral, Oral, Capsule, Capsule - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Kit, Solution, Solution - Oral, Liquid, Liquid - Oral, Tablet, coated, Tablet, coated - Oral
Anorexia Nervosa
, 90.0 mg, 40.0 mg, 20.0 mg, 10.0 mg, 25.0 mg, 50.0 mg, 60.0 mg, 20.0 mg/mL, 15.0 mg
, Capsule, delayed release, Capsule, delayed release - Oral, Oral, Capsule, Capsule - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Kit, Solution, Solution - Oral, Liquid, Liquid - Oral, Tablet, coated, Tablet, coated - Oral
Panic Disorder
, 90.0 mg, 40.0 mg, 20.0 mg, 10.0 mg, 25.0 mg, 50.0 mg, 60.0 mg, 20.0 mg/mL, 15.0 mg
, Capsule, delayed release, Capsule, delayed release - Oral, Oral, Capsule, Capsule - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Kit, Solution, Solution - Oral, Liquid, Liquid - Oral, Tablet, coated, Tablet, coated - Oral
Alcoholism
, 90.0 mg, 40.0 mg, 20.0 mg, 10.0 mg, 25.0 mg, 50.0 mg, 60.0 mg, 20.0 mg/mL, 15.0 mg
, Capsule, delayed release, Capsule, delayed release - Oral, Oral, Capsule, Capsule - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Kit, Solution, Solution - Oral, Liquid, Liquid - Oral, Tablet, coated, Tablet, coated - Oral
Unipolar Depression
, 90.0 mg, 40.0 mg, 20.0 mg, 10.0 mg, 25.0 mg, 50.0 mg, 60.0 mg, 20.0 mg/mL, 15.0 mg
, Capsule, delayed release, Capsule, delayed release - Oral, Oral, Capsule, Capsule - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Kit, Solution, Solution - Oral, Liquid, Liquid - Oral, Tablet, coated, Tablet, coated - Oral
moderate to severe symptoms
, 90.0 mg, 40.0 mg, 20.0 mg, 10.0 mg, 25.0 mg, 50.0 mg, 60.0 mg, 20.0 mg/mL, 15.0 mg
, Capsule, delayed release, Capsule, delayed release - Oral, Oral, Capsule, Capsule - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Kit, Solution, Solution - Oral, Liquid, Liquid - Oral, Tablet, coated, Tablet, coated - Oral
Depression
, 90.0 mg, 40.0 mg, 20.0 mg, 10.0 mg, 25.0 mg, 50.0 mg, 60.0 mg, 20.0 mg/mL, 15.0 mg
, Capsule, delayed release, Capsule, delayed release - Oral, Oral, Capsule, Capsule - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Kit, Solution, Solution - Oral, Liquid, Liquid - Oral, Tablet, coated, Tablet, coated - Oral
Myoclonus
, 90.0 mg, 40.0 mg, 20.0 mg, 10.0 mg, 25.0 mg, 50.0 mg, 60.0 mg, 20.0 mg/mL, 15.0 mg
, Capsule, delayed release, Capsule, delayed release - Oral, Oral, Capsule, Capsule - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Kit, Solution, Solution - Oral, Liquid, Liquid - Oral, Tablet, coated, Tablet, coated - Oral
Bipolar Disorder
, 90.0 mg, 40.0 mg, 20.0 mg, 10.0 mg, 25.0 mg, 50.0 mg, 60.0 mg, 20.0 mg/mL, 15.0 mg
, Capsule, delayed release, Capsule, delayed release - Oral, Oral, Capsule, Capsule - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Kit, Solution, Solution - Oral, Liquid, Liquid - Oral, Tablet, coated, Tablet, coated - Oral
maintenance therapy
, 90.0 mg, 40.0 mg, 20.0 mg, 10.0 mg, 25.0 mg, 50.0 mg, 60.0 mg, 20.0 mg/mL, 15.0 mg
, Capsule, delayed release, Capsule, delayed release - Oral, Oral, Capsule, Capsule - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Kit, Solution, Solution - Oral, Liquid, Liquid - Oral, Tablet, coated, Tablet, coated - Oral
Obsessive-Compulsive Disorder
, 90.0 mg, 40.0 mg, 20.0 mg, 10.0 mg, 25.0 mg, 50.0 mg, 60.0 mg, 20.0 mg/mL, 15.0 mg
, Capsule, delayed release, Capsule, delayed release - Oral, Oral, Capsule, Capsule - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Kit, Solution, Solution - Oral, Liquid, Liquid - Oral, Tablet, coated, Tablet, coated - Oral
Depression
, 90.0 mg, 40.0 mg, 20.0 mg, 10.0 mg, 25.0 mg, 50.0 mg, 60.0 mg, 20.0 mg/mL, 15.0 mg
, Capsule, delayed release, Capsule, delayed release - Oral, Oral, Capsule, Capsule - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Kit, Solution, Solution - Oral, Liquid, Liquid - Oral, Tablet, coated, Tablet, coated - Oral

Warnings

Prozac Contraindications
Condition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
There are 20 known major drug interactions with Prozac.
Common Prozac Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The metabolism of Abemaciclib can be decreased when combined with Fluoxetine.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be decreased when combined with Fluoxetine.
Alectinib
Major
The metabolism of Alectinib can be decreased when combined with Fluoxetine.
Aminophylline
Major
The metabolism of Aminophylline can be decreased when combined with Fluoxetine.
Axitinib
Major
The metabolism of Axitinib can be decreased when combined with Fluoxetine.
Prozac Toxicity & Overdose RiskMost cases of fluoxetine overdose have mild, short-term side effects such as sleepiness, trembling, fast heart rate, nausea, and vomiting. However, in rare cases, serious symptoms may occur. For example, one patient took 1400mg of fluoxetine in a suicide attempt and had a seizure 3 hours later. Another patient took 1.2g of fluoxetine and experienced seizures, symptoms related to serotonin syndrome, and muscle breakdown.
image of a doctor in a lab doing drug, clinical research

Prozac Novel Uses: Which Conditions Have a Clinical Trial Featuring Prozac?

881 active clinical trials are being conducted to evaluate the efficacy of Prozac in treating Disease, Anorexia Nervosa and as a maintenance therapy.
Condition
Clinical Trials
Trial Phases
Depression
218 Actively Recruiting
Phase 3, Phase 2, Not Applicable, Phase 4, Phase 1, Early Phase 1
Bipolar Disorder
0 Actively Recruiting
Unipolar Depression
49 Actively Recruiting
Not Applicable, Phase 4, Early Phase 1, Phase 3, Phase 2, Phase 1
Bulimia Nervosa
0 Actively Recruiting
Alcoholism
7 Actively Recruiting
Not Applicable, Phase 2, Phase 3
Anorexia Nervosa
0 Actively Recruiting
moderate to severe symptoms
0 Actively Recruiting
Depression
324 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Early Phase 1, Phase 4, Phase 3
Panic Disorder
0 Actively Recruiting
Obsessive-Compulsive Disorder
68 Actively Recruiting
Not Applicable, Phase 2, Phase 3, Phase 1, Early Phase 1
maintenance therapy
0 Actively Recruiting
Myoclonus
1 Actively Recruiting
Not Applicable
Cataplexy
0 Actively Recruiting
Premature Ejaculation
0 Actively Recruiting

Prozac Reviews: What are patients saying about Prozac?

5Patient Review
6/7/2022
Prozac for Depression
Prozac was very effective at treating my symptoms, but I experienced some significant weight gain as a result. L-Tryptophan was much more holistic in its approach and helped me feel better overall.
5Patient Review
8/30/2022
Prozac for Repeated Episodes of Anxiety
This medication has only been a part of my life for a short time, but it's already made such a big difference. I can think more clearly, sleep through the night, and feel more in control of my body and mind. The best part is that other people are noticing the changes too. My husband told me the other day that he hasn't seen me smile in years and this medicine helped him get his wife back. I'm so grateful for this treatment; it feels like I've gotten my life back.
4.7Patient Review
2/9/2022
Prozac for Major Depressive Disorder
Being on Prozac has definitely helped me get back to functioning like a normal person again. I'm so grateful for this medication!
4.7Patient Review
4/20/2022
Prozac for Depression
I was pretty dubious about this treatment at first, especially because it took a few weeks to see any effects. But I'm so glad I stuck with it! After increasing my dosage to 20mg, I've seen significant changes for the better in my mood and overall outlook on life.
4.3Patient Review
11/7/2022
Prozac for Premenstrual Disorder with a State of Unhappiness
I've tried a lot of different medications for my PMDD, and this is the only one that's really given me any relief. And it comes with very few side effects, if any.
4Patient Review
5/6/2022
Prozac for Bipolar Depression
Prozac has been a great addition to my bipolar depression medication. I've been on a low dose because Prozac can possibly trigger mania, but it really helps with my winter depression. As long as I monitor my moods, I haven't had any issues.
3.3Patient Review
5/18/2022
Prozac for Depression
I first tried prozac when I was 22. It worked well for a while, but then I stopped taking it. I went back on it when I was 40 and experienced more than 10 panic attacks per day. I thought it was the hospital environment that was causing the panic attacks, but after being discharged, the panic attacks continued. So, I got a new doctor who took me off the prozac immediately. Gradually, the panic attacks stopped.
3Patient Review
3/16/2022
Prozac for Depression
The medication was effective in that it helped me to relax; however, it did so to an extreme. I found myself unable to get upset about things that would normally bother me, and others commented that I seemed like a "robot" or "zombie." I stopped taking the medication after a month because I felt like it was numbing my emotions too much.
2.7Patient Review
11/9/2022
Prozac for Depression
Prozac completely disconnected me from my body and reality. It was like being hypnotized and in a trance, akin to the "sunken place" scene in Get Out. I strongly advise against this medication unless you have severe PTSD and no responsibilities.
2.3Patient Review
5/1/2022
Prozac for Posttraumatic Stress Syndrome
I have panic disorder and starting this medication was really tough because of the intense side effects. I tried different doses (10mg, 20mg, 30mg, 40mg) but none of them felt worth it to me. Yes, the panic stopped, but now I feel lifeless and like I can't enjoy intimacy anymore.
2Patient Review
8/11/2022
Prozac for Depression
Prozac did nothing to alleviate my depression and actually made me more irritable. Once I stopped taking it, the withdrawals were terrible despite my doctor telling me there would be none.
1.7Patient Review
4/2/2022
Prozac for Depression
My daughter was prescribed Prozac a week and a half ago, but it made her feel worse. So much so that she attempted suicide this past weekend. We've now experienced the negative effects of Prozac firsthand.
1.7Patient Review
9/24/2022
Prozac for Obsessive Compulsive Disorder
I tried this drug for my sexual intrusive thoughts, as prescribed by my doctor, but saw zero improvement even after increasing the dosage. If anything, my anxiety and thoughts got worse while taking it. I'm now on a different medication (anafranil) and would not recommend this drug to anyone.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about prozac

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What does Prozac do for a person?

"Fluoxetine, commonly known by the brand name Prozac, is a selective serotonin reuptake inhibitor (SSRI) antidepressant. It is generally considered safe and effective for treating depression, anxiety, OCD, and bulimia. However, some people may experience increased suicidal thoughts."

Answered by AI

What are the side effects of taking Prozac?

"You may experience nausea, drowsiness, dizziness, anxiety, trouble sleeping, loss of appetite, tiredness, sweating, or yawning while taking this medication. Keep in mind that your doctor prescribed this medication because they believe the benefits of it are greater than the risks of any potential side effects."

Answered by AI

How will Prozac make you feel?

"As Prozac begins to work, you may notice an increase in your energy levels. In some people, it may cause symptoms of mania, which include high energy levels, racing thoughts, trouble sleeping, and irritability."

Answered by AI

Is Prozac a happy pill?

"The original "happy pill” Prozac was approved for use in 1987. It was the first drug prescribed and marketed on a large scale for the treatment of depression. The use of Prozac is very common, but it is not without its risks."

Answered by AI

How does Prozac make you feel?

"As Prozac begins to take effect, you may notice an increase in your energy levels. In some cases, it may cause symptoms of mania in some people taking this medication. Symptoms of mania include high energy levels, racing thoughts, trouble sleeping, and irritability."

Answered by AI

What is a major side effect of Prozac?

"The following effects may occur: nausea, drowsiness, dizziness, anxiety, trouble sleeping, loss of appetite, tiredness, sweating, or yawning. If you experience any of these effects for an extended period of time, or if they worsen, tell your doctor."

Answered by AI

Clinical Trials for Prozac

Image of Cedars-Sinai Medical Center in Los Angeles, United States.

Living Well Program for Anxiety in Breast Cancer

18+
Female
Los Angeles, CA
The goal of this study is to evaluate the efficacy and cost-effectiveness of the Living Well Program, a digital therapeutic application with telecoaching support, in breast cancer patients with moderate-to-severe anxiety. The main question the study aims to answer is: does digital cognitive-behavioral therapy-based interventions decrease the overall healthcare costs of patients with stage II to IV breast cancer? The study has one group of participants who will use the Living Well app and telecoaching support. This group will be compared to retroactively matched controls. Over 3 months, patients will complete 21 mental health modules and 5 telecoaching sessions. In the following 3 months, they will complete any outstanding telecoaching sessions and modules while still being monitored, even if they finished all modules and sessions in the first 3 months. The 6 months after that will be the follow-up phase. They will still have access to the Living Well app and may continue to use it, and they will complete the same assessment questionnaires as baseline to identify any changes in their overall mental health.
Waitlist Available
Has No Placebo
Cedars-Sinai Medical CenterScott Irwin, MD
Image of Baylor College of Medicine in Houston, United States.

Stepped Care Treatment for Anxiety

7 - 17
All Sexes
Houston, TX
Childhood anxiety disorders (CAD) are common and impairing. Family based cognitive behavioral therapy (CBT) is efficacious in treating CAD. Yet, many children do not receive care due to barriers such as limited provider availably, high treatment costs, and constrained family resources (e.g., time). To combat these barriers, other treatment methods have been developed. The stepped care treatment models maximize resources by providing low-intensity, low-cost interventions as a first time treatment, while stepping up care for those needing more intensive treatment. Specifically, a stepped care model for CAD that begins with a parent-focus intervention has great promise to deliver efficacious and cost-effective treatment without having to engage the child. While stepped care approaches show promise in treating CAD with comparable efficacy to standard CBT, there remains a large research-to-practice gap. The stepped care model for CAD that begins with a parent-focused intervention has yet been explored, and very little is known about intervention mediators that explain mechanisms of change. This research is being done to improve the reach and quality of services using a stepped care model, offering an affordable and practical solution to the widespread gap in youth mental health care.
Waitlist Available
Has No Placebo
Baylor College of Medicine
Image of Cohen and Associates in Sarasota, United States.

NRX-101 + TMS for Treatment Resistant Depression

18 - 80
All Sexes
Sarasota, FL
Major depressive disorder (MDD) is a significant public health problem and leading cause of worldwide disability. Treatment resistance is common in MDD, however, for these individuals, targeted noninvasive brain stimulation is an alternative. Repetitive transcranial magnetic stimulation (rTMS) and more recently, theta-burst stimulation (TBS), are the noninvasive brain stimulation modalities with the largest evidence base in MDD. Although efficacious, an unacceptable proportion of patients do not significantly improve, and several aspects of the TMS parameter space are under investigation to enhance clinical outcomes. DCS has been shown in a randomized trial of more than double the percent response and remission from traditional TMS. When the AMPA one day (ONE-D) TMS protocol was combined with DCS, the measured response rate was 87% at one week. This trial will compare response and remission at six weeks following Transcranial Magnetic Stimulation + D-cycloserine vs. TMS+placebo.
Phase 2 & 3
Waitlist Available
Cohen and AssociatesNeuroRx, Inc.
Have you considered Prozac clinical trials? We made a collection of clinical trials featuring Prozac, we think they might fit your search criteria.Go to Trials
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AI Chatbot for Postpartum Loneliness

18+
Female
La Jolla, CA
The goal of this clinical trial is to learn whether a postpartum chatbot powered by generative artificial intelligence (genAI) can help new mothers get better pelvic floor health information and feel less lonely after childbirth. The main questions this study aims to answer are: * Does using the chatbot improve postpartum pelvic floor health knowledge? * Does using the chatbot help reduce feelings of loneliness during the postpartum period? * Does using the chatbot impact pelvic floor symptoms? Researchers will compare standard postpartum care to standard care plus the chatbot. Participants will: Be assigned by chance (like flipping a coin) to standard postpartum care with or without access to the chatbot. If in the chatbot group, participants will receive education and support via the chatbot over a 4-week period. Both groups will complete questionnaires to measure their pelvic floor knowledge, pelvic floor symptoms, feelings of loneliness, depression, infant bonding, perceived social support, adverse childhood experiences, and peri-traumatic distress. The chatbot was created by urogynecology experts in collaboration with UC San Diego computer science and biomedical informatics researchers. The chatbot is designed to give new mothers personalized, evidence-based information and support in real time.
Waitlist Available
Has No Placebo
University of California San Diego
Image of Mayo Clinic in Florida in Jacksonville, United States.

Virtual Reality for Cancer

18 - 90
All Sexes
Jacksonville, FL
This clinical trial tests the safety, tolerability, and effectiveness of a virtual reality intervention to improve psychological symptom burden for cancer patients undergoing treatment. Virtual reality (VR) is a technology that allows users to experience and interact with three-dimensional, computer-generated environments that simulate the real world or imagined settings. The VR intervention consists of a preloaded with immersive environments designed to engage the senses through simulated sights and sounds. This may include a walk through of a serene forest, exploring vibrant coral reefs, swimming with dolphins, or standing at the base of a majestic waterfall. These environments are created to provide a relaxing and engaging experience. Completing the VR intervention may be a safe and effective way to improve quality of life, reduce anxiety, enhance focus, and promote healthy living for cancer patients undergoing treatment.
Recruiting
Has No Placebo
Mayo Clinic in FloridaJuan C. Cardenas Rosales, MD
Have you considered Prozac clinical trials? We made a collection of clinical trials featuring Prozac, we think they might fit your search criteria.Go to Trials
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Akashic Records Sessions for Mental Health

18+
All Sexes
Palm City, FL
The goal of this clinical study is to learn the impact of two Akashic Records sessions on mental health symptoms in adults. We want to see how sessions are linked to stress, anxiety, and depression, and to resilience (ability to bounce back) and feelings of connectedness (to self, community, and humanity). Main questions this study will answer are: After two sessions, what is the impact on stress, anxiety, and depression? After two sessions, what is the impact on resilience and connectedness? How do participants describe their experience of the sessions? After two sessions, what are participants' views of their problems (insight), emotional experiences (impact) and observable behaviors in their daily life? What participants will do: Complete online surveys about their mood at four points: before the first session, before the second session, after the second session, and again 2 months later. Surveys include: DASS-21 (Depression, Anxiety, and Stress Scale) CD-RISC-10 (Connor-Davidson Resilience Scale) WATTS (Connectedness Scale) A short demographic form and satisfaction survey Attend two individual Akashic Records sessions (50-90 minutes each) over private video platform with a licensed clinical social worker (principal investigator) The first 50 participants will also join a one-hour interview with open ended questions with a licensed clinical social worker (co-investigator) about one week after the second session to share their experience in their own words. Who can take part: Adults ages 18 and older who can read and consent in English and who have experienced stress, anxiety, or low mood in the past year. How the research will happen: Sessions are held by secure video call. Participants will also complete private online surveys before, during, and after the sessions. Some participants may be invited to share their experiences in a one-on-one interview. All information is kept private and names are removed before analysis. Risks and benefits: Talking about personal topics may bring up strong emotions. Licensed clinicians conduct sessions, offer support, and provide referrals if needed. Possible benefits include new insights, greater peace or meaning, and improved coping; benefits are not guaranteed. Why this matters: Many people seek spiritual or transpersonal support for emotional concerns. This pilot study will provide early evidence on whether Akashic Records sessions may be a helpful, low-risk option and will guide future research.
Waitlist Available
Has No Placebo
Virtual/ No Physical FacilityCandice S Rasa, LCSW
Image of University of California, Los Angeles in Los Angeles, United States.

Virtual Reality Reward Training for Depression

18+
All Sexes
Los Angeles, CA
The purpose of this study is to compare the effects of enhanced Virtual Reality-Reward Training (eVR-RT) with an active control condition, Virtual Reality-Memory Training (VR-MT), on positive affect and other clinical symptoms. Enhanced VR-Reward Training is a novel intervention aimed at enhancing savoring of positive experiences among individuals with depression and low positive affect through guided imaginal recounting following immersion in positive VR experiences. The current study tests an enhanced version of this training using improved virtual reality technology. Target enrollment is 80 participants with low positive affect, depression, and impaired functioning, who are at least 18 years old, who will be randomly assigned to 7 weeks of either enhanced Virtual Reality-Reward Training (VR-RT) or Virtual Reality-Memory Training (VR-MT). Participants will complete in-person VR sessions, laboratory assessments, self-report questionnaires as part of the study. A subset of 8 participants randomly assigned to VR-RT will complete fMRI scans and EMA surveys. The total length of participation is around 3 months.
Phase 2
Recruiting
University of California, Los Angeles
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Peer-Delivered Behavioral Activation for Depression

18+
All Sexes
Detroit, MI
Low-income individuals have limited access to evidence-based interventions for mental health. Peer recovery specialists, individuals in recovery from mental health and/or substance use problems, have the potential to increase access to evidence-based interventions for individuals from low-resource communities, particularly when trained and supervised in models that are acceptable and feasible in these communities. This study will examine the effectiveness and implementation potential of a peer-delivered evidence-based intervention (Behavioral Activation) among individuals receiving services from a community-based treatment setting providing integrated physical and behavioral healthcare.
Waitlist Available
Has No Placebo
Detroit Recovery Project
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