Prozac

maintenance therapy, Alcoholism, Depression + 12 more
Treatment
3 FDA approvals
20 Active Studies for Prozac

What is Prozac

FluoxetineThe Generic name of this drug
Treatment SummaryFluoxetine is an antidepressant medication that was approved by the FDA in 1987. It belongs to a class of drugs called selective serotonin reuptake inhibitors (SSRIs) and is used to treat depression. It has since been used to treat other mental health conditions as well.
Prozacis the brand name
Prozac Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Prozac
Fluoxetine
1987
482

Approved as Treatment by the FDA

Fluoxetine, also known as Prozac, is approved by the FDA for 3 uses such as Unipolar Depression and Depression .
Unipolar Depression
Used to treat Major depressive disorder, recurrent episode in combination with Olanzapine
Depression
Used to treat Depression in combination with Olanzapine
Bipolar Disorder
Used to treat Bipolar 1 Disorder in combination with Olanzapine

Effectiveness

How Prozac Affects PatientsFluoxetine works by keeping serotonin levels high in certain parts of the brain. It has a milder effect on other receptors like dopamine, adrenaline, and histamine compared to other types of antidepressants, which makes it have fewer side effects.
How Prozac works in the bodyThe monoaminergic hypothesis of depression suggests that low levels of serotonin are linked to depression. Fluoxetine is a drug designed to help treat this type of depression. It works by increasing the amount of serotonin available in the brain. It does this by blocking the reuptake of serotonin, which essentially traps it in the brain. Fluoxetine has a strong affinity for serotonin, but only a weak affinity for noradrenaline and no affinity for dopamine. Additionally, it interacts with the 5-HT2C receptor, which increases noradrenaline and dopamine levels in the prefrontal cortex.

When to interrupt dosage

The recommended dosage of Prozac is contingent upon the diagnosed condition, such as Myoclonus, Bipolar Disorder and Unipolar Depression. The dosage amount is dependent upon the administration technique (e.g. Tablet, coated or Oral) detailed in the table below.
Condition
Dosage
Administration
maintenance therapy
90.0 mg, , 40.0 mg, 20.0 mg, 10.0 mg, 20.0 mg/mL, 60.0 mg, 25.0 mg, 50.0 mg, 15.0 mg
Tablet, coated, Oral, Capsule, delayed release pellets, Capsule - Oral, , Tablet, Tablet, film coated - Oral, Capsule, delayed release - Oral, For solution, Solution - Oral, Tablet - Oral, Tablet, coated - Oral, Capsule, Liquid - Oral, Solution, Capsule, delayed release, Tablet, film coated, Kit, Liquid, Capsule, delayed release pellets - Oral, For solution - Oral
Depression
90.0 mg, , 40.0 mg, 20.0 mg, 10.0 mg, 20.0 mg/mL, 60.0 mg, 25.0 mg, 50.0 mg, 15.0 mg
Tablet, coated, Oral, Capsule, delayed release pellets, Capsule - Oral, , Tablet, Tablet, film coated - Oral, Capsule, delayed release - Oral, For solution, Solution - Oral, Tablet - Oral, Tablet, coated - Oral, Capsule, Liquid - Oral, Solution, Capsule, delayed release, Tablet, film coated, Kit, Liquid, Capsule, delayed release pellets - Oral, For solution - Oral
Panic Disorder (With or Without Agoraphobia)
90.0 mg, , 40.0 mg, 20.0 mg, 10.0 mg, 20.0 mg/mL, 60.0 mg, 25.0 mg, 50.0 mg, 15.0 mg
Tablet, coated, Oral, Capsule, delayed release pellets, Capsule - Oral, , Tablet, Tablet, film coated - Oral, Capsule, delayed release - Oral, For solution, Solution - Oral, Tablet - Oral, Tablet, coated - Oral, Capsule, Liquid - Oral, Solution, Capsule, delayed release, Tablet, film coated, Kit, Liquid, Capsule, delayed release pellets - Oral, For solution - Oral
moderate to severe symptoms
90.0 mg, , 40.0 mg, 20.0 mg, 10.0 mg, 20.0 mg/mL, 60.0 mg, 25.0 mg, 50.0 mg, 15.0 mg
Tablet, coated, Oral, Capsule, delayed release pellets, Capsule - Oral, , Tablet, Tablet, film coated - Oral, Capsule, delayed release - Oral, For solution, Solution - Oral, Tablet - Oral, Tablet, coated - Oral, Capsule, Liquid - Oral, Solution, Capsule, delayed release, Tablet, film coated, Kit, Liquid, Capsule, delayed release pellets - Oral, For solution - Oral
Disease
90.0 mg, , 40.0 mg, 20.0 mg, 10.0 mg, 20.0 mg/mL, 60.0 mg, 25.0 mg, 50.0 mg, 15.0 mg
Tablet, coated, Oral, Capsule, delayed release pellets, Capsule - Oral, , Tablet, Tablet, film coated - Oral, Capsule, delayed release - Oral, For solution, Solution - Oral, Tablet - Oral, Tablet, coated - Oral, Capsule, Liquid - Oral, Solution, Capsule, delayed release, Tablet, film coated, Kit, Liquid, Capsule, delayed release pellets - Oral, For solution - Oral
Myoclonus
90.0 mg, , 40.0 mg, 20.0 mg, 10.0 mg, 20.0 mg/mL, 60.0 mg, 25.0 mg, 50.0 mg, 15.0 mg
Tablet, coated, Oral, Capsule, delayed release pellets, Capsule - Oral, , Tablet, Tablet, film coated - Oral, Capsule, delayed release - Oral, For solution, Solution - Oral, Tablet - Oral, Tablet, coated - Oral, Capsule, Liquid - Oral, Solution, Capsule, delayed release, Tablet, film coated, Kit, Liquid, Capsule, delayed release pellets - Oral, For solution - Oral
Bipolar Disorder
90.0 mg, , 40.0 mg, 20.0 mg, 10.0 mg, 20.0 mg/mL, 60.0 mg, 25.0 mg, 50.0 mg, 15.0 mg
Tablet, coated, Oral, Capsule, delayed release pellets, Capsule - Oral, , Tablet, Tablet, film coated - Oral, Capsule, delayed release - Oral, For solution, Solution - Oral, Tablet - Oral, Tablet, coated - Oral, Capsule, Liquid - Oral, Solution, Capsule, delayed release, Tablet, film coated, Kit, Liquid, Capsule, delayed release pellets - Oral, For solution - Oral
Unipolar Depression
90.0 mg, , 40.0 mg, 20.0 mg, 10.0 mg, 20.0 mg/mL, 60.0 mg, 25.0 mg, 50.0 mg, 15.0 mg
Tablet, coated, Oral, Capsule, delayed release pellets, Capsule - Oral, , Tablet, Tablet, film coated - Oral, Capsule, delayed release - Oral, For solution, Solution - Oral, Tablet - Oral, Tablet, coated - Oral, Capsule, Liquid - Oral, Solution, Capsule, delayed release, Tablet, film coated, Kit, Liquid, Capsule, delayed release pellets - Oral, For solution - Oral
Bulimia Nervosa
90.0 mg, , 40.0 mg, 20.0 mg, 10.0 mg, 20.0 mg/mL, 60.0 mg, 25.0 mg, 50.0 mg, 15.0 mg
Tablet, coated, Oral, Capsule, delayed release pellets, Capsule - Oral, , Tablet, Tablet, film coated - Oral, Capsule, delayed release - Oral, For solution, Solution - Oral, Tablet - Oral, Tablet, coated - Oral, Capsule, Liquid - Oral, Solution, Capsule, delayed release, Tablet, film coated, Kit, Liquid, Capsule, delayed release pellets - Oral, For solution - Oral
Cataplexy
90.0 mg, , 40.0 mg, 20.0 mg, 10.0 mg, 20.0 mg/mL, 60.0 mg, 25.0 mg, 50.0 mg, 15.0 mg
Tablet, coated, Oral, Capsule, delayed release pellets, Capsule - Oral, , Tablet, Tablet, film coated - Oral, Capsule, delayed release - Oral, For solution, Solution - Oral, Tablet - Oral, Tablet, coated - Oral, Capsule, Liquid - Oral, Solution, Capsule, delayed release, Tablet, film coated, Kit, Liquid, Capsule, delayed release pellets - Oral, For solution - Oral
Alcoholism
90.0 mg, , 40.0 mg, 20.0 mg, 10.0 mg, 20.0 mg/mL, 60.0 mg, 25.0 mg, 50.0 mg, 15.0 mg
Tablet, coated, Oral, Capsule, delayed release pellets, Capsule - Oral, , Tablet, Tablet, film coated - Oral, Capsule, delayed release - Oral, For solution, Solution - Oral, Tablet - Oral, Tablet, coated - Oral, Capsule, Liquid - Oral, Solution, Capsule, delayed release, Tablet, film coated, Kit, Liquid, Capsule, delayed release pellets - Oral, For solution - Oral
Anorexia Nervosa
90.0 mg, , 40.0 mg, 20.0 mg, 10.0 mg, 20.0 mg/mL, 60.0 mg, 25.0 mg, 50.0 mg, 15.0 mg
Tablet, coated, Oral, Capsule, delayed release pellets, Capsule - Oral, , Tablet, Tablet, film coated - Oral, Capsule, delayed release - Oral, For solution, Solution - Oral, Tablet - Oral, Tablet, coated - Oral, Capsule, Liquid - Oral, Solution, Capsule, delayed release, Tablet, film coated, Kit, Liquid, Capsule, delayed release pellets - Oral, For solution - Oral
Depression
90.0 mg, , 40.0 mg, 20.0 mg, 10.0 mg, 20.0 mg/mL, 60.0 mg, 25.0 mg, 50.0 mg, 15.0 mg
Tablet, coated, Oral, Capsule, delayed release pellets, Capsule - Oral, , Tablet, Tablet, film coated - Oral, Capsule, delayed release - Oral, For solution, Solution - Oral, Tablet - Oral, Tablet, coated - Oral, Capsule, Liquid - Oral, Solution, Capsule, delayed release, Tablet, film coated, Kit, Liquid, Capsule, delayed release pellets - Oral, For solution - Oral
Obsessive-Compulsive Disorder
90.0 mg, , 40.0 mg, 20.0 mg, 10.0 mg, 20.0 mg/mL, 60.0 mg, 25.0 mg, 50.0 mg, 15.0 mg
Tablet, coated, Oral, Capsule, delayed release pellets, Capsule - Oral, , Tablet, Tablet, film coated - Oral, Capsule, delayed release - Oral, For solution, Solution - Oral, Tablet - Oral, Tablet, coated - Oral, Capsule, Liquid - Oral, Solution, Capsule, delayed release, Tablet, film coated, Kit, Liquid, Capsule, delayed release pellets - Oral, For solution - Oral
Premature Ejaculation
90.0 mg, , 40.0 mg, 20.0 mg, 10.0 mg, 20.0 mg/mL, 60.0 mg, 25.0 mg, 50.0 mg, 15.0 mg
Tablet, coated, Oral, Capsule, delayed release pellets, Capsule - Oral, , Tablet, Tablet, film coated - Oral, Capsule, delayed release - Oral, For solution, Solution - Oral, Tablet - Oral, Tablet, coated - Oral, Capsule, Liquid - Oral, Solution, Capsule, delayed release, Tablet, film coated, Kit, Liquid, Capsule, delayed release pellets - Oral, For solution - Oral

Warnings

Prozac Contraindications
Condition
Risk Level
Notes
Toxoplasma Infections
Do Not Combine
Toxoplasma Infections
Do Not Combine
Toxoplasma Infections
Do Not Combine
Toxoplasma Infections
Do Not Combine
Toxoplasma Infections
Do Not Combine
There are 20 known major drug interactions with Prozac.
Common Prozac Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The metabolism of Abemaciclib can be decreased when combined with Fluoxetine.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be decreased when combined with Fluoxetine.
Alectinib
Major
The metabolism of Alectinib can be decreased when combined with Fluoxetine.
Aminophylline
Major
The metabolism of Aminophylline can be decreased when combined with Fluoxetine.
Axitinib
Major
The metabolism of Axitinib can be decreased when combined with Fluoxetine.
Prozac Toxicity & Overdose RiskMost cases of fluoxetine overdose have mild, short-term side effects such as sleepiness, trembling, fast heart rate, nausea, and vomiting. However, in rare cases, serious symptoms may occur. For example, one patient took 1400mg of fluoxetine in a suicide attempt and had a seizure 3 hours later. Another patient took 1.2g of fluoxetine and experienced seizures, symptoms related to serotonin syndrome, and muscle breakdown.

Prozac Novel Uses: Which Conditions Have a Clinical Trial Featuring Prozac?

881 active clinical trials are being conducted to evaluate the efficacy of Prozac in treating Disease, Anorexia Nervosa and as a maintenance therapy.
Condition
Clinical Trials
Trial Phases
Depression
201 Actively Recruiting
Phase 2, Not Applicable, Phase 3, Phase 1, Phase 4, Early Phase 1
Disease
0 Actively Recruiting
Anorexia Nervosa
0 Actively Recruiting
maintenance therapy
0 Actively Recruiting
Cataplexy
6 Actively Recruiting
Phase 2, Phase 3, Not Applicable
Bulimia Nervosa
14 Actively Recruiting
Not Applicable, Phase 2, Phase 3, Early Phase 1
Bipolar Disorder
1 Actively Recruiting
Phase 4
Panic Disorder (With or Without Agoraphobia)
0 Actively Recruiting
moderate to severe symptoms
0 Actively Recruiting
Myoclonus
2 Actively Recruiting
Phase 2, Not Applicable
Depression
644 Actively Recruiting
Phase 2, Not Applicable, Phase 3, Phase 1, Early Phase 1, Phase 4
Obsessive-Compulsive Disorder
15 Actively Recruiting
Not Applicable, Phase 3
Unipolar Depression
52 Actively Recruiting
Not Applicable, Phase 2, Phase 4, Early Phase 1, Phase 3, Phase 1
Premature Ejaculation
0 Actively Recruiting
Alcoholism
8 Actively Recruiting
Phase 3, Not Applicable, Phase 2

Prozac Reviews: What are patients saying about Prozac?

5Patient Review
6/7/2022
Prozac for Depression
Prozac was very effective at treating my symptoms, but I experienced some significant weight gain as a result. L-Tryptophan was much more holistic in its approach and helped me feel better overall.
5Patient Review
8/30/2022
Prozac for Repeated Episodes of Anxiety
This medication has only been a part of my life for a short time, but it's already made such a big difference. I can think more clearly, sleep through the night, and feel more in control of my body and mind. The best part is that other people are noticing the changes too. My husband told me the other day that he hasn't seen me smile in years and this medicine helped him get his wife back. I'm so grateful for this treatment; it feels like I've gotten my life back.
4.7Patient Review
2/9/2022
Prozac for Major Depressive Disorder
Being on Prozac has definitely helped me get back to functioning like a normal person again. I'm so grateful for this medication!
4.7Patient Review
4/20/2022
Prozac for Depression
I was pretty dubious about this treatment at first, especially because it took a few weeks to see any effects. But I'm so glad I stuck with it! After increasing my dosage to 20mg, I've seen significant changes for the better in my mood and overall outlook on life.
4.3Patient Review
11/7/2022
Prozac for Premenstrual Disorder with a State of Unhappiness
I've tried a lot of different medications for my PMDD, and this is the only one that's really given me any relief. And it comes with very few side effects, if any.
4Patient Review
5/6/2022
Prozac for Bipolar Depression
Prozac has been a great addition to my bipolar depression medication. I've been on a low dose because Prozac can possibly trigger mania, but it really helps with my winter depression. As long as I monitor my moods, I haven't had any issues.
3.3Patient Review
5/18/2022
Prozac for Depression
I first tried prozac when I was 22. It worked well for a while, but then I stopped taking it. I went back on it when I was 40 and experienced more than 10 panic attacks per day. I thought it was the hospital environment that was causing the panic attacks, but after being discharged, the panic attacks continued. So, I got a new doctor who took me off the prozac immediately. Gradually, the panic attacks stopped.
3Patient Review
3/16/2022
Prozac for Depression
The medication was effective in that it helped me to relax; however, it did so to an extreme. I found myself unable to get upset about things that would normally bother me, and others commented that I seemed like a "robot" or "zombie." I stopped taking the medication after a month because I felt like it was numbing my emotions too much.
2.7Patient Review
11/9/2022
Prozac for Depression
Prozac completely disconnected me from my body and reality. It was like being hypnotized and in a trance, akin to the "sunken place" scene in Get Out. I strongly advise against this medication unless you have severe PTSD and no responsibilities.
2.3Patient Review
5/1/2022
Prozac for Posttraumatic Stress Syndrome
I have panic disorder and starting this medication was really tough because of the intense side effects. I tried different doses (10mg, 20mg, 30mg, 40mg) but none of them felt worth it to me. Yes, the panic stopped, but now I feel lifeless and like I can't enjoy intimacy anymore.
2Patient Review
8/11/2022
Prozac for Depression
Prozac did nothing to alleviate my depression and actually made me more irritable. Once I stopped taking it, the withdrawals were terrible despite my doctor telling me there would be none.
1.7Patient Review
4/2/2022
Prozac for Depression
My daughter was prescribed Prozac a week and a half ago, but it made her feel worse. So much so that she attempted suicide this past weekend. We've now experienced the negative effects of Prozac firsthand.
1.7Patient Review
9/24/2022
Prozac for Obsessive Compulsive Disorder
I tried this drug for my sexual intrusive thoughts, as prescribed by my doctor, but saw zero improvement even after increasing the dosage. If anything, my anxiety and thoughts got worse while taking it. I'm now on a different medication (anafranil) and would not recommend this drug to anyone.

Patient Q&A Section about prozac

What does Prozac do for a person?

"Fluoxetine, commonly known by the brand name Prozac, is a selective serotonin reuptake inhibitor (SSRI) antidepressant. It is generally considered safe and effective for treating depression, anxiety, OCD, and bulimia. However, some people may experience increased suicidal thoughts." - Anonymous Online Contributor

Unverified Answer

What are the side effects of taking Prozac?

"You may experience nausea, drowsiness, dizziness, anxiety, trouble sleeping, loss of appetite, tiredness, sweating, or yawning while taking this medication. Keep in mind that your doctor prescribed this medication because they believe the benefits of it are greater than the risks of any potential side effects." - Anonymous Online Contributor

Unverified Answer

How will Prozac make you feel?

"As Prozac begins to work, you may notice an increase in your energy levels. In some people, it may cause symptoms of mania, which include high energy levels, racing thoughts, trouble sleeping, and irritability." - Anonymous Online Contributor

Unverified Answer

Is Prozac a happy pill?

"The original "happy pill” Prozac was approved for use in 1987. It was the first drug prescribed and marketed on a large scale for the treatment of depression. The use of Prozac is very common, but it is not without its risks." - Anonymous Online Contributor

Unverified Answer

How does Prozac make you feel?

"As Prozac begins to take effect, you may notice an increase in your energy levels. In some cases, it may cause symptoms of mania in some people taking this medication. Symptoms of mania include high energy levels, racing thoughts, trouble sleeping, and irritability." - Anonymous Online Contributor

Unverified Answer

What is a major side effect of Prozac?

"The following effects may occur: nausea, drowsiness, dizziness, anxiety, trouble sleeping, loss of appetite, tiredness, sweating, or yawning. If you experience any of these effects for an extended period of time, or if they worsen, tell your doctor." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Clinical Trials for Prozac

Image of Icahn School of Medicine at Mount Sinai, Mount Sinai West in New York, United States.
Phase-Based Progress Estimates
1
Effectiveness
1
Safety

Deep Brain Stimulation (DBS) For Treatment Resistant Depressionfor Major Depressive Disorder

25 - 70
All Sexes
New York, NY
Of the estimated 30 million Americans who suffer from Major Depressive Disorder, approximately 10% are considered treatment resistant. Deep brain stimulation (DBS) to a region of the brain called the subcallosal cingulate (SCC) is an emerging strategy for treatment resistant depression (TRD), which involves placement of electrodes in a specific region of the brain and stimulating that area with electricity. This is believed to reset the brain network responsible for symptoms and results in a significant antidepressant response. A series of open-label studies have demonstrated sustained, long-term antidepressant effects in 40-60% of patients who received this treatment. A challenge to the effective dissemination of this fledgling treatment is the absence of biomarkers (objective, measureable indications of the state of the body and brain) to guide device placement and select stimulation parameters during follow-up care. By using a DBS device called the Percept PC (Medtronic, Inc) which has the ability to both deliver stimulation to and record electrical signals directly from the brain, this study aims to identify changes in local field potentials (LFPs), specific electrical signals that are thought to represent how the brain communicates information from one region to another, to see how this relates to DBS parameter settings and patient depressive symptomatology. The goal of this study is to study LFPs before and during active DBS stimulation to identify changes that correlate with the antidepressant effects of SCC DBS. The study team will recruit 10 patients with TRD and implant them with the Percept PC system. Participants will be asked to complete short questionnaires and collect LFP data twice daily for the first year of the study, as well as have weekly in person research procedures and assessments with the study team for up to one year. These include meetings with the study psychiatrist, psychologist, symptom ratings, and movement, voice, and video recordings. A brief discontinuation experiment will be conducted after 6 months of stimulation, in which the stimulation will be turned off and patterns of LFP changes will be recorded. The entire study is expected to last about 5 years, parcellated into several study phases. All participants are required to live in the New York metropolitan area for the first several months of the study.
Recruiting
Has No Placebo
Icahn School of Medicine at Mount Sinai, Mount Sinai WestHelen Mayberg, MD
Have you considered Prozac clinical trials? We made a collection of clinical trials featuring Prozac, we think they might fit your search criteria.
Have you considered Prozac clinical trials? We made a collection of clinical trials featuring Prozac, we think they might fit your search criteria.
Have you considered Prozac clinical trials? We made a collection of clinical trials featuring Prozac, we think they might fit your search criteria.
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