Protamine Sulfate
heparin
Treatment
1 FDA approval
0 Active Studies for Protamine Sulfate
Treatment for
heparin
What is Protamine Sulfate
Protamine sulfate
The Generic name of this drug
Treatment Summary
Protamine sulfate is a medication used to reverse the effects of heparin, a blood thinner used in surgeries. It has been used for over 77 years and is the only viable option for reversing heparin effect. While it is usually effective, it can cause severe side effects like low blood pressure, lung pressure, and organ damage. Doctors must be careful when considering using protamine sulfate as it could worsen recovery in patients or make the procedure less safe. Although there are alternatives to protamine sulfate, most of them have similar side effects and can be expensive or limited in their effectiveness.
Protamine Sulfate
is the brand name
Protamine Sulfate Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Protamine Sulfate
Protamine sulfate
2000
3
Approved as Treatment by the FDA
Protamine sulfate, also known as Protamine Sulfate, is approved by the FDA for 1 uses like heparin .
heparin
Effectiveness
How Protamine Sulfate Affects Patients
When not combined with heparin, protamine sulfate alone has a weak blood thinning effect. It may also help regulate blood sugar levels when used as an ingredient in certain insulin injections. Animal studies suggest that taking it orally for a long time may help lower cholesterol, decrease fat absorption in the intestine, and have some antibacterial properties. Additionally, protamine sulfate affects two clotting factors in the body (human factor Xa and human antithrombin). It can convert and degrade factor Xa into inactive parts, transform Xa-AT complexes, break down primary Xa-AT complexes into tertiary complexes, and
How Protamine Sulfate works in the body
Protamine sulfate is used to counteract the effects of heparin, a blood-thinning medication. It binds to heparin, forming an inactive complex that neutralizes heparin's anticoagulant properties. This helps to prevent or stop bleeding caused by an overdose of heparin or low-molecular weight heparin. It is also used to reverse the effects of heparin given before surgery or during certain medical procedures.
When to interrupt dosage
The recommended dosage of Protamine Sulfate is contingent upon the indicated condition. The quantity of dosage varies, depending on the method of delivery outlined in the table below.
Condition
Dosage
Administration
heparin
10.0 mg/mL,
, Injection, solution, Intravenous, Injection, solution - Intravenous, Solution, Solution - Intravenous, Liquid, Liquid - Intravenous
Warnings
Common Protamine Sulfate Drug Interactions
Drug Name
Risk Level
Description
Protamine Sulfate Toxicity & Overdose Risk
Taking too much protamine sulfate can cause a sudden drop in blood pressure, difficulty breathing, slowed heart rate, lung pressure, and allergic reactions. Nausea, vomiting, fatigue, and bleeding may also occur. There is no evidence of any cancer-causing, gene-altering, or other harm to pregnant women, newborns, children, or elderly people.
Protamine Sulfate Novel Uses: Which Conditions Have a Clinical Trial Featuring Protamine Sulfate?
Zero active clinical trials are presently being conducted to explore the potential of Protamine Sulfate in the treatment of heparin-related conditions.
Condition
Clinical Trials
Trial Phases
heparin
0 Actively Recruiting
Patient Q&A Section about protamine sulfate
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
How is protamine sulfate given?
"Protamine sulfate should be slowly injected into a vein over the course of 10 minutes. A maximum of 50mg should be given in one dose."
Answered by AI
How does protamine sulfate work?
"Protamine is an effective medication for reversing and counteracting the anticoagulant effects of heparin. It is the specific agent that is able to effectively neutralize heparin's ability to promote blood clotting."
Answered by AI
What is protamine sulfate injection used for?
"Protamine sulfate is used to stop the blood-thinning effects of heparin. This can be before surgery, after surgery, if there is too much bleeding, or if too much heparin has been given by mistake."
Answered by AI
Is protamine sulphate an anticoagulant?
"0b013e3181debc86
In the presence of platelets or elevated factor VIII concentrations, the anticoagulant effect of protamine sulfate is not as strong."
Answered by AI