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What is Promacta
EltrombopagThe Generic name of this drug
Treatment SummaryEltrombopag is a medication used to treat low platelet counts in adults with chronic immune thrombocytopenia (ITP), when other treatments such as surgery have not been effective. It is also approved for use in people with hepatitis C to help them start and maintain interferon-based therapy. Eltrombopag can help reduce unusual bruising and bleeding caused by having too few platelets in the blood.
Promactais the brand name
Promacta Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Promacta
Eltrombopag
2008
13
Effectiveness
How Promacta works in the bodyEltrombopag is a drug taken orally that helps to increase platelet counts. It does this by interacting with and stimulating a specific protein in the body, called the TPO-receptor. This stimulation causes platelet production to increase, and potentially other lineages as well. It does not activate the AKT pathway, which means that it does not work in the same way as other drugs used to treat aplastic anemia.
When to interrupt dosage
The proposed dosage of Promacta is dependent upon the diagnosed disorder, including Aplastic Anemia, Chronic Hepatitis C and Low Platelet Count. The quantity of dosage can be deduced from the table below, contingent upon the delivery system (e.g. Tablet - Oral or Oral).Condition
Dosage
Administration
Immunosuppressive Treatment
100.0 mg, , 75.0 mg, 50.0 mg, 25.0 mg, 12.5 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Powder, for suspension, Powder, for suspension - Oral
Chronic Hepatitis C
100.0 mg, , 75.0 mg, 50.0 mg, 25.0 mg, 12.5 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Powder, for suspension, Powder, for suspension - Oral
Aplastic Anemia
100.0 mg, , 75.0 mg, 50.0 mg, 25.0 mg, 12.5 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Powder, for suspension, Powder, for suspension - Oral
Low Platelet Count
100.0 mg, , 75.0 mg, 50.0 mg, 25.0 mg, 12.5 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Powder, for suspension, Powder, for suspension - Oral
chronic immune thrombocytopenia
100.0 mg, , 75.0 mg, 50.0 mg, 25.0 mg, 12.5 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Powder, for suspension, Powder, for suspension - Oral
Treatment Naive
100.0 mg, , 75.0 mg, 50.0 mg, 25.0 mg, 12.5 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Powder, for suspension, Powder, for suspension - Oral
Therapeutic procedure
100.0 mg, , 75.0 mg, 50.0 mg, 25.0 mg, 12.5 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Powder, for suspension, Powder, for suspension - Oral
Interferon Treatment
100.0 mg, , 75.0 mg, 50.0 mg, 25.0 mg, 12.5 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Powder, for suspension, Powder, for suspension - Oral
Therapeutic immunosuppression
100.0 mg, , 75.0 mg, 50.0 mg, 25.0 mg, 12.5 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Powder, for suspension, Powder, for suspension - Oral
inadequate response to other therapeutic measures
100.0 mg, , 75.0 mg, 50.0 mg, 25.0 mg, 12.5 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Powder, for suspension, Powder, for suspension - Oral
Warnings
There are 20 known major drug interactions with Promacta.Common Promacta Drug Interactions
Drug Name
Risk Level
Description
Amiodarone
Major
The metabolism of Amiodarone can be decreased when combined with Eltrombopag.
Axitinib
Major
The metabolism of Axitinib can be decreased when combined with Eltrombopag.
Belinostat
Major
The metabolism of Belinostat can be decreased when combined with Eltrombopag.
Binimetinib
Major
The metabolism of Binimetinib can be decreased when combined with Eltrombopag.
Brigatinib
Major
The metabolism of Brigatinib can be decreased when combined with Eltrombopag.
Promacta Toxicity & Overdose RiskTaking eltrombopag can cause liver damage, especially if combined with interferon and ribavirin when treating chronic hepatitis C. This can increase the risk of liver failure.
Promacta Novel Uses: Which Conditions Have a Clinical Trial Featuring Promacta?
59 active clinical trials are currently being conducted to assess the efficacy of Promacta in relieving Aplastic Anemia, Low Platelet Count and Thrombocytopenia.Condition
Clinical Trials
Trial Phases
Chronic Hepatitis C
0 Actively Recruiting
inadequate response to other therapeutic measures
0 Actively Recruiting
Immunosuppressive Treatment
0 Actively Recruiting
Aplastic Anemia
16 Actively Recruiting
Phase 2, Phase 1, Phase 3
chronic immune thrombocytopenia
0 Actively Recruiting
Treatment Naive
0 Actively Recruiting
Low Platelet Count
7 Actively Recruiting
Phase 2, Not Applicable, Phase 1, Early Phase 1
Interferon Treatment
0 Actively Recruiting
Therapeutic procedure
0 Actively Recruiting
Therapeutic immunosuppression
0 Actively Recruiting
Promacta Reviews: What are patients saying about Promacta?
5Patient Review
8/18/2011 Promacta has been an absolute lifesaver for me. If you're struggling with chronic ITP, it's definitely worth considering this treatment option. Just be sure to talk to your hematologist first and be aware of the potential side effects.
5Patient Review
9/6/2009 This treatment has been crucial in maintaining my platelet count above 200. It's easy to take and I don't have to go for a platelet transfusion every week like I used to.
4.7Patient Review
9/22/2010 I have been taking 50mg Promacta for about 3 weeks now and platelets have risen from 34 to 140. So far, the only side effect I think is mild indigestion. This medication has been working well for me so far and I'm hopeful that my platelet count will continue to rise.
4.7Patient Review
7/15/2011 I've been on Promacta for about two years now and it has really helped to regulate my platelet levels. I was getting monthly blood tests anyway, but they've all come back looking good since I started this medication.
4.3Patient Review
1/29/2010 My platelet count has stayed at a steady 90,000 since I began this treatment; however, I have developed watery eyes and my hair has lost its curl. Additionally, my blood pressure has risen to an unhealthy 170/103. As a result, I now have to take more medication for high blood pressure. My insurance company isn't thrilled about the price tag of this drug, but it seems to be working well for me so far.
Patient Q&A Section about promacta
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What are the side effects of PROMACTA?
"The most common side effects of the medication are nausea, diarrhea, and an upper respiratory tract infection, which may include a runny nose, stuffy nose, and sneezing. Other common side effects include vomiting and a urinary tract infection."
Answered by AI
What type of medication is PROMACTA?
"This medication is used to treat low platelet levels in people who have a certain blood disorder called chronic immune (idiopathic) thrombocytopenia purpura (ITP). It may also be used to treat people with a certain blood disorder (aplastic anemia)."
Answered by AI
What is PROMACTA used for?
"PROMACTA is a prescription medicine used to increase blood platelet counts in adults and children who have persistent or chronic immune thrombocytopenia (ITP). PROMACTA may be used when other medicines to treat ITP or surgery to remove the spleen have not worked well enough."
Answered by AI
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