Primacor

Cardiac monitoring, Congestive Heart Failure, Heart Failure

Treatment

19 Active Studies for Primacor

Treatment for

Cardiac monitoring

What is Primacor

MilrinoneThe Generic name of this drug

Treatment SummaryMilrinone is a medication used to treat heart failure, a condition in which the heart is not able to pump enough blood and oxygen to the body. It increases levels of a molecule called cAMP, which helps the heart contract and improve blood flow. Milrinone was created in the 1980s and was approved by the FDA in 1987. It was sold under the brand name PRIMACOR® by Sanofi-Aventis US, but has since been discontinued.

Primacoris the brand name

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Primacor Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Primacor

Milrinone

1987

Effectiveness

How Primacor Affects PatientsMilrinone is a medicine that helps the heart work better by improving its pumping and relaxing blood vessels, but with minimal effect on heart rate. It is used to treat congestive heart failure. However, it can also cause an increased risk of ventricular arrhythmias and sudden death, so it should only be used for up to 48 hours. Additionally, the dose may need to be adjusted in patients with kidney problems as milrinone is mainly excreted by the kidneys.

How Primacor works in the bodyMilrinone is a drug used to treat heart failure. It works by stopping an enzyme called phosphodiesterase III, which stops the production of a chemical called cAMP. cAMP is responsible for making the heart beat stronger and more efficiently. It can also widen the blood vessels to help with circulation. Since milrinone stops the enzyme, it increases cAMP levels, even in people whose bodies are not responding well to other treatments. This makes it a good option for people with desensitized or downregulated beta-adrenergic receptors.

When to interrupt dosage

The advised dose of Primacor is contingent upon the diagnosed circumstance, including Acute Decompensated Heart Failure (ADHF), Cardiac observation and Congestive Heart Failure. The dosage is dependent on the administration technique (e.g. Injection, solution - Intravenous or Injection, solution) detailed in the table beneath.

Condition

Dosage

Administration

Cardiac monitoring

, 2.0 mg/mL, 1.0 mg/mL, 5.0 mg/mL, 0.2 mg/mL

, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, Injection - Intravenous, Solution, Solution - Intravenous

Congestive Heart Failure

, 2.0 mg/mL, 1.0 mg/mL, 5.0 mg/mL, 0.2 mg/mL

, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, Injection - Intravenous, Solution, Solution - Intravenous

Heart Failure

, 2.0 mg/mL, 1.0 mg/mL, 5.0 mg/mL, 0.2 mg/mL

, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, Injection - Intravenous, Solution, Solution - Intravenous

Warnings

Primacor has one contraindication, thus it should be avoided for any of the circumstances indicated in the table below.Primacor Contraindications

Condition

Risk Level

Notes

Severe Hypersensitivity Reactions

Do Not Combine

Milrinone may interact with Pulse Frequency

There are 20 known major drug interactions with Primacor.

Common Primacor Drug Interactions

Drug Name

Risk Level

Description

Amrinone

Major

The risk or severity of congestive heart failure, bleeding, hypotension, and Tachycardia can be increased when Milrinone is combined with Amrinone.

Anagrelide

Major

The risk or severity of congestive heart failure, bleeding, hypotension, and Tachycardia can be increased when Milrinone is combined with Anagrelide.

Cilostazol

Major

The risk or severity of congestive heart failure, bleeding, hypotension, and Tachycardia can be increased when Milrinone is combined with Cilostazol.

Enoximone

Major

The risk or severity of congestive heart failure, bleeding, hypotension, and Tachycardia can be increased when Milrinone is combined with Enoximone.

Abacavir

Minor

Milrinone may decrease the excretion rate of Abacavir which could result in a higher serum level.

Primacor Toxicity & Overdose RiskThere is limited information about how toxic milrinone is. Taking too much may lead to dangerously low blood pressure and abnormal heart rhythms. Treatment for an overdose should focus on relieving symptoms and providing support.

Primacor Novel Uses: Which Conditions Have a Clinical Trial Featuring Primacor?

36 active trials are presently researching the utility of Primacor in the management of Congestive Heart Failure, Cardiac monitoring and Acute Decompensated Heart Failure (ADHF).

Condition

Clinical Trials

Trial Phases

Heart Failure

7 Actively Recruiting

Not Applicable, Phase 4, Phase 1, Phase 2, Phase 3

Congestive Heart Failure

12 Actively Recruiting

Not Applicable, Phase 1, Phase 2

Cardiac monitoring

0 Actively Recruiting

Primacor Reviews: What are patients saying about Primacor?

4.7Patient Review

4/21/2017

Primacor for Suddenly Serious Symptoms of Heart Failure

I was in organ failure and on life support when I woke up to find that I was in stage 4 CHF. My doctors put me on Primacor, which saved my life but had some serious side effects that no one saw coming. It was worth it to save my life before they tried cutting me open.

4.3Patient Review

10/2/2008

Primacor for Chronic Heart Failure Not Suddenly Currently Controlled by Medication

This medication has improved my quality of life greatly. I only wish that it was available in pill form instead of the current liquid form.

4.3Patient Review

4/26/2013

Primacor for Heart Failure

I've only just started this treatment, but things are looking promising so far.

3.3Patient Review

7/27/2009

Primacor for Chronic Heart Failure

This treatment is helping my patient with end stage COPD. Their chest x-ray showed a right lower lobe infiltrate, bilateral pleural effusion and pulmonary edema. It's possible they have atypical pneumonia with microplasma. They are currently on Ativan IV PRN, Lasix 80mg IV three times daily, and continuous bipap except for eating. Their BUN is currently 41, creatine clearance 1.2.

1Patient Review

11/27/2013

Primacor for Chronic Heart Failure

End-of-life care in hospice was not up to my standards.

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Patient Q&A Section about primacor

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is PRIMACOR the same as milrinone?

"Milrinone, sold as Primacor, is a drug that improves heart function and reduces pulmonary artery pressure. It does this by inhibiting an enzyme that ordinarily would reduce the heart's output."

Answered by AI

What is PRIMACOR used for?

"This medication is used to relieve symptoms of heart failure. By increasing the strength of your heart beat and relaxing certain blood vessels, it allows your heart to pump more blood. This can help reduce symptoms of heart failure, such as shortness of breath and fatigue."

Answered by AI

What type of drug is PRIMACOR?

"Primacor IV is a prescription medicine that is used to relieve the symptoms of congestive heart failure. It may be used alone or in combination with other drugs. Primacor IV is classified as an inotropic agent and a phosphodiesterase-3 enzyme inhibitor."

Answered by AI

What is milrinone used for?

"Milrinone is a medication typically used to support cardiac function in patients with acute heart failure, pulmonary hypertension, or chronic heart failure."

Answered by AI

Clinical Trials for Primacor

Have you considered Primacor clinical trials? We made a collection of clinical trials featuring Primacor, we think they might fit your search criteria.

Have you considered Primacor clinical trials? We made a collection of clinical trials featuring Primacor, we think they might fit your search criteria.