Pergolide Mesylate

Parkinson's Disease
Treatment
1 FDA approval
20 Active Studies for Pergolide Mesylate

What is Pergolide Mesylate

PergolideThe Generic name of this drug
Treatment SummaryPergolide was designed to treat Parkinson’s Disease and was approved for use in 1982. It works by activating dopamine receptors and other related receptors in the body. Later, it was found to increase the risk of heart valve problems and was withdrawn from the US and Canadian markets in 2007. Nowadays, Pergolide is mainly used for veterinary purposes and is only approved for human use in some countries.
Pergolide Mesylateis the brand name
image of different drug pills on a surface
Pergolide Mesylate Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Pergolide Mesylate
Pergolide
2002
9

Approved as Treatment by the FDA

Pergolide, also known as Pergolide Mesylate, is approved by the FDA for 1 uses such as Parkinson's Disease .
Parkinson's Disease
Used to treat Parkinson's Disease (PD) in combination with Carbidopa

Effectiveness

How Pergolide Mesylate Affects PatientsPergolide is a drug used to help treat Parkinson's disease. It works by activating the dopamine receptors in the brain, which helps to regulate muscle activity, balance, and walking. It can also increase the risk of hallucinations and delusions, as well as causing restlessness, involuntary movements, and neuroleptic malignant syndrome. Pergolide also affects hormones in the body, reducing prolactin secretion and increasing growth hormone and decreasing luteinizing hormone.
How Pergolide Mesylate works in the bodyThe dopamine D2 receptor is a protein on the surface of cells that binds to dopamine. When this happens, the cell stops sending signals to increase calcium levels. This can block the release of calcium from inside cells, as well as prevent calcium from entering the cell. It can also stop the cell from sending signals to grow and divide. Lastly, when dopamine binds to this receptor in certain brain regions, it can improve coordination in people with movement disorders.

When to interrupt dosage

The suggested measure of Pergolide Mesylate relies on the diagnosed condition. The dosage fluctuates as indicated by the method of administration (e.g. Oral or Tablet) provided in the following table.
Condition
Dosage
Administration
Parkinson's Disease
, 0.05 mg, 0.25 mg, 1.0 mg
, Oral, Tablet, Tablet - Oral

Warnings

Pergolide Mesylate Contraindications
Condition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Pergolide may interact with Pulse Frequency
Severe Hypersensitivity Reactions
Do Not Combine
Pergolide may interact with Pulse Frequency
There are 20 known major drug interactions with Pergolide Mesylate.
Common Pergolide Mesylate Drug Interactions
Drug Name
Risk Level
Description
4-Bromo-2,5-dimethoxyphenethylamine
Major
Pergolide may increase the hypertensive and vasoconstricting activities of 4-Bromo-2,5-dimethoxyphenethylamine.
4-Methoxyamphetamine
Major
Pergolide may increase the hypertensive and vasoconstricting activities of 4-Methoxyamphetamine.
5-methoxy-N,N-dimethyltryptamine
Major
Pergolide may increase the vasoconstricting activities of 5-methoxy-N,N-dimethyltryptamine.
Abediterol
Major
Pergolide may increase the hypertensive and vasoconstricting activities of Abediterol.
Adrafinil
Major
Pergolide may increase the hypertensive and vasoconstricting activities of Adrafinil.
Pergolide Mesylate Toxicity & Overdose RiskThe lowest toxic dose of the drug in rats has been found to be 15mg/kg. Overdosing can lead to nausea, vomiting, seizures, low blood pressure, and increased activity in the central nervous system.
image of a doctor in a lab doing drug, clinical research

Pergolide Mesylate Novel Uses: Which Conditions Have a Clinical Trial Featuring Pergolide Mesylate?

45 active trials are currently in progress to evaluate the potential of Pergolide Mesylate in managing Parkinson's Disease.
Condition
Clinical Trials
Trial Phases
Parkinson's Disease
46 Actively Recruiting
Phase 3, Not Applicable, Phase 1, Phase 2, Early Phase 1

Patient Q&A Section about pergolide mesylate

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is pergolide mesylate a dopamine agonist?

"Dopamine agonist pergolide mesylate is the best treatment for PPID and is now legally allowed to be used on horses in many countries."

Answered by AI

What is pergolide used for?

"Pergolide is a drug that is used to treat Parkinson's disease in some countries by activating dopamine receptors."

Answered by AI

Why was pergolide taken off the market?

"The FDA today announced that manufacturers of pergolide drugs will voluntarily remove them from the market because of the risk of serious damage to patients' heart valves."

Answered by AI

What is pergolide mesylate?

"Pergolide mesylate is a long-acting dopamine agonist that was approved in 1982 for the treatment of Parkinson's disease. It is an ergot derivative that acts on the dopamine D2 and D3, alpha2- and alpha1-adrenergic, and 5-hydroxytryptamine (5-HT) receptors."

Answered by AI

Clinical Trials for Pergolide Mesylate

Have you considered Pergolide Mesylate clinical trials? We made a collection of clinical trials featuring Pergolide Mesylate, we think they might fit your search criteria.
Have you considered Pergolide Mesylate clinical trials? We made a collection of clinical trials featuring Pergolide Mesylate, we think they might fit your search criteria.
Have you considered Pergolide Mesylate clinical trials? We made a collection of clinical trials featuring Pergolide Mesylate, we think they might fit your search criteria.