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What is Paricalcitol
ParicalcitolThe Generic name of this drug
Treatment SummaryParicalcitol is a type of synthetic vitamin D that helps lower parathyroid hormone levels. It is used to prevent and treat high levels of parathyroid hormone in people with chronic kidney disease.
Zemplaris the brand name
Paricalcitol Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Zemplar
Paricalcitol
1998
84
Approved as Treatment by the FDA
Paricalcitol, also known as Zemplar, is approved by the FDA for 4 uses which include Chronic Kidney Disease, Stage 3 (Moderate) and Stage 4 Chronic Kidney Disease .Chronic Kidney Disease, Stage 3 (Moderate)
Stage 4 Chronic Kidney Disease
Hyperparathyroidism, Secondary
Hyperparathyroidism, Secondary
Effectiveness
How Paricalcitol Affects PatientsSecondary hyperparathyroidism is a condition in which the body has too much of the hormone parathyroid hormone (PTH) due to inadequate levels of active vitamin D. Vitamin D helps form and maintain normal bones and is created in the skin and from food. Vitamin D needs to be changed in the liver and kidneys before it works properly. When the kidneys are not healthy, the activation of vitamin D is lowered, causing PTH to rise. This leads to problems with calcium and phosphorus levels in the body and can cause renal osteodystrophy (loss of bone mass). Paricalcitol is a drug that helps regulate P
How Paricalcitol works in the bodyParicalcitol is a man-made version of vitamin D that works to reduce parathyroid hormone levels. It does this by binding to the vitamin D receptor and activating pathways that respond to vitamin D. This helps stop the body from making too much parathyroid hormone.
When to interrupt dosage
The suggested dosage of Paricalcitol is contingent upon the determined disorder, including Hyperparathyroidism, Secondary, Hemodialysis and Stage 4 Chronic Kidney Disease. The measure of dosage differs as outlined by the technique of delivery outlined in the table below.Condition
Dosage
Administration
Hyperparathyroidism, Secondary
, 0.005 mg/mL, 0.002 mg/mL, 0.001 mg, 0.002 mg, 0.004 mg, 1.0 mg, 2.0 mg, 4.0 mg, 0.01 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, Injection - Intravenous, Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Capsule, Capsule - Oral, Solution, Solution - Intravenous
Hyperparathyroidism, Secondary
, 0.005 mg/mL, 0.002 mg/mL, 0.001 mg, 0.002 mg, 0.004 mg, 1.0 mg, 2.0 mg, 4.0 mg, 0.01 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, Injection - Intravenous, Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Capsule, Capsule - Oral, Solution, Solution - Intravenous
Chronic Kidney Disease, Stage 3 (Moderate)
, 0.005 mg/mL, 0.002 mg/mL, 0.001 mg, 0.002 mg, 0.004 mg, 1.0 mg, 2.0 mg, 4.0 mg, 0.01 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, Injection - Intravenous, Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Capsule, Capsule - Oral, Solution, Solution - Intravenous
Stage 4 Chronic Kidney Disease
, 0.005 mg/mL, 0.002 mg/mL, 0.001 mg, 0.002 mg, 0.004 mg, 1.0 mg, 2.0 mg, 4.0 mg, 0.01 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, Injection - Intravenous, Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Capsule, Capsule - Oral, Solution, Solution - Intravenous
Warnings
There are 20 known major drug interactions with Paricalcitol.Common Paricalcitol Drug Interactions
Drug Name
Risk Level
Description
Sucralfate
Major
The serum concentration of Sucralfate can be increased when it is combined with Paricalcitol.
1alpha,24S-Dihydroxyvitamin D2
Moderate
The risk or severity of adverse effects can be increased when Paricalcitol is combined with 1alpha,24S-Dihydroxyvitamin D2.
1alpha-Hydroxyvitamin D5
Moderate
The risk or severity of adverse effects can be increased when Paricalcitol is combined with 1alpha-Hydroxyvitamin D5.
Acetyldigitoxin
Moderate
The risk or severity of ventricular arrhythmias and Cardiac Arrhythmia can be increased when Paricalcitol is combined with Acetyldigitoxin.
Acetyldigoxin
Moderate
The risk or severity of ventricular arrhythmias and Cardiac Arrhythmia can be increased when Paricalcitol is combined with Acetyldigoxin.
Paricalcitol Novel Uses: Which Conditions Have a Clinical Trial Featuring Paricalcitol?
Fifteen clinical trials are assessing the potential of Paricalcitol to control Stage 4 Chronic Kidney Disease, Chronic Kidney Disease Stage 3 (Moderate) and Hemodialysis.Condition
Clinical Trials
Trial Phases
Hyperparathyroidism, Secondary
5 Actively Recruiting
Phase 3
Stage 4 Chronic Kidney Disease
5 Actively Recruiting
Not Applicable, Phase 4, Phase 1, Phase 2, Phase 3
Hyperparathyroidism, Secondary
0 Actively Recruiting
Chronic Kidney Disease, Stage 3 (Moderate)
5 Actively Recruiting
Not Applicable, Phase 3, Phase 2
Paricalcitol Reviews: What are patients saying about Paricalcitol?
4.7Patient Review
9/1/20083.3Patient Review
3/26/20103Patient Review
6/27/2011Patient Q&A Section about paricalcitol
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Is paricalcitol a steroid?
"It is a seco-cholestane and a hydroxy seco-steroid derivative.
Paricalcitol is a seco-cholestane and a hydroxy seco-steroid. It acts as an antiparathyroid drug. It is a seco-cholestane and a hydroxy seco-steroid derivative."
Answered by AI
What is another name for paricalcitol?
"Zemplar (paricalcitol) Injection is a form of vitamin d that is indicated for the prevention and treatment of secondary hyperparathyroidism associated with chronic kidney disease Stage 5."
Answered by AI
Is paricalcitol a vitamin D?
"A synthetic form of vitamin D2 called paricalcitol was created to treat secondary hyperthyroidism connected to chronic renal failure."
Answered by AI
What is paricalcitol prescribed for?
"Paricalcitol is used to treat and prevent hyperparathyroidism in patients with chronic kidney disease who are on dialysis. Hyperparathyroidism is a condition caused by the parathyroid glands located in the neck making too much parathyroid hormone (PTH)."
Answered by AI