Ortho Evra

Birth Control, Acne Vulgaris, Folate supplementation therapy + 5 more
Treatment
1 FDA approval
20 Active Studies for Ortho Evra

What is Ortho Evra

EthinylestradiolThe Generic name of this drug
Treatment SummaryEthinylestradiol is a synthetic form of the hormone estrogen. It was created in 1938 and is used in birth control pills. It has a higher rate of absorption in the body than other forms of estrogen, making it more effective. Ethinylestradiol was officially approved by the FDA in 1943.
LOESTRIN Fe 1.5/30is the brand name
image of different drug pills on a surface
Ortho Evra Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
LOESTRIN Fe 1.5/30
Ethinylestradiol
1973
679

Approved as Treatment by the FDA

Ethinylestradiol, also known as LOESTRIN Fe 1.5/30, is approved by the FDA for 1 uses including Birth Control .
Birth Control
Used to treat Contraception in combination with Levonorgestrel

Effectiveness

How Ortho Evra Affects PatientsEthinylestradiol is a type of synthetic estrogen that helps stop the body from releasing hormones that can lead to ovulation and thickening of the womb lining. It stays in the body for a long time after taking it, and it is generally safe even at higher doses. However, patients should be warned that this drug can increase the risk of blood clots.
How Ortho Evra works in the bodyEthinylestradiol is a synthetic form of estrogen that has several effects on the body. It can reduce bone density, suppress ovulation, and thicken cervical mucus to prevent pregnancy. It also decreases luteinizing hormone and increases sex hormone binding globulin. These changes work together to prevent pregnancy.

When to interrupt dosage

The proposed measure of Ortho Evra is subject to the diagnosed condition, such as Acne Vulgaris, Hormonal Contraception and Folate supplementation therapy. The amount of dosage changes in accordance with the administration technique depicted in the table beneath.
Condition
Dosage
Administration
Birth Control
, 0.02 mg, 0.0025 mg, 0.03 mg, 0.0035 mg/hour, 0.005 mg, 2.7 mg, 0.035 mg, 0.6 mg, 2.6 mg, 0.05 mg, 0.5 mg, 0.75 mg, 0.025 mg, 0.0015 mg/hour, 0.04 mg, 0.01 mg, 1.0 mg, 0.075 mg, 0.105 mg, 0.07 mg, 0.1 mg, 0.75 mg/[USP'U], 0.0075 mg/hour, 17.4 mg, 0.085 mg, 2.3 mg
, Kit, Tablet - Oral, Oral, Tablet, Kit - Oral, Patch, extended release, Patch, extended release - Transdermal, Transdermal, Insert, extended release, Vaginal, Insert, extended release - Vaginal, Ring - Vaginal, Ring, Tablet, chewable, Tablet, chewable - Oral, Tablet, film coated, Tablet, film coated - Oral, Patch, Patch - Transdermal, Capsule, Capsule - Oral
Menopausal Osteoporosis
, 0.02 mg, 0.0025 mg, 0.03 mg, 0.0035 mg/hour, 0.005 mg, 2.7 mg, 0.035 mg, 0.6 mg, 2.6 mg, 0.05 mg, 0.5 mg, 0.75 mg, 0.025 mg, 0.0015 mg/hour, 0.04 mg, 0.01 mg, 1.0 mg, 0.075 mg, 0.105 mg, 0.07 mg, 0.1 mg, 0.75 mg/[USP'U], 0.0075 mg/hour, 17.4 mg, 0.085 mg, 2.3 mg
, Kit, Tablet - Oral, Oral, Tablet, Kit - Oral, Patch, extended release, Patch, extended release - Transdermal, Transdermal, Insert, extended release, Vaginal, Insert, extended release - Vaginal, Ring - Vaginal, Ring, Tablet, chewable, Tablet, chewable - Oral, Tablet, film coated, Tablet, film coated - Oral, Patch, Patch - Transdermal, Capsule, Capsule - Oral
Mild to Moderate Acne
, 0.02 mg, 0.0025 mg, 0.03 mg, 0.0035 mg/hour, 0.005 mg, 2.7 mg, 0.035 mg, 0.6 mg, 2.6 mg, 0.05 mg, 0.5 mg, 0.75 mg, 0.025 mg, 0.0015 mg/hour, 0.04 mg, 0.01 mg, 1.0 mg, 0.075 mg, 0.105 mg, 0.07 mg, 0.1 mg, 0.75 mg/[USP'U], 0.0075 mg/hour, 17.4 mg, 0.085 mg, 2.3 mg
, Kit, Tablet - Oral, Oral, Tablet, Kit - Oral, Patch, extended release, Patch, extended release - Transdermal, Transdermal, Insert, extended release, Vaginal, Insert, extended release - Vaginal, Ring - Vaginal, Ring, Tablet, chewable, Tablet, chewable - Oral, Tablet, film coated, Tablet, film coated - Oral, Patch, Patch - Transdermal, Capsule, Capsule - Oral
Patient desires oral contraception for birth control
, 0.02 mg, 0.0025 mg, 0.03 mg, 0.0035 mg/hour, 0.005 mg, 2.7 mg, 0.035 mg, 0.6 mg, 2.6 mg, 0.05 mg, 0.5 mg, 0.75 mg, 0.025 mg, 0.0015 mg/hour, 0.04 mg, 0.01 mg, 1.0 mg, 0.075 mg, 0.105 mg, 0.07 mg, 0.1 mg, 0.75 mg/[USP'U], 0.0075 mg/hour, 17.4 mg, 0.085 mg, 2.3 mg
, Kit, Tablet - Oral, Oral, Tablet, Kit - Oral, Patch, extended release, Patch, extended release - Transdermal, Transdermal, Insert, extended release, Vaginal, Insert, extended release - Vaginal, Ring - Vaginal, Ring, Tablet, chewable, Tablet, chewable - Oral, Tablet, film coated, Tablet, film coated - Oral, Patch, Patch - Transdermal, Capsule, Capsule - Oral
Acne Vulgaris
, 0.02 mg, 0.0025 mg, 0.03 mg, 0.0035 mg/hour, 0.005 mg, 2.7 mg, 0.035 mg, 0.6 mg, 2.6 mg, 0.05 mg, 0.5 mg, 0.75 mg, 0.025 mg, 0.0015 mg/hour, 0.04 mg, 0.01 mg, 1.0 mg, 0.075 mg, 0.105 mg, 0.07 mg, 0.1 mg, 0.75 mg/[USP'U], 0.0075 mg/hour, 17.4 mg, 0.085 mg, 2.3 mg
, Kit, Tablet - Oral, Oral, Tablet, Kit - Oral, Patch, extended release, Patch, extended release - Transdermal, Transdermal, Insert, extended release, Vaginal, Insert, extended release - Vaginal, Ring - Vaginal, Ring, Tablet, chewable, Tablet, chewable - Oral, Tablet, film coated, Tablet, film coated - Oral, Patch, Patch - Transdermal, Capsule, Capsule - Oral
Folate supplementation therapy
, 0.02 mg, 0.0025 mg, 0.03 mg, 0.0035 mg/hour, 0.005 mg, 2.7 mg, 0.035 mg, 0.6 mg, 2.6 mg, 0.05 mg, 0.5 mg, 0.75 mg, 0.025 mg, 0.0015 mg/hour, 0.04 mg, 0.01 mg, 1.0 mg, 0.075 mg, 0.105 mg, 0.07 mg, 0.1 mg, 0.75 mg/[USP'U], 0.0075 mg/hour, 17.4 mg, 0.085 mg, 2.3 mg
, Kit, Tablet - Oral, Oral, Tablet, Kit - Oral, Patch, extended release, Patch, extended release - Transdermal, Transdermal, Insert, extended release, Vaginal, Insert, extended release - Vaginal, Ring - Vaginal, Ring, Tablet, chewable, Tablet, chewable - Oral, Tablet, film coated, Tablet, film coated - Oral, Patch, Patch - Transdermal, Capsule, Capsule - Oral
Hormonal Contraception
, 0.02 mg, 0.0025 mg, 0.03 mg, 0.0035 mg/hour, 0.005 mg, 2.7 mg, 0.035 mg, 0.6 mg, 2.6 mg, 0.05 mg, 0.5 mg, 0.75 mg, 0.025 mg, 0.0015 mg/hour, 0.04 mg, 0.01 mg, 1.0 mg, 0.075 mg, 0.105 mg, 0.07 mg, 0.1 mg, 0.75 mg/[USP'U], 0.0075 mg/hour, 17.4 mg, 0.085 mg, 2.3 mg
, Kit, Tablet - Oral, Oral, Tablet, Kit - Oral, Patch, extended release, Patch, extended release - Transdermal, Transdermal, Insert, extended release, Vaginal, Insert, extended release - Vaginal, Ring - Vaginal, Ring, Tablet, chewable, Tablet, chewable - Oral, Tablet, film coated, Tablet, film coated - Oral, Patch, Patch - Transdermal, Capsule, Capsule - Oral
Menopause
, 0.02 mg, 0.0025 mg, 0.03 mg, 0.0035 mg/hour, 0.005 mg, 2.7 mg, 0.035 mg, 0.6 mg, 2.6 mg, 0.05 mg, 0.5 mg, 0.75 mg, 0.025 mg, 0.0015 mg/hour, 0.04 mg, 0.01 mg, 1.0 mg, 0.075 mg, 0.105 mg, 0.07 mg, 0.1 mg, 0.75 mg/[USP'U], 0.0075 mg/hour, 17.4 mg, 0.085 mg, 2.3 mg
, Kit, Tablet - Oral, Oral, Tablet, Kit - Oral, Patch, extended release, Patch, extended release - Transdermal, Transdermal, Insert, extended release, Vaginal, Insert, extended release - Vaginal, Ring - Vaginal, Ring, Tablet, chewable, Tablet, chewable - Oral, Tablet, film coated, Tablet, film coated - Oral, Patch, Patch - Transdermal, Capsule, Capsule - Oral

Warnings

Ortho Evra has twenty-six contraindications and should not be taken alongside the conditions delineated in the following table.Ortho Evra Contraindications
Condition
Risk Level
Notes
Heavy Smoking
Do Not Combine
Metrorrhagia
Do Not Combine
estrogen-sensitive cancer
Do Not Combine
Thrombophlebitis
Do Not Combine
high risk of venous thrombotic disease
Do Not Combine
history of deep venous thrombosis
Do Not Combine
Pulse Frequency
Do Not Combine
Breast
Do Not Combine
Coronary Artery Disease
Do Not Combine
high risk of arterial thrombotic disease
Do Not Combine
Thromboembolism
Do Not Combine
Coronary Artery Disease (CAD)
Do Not Combine
Hypersensitivity
Do Not Combine
Pulse Frequency
Do Not Combine
Adrenal Insufficiency
Do Not Combine
major surgery with prolonged immobilization
Do Not Combine
Pulse Frequency
Do Not Combine
Severe Hypertension
Do Not Combine
undiagnosed abnormal genital bleeding
Do Not Combine
Breast Cancer
Do Not Combine
Neoplasms, Hepatic
Do Not Combine
Deep Vein Thrombosis
Do Not Combine
Decompensated Cirrhosis
Do Not Combine
Breast
Do Not Combine
Impaired Renal Function
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Ethinylestradiol may interact with Pulse Frequency
There are 20 known major drug interactions with Ortho Evra.
Common Ortho Evra Drug Interactions
Drug Name
Risk Level
Description
Anastrozole
Major
The therapeutic efficacy of Anastrozole can be decreased when used in combination with Ethinylestradiol.
Astemizole
Major
The metabolism of Astemizole can be decreased when combined with Ethinylestradiol.
Axitinib
Major
The metabolism of Axitinib can be decreased when combined with Ethinylestradiol.
Belinostat
Major
The metabolism of Belinostat can be increased when combined with Ethinylestradiol.
Binimetinib
Major
The metabolism of Binimetinib can be increased when combined with Ethinylestradiol.
Ortho Evra Toxicity & Overdose RiskWomen who overdose on Yaz may experience bleeding, nausea, vomiting, chest pain, abdominal discomfort, drowsiness, and fatigue. Treatment should include monitoring potassium, sodium, and signs of acidosis, and providing supportive care.
image of a doctor in a lab doing drug, clinical research

Ortho Evra Novel Uses: Which Conditions Have a Clinical Trial Featuring Ortho Evra?

38 active trials are examining the potential of Ortho Evra in providing Folate supplementation therapy, alleviating Premenstrual Dysphoric Disorder symptoms and managing Menopausal symptoms.
Condition
Clinical Trials
Trial Phases
Birth Control
28 Actively Recruiting
Not Applicable, Phase 3, Phase 4, Early Phase 1
Patient desires oral contraception for birth control
0 Actively Recruiting
Folate supplementation therapy
0 Actively Recruiting
Hormonal Contraception
0 Actively Recruiting
Mild to Moderate Acne
0 Actively Recruiting
Menopausal Osteoporosis
0 Actively Recruiting
Menopause
0 Actively Recruiting
Acne Vulgaris
0 Actively Recruiting

Ortho Evra Reviews: What are patients saying about Ortho Evra?

4.7Patient Review
3/19/2014
Ortho Evra for Birth Control
I've only been using Ortho Evra for two weeks, so I may update this later. So far, I much prefer it to the shot because there are no needles and I haven't experienced any negative mood swings. The patch has boosted my sex drive, which is amazing. The only downside is that my breasts have been sore and enlarged, but hopefully that will go away soon.
4.7Patient Review
6/7/2020
Ortho Evra for Birth Control
Protected me from pregnancy with no effects near as bad as the pill. Only side effect is dramatic changes in my sec drive: extremely high for a month or so to extremely low. I also got bigger breasts. Half a cup size To a cup size bigger. For first three months I was slightly more sensitive emotionally than I was without it - however it was very mild and I got used to it very quickly. Overall much better for my mental health, and my bad stomach than the pill was
4.7Patient Review
9/26/2016
Ortho Evra for Birth Control
I got nauseous from the pill, but the patch was okay. I spotted at the end of week two for a few days, and my period was lighter. Alcohol swabbing the area (upper thigh for me) letting it dry and applying straight after helped keep the patch on. My skin did react so I change thighs and areas each week, but it always went back to normal after a few days.
4Patient Review
9/23/2014
Ortho Evra for Birth Control
It's important to remember that everyone experiences things differently. For me, I had severe nausea from the patch. Additionally, after four months I started getting cystic acne; my face was covered in it. However, there were some benefits: a dramatic increase in breast size (almost two cups!) and more energy overall.
3.7Patient Review
5/19/2014
Ortho Evra for Birth Control
The first two months were tough going. I had nausea and my breasts were bloated and swollen.
2.7Patient Review
4/21/2014
Ortho Evra for Birth Control
I had a really tough time when I was on this patch. Lots of unpleasant symptoms like headaches, nausea, diarrhea, and lightheadedness. Sometimes I felt so bad that I thought something serious must be wrong with me. Thankfully, it was just the patch!
2.3Patient Review
8/13/2013
Ortho Evra for Birth Control
The Orth Evra Patch was not effective for me; in fact, I got pregnant twice while using it.
2.3Patient Review
3/31/2019
Ortho Evra for Birth Control
I used this treatment for three years and generally liked it. It was easy to use with few side effects, mostly just breast soreness. However, my third year on the patch I started having two month long periods with terrible cramping that Ibuprofen couldn't even touch. If it weren't for those issues, I would still be using this product.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about ortho evra

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the generic name for Ortho Evra?

"The generic version of Ortho Evra® will be marketed under the name Zafemy™."

Answered by AI

What is Ortho Evra used for?

"This patch contains a combination of hormone medication and is used to prevent pregnancy. It contains 2 hormones: a progestin (norelgestromin) and an estrogen (ethinyl estradiol). This medication will not protect you or your partner against sexually transmitted diseases (such as HIV, gonorrhea, chlamydia)."

Answered by AI

Is Ortho Evra still available?

"Ortho Evra is no longer available in the U.S., after the FDA approved Xulane, a generic hormonal birth control patch, in 2014. Xulane provides the same high levels of estrogen that Ortho Evra did. Like Ortho Evra, Xulane has a boxed warning on its label about potential side effects."

Answered by AI

Is Xulane the same as Ortho Evra?

"If you're familiar with the brand Ortho Evra, you'll know that Xulane contains the same active ingredients. Xulane is the generic version of Ortho Evra, which was discontinued in the United States in 2014. Now, Twirla is one of the primary options available."

Answered by AI

Clinical Trials for Ortho Evra

Have you considered Ortho Evra clinical trials? We made a collection of clinical trials featuring Ortho Evra, we think they might fit your search criteria.
Have you considered Ortho Evra clinical trials? We made a collection of clinical trials featuring Ortho Evra, we think they might fit your search criteria.
Have you considered Ortho Evra clinical trials? We made a collection of clinical trials featuring Ortho Evra, we think they might fit your search criteria.
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