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What is Orenitram
TreprostinilThe Generic name of this drug
Treatment SummaryTreprostinil is a medication that mimics the effects of prostacyclin hormone to treat pulmonary hypertension.
Remodulinis the brand name
Orenitram Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Remodulin
Treprostinil
2002
47
Effectiveness
How Orenitram Affects PatientsTreprostinil is a drug that works to widen blood vessels and reduce the risk of platelet clumping. In animals, this leads to lower pressure in the heart and an increase in blood flow. In humans, taking treprostinil can lead to a short-term change in the electrical activity of the heart. When taken orally, the effect on the heart has not been studied. Treprostinil can also cause low blood pressure, worsen symptoms of pulmonary arterial hypertension, and cause bronchospasms in those with asthma or COPD. Those taking treprostinil intravenously may experience infusion complications
How Orenitram works in the bodyTreprostinil is a drug used to treat pulmonary arterial hypertension, a condition that causes high blood pressure in the arteries connecting the heart and lungs. Treprostinil works by activating receptors that increase levels of cAMP, a molecule that helps relax blood vessels and prevents blood clots. This promotes vasodilation and reduces inflammation, which helps lower blood pressure and improve heart function.
When to interrupt dosage
The prescribed dosage of Orenitram is subject to the declared condition, including refractory to conventional therapy, Pulmonary Arterial Hypertension and NYHA class IV. The amount of dosage is contingent upon the technique of delivery (e.g. Solution or Inhalant) detailed in the table below.Condition
Dosage
Administration
NYHA Functional Class III
2.0 mg/mL, , 5.0 mg/mL, 10.0 mg/mL, 20.0 mg/mL, 2.5 mg, 1.0 mg, 5.0 mg, 1.74 mg/mL, 0.125 mg, 0.25 mg, 1.0 mg/mL, 2.5 mg/mL, 40.0 mg/mL, 0.048 mg, 0.064 mg, 0.016 mg, 0.032 mg
, Intravenous; Subcutaneous, Injection, solution, Injection, solution - Intravenous; Subcutaneous, Solution, Solution - Intravenous; Subcutaneous, Inhalant, Respiratory (inhalation), Inhalant - Respiratory (inhalation), Tablet, extended release, Tablet, extended release - Oral, Oral, Inhalant - Oral, Injection, Injection - Intravenous; Subcutaneous, Subcutaneous, Injection, solution - Subcutaneous, Inhalant; Kit - Oral, Inhalant; Kit
Pulmonary Arterial Hypertension
2.0 mg/mL, , 5.0 mg/mL, 10.0 mg/mL, 20.0 mg/mL, 2.5 mg, 1.0 mg, 5.0 mg, 1.74 mg/mL, 0.125 mg, 0.25 mg, 1.0 mg/mL, 2.5 mg/mL, 40.0 mg/mL, 0.048 mg, 0.064 mg, 0.016 mg, 0.032 mg
, Intravenous; Subcutaneous, Injection, solution, Injection, solution - Intravenous; Subcutaneous, Solution, Solution - Intravenous; Subcutaneous, Inhalant, Respiratory (inhalation), Inhalant - Respiratory (inhalation), Tablet, extended release, Tablet, extended release - Oral, Oral, Inhalant - Oral, Injection, Injection - Intravenous; Subcutaneous, Subcutaneous, Injection, solution - Subcutaneous, Inhalant; Kit - Oral, Inhalant; Kit
Pulmonary Hypertension
2.0 mg/mL, , 5.0 mg/mL, 10.0 mg/mL, 20.0 mg/mL, 2.5 mg, 1.0 mg, 5.0 mg, 1.74 mg/mL, 0.125 mg, 0.25 mg, 1.0 mg/mL, 2.5 mg/mL, 40.0 mg/mL, 0.048 mg, 0.064 mg, 0.016 mg, 0.032 mg
, Intravenous; Subcutaneous, Injection, solution, Injection, solution - Intravenous; Subcutaneous, Solution, Solution - Intravenous; Subcutaneous, Inhalant, Respiratory (inhalation), Inhalant - Respiratory (inhalation), Tablet, extended release, Tablet, extended release - Oral, Oral, Inhalant - Oral, Injection, Injection - Intravenous; Subcutaneous, Subcutaneous, Injection, solution - Subcutaneous, Inhalant; Kit - Oral, Inhalant; Kit
refractory to conventional therapy
2.0 mg/mL, , 5.0 mg/mL, 10.0 mg/mL, 20.0 mg/mL, 2.5 mg, 1.0 mg, 5.0 mg, 1.74 mg/mL, 0.125 mg, 0.25 mg, 1.0 mg/mL, 2.5 mg/mL, 40.0 mg/mL, 0.048 mg, 0.064 mg, 0.016 mg, 0.032 mg
, Intravenous; Subcutaneous, Injection, solution, Injection, solution - Intravenous; Subcutaneous, Solution, Solution - Intravenous; Subcutaneous, Inhalant, Respiratory (inhalation), Inhalant - Respiratory (inhalation), Tablet, extended release, Tablet, extended release - Oral, Oral, Inhalant - Oral, Injection, Injection - Intravenous; Subcutaneous, Subcutaneous, Injection, solution - Subcutaneous, Inhalant; Kit - Oral, Inhalant; Kit
NYHA class IV
2.0 mg/mL, , 5.0 mg/mL, 10.0 mg/mL, 20.0 mg/mL, 2.5 mg, 1.0 mg, 5.0 mg, 1.74 mg/mL, 0.125 mg, 0.25 mg, 1.0 mg/mL, 2.5 mg/mL, 40.0 mg/mL, 0.048 mg, 0.064 mg, 0.016 mg, 0.032 mg
, Intravenous; Subcutaneous, Injection, solution, Injection, solution - Intravenous; Subcutaneous, Solution, Solution - Intravenous; Subcutaneous, Inhalant, Respiratory (inhalation), Inhalant - Respiratory (inhalation), Tablet, extended release, Tablet, extended release - Oral, Oral, Inhalant - Oral, Injection, Injection - Intravenous; Subcutaneous, Subcutaneous, Injection, solution - Subcutaneous, Inhalant; Kit - Oral, Inhalant; Kit
Warnings
Orenitram ContraindicationsCondition
Risk Level
Notes
Severe Hepatic Impairment
Do Not Combine
Common Orenitram Drug Interactions
Drug Name
Risk Level
Description
Amifostine
Major
Treprostinil may increase the hypotensive activities of Amifostine.
Amiodarone
Major
The metabolism of Amiodarone can be decreased when combined with Treprostinil.
Brigatinib
Major
The metabolism of Brigatinib can be decreased when combined with Treprostinil.
Cabazitaxel
Major
The metabolism of Cabazitaxel can be decreased when combined with Treprostinil.
Enasidenib
Major
The metabolism of Enasidenib can be decreased when combined with Treprostinil.
Orenitram Toxicity & Overdose RiskExcessive treprostinil use can lead to side effects such as flushing, headaches, nausea, vomiting, diarrhea, and low blood pressure. In one case, a pediatric patient had a seizure-like activity and loss of consciousness after an accidental bolus administration. There is no evidence that treprostinil affects fertility or causes cancer in rats, but it has been linked to mutagenic and clastogenic effects in laboratory studies.
Orenitram Novel Uses: Which Conditions Have a Clinical Trial Featuring Orenitram?
54 active clinical trials are underway to assess the efficacy of Orenitram in providing relief for Pulmonary Arterial Hypertension, NYHA Functional Class III and Pulmonary Arterial Hypertension-related disorders.Condition
Clinical Trials
Trial Phases
NYHA Functional Class III
0 Actively Recruiting
refractory to conventional therapy
0 Actively Recruiting
Pulmonary Hypertension
25 Actively Recruiting
Phase 2, Phase 3, Phase 1, Phase 4, Not Applicable, Early Phase 1
NYHA class IV
0 Actively Recruiting
Pulmonary Arterial Hypertension
5 Actively Recruiting
Phase 1, Not Applicable, Phase 2
Orenitram Reviews: What are patients saying about Orenitram?
4Patient Review
11/17/2016 I've been on this medication for two years and have definitely seen an improvement in my stamina. The side effects have also lessened, which is great.
3.3Patient Review
3/13/2022 So far, I've had very few side effects from Orenitram. I was diagnosed with PAH and told that I only have five years to live, but this medication has given me hope. I'm still getting tired easily, but hopefully that will improve with time.
2.3Patient Review
2/3/2017 I've been taking this medicine for one and a half years now, and I'm really tired of it. It gives me ulcers and I often vomit blood. My doctor can see how exhausted I am and he wants me to change to a pump instead of the medication. I hate both options, but I've never tried the pump before so I'm not sure if that's what I'm going to do. Orenitram did kill me with its side effects.
1Patient Review
6/19/2020 The side effects of this medication were awful. I lost my appetite and 16lbs in 3 weeks, had severe back pain and headaches, and felt totally exhausted all the time. I was able to get off of it eventually, but I wouldn't recommend it to anyone else.
1Patient Review
3/17/2015 My brother passed away less than three months after starting orenitram. We are currently investigating the matter. Has anyone else had a similar experience? Please share if you have.
1Patient Review
3/17/2016 I would not recommend this drug to anyone. It killed my husband who was only on it for six months. He is now on hospice care.
Patient Q&A Section about orenitram
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Does Orenitram have generic?
"If a generic version of Orenitram is not available in the United States, then it is likely that fraudulent online pharmacies will try to sell illegal versions of the drug. These versions of the drug may be counterfeit and potentially unsafe for patients."
Answered by AI
What is Orenitram used for?
"This medication helps to relax the blood vessels in your lungs which in turn decreases the pulmonary arterial hypertension and helps you to be more active."
Answered by AI
Does Orenitram lower blood pressure?
"Orenitram expands the arteries and decreases the amount of blood clotting platelets in your body. These effects lower blood pressure in the pulmonary artery that leads from the heart to the lungs."
Answered by AI
Is Orenitram a prostacyclin?
"Orenitram is a medication used to treat pulmonary arterial hypertension. It is designed to improve exercise capacity and delay disease progression."
Answered by AI