Naropin

Anesthesia procedures, Postoperative Pain, Labour + 1 more

Treatment

1 FDA approval

20 Active Studies for Naropin

Treatment for

Anesthesia procedures

What is Naropin

RopivacaineThe Generic name of this drug

Treatment SummaryRopivacaine, sold under the brand name Naropin, is a local anaesthetic drug made up of two mirror-image molecules called enantiomers. Only one of the molecules, the ‘S’ enantiomer, is active and this is the form that is used in the drug. Ropivacaine is used to provide pain relief during medical procedures.

Naropinis the brand name

image of different drug pills on a surface

Naropin Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Naropin

Ropivacaine

1996

Approved as Treatment by the FDA

Ropivacaine, commonly known as Naropin, is approved by the FDA for 1 uses including Postoperative Pain .

Postoperative Pain

Helps manage Postoperative pain

Effectiveness

How Naropin Affects PatientsRopivacaine is a local anesthetic that does not have a different onset time, duration of action, or absorb into the bloodstream differently whether epinephrine is present or not.

How Naropin works in the bodyRopivacaine is a local anesthetic that works by blocking nerve signals. It does this by making it harder for the nerves to get excited and send messages, as well as by slowing down the speed at which those messages travel. It does this by blocking the sodium channel and keeping it from allowing the nerves to depolarize and send signals. How fast the anesthetic takes effect depends on the size, myelination, and speed of the nerves being blocked.

When to interrupt dosage

The recommended amount of Naropin is contingent upon the established condition, including Labour, Anesthesia procedures and Acute Pain. The dosage is subject to the mode of delivery (e.g. Epidural; Perineural or Solution - Epidural; Infiltration) featured in the table beneath.

Condition

Dosage

Administration

Postoperative Pain

, 5.0 mg/mL, 10.0 mg/mL, 2.0 mg/mL, 7.5 mg/mL, 15.0 mg/mL, 20.0 mg/mL, 4.0 mg/mL

Parenteral, , Injection, solution, Injection, solution - Parenteral, Injection, solution - Epidural; Infiltration; Perineural, Epidural; Infiltration; Perineural, Epidural, Injection, solution - Epidural, Epidural; Perineural, Injection, solution - Epidural; Perineural, Epidural; Infiltration, Injection, solution - Epidural; Infiltration, Liquid, Liquid - Parenteral, Solution, Solution - Epidural; Infiltration, Solution - Epidural, Infiltration, Injection, Injection - Epidural, Injection - Epidural; Infiltration; Perineural, Injection - Epidural; Perineural, Kit - Epidural; Infiltration; Intramuscular; Intravenous; Perineural; Topical, Epidural; Infiltration; Intramuscular; Intravenous; Perineural; Topical, Kit, Injection - Epidural; Infiltration

Anesthesia procedures

, 5.0 mg/mL, 10.0 mg/mL, 2.0 mg/mL, 7.5 mg/mL, 15.0 mg/mL, 20.0 mg/mL, 4.0 mg/mL

Acute Pain

, 5.0 mg/mL, 10.0 mg/mL, 2.0 mg/mL, 7.5 mg/mL, 15.0 mg/mL, 20.0 mg/mL, 4.0 mg/mL

Labour

, 5.0 mg/mL, 10.0 mg/mL, 2.0 mg/mL, 7.5 mg/mL, 15.0 mg/mL, 20.0 mg/mL, 4.0 mg/mL

Warnings

Naropin has one prohibition, so it should not be used when dealing with any of the conditions in the following table.Naropin Contraindications

Condition

Risk Level

Notes

Severe Hypersensitivity Reactions

Do Not Combine

Ropivacaine may interact with Pulse Frequency

There are 20 known major drug interactions with Naropin.

Common Naropin Drug Interactions

Drug Name

Risk Level

Description

Azelastine

Major

Ropivacaine may increase the central nervous system depressant (CNS depressant) activities of Azelastine.

Ethanol

Major

Ropivacaine may increase the central nervous system depressant (CNS depressant) activities of Ethanol.

Oliceridine

Major

The risk or severity of hypotension, sedation, death, somnolence, and respiratory depression can be increased when Ropivacaine is combined with Oliceridine.

Technetium Tc-99m tilmanocept

Major

Ropivacaine may decrease effectiveness of Technetium Tc-99m tilmanocept as a diagnostic agent.

Thalidomide

Major

Ropivacaine may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.

Naropin Toxicity & Overdose RiskTaking too much ropivacaine can harm the central nervous system and cardiovascular system. Symptoms include nervousness, tingling, ringing in the ears, shaking, dizziness, blurry vision, drowsiness, loss of consciousness, shallow breathing, low blood pressure, slow heartbeat, irregular heartbeat, and cardiac arrest.

Naropin Novel Uses: Which Conditions Have a Clinical Trial Featuring Naropin?

30 trials are actively assessing the impact of Naropin on providing Surgical Anesthesia, Acute Pain and Anesthesia procedures.

Condition

Clinical Trials

Trial Phases

Acute Pain

21 Actively Recruiting

Early Phase 1, Not Applicable, Phase 4, Phase 2, Phase 1

Labour

2 Actively Recruiting

Phase 4, Phase 3

Postoperative Pain

19 Actively Recruiting

Phase 4, Phase 1, Not Applicable, Phase 3, Early Phase 1, Phase 2

Anesthesia procedures

0 Actively Recruiting

Naropin Reviews: What are patients saying about Naropin?

5Patient Review

3/7/2009

Naropin for Regional Anesthesia for Post-Operative Pain

I had rotator cuff surgery and was amazed at how painless it was until the pump ran out.

5Patient Review

10/8/2009

Naropin for Regional Anesthesia for Post-Operative Pain

Had surgery on my rotator cuff and it was a total success! I barely felt any pain afterwards and the treatment only lasted for 42-43 hours. I would highly recommend this to anyone considering it.

5Patient Review

10/15/2010

Naropin for Regional Anesthesia for Post-Operative Pain

This was a very effective treatment for me.

image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about naropin

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is Naropin used for?

"Naropin is a type of local anaesthesia which is used in a spinal block, or epidural. It is used to provide anaesthesia during a surgery or C-section, or to ease labour pains."

Answered by AI

How long does it take for ropivacaine to start working?

"Ropivacaine can be used to produce surgical anaesthesia or a sensory block. These effects usually begin within a few minutes and last for 2-6 hours when ropivacaine is used for field blocks."

Answered by AI

How long does ropivacaine block last?

"For ropivacaine, the shortest time it will work is 3.75 hours, the longest time it will work is 9 hours, most of the time it will work for between 5.1 and 7.04 hours, and on average it will work for 6 hours."

Answered by AI