Mupirocin

Impetigo, Communicable Diseases, staphylococcus aurea colonization of the nasal passage + 3 more

Treatment

7 FDA approvals

0 Active Studies for Mupirocin

What is Mupirocin

Mupirocin

The Generic name of this drug

Treatment Summary

Mupirocin is a naturally occurring antibiotic produced by fermentation of the Pseudomonas fluorescens bacteria. It works by blocking protein synthesis in bacteria and is effective against many types of gram-positive bacteria and some gram-negative bacteria. It does not have cross-resistance with other types of antibiotics, making it a useful and safe treatment option. Mupirocin is only available in topical formulations and is used to treat skin conditions such as impetigo caused by Staphylococcus aureus and Streptococcus pyogenes, as well as traumatic skin lesions caused by these bacteria. It may also be

Bactroban

is the brand name

image of different drug pills on a surface

Mupirocin Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Bactroban

Mupirocin

1996

98

Approved as Treatment by the FDA

Mupirocin, also called Bactroban, is approved by the FDA for 7 uses which include staphylococcus aurea colonization of the nasal passage and Secondary infection Skin infection .

staphylococcus aurea colonization of the nasal passage

Secondary infection Skin infection

Bacterial infection due to streptococcus, group A

Impetigo

Bacterial Infections

Impetigo

Communicable Diseases

Effectiveness

How Mupirocin Affects Patients

Mupirocin is an antibiotic used to fight certain bacteria like Staphylococcus aureus and Streptococcus pyogenes. It works by blocking the bacteria's ability to make proteins, which are necessary for survival. Studies have found that it has a high success rate of 94 to 98% when treating impetigo, as well as a 90% success rate when treating skin infections. Mupirocin can become resistant to the bacteria, with some reports of resistance as high as 81%. This resistance is more common in bacteria that are already resistant to other antibiotics, and can be caused by a modified isoleu

How Mupirocin works in the body

Mupirocin works by attaching to a special enzyme that helps create proteins and RNA in bacteria. By blocking this enzyme, it stops the bacteria from making new proteins and RNA. This usually stops the bacteria from reproducing, although with prolonged exposure, it can be lethal.

When to interrupt dosage

The suggested dosage of Mupirocin is contingent upon the determined condition, such as Communicable Diseases, Bacterial Infections and staphylococcus aurea colonization of the nasal passage. The amount of dosage is subject to the technique of delivery (e.g. Ointment or Cream) specified in the table beneath.

Condition

Dosage

Administration

staphylococcus aurea colonization of the nasal passage

0.02 mg/mg, , 0.0215 mg/mg, 2.0 %

, Topical, Ointment - Topical, Cream, Cream - Topical, Ointment, Nasal, Ointment - Nasal, Kit - Topical, Kit

Impetigo

0.02 mg/mg, , 0.0215 mg/mg, 2.0 %

, Topical, Ointment - Topical, Cream, Cream - Topical, Ointment, Nasal, Ointment - Nasal, Kit - Topical, Kit

Impetigo

0.02 mg/mg, , 0.0215 mg/mg, 2.0 %

, Topical, Ointment - Topical, Cream, Cream - Topical, Ointment, Nasal, Ointment - Nasal, Kit - Topical, Kit

Communicable Diseases

0.02 mg/mg, , 0.0215 mg/mg, 2.0 %

, Topical, Ointment - Topical, Cream, Cream - Topical, Ointment, Nasal, Ointment - Nasal, Kit - Topical, Kit

Impetigo

0.02 mg/mg, , 0.0215 mg/mg, 2.0 %

, Topical, Ointment - Topical, Cream, Cream - Topical, Ointment, Nasal, Ointment - Nasal, Kit - Topical, Kit

Bacterial Infections

0.02 mg/mg, , 0.0215 mg/mg, 2.0 %

, Topical, Ointment - Topical, Cream, Cream - Topical, Ointment, Nasal, Ointment - Nasal, Kit - Topical, Kit

Warnings

Mupirocin Contraindications

Condition

Risk Level

Notes

Severe Hypersensitivity Reactions

Do Not Combine

Mupirocin may interact with Pulse Frequency

There are 16 known major drug interactions with Mupirocin.

Common Mupirocin Drug Interactions

Drug Name

Risk Level

Description

Vibrio cholerae CVD 103-HgR strain live antigen

Major

The therapeutic efficacy of Vibrio cholerae CVD 103-HgR strain live antigen can be decreased when used in combination with Mupirocin.

(R)-warfarin

Moderate

The risk or severity of bleeding can be increased when Mupirocin is combined with (R)-warfarin.

(S)-Warfarin

Moderate

The risk or severity of bleeding can be increased when Mupirocin is combined with (S)-Warfarin.

4-hydroxycoumarin

Moderate

The risk or severity of bleeding can be increased when Mupirocin is combined with 4-hydroxycoumarin.

Acenocoumarol

Moderate

The risk or severity of bleeding can be increased when Mupirocin is combined with Acenocoumarol.

Mupirocin Toxicity & Overdose Risk

The highest dose of mupirocin found to be non-toxic in rats is 5000mg/kg. Tests have not shown any link between mupirocin and cancer. Animal and bacterial studies have also not shown any connection to genetic damage. Reproduction studies in rats have not found any impact on fertility. Mupirocin has been found in human milk, so pregnant women should use it with caution. Clinical trials have shown that mupirocin is safe for use in children ages two months to sixteen years.

image of a doctor in a lab doing drug, clinical research

Mupirocin Novel Uses: Which Conditions Have a Clinical Trial Featuring Mupirocin?

An active clinical trial is investigating the potential of Mupirocin in providing a remedy for Bacterial Infections, Impetigo and Communicable Diseases.

Condition

Clinical Trials

Trial Phases

Bacterial Infections

0 Actively Recruiting

staphylococcus aurea colonization of the nasal passage

0 Actively Recruiting

Communicable Diseases

0 Actively Recruiting

Impetigo

0 Actively Recruiting

Impetigo

0 Actively Recruiting

Impetigo

0 Actively Recruiting

Mupirocin Reviews: What are patients saying about Mupirocin?

5

Patient Review

8/27/2021

Mupirocin for Type of Skin Infection - Impetigo

I had a really bad case of dry hands, to the point where my fingers would randomly split open and bleed. It was excruciating. I tried Mupirocin 2% first, but saw little improvement, so I decided to buy O'Keeffe's Working Hands Cream over-the-counter. That worked like a charm and finally healed my hands.

5

Patient Review

9/14/2021

Mupirocin for Burn

My doctor prescribed this to me because my chin had a terrible breakout. It turned into staph or impetigo, but after using this ointment for three days every night, it went away. The only downside is that there's some scarring left behind, but overall it worked great for me.

5

Patient Review

9/30/2021

Mupirocin for Minor Skin Infection caused by Bacteria

This medication has been a big help to me. Before I was using it, my legs were swollen and painful. Now, after just two days, they're only slightly swollen with no pain.

5

Patient Review

9/30/2021

Mupirocin for Minor Skin Infection caused by Bacteria

I seriously burned my hand a few weeks ago, but this treatment has helped the area to heal up nicely.

5

Patient Review

6/5/2018

Mupirocin for Minor Skin Infection caused by Bacteria

This product has been a godsend. It's prevented my nose from getting sore and raw, which was a regular occurrence before I started using it.

5

Patient Review

6/22/2017

Mupirocin for Minor Skin Infection caused by Bacteria

This cream worked great for me a couple months ago, but recently I had a really bad reaction to it. I developed severe burning and swelling after using it, but thankfully those symptoms went away after I stopped using the cream.

5

Patient Review

5/9/2019

Mupirocin for Type of Skin Infection - Impetigo

I developed a large blister that tore immediately, leaving a quarter sized sound in my palm. I had mupirocin on hand for past bouts of MRSA in the nose, so I cleaned the are, and used the 2% mupirocin for 3 days now, with the wound covered. The ointment has worked great to treat the infection and promote healing.

4.7

Patient Review

6/13/2022

Mupirocin for Type of Skin Infection - Impetigo

I use this when Neosporin just isn't enough. I have had historical problems with skin infections for many years - this is the backup medication of choice. 1 to 3 days and the infection is much better.

4.3

Patient Review

7/8/2016

Mupirocin for Methicillin-Resistant Staphylococcus Aureus Bacteria in Nose

My surgeon prescribed this for me to PREVENT MRSA from occurring when I am admitted into the hospital immediately following my surgery. I am to apply this ointment topically with a Qtip into my nostril rwice daily for 5 days prior to my surgery. Hopefully, this will be effective in preventing MRSA.

3.7

Patient Review

11/6/2015

Mupirocin for Methicillin-Resistant Staphylococcus Aureus Bacteria in Nose

I got poison ivy that somehow became infected, and this medication helped to clear most of it up. However, it also made my skin very sensitive and caused hives that spread. I still itch and my skin is very red. I would not recommend this to anyone!

3.3

Patient Review

10/20/2014

Mupirocin for Methicillin-Resistant Staphylococcus Aureus Bacteria in Nose

3

Patient Review

8/25/2015

Mupirocin for A Severe Skin Infection - Ecthyma

I originally got this for my child's impetigo, but it worked so well that I started using it on myself for pimples. Acne scars and scabs clear up within days, which is amazing. Once this tube runs out, I'm definitely going to ask my doctor if they can prescribe me another one.

3

Patient Review

12/21/2014

Mupirocin for Methicillin-Resistant Staphylococcus Aureus Bacteria in Nose

I have not experienced any negative side effects.

2.7

Patient Review

7/17/2021

Mupirocin for Minor Skin Infection caused by Bacteria

My husband tried this for a brown recluse bite and it did nothing. He needed to be given steroids and antibiotics before he got better. I decided to try it on my arm where my dog had scratched me after seeing that it didn't work for him. Within an hour, I started having an allergic reaction with a rash, swelling tongue, and difficulty breathing. I washed it off immediately and took a Benadryl. If I don't get better, I'll go to the hospital.

2

Patient Review

5/20/2020

Mupirocin for Skin Ulcer

I've only been using this product for two days, but so far it seems to be working well.

1

Patient Review

1/25/2021

Mupirocin for Type of Skin Infection - Impetigo

The ointment caused a lot of pain when applied to my diabetic foot ulcer.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about mupirocin

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is mupirocin ointment used for?

"Mupirocin topical cream is used to treat skin lesions that have become infected with specific bacteria. Mupirocin topical ointment is used to treat impetigo. This medicine works by killing bacteria or preventing their growth. You will need a prescription from your doctor to get this medicine."

Answered by AI

When should you not use mupirocin?

"Do not apply this medication to skin that is damaged or broken, or around the eyes, nose, or mouth, unless your doctor tells you to. If it accidentally gets on these areas, rinse it off right away with plenty of water. If your condition does not improve within 3 to 5 days, tell your doctor."

Answered by AI

Is mupirocin the same as Neosporin?

"No, mupirocin is not the same as Neosporin."

Answered by AI

What kind of antibiotic is mupirocin?

"Mupirocin binds reversibly to bacterial isoleucyl-transfer RNA synthetase, thereby inhibiting protein synthesis. Mupirocin, which was formerly called pseudomonic acid A, is a topical antibiotic that is being researched for the treatment of impetigo and other superficial primary and secondary skin infections. Mupirocin (Bactroban, Beecham Laboratories) is currently formulated as a 2% ointment in a water-miscible polyethylene glycol base. Mupirocin binds reversibly to bacterial isoleucyl-transfer RNA synthetase, which inhibits protein synthesis."

Answered by AI