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What is Mupirocin
MupirocinThe Generic name of this drug
Treatment SummaryMupirocin is a naturally occurring antibiotic produced by fermentation of the Pseudomonas fluorescens bacteria. It works by blocking protein synthesis in bacteria and is effective against many types of gram-positive bacteria and some gram-negative bacteria. It does not have cross-resistance with other types of antibiotics, making it a useful and safe treatment option. Mupirocin is only available in topical formulations and is used to treat skin conditions such as impetigo caused by Staphylococcus aureus and Streptococcus pyogenes, as well as traumatic skin lesions caused by these bacteria. It may also be
Bactrobanis the brand name
Mupirocin Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Bactroban
Mupirocin
1996
98
Approved as Treatment by the FDA
Mupirocin, also called Bactroban, is approved by the FDA for 7 uses which include Bacterial infection due to streptococcus, group A and staphylococcus aurea colonization of the nasal passage .Bacterial infection due to streptococcus, group A
staphylococcus aurea colonization of the nasal passage
Impetigo
Secondary infection Skin infection
Bacterial Infections
Impetigo
Communicable Diseases
Effectiveness
How Mupirocin Affects PatientsMupirocin is an antibiotic used to fight certain bacteria like Staphylococcus aureus and Streptococcus pyogenes. It works by blocking the bacteria's ability to make proteins, which are necessary for survival. Studies have found that it has a high success rate of 94 to 98% when treating impetigo, as well as a 90% success rate when treating skin infections. Mupirocin can become resistant to the bacteria, with some reports of resistance as high as 81%. This resistance is more common in bacteria that are already resistant to other antibiotics, and can be caused by a modified isoleu
How Mupirocin works in the bodyMupirocin works by attaching to a special enzyme that helps create proteins and RNA in bacteria. By blocking this enzyme, it stops the bacteria from making new proteins and RNA. This usually stops the bacteria from reproducing, although with prolonged exposure, it can be lethal.
When to interrupt dosage
The suggested dosage of Mupirocin is contingent upon the determined condition, such as Communicable Diseases, Bacterial Infections and staphylococcus aurea colonization of the nasal passage. The amount of dosage is subject to the technique of delivery (e.g. Ointment or Cream) specified in the table beneath.Condition
Dosage
Administration
staphylococcus aurea colonization of the nasal passage
0.02 mg/mg, , 0.0215 mg/mg, 2.0 %
, Topical, Ointment, Ointment - Topical, Cream, Cream - Topical, Ointment - Nasal, Nasal, Kit, Kit - Topical
Impetigo
0.02 mg/mg, , 0.0215 mg/mg, 2.0 %
, Topical, Ointment, Ointment - Topical, Cream, Cream - Topical, Ointment - Nasal, Nasal, Kit, Kit - Topical
Impetigo
0.02 mg/mg, , 0.0215 mg/mg, 2.0 %
, Topical, Ointment, Ointment - Topical, Cream, Cream - Topical, Ointment - Nasal, Nasal, Kit, Kit - Topical
Communicable Diseases
0.02 mg/mg, , 0.0215 mg/mg, 2.0 %
, Topical, Ointment, Ointment - Topical, Cream, Cream - Topical, Ointment - Nasal, Nasal, Kit, Kit - Topical
Impetigo
0.02 mg/mg, , 0.0215 mg/mg, 2.0 %
, Topical, Ointment, Ointment - Topical, Cream, Cream - Topical, Ointment - Nasal, Nasal, Kit, Kit - Topical
Bacterial Infections
0.02 mg/mg, , 0.0215 mg/mg, 2.0 %
, Topical, Ointment, Ointment - Topical, Cream, Cream - Topical, Ointment - Nasal, Nasal, Kit, Kit - Topical
Warnings
Mupirocin ContraindicationsCondition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Mupirocin may interact with Pulse Frequency
Common Mupirocin Drug Interactions
Drug Name
Risk Level
Description
Vibrio cholerae CVD 103-HgR strain live antigen
Major
The therapeutic efficacy of Vibrio cholerae CVD 103-HgR strain live antigen can be decreased when used in combination with Mupirocin.
(R)-warfarin
Moderate
The risk or severity of bleeding can be increased when Mupirocin is combined with (R)-warfarin.
(S)-Warfarin
Moderate
The risk or severity of bleeding can be increased when Mupirocin is combined with (S)-Warfarin.
4-hydroxycoumarin
Moderate
The risk or severity of bleeding can be increased when Mupirocin is combined with 4-hydroxycoumarin.
Acenocoumarol
Moderate
The risk or severity of bleeding can be increased when Mupirocin is combined with Acenocoumarol.
Mupirocin Toxicity & Overdose RiskThe highest dose of mupirocin found to be non-toxic in rats is 5000mg/kg. Tests have not shown any link between mupirocin and cancer. Animal and bacterial studies have also not shown any connection to genetic damage. Reproduction studies in rats have not found any impact on fertility. Mupirocin has been found in human milk, so pregnant women should use it with caution. Clinical trials have shown that mupirocin is safe for use in children ages two months to sixteen years.
Mupirocin Novel Uses: Which Conditions Have a Clinical Trial Featuring Mupirocin?
An active clinical trial is investigating the potential of Mupirocin in providing a remedy for Bacterial Infections, Impetigo and Communicable Diseases.Condition
Clinical Trials
Trial Phases
Bacterial Infections
3 Actively Recruiting
Phase 1, Phase 2, Not Applicable
staphylococcus aurea colonization of the nasal passage
0 Actively Recruiting
Communicable Diseases
0 Actively Recruiting
Impetigo
0 Actively Recruiting
Impetigo
0 Actively Recruiting
Impetigo
0 Actively Recruiting
Mupirocin Reviews: What are patients saying about Mupirocin?
5Patient Review
8/27/2021 I had a really bad case of dry hands, to the point where my fingers would randomly split open and bleed. It was excruciating. I tried Mupirocin 2% first, but saw little improvement, so I decided to buy O'Keeffe's Working Hands Cream over-the-counter. That worked like a charm and finally healed my hands.
5Patient Review
9/14/2021 My doctor prescribed this to me because my chin had a terrible breakout. It turned into staph or impetigo, but after using this ointment for three days every night, it went away. The only downside is that there's some scarring left behind, but overall it worked great for me.
5Patient Review
9/30/2021 This medication has been a big help to me. Before I was using it, my legs were swollen and painful. Now, after just two days, they're only slightly swollen with no pain.
5Patient Review
9/30/2021 I seriously burned my hand a few weeks ago, but this treatment has helped the area to heal up nicely.
5Patient Review
6/5/2018 This product has been a godsend. It's prevented my nose from getting sore and raw, which was a regular occurrence before I started using it.
Patient Q&A Section about mupirocin
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is mupirocin ointment used for?
"Mupirocin topical cream is used to treat skin lesions that have become infected with specific bacteria. Mupirocin topical ointment is used to treat impetigo. This medicine works by killing bacteria or preventing their growth. You will need a prescription from your doctor to get this medicine."
Answered by AI
When should you not use mupirocin?
"Do not apply this medication to skin that is damaged or broken, or around the eyes, nose, or mouth, unless your doctor tells you to. If it accidentally gets on these areas, rinse it off right away with plenty of water. If your condition does not improve within 3 to 5 days, tell your doctor."
Answered by AI
Is mupirocin the same as Neosporin?
"No, mupirocin is not the same as Neosporin."
Answered by AI
What kind of antibiotic is mupirocin?
"Mupirocin binds reversibly to bacterial isoleucyl-transfer RNA synthetase, thereby inhibiting protein synthesis. Mupirocin, which was formerly called pseudomonic acid A, is a topical antibiotic that is being researched for the treatment of impetigo and other superficial primary and secondary skin infections. Mupirocin (Bactroban, Beecham Laboratories) is currently formulated as a 2% ointment in a water-miscible polyethylene glycol base. Mupirocin binds reversibly to bacterial isoleucyl-transfer RNA synthetase, which inhibits protein synthesis."
Answered by AI
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