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What is Mirapex Er
PramipexoleThe Generic name of this drug
Treatment SummaryPramipexole is a medication used to treat the symptoms of Parkinson's Disease. It helps to reduce tremors, stiffness, and slowness of movement caused by the condition. Pramipexole was first approved by the FDA in 1997 and is used to help people with Parkinson's Disease manage their daily activities. The number of people living with Parkinson's Disease has increased over the years and is now estimated to be 6.1 million worldwide. In addition to treating Parkinson's, pramipexole was also approved by the FDA in 2006 to treat Restless Legs Syndrome (RLS). RLS is a sleep disorder
Mirapexis the brand name
Mirapex Er Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Mirapex
Pramipexole
2003
318
Effectiveness
How Mirapex Er Affects Patients**Parkinson's Disease**
Pramipexole helps improve the symptoms of Parkinson's Disease by stimulating dopamine receptors. This is important because people with Parkinson's Disease have lower levels of dopamine in the brain, which affects their ability to control their movements.
**Restless Legs Syndrome**
Pramipexole helps restore balance to the dopaminergic system which helps to control the symptoms of Restless Legs Syndrome. This condition is caused by dysfunction of the dopaminergic system, which causes unpleasant feelings in the legs.
**Other effects
How Mirapex Er works in the bodyPramipexole is used to treat Parkinson's disease, but we don't know exactly how it works. It's thought that the drug stimulates dopamine receptors in the brain, which helps regulate certain functions. Studies in animals show that it can increase the rate of nerve transmission in the brain. Pramipexole binds to dopamine receptors, particularly the D2 and D3 subtypes. Scientists don't know what this binding does, but it is believed to be important for its effects.
When to interrupt dosage
The measure of Mirapex Er is contingent upon the determined illness, such as Restless Legs Syndrome, Parkinson's Disease and Restless Legs Syndrome. The magnitude of dosage vacillates, as indicated by the arrangement of administration featured in the table below.Condition
Dosage
Administration
Parkinson's Disease
, 0.125 mg, 0.25 mg, 0.5 mg, 1.0 mg, 1.5 mg, 0.75 mg, 0.375 mg, 3.0 mg, 4.5 mg, 2.25 mg, 3.75 mg, 0.088 mg, 0.18 mg, 1.1 mg, 0.7 mg, 0.35 mg, 0.26 mg, 0.52 mg, 1.05 mg, 2.1 mg, 3.15 mg, 1.57 mg, 2.62 mg
, Oral, Tablet, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Kit
Restless Legs Syndrome
, 0.125 mg, 0.25 mg, 0.5 mg, 1.0 mg, 1.5 mg, 0.75 mg, 0.375 mg, 3.0 mg, 4.5 mg, 2.25 mg, 3.75 mg, 0.088 mg, 0.18 mg, 1.1 mg, 0.7 mg, 0.35 mg, 0.26 mg, 0.52 mg, 1.05 mg, 2.1 mg, 3.15 mg, 1.57 mg, 2.62 mg
, Oral, Tablet, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Kit
Restless Legs Syndrome
, 0.125 mg, 0.25 mg, 0.5 mg, 1.0 mg, 1.5 mg, 0.75 mg, 0.375 mg, 3.0 mg, 4.5 mg, 2.25 mg, 3.75 mg, 0.088 mg, 0.18 mg, 1.1 mg, 0.7 mg, 0.35 mg, 0.26 mg, 0.52 mg, 1.05 mg, 2.1 mg, 3.15 mg, 1.57 mg, 2.62 mg
, Oral, Tablet, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Kit
Warnings
Mirapex Er ContraindicationsCondition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Pramipexole may interact with Pulse Frequency
Common Mirapex Er Drug Interactions
Drug Name
Risk Level
Description
Abacavir
Minor
Pramipexole may decrease the excretion rate of Abacavir which could result in a higher serum level.
Acebutolol
Minor
The risk or severity of adverse effects can be increased when Pramipexole is combined with Acebutolol.
Aclidinium
Minor
Pramipexole may decrease the excretion rate of Aclidinium which could result in a higher serum level.
Acrivastine
Minor
Pramipexole may decrease the excretion rate of Acrivastine which could result in a higher serum level.
Albutrepenonacog alfa
Minor
Pramipexole may decrease the excretion rate of Albutrepenonacog alfa which could result in a higher serum level.
Mirapex Er Toxicity & Overdose RiskThe toxic dose of Pramipexole in rats is more than 800mg/kg. No increased risk of cancer has been found in mice or rats, and no mutagenic effects have been observed. Animal studies have shown that Pramipexole can cause birth defects, but there are no studies on its effects in humans. Pramipexole is considered a pregnancy Category C drug, and should only be used if the potential benefits outweigh the possible risks to the fetus. It is not known if Pramipexole is excreted in human milk, so a decision should be made about whether to take the drug
Mirapex Er Novel Uses: Which Conditions Have a Clinical Trial Featuring Mirapex Er?
45 active studies are currently underway to evaluate the efficacy of Mirapex ER in providing relief from Restless Legs Syndrome, Idiopathic Restless Legs Syndrome and Parkinson's Disease.Condition
Clinical Trials
Trial Phases
Parkinson's Disease
46 Actively Recruiting
Phase 3, Not Applicable, Phase 1, Phase 2, Early Phase 1
Restless Legs Syndrome
0 Actively Recruiting
Restless Legs Syndrome
0 Actively Recruiting
Mirapex Er Reviews: What are patients saying about Mirapex Er?
5Patient Review
12/26/2012 I'm a 55-year-old man who was placed on this medication by my neurologist due to sudden onset RLS/PLMD. The previous medication I was only lasted for about four hours and the symptoms returned. Mirapex ER has completely stopped all these symptoms, but I now have chronic severe insomnia and nausea each day with stomach bloating. I'm happy with the results except for the side effect, which means another call to the neurologist.
5Patient Review
8/17/2013 This drug does an incredible job at managing the symptoms of my Parkinson's Disease. My mobility has improved greatly, and I no longer have to worry about drooling. The only downside is how expensive it is; $450 for a month's supply.
4.3Patient Review
3/19/2011 I am currently taking Mirapex per my doctor's orders. I have been wondering if I may have Parkinson's disease, but will raise this question with him when I have my appointment later this month. One symptom that has me concerned is waking up to find things near me that disappear moments after waking up.
4.3Patient Review
9/23/2010 Mirapex has dramatically improved my quality of sleep. I used to have restless legs and would often wake up in the middle of the night. However, ever since taking this medication, I've been sleeping soundly through the night.
4Patient Review
4/4/2012 The doctor and I came to the decision that taking 3.0 mg twice a day would be more effective for me than 4.5 mg once a day. This new dosage doesn't give me as many tremors and seems to make the medication last longer throughout the day. The only downside is the cost, which insurance unfortunately does not completely cover.
4Patient Review
6/16/20104Patient Review
6/24/2010 At first, this medication really helped me get my mobility back. However, I started to experience a rash that spread quickly over my body. Once I stopped taking the medication, the rash went away within a day.
3.7Patient Review
6/12/20103.3Patient Review
2/29/2012 At first, I had difficulty falling asleep due to the medication. But then my doctor switched me to a timed-release pill and it's helped a lot. I've also experienced some relief from restless leg syndrome and Parkinson's. Overall, I'm pretty happy with the results. However, it can be tough to make the copayments when you're on a fixed income.
2.7Patient Review
3/8/2011 I've had issues with restless legs for a few years now, and I've tried a lot of different things to no avail. However, when my doctor gave me some samples of this medication, I found relief immediately. It's been a wonder drug for me.
1.7Patient Review
2/6/2013 I was extremely disappointed with this medication. I have severe fibromyalgia and it did nothing to help me. I feel like a guinea pig, trying all these different medications with no relief.
Patient Q&A Section about mirapex er
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.When do you take Mirapex ER?
"You should take Mirapex ER tablets once a day, with or without food. Swallow them whole and don't chew, crush or divide them."
Answered by AI
What are the side effects of Mirapex?
"These are some of the possible side effects of this medication. If you experience any of these side effects, talk to your doctor. Taking this medication may also cause dizziness or lightheadedness. If this happens, get up slowly when standing up to avoid falling."
Answered by AI
What is Mirapex ER used for?
"Pramipexole is also used to treat restless legs syndrome (RLS).
The drug Pramipexole is used to treat Parkinson's disease, either by itself or in combination with other medications. It improves the patient's ability to move and decreases tremors, stiffness, slowed movement, and unsteadiness. Additionally, it may also decrease the number of episodes of not being able to move ("on-off syndrome"). Pramipexole is also used to treat restless legs syndrome (RLS)."
Answered by AI
Is there a generic for Mirapex ER?
"Dr. Reddy's Laboratories announced the launch of Pramipexole Dihydrochloride Extended-Release Tablets, the generic version of Boehringer Ingelheim's Mirapex ER. Mirapex ER is a non-ergot dopamine agonist indicated for the treatment of idiopathic Parkinson's disease."
Answered by AI