Methylprednisolone Acetate

Iridocyclitis, Psoriasis, Chorioretinitis + 99 more

Treatment

83 FDA approvals

20 Active Studies for Methylprednisolone Acetate

Treatment for

Iridocyclitis

What is Methylprednisolone Acetate

Methylprednisolone

The Generic name of this drug

Treatment Summary

Methylprednisolone is a type of steroid medication used to treat inflammation. It is much more powerful than prednisone and was approved by the FDA in 1957. Recently, a low dose of methylprednisolone has been used to treat COVID-19-associated pneumonia in patients with weakened immune systems. Researchers are looking into the effectiveness of this drug in treating novel coronavirus pneumonia.

Medrol

is the brand name

Methylprednisolone Acetate Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Medrol

Methylprednisolone

1957

215

Approved as Treatment by the FDA

Methylprednisolone, also called Medrol, is approved by the FDA for 83 uses including Leukemia and Hay Fever .

Leukemia

Helps manage Leukemias

Hay Fever

Helps manage Seasonal Allergic Rhinitis

Erythema Multiforme

Choroiditis

Conjunctivitis

Helps manage anterior eye segment inflammation

Anemia, Hemolytic, Autoimmune

Lupus

Helps manage Systemic Lupus Erythematosus (SLE)

Secondary adrenocortical insufficiency

Psoriasis

Iritis

Acute Gouty Arthritis

Used in combination with other therapies

Adrenal Insufficiency

Acute Coryza

Helps manage acute rheumatic carditis

Optic Neuritis

Iridocyclitis

Asthma

Helps manage Asthma

Perennial Allergic Rhinitis (PAR)

Helps manage Perennial Allergic Rhinitis (PAR)

Secondary thrombocytopenia

Severe Seborrheic Dermatitis

Contact Dermatitis

Helps manage Contact Dermatitis

Bronchial Asthma

Autoimmune Hemolytic Anemia

Loeffler's syndrome

Congenital Adrenal Hyperplasia (CAH)

Helps manage Congenital Adrenal Hyperplasia (CAH)

Drug hypersensitivity reaction

Helps manage Drug hypersensitivity reaction

Leukemias

Helps manage Leukemias

Rheumatoid Arthritis, Juvenile

Used in combination with other therapies

anterior eye segment inflammation

Helps manage anterior eye segment inflammation

Malignant Lymphomas

Helps manage Malignant Lymphomas

Erythroblastopenia

Keratitis

Systemic Lupus Erythematosus (SLE)

Helps manage Systemic Lupus Erythematosus (SLE)

Aspiration Pneumonitis

Seasonal Allergic Rhinitis

Helps manage Seasonal Allergic Rhinitis

Posttraumatic Osteoarthritis

Acute Leukemia (Category)

Helps manage Acute Leukemia (Category)

Tuberculosis, Pulmonary

Used to treat fulminating Pulmonary Tuberculosis in combination with null

Epicondylitis

Used in combination with other therapies

systemic Dermatomyositis

subacute Bursitis

Used in combination with other therapies

Subarachnoid Block

Used to treat Subarachnoid Block in combination with null

severe Psoriasis

Primary adrenocortical insufficiency

Immune Thrombocytopenia (ITP)

Atopic Dermatitis

Helps manage Atopic Dermatitis

non-suppurative Thyroiditis

Helps manage non-suppurative Thyroiditis

varicella-zoster virus acute retinal necrosis

Helps manage varicella-zoster virus acute retinal necrosis

severe Erythema multiforme

Choroiditis

Tennis Elbow

Used in combination with other therapies

Drug Allergy

Helps manage Drug hypersensitivity reaction

Allergic Conjunctivitis (AC)

acute Bursitis

Used in combination with other therapies

Degenerative polyarthritis

Rheumatoid Arthritis

Used in combination with other therapies

Thyroiditis

Helps manage non-suppurative Thyroiditis

Iridocyclitis

Bullous dermatitis herpetiformis

Helps manage Bullous dermatitis herpetiformis

Dermatomyositis

Stevens-Johnson Syndrome

exfoliative erythroderma

Congenital adrenal hyperplasia

Helps manage Congenital Adrenal Hyperplasia (CAH)

Addison Disease

Arthritis, Gouty

Used in combination with other therapies

Thrombocytopenia

Psoriatic Arthritis

Used in combination with other therapies

Allergic corneal marginal ulcers

Optic Neuritis

Seborrheic dermatitis

Serum Sickness

Helps manage Serum Sickness

Asthma

Pulmonary Eosinophilia

Arthritis, Juvenile

Used in combination with other therapies

Chorioretinitis

Malignant Neoplasms

Iritis

Palliative Treatment

Helps manage Palliative Treatment

Bursitis

Used in combination with other therapies

Asthma

Helps manage Asthma

Acute Myeloid Leukemia (AML)

Helps manage Acute Leukemia (Category)

Lymphoma, Non-Hodgkin

Helps manage Malignant Lymphomas

Tuberculosis, Pulmonary

Used to treat disseminated Pulmonary Tuberculosis (TB) in combination with null

Rhinitis, Allergic

Helps manage Perennial Allergic Rhinitis (PAR)

Effectiveness

How Methylprednisolone Acetate Affects Patients

Corticosteroids work to reduce inflammation by blocking certain signals and promoting others. These drugs can be taken in doses that are much higher than the body naturally produces. However, patients should be aware that taking corticosteroids can reduce the strength of the body's natural immune system, leaving them more vulnerable to infections.

How Methylprednisolone Acetate works in the body

Corticosteroids reduce swelling and stop white blood cells from moving to sites of inflammation in the short-term. They work by binding to a receptor in the body and changing the way genes are expressed. This can have effects lasting hours to days. Corticosteroids also prevent cells from dying and limit the production of a chemical needed for inflammation. Lower doses help with inflammation, while higher doses suppress the immune system. When taken for an extended period, corticosteroids can also increase sodium levels and lower potassium levels in the body.

When to interrupt dosage

The dosage of Methylprednisolone Acetate is contingent upon the diagnosed condition, including Inflammation, Necrobiosis lipoidica diabeticorum and Diuresis. The measure of dosage is dependent on the administration approach specified in the table beneath.

Condition

Dosage

Administration

Arthritis, Gouty

16.0 mg, , 40.0 mg/mL, 125.0 mg/mL, 80.0 mg/mL, 4.0 mg, 32.0 mg, 40.0 mg, 1000.0 mg, 0.01 mg/mg, 8.0 mg, 100.0 mg/mL, 500.0 mg, 125.0 mg, 5000.0 mg, 2.0 mg, 500.0 mg/mL, 1000.0 mg/mL, 2000.0 mg, 20.0 mg/mL, 100.0 mg, 24.0 mg, 0.0025 mg/mg, 2.5 mg/mL

, Oral, Tablet, Tablet - Oral, Injection, powder, lyophilized, for solution - Intramuscular; Intravenous, Intramuscular; Intravenous, Intra-articular; Intralesional; Intramuscular; Soft tissue, Injection, suspension, Injection, suspension - Intra-articular; Intralesional; Intramuscular; Soft tissue, Intra-articular; Intralesional; Intramuscular; Parenteral; Soft tissue, Injection, suspension - Intra-articular; Intralesional; Intramuscular; Parenteral; Soft tissue, Intralesional; Intramuscular; Intrasynovial; Soft tissue, Injection, suspension - Intralesional; Intramuscular; Intrasynovial; Soft tissue, Powder, for solution, Injection, powder, for solution - Intramuscular; Intravenous, Intramuscular; Intrasynovial; Soft tissue, Injection, suspension - Intramuscular; Intrasynovial; Soft tissue, Topical, Gel, Gel - Topical, Kit, Kit; Powder, for solution, Kit; Powder, for solution - Intramuscular; Intravenous, Intra-articular; Intralesional; Intramuscular; Intrasynovial, Suspension, Suspension - Intra-articular; Intralesional; Intramuscular; Intrasynovial, Intra-articular; Intrabursal, Powder, for solution - Intramuscular; Intravenous, Intra-articular; Intramuscular; Intrasynovial; Soft tissue, Suspension - Intra-articular; Intramuscular; Intrasynovial; Soft tissue, Cream, Cream - Topical, Kit; Powder, Kit; Powder - Intramuscular; Intravenous, Lotion, Lotion - Topical, Epidural; Infiltration; Intra-articular; Intralesional; Intramuscular; Soft tissue, Kit - Epidural; Infiltration; Intra-articular; Intralesional; Intramuscular; Soft tissue, Kit - Epidural; Infiltration; Intramuscular; Intrasynovial; Soft tissue; Topical, Epidural; Infiltration; Intramuscular; Intrasynovial; Soft tissue; Topical, Epidural; Infiltration; Intra-articular; Intralesional; Intramuscular; Intravenous; Soft tissue; Subcutaneous; Topical, Infiltration; Intra-articular; Intralesional; Intramuscular; Soft tissue; Topical, Kit - Infiltration; Intra-articular; Intralesional; Intramuscular; Soft tissue; Topical, Kit - Infiltration; Soft tissue; Topical, Infiltration; Soft tissue; Topical, Kit - Epidural; Infiltration; Intra-articular; Intralesional; Intramuscular; Intravenous; Soft tissue; Subcutaneous; Topical, Epidural; Infiltration; Intra-articular; Intralesional; Intramuscular; Soft tissue; Topical, Kit - Epidural; Infiltration; Intra-articular; Intralesional; Intramuscular; Soft tissue; Topical, Infiltration; Intra-articular; Intralesional; Intramuscular; Soft tissue, Kit - Infiltration; Intra-articular; Intralesional; Intramuscular; Soft tissue, Injection, suspension - Intra-articular; Intralesional; Intramuscular; Intrasynovial; Soft tissue, Intra-articular; Intralesional; Intramuscular; Intrasynovial; Soft tissue, Kit - Epidural; Infiltration; Intracaudal, Epidural; Infiltration; Intracaudal, Suspension - Intra-articular; Intrabursal, Epidural; Intracaudal; Perineural, Injection, suspension - Intrabronchial; Intralesional; Intramuscular; Parenteral; Soft tissue, Intrabronchial; Intralesional; Intramuscular; Parenteral; Soft tissue, Kit - Intra-articular; Intralesional; Intramuscular; Soft tissue; Topical, Intra-articular; Intralesional; Intramuscular; Soft tissue; Topical

Craniotomy

Lupus Erythematosus, Discoid

Inflammation

Tendon structure

Crohn Disease

Lichen Planus

Rheumatoid Arthritis

Alopecia Areata

Cystitis

Dermatitis, Seborrheic

Adrenal Cortex Hormones

Iritis

Serum Sickness

Adrenal Insufficiency

Neurodermatitis

Red-Cell Aplasia, Pure

Brain

Asthma

Optic Neuritis

Warnings

Methylprednisolone Acetate has five contraindications and should not be consumed when dealing with any of the conditions in the subsequent table.

Methylprednisolone Acetate Contraindications

Condition

Risk Level

Notes

Pulse Frequency

Do Not Combine

Mycoses

Do Not Combine

neomycin

Do Not Combine

Pulse Frequency

Do Not Combine

Severe Hypersensitivity Reactions

Do Not Combine

Methylprednisolone may interact with Pulse Frequency

There are 20 known major drug interactions with Methylprednisolone Acetate.

Common Methylprednisolone Acetate Drug Interactions

Drug Name

Risk Level

Description

2-Methoxyethanol

Major

The risk or severity of adverse effects can be increased when Methylprednisolone is combined with 2-Methoxyethanol.

9-(N-methyl-L-isoleucine)-cyclosporin A

Major

The risk or severity of adverse effects can be increased when Methylprednisolone is combined with 9-(N-methyl-L-isoleucine)-cyclosporin A.

Abatacept

Major

The risk or severity of adverse effects can be increased when Methylprednisolone is combined with Abatacept.

Abemaciclib

Major

The metabolism of Abemaciclib can be increased when combined with Methylprednisolone.

Abetimus

Major

The risk or severity of adverse effects can be increased when Methylprednisolone is combined with Abetimus.

Methylprednisolone Acetate Toxicity & Overdose Risk

Glucocorticoid overdose has a toxic dose of more than 4g/kg for rats and 2292mg/kg for mice when taken by mouth. Chronic high doses of glucocorticoids can lead to a variety of side effects such as cataracts, glaucoma, high blood pressure, water retention, and mood changes. Immediate overdoses should be treated with supportive care. For chronic overdoses, it is necessary to lower the dosage temporarily.

Methylprednisolone Acetate Novel Uses: Which Conditions Have a Clinical Trial Featuring Methylprednisolone Acetate?

594 active studies are presently investigating the potential of Methylprednisolone Acetate to mitigate Asthma, Atopic Dermatitis and Ulcerative Colitis.

Condition

Clinical Trials

Trial Phases

Ulcerative Colitis

14 Actively Recruiting

Phase 3, Phase 2, Not Applicable, Phase 4, Phase 1

Asthma

92 Actively Recruiting

Phase 1, Phase 4, Early Phase 1, Phase 2, Not Applicable, Phase 3

Rheumatoid Arthritis

55 Actively Recruiting

Not Applicable, Phase 4, Phase 3, Phase 2, Phase 1

Lichen Planus

0 Actively Recruiting

Keloids Scars

0 Actively Recruiting

Arthritis, Gouty

0 Actively Recruiting

exfoliative erythroderma

0 Actively Recruiting

Congenital adrenal hyperplasia

7 Actively Recruiting

Phase 3, Phase 1, Phase 2, Not Applicable

Stevens-Johnson Syndrome

1 Actively Recruiting

Phase 1

Dermatomyositis

0 Actively Recruiting

Psoriatic Arthritis

30 Actively Recruiting

Phase 3, Not Applicable, Phase 1, Phase 4, Phase 2

Ankylosing Spondylitis

3 Actively Recruiting

Phase 3, Not Applicable

Serum Sickness

0 Actively Recruiting

Hay Fever

0 Actively Recruiting

Anemia, Diamond-Blackfan

4 Actively Recruiting

Not Applicable, Phase 1, Phase 2

Granuloma Annulare

0 Actively Recruiting

Craniotomy

0 Actively Recruiting

Addison Disease

0 Actively Recruiting

Brain

0 Actively Recruiting

Psoriasis

0 Actively Recruiting

Methylprednisolone Acetate Reviews: What are patients saying about Methylprednisolone Acetate?

Patient Review

5/18/2011

Methylprednisolone Acetate for Joint Disease which may include Attacks of Acute Arthritis

I was able to do things I love again pain-free within two days. However, the effects only last for about two months before needing another injection

Patient Review

6/30/2014

Methylprednisolone Acetate for Inflammation of the Tendon

After weeks of struggling to breathe due to an allergic reaction and overusing sinus sprays, this intramuscular injection finally provided me with some relief. The swelling in my sinuses and nasal passages went down almost immediately, and I was able to breathe normally again. Follow up treatments with (generic) Flonase and Claritin D have continued the relief.

Patient Review

10/28/2015

Methylprednisolone Acetate for Joint Disease which may include Attacks of Acute Arthritis

This injection treatment quickly (within an hour) and effectively improved my quality of life by reducing the severe pain in my left hip joint. It lasted for about 4-5 weeks before I needed another treatment.

4.7

Patient Review

4/6/2011

Methylprednisolone Acetate for Inflammation of Several Cartilages of the Body

I've had a fracture in my ankle for over two years now, and this treatment has been really effective in helping the healing process. I haven't had to surgery yet, which is great.

4.3

Patient Review

11/10/2013

Methylprednisolone Acetate for Rheumatoid Arthritis

I had this injection to try and help with my pelvic pain, but it's only made things worse. I've been having a lot of bad side effects like numbness and tingling in my feet, and I'm still feeling sick even after a month. I would never do this again.

4.3

Patient Review

10/7/2012

Methylprednisolone Acetate for Rheumatoid Arthritis

I found that the injections took a couple days to work, but they really helped with my fibromyalgia. I was able to do normal household chores and go about my day without having to take as many pain medications. I've had 42 injections so far, and even though it's a lot, I would continue getting them if it means limiting the amount of pain I'm in.

Patient Review

11/25/2009

Methylprednisolone Acetate for Joint Disease which may include Attacks of Acute Arthritis

It's been working pretty well for me so far. Depending on the person, it might take a little longer to work though.

Patient Review

2/1/2017

Methylprednisolone Acetate for Inflammation of the Lining of a Joint

The doctor used this treatment to address my bursitis, which had been severely limiting my mobility and causing a lot of pain. The good news is that the pain was reduced and I have most of my mobility back. However, the injection itself was quite uncomfortable. I'm hoping this will be a permanent fix for my shoulders, but based on what I've read in other people's comments, it sounds like it might only be temporary.

Patient Review

4/10/2009

Methylprednisolone Acetate for Joint Disease which may include Attacks of Acute Arthritis

Patient Review

3/11/2013

Methylprednisolone Acetate for Muscle Pain and Stiffness in Shoulder, Neck and Pelvis

This medication is usually pretty good, but my last injection only lasted for two days. I was in a lot of pain for the month of July as a result.

Patient Review

7/11/2013

Methylprednisolone Acetate for Rheumatoid Arthritis

After watching 60-minutes, I'm convinced that this medication from NECC is deadly.

Patient Review

9/29/2009

Methylprednisolone Acetate for Inflammation of the Lining of a Joint

image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about methylprednisolone acetate

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is methylprednisolone a strong steroid?

"Methylprednisolone is five times as potent as cortisol, while prednisone is only four times as potent."

Answered by AI

Is methylprednisolone acetate a steroid?

"Methylprednisolone is a type of corticosteroid that helps to reduce swelling, redness, itching, and allergic reactions by working on the immune system."

Answered by AI

How long does methylprednisolone acetate injection last?

"The average amount of time it takes for half of the methylprednisolone to be eliminated from the body is 1.8 to 5.2 hours. Total clearance is approximately 5 to 6 ml/min/kg. No dosing adjustments are necessary in renal failure. Methylprednisolone can be removed from the blood by dialysis."

Answered by AI

What is methylprednisolone acetate used for?

"Methylprednisolone can be used to treat pain and swelling that is caused by arthritis or other joint disorders. The medication can also be used to help treat conditions such as blood disorders, severe allergies, certain types of cancer, eye conditions, and diseases affecting the skin, intestines, kidneys, or lungs. Additionally, it can be used to help treat disorders of the immune system."

Answered by AI