Methergine

Angina Pectoris, Variant, Postpartum uterine subinvolution, Vaginal Bleeding + 3 more
Treatment
9 Active Studies for Methergine

What is Methergine

MethylergometrineThe Generic name of this drug
Treatment SummaryErgometrine is a medication similar to ergonovine with an added CH2 group.
Methergineis the brand name
image of different drug pills on a surface
Methergine Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Methergine
Methylergometrine
1946
32

Effectiveness

How Methergine Affects PatientsMethylergometrine is a medicine used to prevent and control bleeding after childbirth or abortion. It belongs to a group of drugs called ergot alkaloids, which work by interacting with certain receptors in the body. These drugs increase the strength and frequency of uterine contractions, and higher doses can lead to sustained contractions.
How Methergine works in the bodyMethylergometrine helps reduce blood loss during labor by increasing the strength and speed of the uterus' contractions. It does this by binding to and blocking the dopamine receptor in the uterus, which causes the uterus to contract more strongly.

When to interrupt dosage

The recommended dosage of Methergine is contingent upon the diagnosed condition, including Uterine Atony, Vaginal Bleeding and Postpartum Haemorrhage (PPH). The measurement of dosage is contingent upon the manner of administration (e.g. Oral or Tablet, coated), as detailed in the table beneath.
Condition
Dosage
Administration
Postpartum Haemorrhage (PPH)
0.2 mg, , 0.2 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Intravenous, Injection - Intravenous
Angina Pectoris, Variant
0.2 mg, , 0.2 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Intravenous, Injection - Intravenous
Spasm provocation test
0.2 mg, , 0.2 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Intravenous, Injection - Intravenous
Vaginal Bleeding
0.2 mg, , 0.2 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Intravenous, Injection - Intravenous
Postpartum uterine subinvolution
0.2 mg, , 0.2 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Intravenous, Injection - Intravenous
Uterine Atony
0.2 mg, , 0.2 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Intravenous, Injection - Intravenous

Warnings

Methergine has two contraindications, and it should not be blended with the conditions indicated in the following table.Methergine Contraindications
Condition
Risk Level
Notes
Pre-eclampsia
Do Not Combine
Hypertensive disease
Do Not Combine
There are 20 known major drug interactions with Methergine.
Common Methergine Drug Interactions
Drug Name
Risk Level
Description
4-Bromo-2,5-dimethoxyphenethylamine
Major
Methylergometrine may increase the hypertensive and vasoconstricting activities of 4-Bromo-2,5-dimethoxyphenethylamine.
4-Methoxyamphetamine
Major
Methylergometrine may increase the hypertensive and vasoconstricting activities of 4-Methoxyamphetamine.
5-methoxy-N,N-dimethyltryptamine
Major
Methylergometrine may increase the vasoconstricting activities of 5-methoxy-N,N-dimethyltryptamine.
Abediterol
Major
Methylergometrine may increase the hypertensive and vasoconstricting activities of Abediterol.
Abemaciclib
Major
The metabolism of Abemaciclib can be decreased when combined with Methylergometrine.
Methergine Toxicity & Overdose RiskOverexposure to this drug can lead to high blood pressure, headaches, low blood pressure, nausea, vomiting, and seizures.

Methergine Novel Uses: Which Conditions Have a Clinical Trial Featuring Methergine?

8 active clinical trials are in progress to assess the potential of Methergine to alleviate Uterine Atony, Postpartum Uterine Subinvolution and Variant Angina Pectoris.
Condition
Clinical Trials
Trial Phases
Postpartum uterine subinvolution
0 Actively Recruiting
Spasm provocation test
0 Actively Recruiting
Uterine Atony
0 Actively Recruiting
Angina Pectoris, Variant
0 Actively Recruiting
Postpartum Haemorrhage (PPH)
3 Actively Recruiting
Phase 2, Not Applicable
Vaginal Bleeding
7 Actively Recruiting
Phase 4, Phase 3, Not Applicable, Phase 2

Methergine Reviews: What are patients saying about Methergine?

5Patient Review
9/26/2009
Methergine for Hemorrhage Following Delivery of Baby
This medication induced labor and allowed me to miscarry.
3Patient Review
2/20/2010
Methergine for Incomplete Abortion
I've only been on this medication for a short time, but it has already made a big difference in my quality of life. I used to suffer from migraines every day, and now I'm almost migraine-free. It's fantastic! I hope there are no long-term side effects though.
2.7Patient Review
2/24/2012
Methergine for Hemorrhage Following Delivery of Baby
I'm not sure if this did anything positive. I would be curious to know if there are any effects on fertility. From my perspective, it seems like time is the best healer.
1Patient Review
1/15/2012
Methergine for Incomplete Abortion
After miscarrying, I was prescribed this medication to help with any residual bleeding. Unfortunately, it made me feel incredibly dizzy and only slightly eased the cramps I was experiencing.
1Patient Review
7/24/2012
Methergine for Incomplete Abortion
After an abortion, I was given this medication which made me feel nauseous and gave me shortness of breath, lightheadedness, numbness/tingling in my chest, and severe pain/heaviness in the center of my chest.
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Patient Q&A Section about methergine

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is Methergine used for?

"Methylergonovine is a medication used to prevent and control bleeding from the uterus that can occur after childbirth. It is classified as an ergot alkaloid. This medicine works by directly affecting the smooth muscles of the uterus and prevents bleeding after childbirth."

Answered by AI

When should Methergine not be given?

"The use of methylergonovine is not recommended for patients who have high blood pressure. Giving methylergonovine intravenously should not be done regularly because it might cause a sudden, severe increase in blood pressure that could lead to a stroke."

Answered by AI

When do you give Methergine?

"To use Methergine, take it by mouth with or without food 3 to 4 times daily for up to 1 week after delivery, or as directed by your doctor. The dosage is based on your medical condition and response to treatment. To get the most benefit from Methergine, use it regularly."

Answered by AI

Why Methergine is given?

"administration of Methergine is rapid, peak effects occur in 2 to 5 minutes, and the duration of action is about 2 hours.

Methergine (methylergonovine maleate)

Methergine is a drug that acts directly on the smooth muscle of the uterus. It increases the tone, rate, and amplitude of rhythmic contractions, which induces a rapid and sustained tetanic uterotonic effect. This effect shortens the third stage of labor and reduces blood loss. The onset of action after I.V. administration of Methergine is rapid, and peak effects occur in 2 to 5 minutes. The duration of action is about 2 hours."

Answered by AI

Clinical Trials for Methergine

Have you considered Methergine clinical trials? We made a collection of clinical trials featuring Methergine, we think they might fit your search criteria.