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What is Methadose
MethadoneThe Generic name of this drug
Treatment SummaryMethadone is an opioid painkiller used to treat severe pain, opioid addiction, and withdrawal symptoms. It works by activating the body’s natural opioids, endorphins, and enkephalins to reduce pain. Compared to other opioids, methadone has a lower risk of neuropsychiatric toxicity and a long-lasting effect, meaning that it requires fewer doses to maintain pain relief or prevent opioid withdrawal. It also has been found to have an anti-excitatory action on the central nervous system, which can improve analgesic efficacy and reduce opioid tolerance. Methadone is a powerful drug and can cause serious side
Methadone Hydrochlorideis the brand name
Methadose Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Methadone Hydrochloride
Methadone
1947
115
Effectiveness
How Methadose Affects PatientsMethadone is a painkiller that can reduce symptoms of opioid withdrawal, and has a lower risk of neuropsychiatric side effects compared to other opioids. It can cause physical dependence and tolerance when taken for a long time, and should be tapered off gradually if no longer needed for pain control. Methadone can cause serious respiratory depression, so it should be used cautiously in elderly or weak people, and those with conditions that affect their breathing. It can also cause QT interval prolongation, which can lead to dangerous arrhythmias, especially when taken in high doses. Taking methadone can cause constipation, decreased reproductive
How Methadose works in the bodyMethadone is a synthetic opioid used to treat pain. It works by binding to opioid receptors in the body, which reduces pain signals. It also blocks a chemical called NMDA and reduces the activity of serotonin and norepinephrine, which also helps reduce pain. Methadone is made up of two different molecules, one of which is more powerful than the other. The more powerful molecule is responsible for the majority of the drug's effects. Methadone has similar effects to morphine, hydromorphone, oxycodone, and fentanyl, but has different properties that make it useful for treating opioid addiction. People
When to interrupt dosage
The proposed dosage of Methadose is contingent upon the diagnosed condition, comprising of Therapeutic procedure, Pain and Opioids. The measure of dosage is subject to the approach of delivery (e.g. Tablet or Oral) as described in the table underneath.Condition
Dosage
Administration
Opioids
, 5.0 mg, 10.0 mg/mL, 10.0 mg, 40.0 mg, 1.0 mg, 25.0 mg, 5.0 mg/mL, 1.0 mg/mg, 0.005 mg, 0.01 mg, 1.0 mg/mL
, Oral, Tablet, Tablet - Oral, Concentrate, Concentrate - Oral, Solution, Solution - Oral, Intramuscular; Intravenous; Subcutaneous, Injection, solution, Injection, solution - Intramuscular; Intravenous; Subcutaneous, Powder, Powder - Oral, Intravenous, Injection, solution - Intravenous
Pain
, 5.0 mg, 10.0 mg/mL, 10.0 mg, 40.0 mg, 1.0 mg, 25.0 mg, 5.0 mg/mL, 1.0 mg/mg, 0.005 mg, 0.01 mg, 1.0 mg/mL
, Oral, Tablet, Tablet - Oral, Concentrate, Concentrate - Oral, Solution, Solution - Oral, Intramuscular; Intravenous; Subcutaneous, Injection, solution, Injection, solution - Intramuscular; Intravenous; Subcutaneous, Powder, Powder - Oral, Intravenous, Injection, solution - Intravenous
Therapeutic procedure
, 5.0 mg, 10.0 mg/mL, 10.0 mg, 40.0 mg, 1.0 mg, 25.0 mg, 5.0 mg/mL, 1.0 mg/mg, 0.005 mg, 0.01 mg, 1.0 mg/mL
, Oral, Tablet, Tablet - Oral, Concentrate, Concentrate - Oral, Solution, Solution - Oral, Intramuscular; Intravenous; Subcutaneous, Injection, solution, Injection, solution - Intramuscular; Intravenous; Subcutaneous, Powder, Powder - Oral, Intravenous, Injection, solution - Intravenous
Opioid Addiction
, 5.0 mg, 10.0 mg/mL, 10.0 mg, 40.0 mg, 1.0 mg, 25.0 mg, 5.0 mg/mL, 1.0 mg/mg, 0.005 mg, 0.01 mg, 1.0 mg/mL
, Oral, Tablet, Tablet - Oral, Concentrate, Concentrate - Oral, Solution, Solution - Oral, Intramuscular; Intravenous; Subcutaneous, Injection, solution, Injection, solution - Intramuscular; Intravenous; Subcutaneous, Powder, Powder - Oral, Intravenous, Injection, solution - Intravenous
maintenance therapy
, 5.0 mg, 10.0 mg/mL, 10.0 mg, 40.0 mg, 1.0 mg, 25.0 mg, 5.0 mg/mL, 1.0 mg/mg, 0.005 mg, 0.01 mg, 1.0 mg/mL
, Oral, Tablet, Tablet - Oral, Concentrate, Concentrate - Oral, Solution, Solution - Oral, Intramuscular; Intravenous; Subcutaneous, Injection, solution, Injection, solution - Intramuscular; Intravenous; Subcutaneous, Powder, Powder - Oral, Intravenous, Injection, solution - Intravenous
Warnings
Methadose has seventeen contraindications, and combining it with any of the conditions in the following table should be avoided.Methadose ContraindicationsCondition
Risk Level
Notes
Paralytic Ileus
Do Not Combine
Labor and Delivery
Do Not Combine
Alcohol Withdrawal Delirium
Do Not Combine
Intestinal Obstruction
Do Not Combine
Respiratory Depression
Do Not Combine
Asthma
Do Not Combine
Colitis
Do Not Combine
Status Asthmaticus
Do Not Combine
convulsive disorders
Do Not Combine
opioid naive
Do Not Combine
Cor Pulmonale
Do Not Combine
Pain
Do Not Combine
Pulse Frequency
Do Not Combine
Mental Depression
Do Not Combine
ethanol
Do Not Combine
Hypercarbia
Do Not Combine
Abdomen
Do Not Combine
Common Methadose Drug Interactions
Drug Name
Risk Level
Description
2,5-Dimethoxy-4-ethylthioamphetamine
Major
The risk or severity of adverse effects can be increased when Methadone is combined with 2,5-Dimethoxy-4-ethylthioamphetamine.
4-Bromo-2,5-dimethoxyamphetamine
Major
The risk or severity of adverse effects can be increased when Methadone is combined with 4-Bromo-2,5-dimethoxyamphetamine.
4-Methoxyamphetamine
Major
The risk or severity of adverse effects can be increased when Methadone is combined with 4-Methoxyamphetamine.
5-methoxy-N,N-dimethyltryptamine
Major
The risk or severity of adverse effects can be increased when Methadone is combined with 5-methoxy-N,N-dimethyltryptamine.
7-Nitroindazole
Major
The risk or severity of adverse effects can be increased when Methadone is combined with 7-Nitroindazole.
Methadose Toxicity & Overdose RiskIn cases of severe overdose, particularly when taken intravenously, apnea, circulation failure, cardiac arrest, and death may occur.
Methadose Novel Uses: Which Conditions Have a Clinical Trial Featuring Methadose?
Presently, there are 7 active clinical trials investigating the utility of Methadose in performing Therapeutic procedures, treating Opioids and decreasing Opioid Addiction.Condition
Clinical Trials
Trial Phases
Opioid Addiction
6 Actively Recruiting
Not Applicable, Phase 2, Phase 3
maintenance therapy
0 Actively Recruiting
Pain
0 Actively Recruiting
Opioids
0 Actively Recruiting
Therapeutic procedure
0 Actively Recruiting
Methadose Reviews: What are patients saying about Methadose?
5Patient Review
5/19/2010 Methadone was a godsend during my withdrawal from heroin. It eased my pain and helped me feel normal again. I would highly recommend it to anyone struggling with opiod abuse.
5Patient Review
6/5/2010 This medication has been hugely effective in managing my pain, with no negative side effects. I've been taking it for three years now and have no complaints.
5Patient Review
5/24/2011 This treatment was vital for my recovery.
4.7Patient Review
6/10/2010 Addresses pain effectively when taken as directed. The only side effect I've experienced is hot flashes.
4.7Patient Review
9/26/2013 The 40 Mg. Dispersable tabs are great for chronic pain relief.
4.3Patient Review
1/3/2010 I've been managing my pain for twelve years and have tried every medication out there. When my surgeon disagreed with my pain management doctor's treatment plan, they decided it would be best if I found a new doctor. However, I'm doing much better now that I'm on methadone. It controls the pain and helps with my appetite. Plus, it only needs to be taken once a day!
4.3Patient Review
11/3/2010 I found this treatment really helped with my mobility.
4.3Patient Review
9/25/20093.7Patient Review
12/2/2009 I had no idea that it would take this long for the drug to leave my system. I also didn't know that withdrawing from it, even slowly, could cause such severe problems. I think people need more education before prescribing this medication so they can make an informed decision about whether or not to use it.
3.3Patient Review
4/30/2010 Methadone stays in your system for a long time. I would recommend seeking professional help if you're struggling with addiction.
3.3Patient Review
9/1/2013 What other drugs does methadone interact with?
3.3Patient Review
6/1/2014 I found this didn't do much for my sore throat and it wasn't long lasting either.
1.7Patient Review
2/25/2020 This new version of Methadone is complete garbage. I never once felt the supposed 24 hours of effectiveness. Most of the time, I took my dose at 10 am and felt withdrawal symptoms as early as 3:30 am or 5 am. That's only 19 to 17.5 hours of coverage!
Patient Q&A Section about methadose
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is another name for methadone?
"Methadone is a type of drug known as an opioid agonist. This means that it mimics the effects of drugs like heroin and morphine. It is used to treat chronic pain, as well as addiction to other opioids."
Answered by AI
What is Methadose pill?
"Methadone is a medication used to treat severe chronic pain and opioid addiction. It is a very strong painkiller and has serious risks for deadly overdose and drug dependence."
Answered by AI
Is methadone and Methadose the same thing?
"Methadone is a medication that has been used to treat opioid addiction for more than 50 years. It is available in different brands, including Methadose and generic versions. There are no clinical differences between the various types of methadone."
Answered by AI