Mellaril

Schizophrenia, Schizophrenia, Alzheimer's Disease
Treatment
1 FDA approval
20 Active Studies for Mellaril

What is Mellaril

ThioridazineThe Generic name of this drug
Treatment SummaryThioridazine is a type of antipsychotic medication used to treat schizophrenia and agitation. It does not have the same anti-nausea effects as other similar medications, but it has a lower risk of causing side effects like muscle stiffness. Thioridazine was taken off the market in 2005 due to its association with heart rhythm problems.
Thioridazine Hydrochlorideis the brand name
Mellaril Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Thioridazine Hydrochloride
Thioridazine
1983
20

Approved as Treatment by the FDA

Thioridazine, also called Thioridazine Hydrochloride, is approved by the FDA for 1 uses which include Schizophrenia .
Schizophrenia
Helps manage Schizophrenia

Effectiveness

How Mellaril Affects PatientsThioridazine is a drug used to treat schizophrenia and other mental health disorders. It has not been found to be helpful in managing behavioral issues in people with intellectual disabilities.
How Mellaril works in the bodyThioridazine works by blocking two types of dopamine receptors in the brain. It also reduces the effects of certain hormones released by the hypothalamus and pituitary gland, and suppresses activity in the parts of the brain that control metabolism, body temperature, alertness and vomiting.

When to interrupt dosage

The advised dose of Mellaril is contingent upon the diagnosed condition, like Schizophrenia, Alzheimer's Disease and Schizophrenia. The measure of dosage fluctuates as per the method of administration depicted in the table below.
Condition
Dosage
Administration
Schizophrenia
5.0 mg/mL, 50.0 mg, 25.0 mg, , 100.0 mg, 200.0 mg, 10.0 mg, 2.0 mg/mL, 30.0 mg/mL, 10.0 mg/mL
Tablet, , Suspension, Solution, Tablet, film coated - Oral, Oral, Tablet - Oral, Tablet, film coated, Solution - Oral, Liquid, Suspension - Oral, Liquid - Oral
Alzheimer's Disease
5.0 mg/mL, 50.0 mg, 25.0 mg, , 100.0 mg, 200.0 mg, 10.0 mg, 2.0 mg/mL, 30.0 mg/mL, 10.0 mg/mL
Tablet, , Suspension, Solution, Tablet, film coated - Oral, Oral, Tablet - Oral, Tablet, film coated, Solution - Oral, Liquid, Suspension - Oral, Liquid - Oral
Schizophrenia
5.0 mg/mL, 50.0 mg, 25.0 mg, , 100.0 mg, 200.0 mg, 10.0 mg, 2.0 mg/mL, 30.0 mg/mL, 10.0 mg/mL
Tablet, , Suspension, Solution, Tablet, film coated - Oral, Oral, Tablet - Oral, Tablet, film coated, Solution - Oral, Liquid, Suspension - Oral, Liquid - Oral

Warnings

Mellaril Contraindications
Condition
Risk Level
Notes
Mental Depression
Do Not Combine
Cardiac Arrhythmia
Do Not Combine
Comatose
Do Not Combine
Toxoplasma Infections
Do Not Combine
Hypotension
Do Not Combine
Cytochrome P450
Do Not Combine
Long QT Syndrome
Do Not Combine
extremely hypertensive heart disease
Do Not Combine
Toxoplasma Infections
Do Not Combine
There are 20 known major drug interactions with Mellaril.
Common Mellaril Drug Interactions
Drug Name
Risk Level
Description
4-Methoxyamphetamine
Major
The metabolism of 4-Methoxyamphetamine can be decreased when combined with Thioridazine.
5-methoxy-N,N-dimethyltryptamine
Major
The metabolism of 5-methoxy-N,N-dimethyltryptamine can be decreased when combined with Thioridazine.
Acebutolol
Major
The metabolism of Acebutolol can be decreased when combined with Thioridazine.
Acepromazine
Major
Thioridazine may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Acepromazine.
Alfuzosin
Major
Thioridazine may increase the hypotensive activities of Alfuzosin.
Mellaril Toxicity & Overdose RiskThe lowest toxic dose of the drug in rats is between 956-1034mg/kg when taken orally. Overdosing can cause symptoms such as agitation, blurred vision, confusion, constipation, difficulty breathing, dilated or constricted pupils, dry mouth and skin, low body temperature, low blood pressure, fluid in the lungs, heart abnormalities, inability to urinate, intestinal blockage, nasal congestion, restlessness, sedation, seizures, and shock.

Mellaril Novel Uses: Which Conditions Have a Clinical Trial Featuring Mellaril?

241 active clinical trials are presently examining the potential of Mellaril to alleviate Schizophrenia, Alzheimer's Disease and Schizophrenic Symptoms.
Condition
Clinical Trials
Trial Phases
Schizophrenia
29 Actively Recruiting
Not Applicable, Early Phase 1, Phase 4
Alzheimer's Disease
41 Actively Recruiting
Phase 2, Phase 3, Phase 4, Not Applicable, Phase 1
Schizophrenia
171 Actively Recruiting
Not Applicable, Phase 2, Phase 3, Early Phase 1, Phase 4, Phase 1

Mellaril Reviews: What are patients saying about Mellaril?

5Patient Review
10/24/2007
Mellaril for Schizophrenia
Millaril was much more effective than Seroquel in helping my anxiety and nervous habits, like pulling out my hair. And it's way cheaper too!
3.7Patient Review
5/7/2009
Mellaril for Schizophrenia
I'm starting to experience congestive heart failure.
1Patient Review
3/9/2008
Mellaril for Schizophrenia
I was misdiagnosed with Schizophrenia over 14 years ago and as a result, took Mellaril for an extended period of time. I have since stopped taking the medication, but have developed a heart condition because of it. This is extremely frustrating as I never actually had a mental illness to begin with.

Patient Q&A Section about mellaril

Is Mellaril still available?

"The Mellaril brand name has been discontinued, but there may be generic equivalents available in the US." - Anonymous Online Contributor

Unverified Answer

What kind of drug is Mellaril?

"Mellaril is a medication used to treat psychotic disorders such as schizophrenia. It is usually given after other medications have been tried without successful treatment of schizophrenia." - Anonymous Online Contributor

Unverified Answer

Is Mellaril the same as Thorazine?

"Thorazine and Mellaril are two different brands of drugs that have similar effects. Thorazine is a brand name for chlorpromazine, and thioridazine is the generic name of Mellaril. Both of these drugs are antipsychotics that work by blocking dopamine receptors in the brain." - Anonymous Online Contributor

Unverified Answer

What is Mellaril prescribed for?

"It can reduce aggression and the desire to hurt others. It can reduce aggression and the desire to hurt others.

  1. This medication is used to treat certain mental/mood disorders (such as schizophrenia).

  2. This medication helps you to think more clearly, feel less nervous, and take part in everyday life.

  3. It can also help prevent suicide in people likely to harm themselves and reduce aggression and the desire to hurt others.

  4. It can reduce aggression and the desire to hurt others.

  5. It can reduce aggression and the desire to hurt others.

  6. This medication is a psychiatric medication (a type of drug) that works by restoring the balance of certain natural substances (neurotransmitters) in the brain.

  7. This medication is a psychiatric medication (a type of drug) that works by restoring the balance of certain natural substances (neurotransmitters) in the brain.

  8. This medication is a psychiatric medication (a type of drug) that works by restoring the balance of certain natural substances (neurotransmitters) in the brain.

  9. This medication is a psychiatric medication (a type of drug) that works by restoring the balance of certain natural substances (neurotransmitters) in the brain.

  10. This medication is a psychiatric medication (a type of drug) that works by restoring the balance of certain natural substances (neurotransmitters) in the brain.

  11. This medication is a psychiatric medication (a type of drug) that works by restoring the balance of certain natural substances (neurotransmitters) in the brain.

  12. This medication is a psychiatric medication (a type of drug) that works by restoring the balance of certain natural substances (neurotransmitters) in the brain." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Clinical Trials for Mellaril

Image of Collaborative Neuroscience Research in Garden Grove, United States.
Phase-Based Progress Estimates
1
Effectiveness
2
Safety

RL-007 20 Mgfor Cognitive Impairment Associated With Schizophrenia

Garden Grove, CA
18 - 55
All Sexes
The goal of this clinical trial is to evaluate if the investigational drug, RL-007, can improve the cognitive performance of subjects with schizophrenia. The main questions the study aims to answer are: Does RL-007 improve subjects performance in a set of cognitive tasks? Which dose of RL-007 (20 mg or 40 mg) has a larger effect on cognitive performance? How well do subjects tolerate RL-007? In the study, subjects will perform the cognitive tasks at the beginning to get familiar with the tasks. Then, subjects will be given either RL-007 or a placebo for 6 weeks and then repeat the cognitive tasks. The researchers will compare the results at the end of the treatment period to the baseline to see if there have been any changes in performance. Additionally, several safety measures will be collected throughout the study (blood pressure, physical exam, ECGs, etc) to evaluate if there are any side effects from taking RL-007.
Phase 2
Recruiting
Collaborative Neuroscience ResearchGary Walker, PhDRecognify Life Sciences
Have you considered Mellaril clinical trials? We made a collection of clinical trials featuring Mellaril, we think they might fit your search criteria.
Image of Massachusetts Institute of Technology in Cambridge, United States.
Phase-Based Progress Estimates
1
Effectiveness
1
Safety

Alzheimer's Active Armfor Alzheimer's Disease

Cambridge, MA
50 - 100
All Sexes
Alzheimer's disease (AD) is characterized by significant memory loss, toxic protein deposits amyloid and tau) in the brain, and changes in the gamma frequency band on EEG. The investigator's lab found that boosting gamma waves in AD mouse models using light and sound stimulation at 40Hz not only reduced amyloid and tau in the brain, but also improved memory. The investigators developed a light and sound device for humans that stimulates the brain at 40Hz that can be used safely at home. For the present study, 50 participants with mild Alzheimer's disease will be enrolled and will use this light and sound device at-home daily for 6-months. Investigators will measure changes in brain waves with EEG, blood biomarkers, the microbiome via fecal samples, functional and structural MRI scans, memory and cognitive testing, and questionnaires at 3 in-person visits throughout the study. After the 6-month time point, participants will have the option of continuing in the study for one additional year and completing an 18-month study visit. This study will provide critical insight into extended therapy involving non-invasive 40Hz sensory stimulation as a possible therapeutic strategy for mild to moderate Alzheimer's disease.
Recruiting
Device
Massachusetts Institute of TechnologyLi Huei Tsai, PhD
Have you considered Mellaril clinical trials? We made a collection of clinical trials featuring Mellaril, we think they might fit your search criteria.
Image of NYU Langone Brooklyn in Brooklyn, United States.
Phase-Based Progress Estimates
1
Effectiveness
2
Safety

Sham, Then Pulsed Low-Intensity Focused Ultrasound (PLIFUS)for Schizophrenia

Brooklyn, NY
18 - 50
All Sexes
This is a single-site, phase 2, sham-controlled random-order cross-over pilot trial of PLIFUS targeting the right GPi in individuals with schizophrenia. Twelve individuals with schizophrenia who report continuous hallucinations or delusions of mild or greater severity will receive one session of PLIFUS and one session of sham PLIFUS in random order, one week apart. If no effect of PLIFUS is detected on measures of functional connectivity or psychotic symptoms in the first four completers, the trial will be changed to 3 sessions of PLIFUS or sham administered over 5 days.
Phase 2
Waitlist Available
NYU Langone Brooklyn (+1 Sites)Donald Goff, MD
Image of Advanced Discovery Research, LLC in Atlanta, United States.
Phase-Based Progress Estimates
2
Effectiveness
3
Safety

KarXTfor Schizophrenia

Atlanta, GA
18 - 65
All Sexes
This is a Phase 3b, 3-year, open-label, multi-center study in which patients with DSM-5 diagnosis of schizophrenia whose current medication(s) is not well tolerated and/or clinical symptoms are not well controlled will be switched to receive KarXT. The primary objectives of the study are to assess the long-term safety and tolerability of KarXT and assess effectiveness, persistence, and durability of effect of KarXT through the Investigator Assessment Questionnaire (IAQ) and Clinical Global Impression - Severity of Illness (CGI-S) scale in patients with a diagnosis of schizophrenia. The secondary objectives are to further assess the effectiveness using the Clinical Global Impression, Global Improvement (CGI-I), long-term safety and tolerability of KarXT, and evaluation of scores from multiple additional patient scales and assessments throughout the study.
Phase 3
Recruiting
Advanced Discovery Research, LLC (+4 Sites)Karuna Therapeutics
Have you considered Mellaril clinical trials? We made a collection of clinical trials featuring Mellaril, we think they might fit your search criteria.