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What is Maxzide-25
TriamtereneThe Generic name of this drug
Treatment SummaryTriamterene is a medication used to treat high blood pressure. It helps the body to get rid of excess salt and water while also preventing the loss of potassium. Triamterene can cause high levels of potassium in the blood and can also make the skin more sensitive to sunlight. It was first approved by the FDA in 1964 and is often used in combination with other diuretics to enhance the effects.
Maxzideis the brand name
Maxzide-25 Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Maxzide
Triamterene
1988
188
Effectiveness
How Maxzide-25 Affects PatientsTriamterene is a medicine used to control high blood pressure and fluid retention (edema). It works by reducing the amount of sodium and potassium lost in the urine. While this usually leads to lower sodium levels in the body, it can also cause higher than normal levels of potassium in the blood (hyperkalemia) which can lead to heart problems. In addition, it increases the amount of sodium and magnesium lost in the urine, and decreases the amount of uric acid and creatinine. Triamterene does not affect calcium excretion. Studies have shown that taking it with a diuretic (hyd
How Maxzide-25 works in the bodyTriamterene helps reduce water in the body by blocking sodium from entering cells. This decreases the amount of sodium that can be exchanged for potassium and hydrogen ions, forcing more sodium to be excreted in urine. Triamterene also helps to reduce the loss of potassium, hydrogen, and chloride ions by inhibiting sodium exchange. Its effects are similar to those of amiloride, but it also increases the amount of magnesium excreted in urine.
When to interrupt dosage
The recommended dosage of Maxzide-25 hinges upon the determined illness, for example Cirrhosis, Hypokalemia and Edema. The amount of dosage also varies as per the method of delivery (e.g. Capsule or Tablet - Oral) specified in the table below.Condition
Dosage
Administration
Edema
, 75.0 mg, 37.5 mg, 50.0 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral
Diuretics
, 75.0 mg, 37.5 mg, 50.0 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral
Hypokalemia
, 75.0 mg, 37.5 mg, 50.0 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral
Cirrhosis
, 75.0 mg, 37.5 mg, 50.0 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral
Hypertensive disease
, 75.0 mg, 37.5 mg, 50.0 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral
Swollen feet or ankles
, 75.0 mg, 37.5 mg, 50.0 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral
Nephrotic Syndrome
, 75.0 mg, 37.5 mg, 50.0 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral
Edema
, 75.0 mg, 37.5 mg, 50.0 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral
Edema
, 75.0 mg, 37.5 mg, 50.0 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral
Thiazides
, 75.0 mg, 37.5 mg, 50.0 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral
Congestive Heart Failure
, 75.0 mg, 37.5 mg, 50.0 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral
Warnings
Maxzide-25 has five contraindications, so it should not be compounded with any of the conditions in the given table.Maxzide-25 ContraindicationsCondition
Risk Level
Notes
severe progressive kidney disease
Do Not Combine
elevated serum potassium levels
Do Not Combine
Pulse Frequency
Do Not Combine
Anuria
Do Not Combine
Liver diseases
Do Not Combine
Common Maxzide-25 Drug Interactions
Drug Name
Risk Level
Description
Cyclosporine
Major
The risk or severity of hyperkalemia can be increased when Triamterene is combined with Cyclosporine.
Neomycin
Major
The risk or severity of nephrotoxicity can be increased when Triamterene is combined with Neomycin.
Tacrolimus
Major
The risk or severity of hyperkalemia can be increased when Triamterene is combined with Tacrolimus.
Tenofovir
Major
Triamterene may increase the nephrotoxic activities of Tenofovir.
Tenofovir alafenamide
Major
Triamterene may increase the nephrotoxic activities of Tenofovir alafenamide.
Maxzide-25 Toxicity & Overdose RiskTriamterene is toxic in high doses, with an oral LD50 of 400mg/kg in rats and 285-380mg/kg in mice. If a person ingests too much Triamterene, they may experience nausea, vomiting, weakness, and low blood pressure due to electrolyte imbalances. There is no specific antidote, so treatment involves inducing vomiting or using gastric lavage to remove the drug and monitoring electrolyte levels. Animal studies have shown an increased incidence of liver tumors, but this was not dose-dependent and there was no difference from control groups. Triamterene has not
Maxzide-25 Novel Uses: Which Conditions Have a Clinical Trial Featuring Maxzide-25?
138 ongoing clinical trials are assessing the potential of Maxzide-25 for the alleviation of Cirrhosis, Hypokalemia and Nephrotic Syndrome.Condition
Clinical Trials
Trial Phases
Nephrotic Syndrome
10 Actively Recruiting
Phase 2, Not Applicable, Phase 3
Edema
0 Actively Recruiting
Swollen feet or ankles
40 Actively Recruiting
Phase 1, Phase 2, Not Applicable, Early Phase 1, Phase 3, Phase 4
Cirrhosis
50 Actively Recruiting
Phase 1, Phase 2, Not Applicable, Phase 4, Phase 3, Early Phase 1
Diuretics
0 Actively Recruiting
Edema
0 Actively Recruiting
Congestive Heart Failure
24 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 1
Thiazides
0 Actively Recruiting
Edema
0 Actively Recruiting
Hypertensive disease
19 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Hypokalemia
0 Actively Recruiting
Maxzide-25 Reviews: What are patients saying about Maxzide-25?
5Patient Review
5/28/2011 I was diagnosed with Menier's disease about a year ago. I'm a PhD candidate and had a lot of stress. After six months of taking this medicine (once a day) it often caused me very painful muscle cramps, almost daily. My doctor encouraged me to eat banana, drink more water, avoid caffeine (especially coffee), and to drink a little of Tonic Water for muscle cramps. My doctor advised me to take it every other day and it works for me.
5Patient Review
5/23/2013 I was only on this medication for a month, and it dangerously lowered my sodium levels. I had to be hospitalized as a result.
5Patient Review
3/25/2011 I found that this medication only started working for me when I lowered the stress in my life and added grapefruit and bananas to my diet. It made me tired, blurry-eyed, and increased the pain in my ankles and feet. I also experienced skin rashes while taking it. I am currently tapering off of the medication. Magnesium Oxide (OTC) and Inositol Choline have helped me with no side effects at all.
4.7Patient Review
11/26/2013 I am experiencing vertigo and nausea.
4.3Patient Review
6/29/2011 The medication has helped lower my blood pressure. The only downside is that I seem to need to urinate all the time.
4.3Patient Review
3/10/2011 I occasionally felt dizzy or tired, but this is to be expected with any medication.
3.7Patient Review
7/13/2014 I have an enlarged liver and I'm wondering if this drug is the cause. I take 12.5mg of it every morning as prescribed by my doctor for pre-hypertension. Can anyone help me out?
3.7Patient Review
1/16/20113Patient Review
9/14/2011 Maxzide does what it's supposed to do, but I'm now dealing with an itchy rash all over my body. Not sure if this is a side effect of the medication or not.
3Patient Review
3/11/20103Patient Review
1/30/2012 I get nauseous from this medication.
3Patient Review
2/21/2013 I had some swelling in my extremities.
2.3Patient Review
1/27/20102Patient Review
7/18/2011 Since taking this medication, my sex life has decreased significantly. While it does help keep my blood pressure under control, the trade-off is not worth it.
1.7Patient Review
8/20/2013 The medication is effective, but I have to use the restroom more frequently at night.
1Patient Review
9/17/2012 I started experiencing joint and muscle pain after only 45 days of taking this medication. It's similar to the pain I felt when I was taking cholesterol-reducing medication.
Patient Q&A Section about maxzide-25
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is Maxzide used to treat?
"This drug lowers blood pressure by helping the body get rid of excess water and salt."
Answered by AI
What are the side effects of Triamterene HCTZ 37.5 25?
"The following are potential side effects: stomach pain, nausea, diarrhea, constipation, dizziness, headache, blurred vision, or dry mouth."
Answered by AI
What are the side effects of maxzide 25?
"If you experience any of the following symptoms, you should seek medical attention immediately as they may be signs of a serious allergic reaction: yellowing of the skin or eyes, a blistering, peeling, red skin rash, unusual bleeding or bruising, confusion, weakness, an uneven heartbeat, difficulty breathing, numbness or tingling in the extremities, or a fever accompanied by chills, a cough, a sore throat, or body aches."
Answered by AI
What is the generic name for Maxzide?
"The generic name for the oral drug triamterene/hydrochlorothiazide is hydrochlorothiazide/triamterene."
Answered by AI